T. Shiba

发表

Chemical structure of lipid A

E. Rietschel, C. Galanos, S. Kusumoto, 1985 .

Synthesis of 6-O-Acyl Derivatives of Immunoadjuvant Active N-Acetylmuramyl-L-alanyl-D-isoglutamine

S. Kusumoto, S. Okada, Koji Yamamoto, 1978 .

Possible Chemotaxis of Human Monocytes by N-Acetylmuramyl-l-Alanyl-d-Isoglutamine

T. Ogawa, S. Kusumoto, T. Shiba, 1983, Infection and Immunity.

Stimulation ofMigration ofHumanMonocytes byBacterial CellWallsandMuramylPeptides

T. Ogawa, S. Kusumoto, T. Shiba, 1982 .

Aldehyde oxidase-dependent marked species difference in hepatic metabolism of the sedative-hypnotic, zaleplon, between monkeys and rats.

T. Naruke, T. Shiba, K. Kawashima, 1999, Drug metabolism and disposition: the biological fate of chemicals.

Total synthesis of peptide antibiotic nisin

H. Fujita, K. Fukase, A. Sano, 1988 .

Interactive nmr and computer simulation studies of lanthionine‐ring structures

H. Fujita, K. Fukase, D. Mierke, 1989, Biopolymers.

Comparative X-ray and Fourier-transform-infrared investigations of conformational properties of bacterial and synthetic lipid A of Escherichia coli and Salmonella minnesota as well as partial structures and analogues thereof.

D. Naumann, S. Kusumoto, E. Rietschel, 1989, European journal of biochemistry.

Activation of the Human Complement Cascade by Bacterial Cell Walls, Peptidoglycans, Water‐Soluble Peptidoglycan Components, and Synthetic Muramylpeptides—Studies on Active Components and Structural Requirements

S. Kusumoto, M. Matsumoto, H. Takada, 1987, Microbiology and immunology.

Solid phase synthesis of N- and O-glycopeptide by Boc-strategy

K. Nakajima, T. Shiba, T. Teshima, 2002 .

Laser desorption mass spectrometry of synthetic lipid A-like compounds.

U. Zähringer, S. Kusumoto, E. Rietschel, 1984, Biomedical mass spectrometry.

Purification and cDNA cloning of porcine brain GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1-->6fucosyltransferase.

S. Fujii, N. Taniguchi, E. Miyoshi, 1996, The Journal of biological chemistry.

The structure of ancovenin, a new peptide inhibitor of angiotensin I converting enzyme

T. Shiba, T. Wakamiya, Y. Ueki, 1985 .

A rigid 1,3,5-phenylene-based metallodendrimer containing a ruthenium(II) bis(terpyridyl) complex

K. Hanabusa, H. Shirai, M. Kimura, 2000 .

Mitogenic Effects of Bacterial Cell Walls, Their Fragments, and Related Synthetic Compounds on Thymocytes and Splenocytes of Guinea Pigs

S. Kusumoto, I. Yano, H. Takada, 1979, Infection and immunity.

Synthesis of a new neurotoxin NSTX-3 of Papua New Guinean spider

N. Kawai, T. Nakajima, T. Shiba, 1987 .

Liberation of serotonin from rabbit blood platelets by bacterial cell walls and related compounds

T. Nakajima, S. Kusumoto, H. Takada, 1982, Infection and immunity.

Inhibition of macrophage migration by muramyl peptides

T. Shiba, S. Nagao, S. Kotani, 1979, Infection and immunity.

Structure determination of lepidopteran, self-defense substance produced by silkworm

T. Shiba, T. Nakai, Y. Ueki, 1986 .

Macrophages are stimulated by muramyl dipeptide to induce polymorphonuclear leukocyte accumulation in the peritoneal cavities of guinea pigs

S. Kusumoto, T. Shiba, K. Yagawa, 1990, Infection and immunity.

Key structures of bacterial peptidoglycan and lipopolysaccharide triggering the innate immune system of higher animals: Chemical synthesis and functional studies

K. Fukase, S. Kusumoto, T. Shiba, 2010, Proceedings of the Japan Academy. Series B, Physical and biological sciences.

Construction of regulated nanospace around a porphyrin core.

K. Hanabusa, M. Kimura, N. Kobayashi, 2001, Journal of the American Chemical Society.

Stereochemical studies of a selenium-containing hydrogenase from Methanococcus vannielii: determination of the absolute configuration of C-5 chirally labeled dihydro-8-hydroxy-5-deazaflavin cofactor.

T. Stadtman, S. Yamazaki, A. Nakaji, 1985, Proceedings of the National Academy of Sciences of the United States of America.

Polyclonal B Cell Activation by Cell Wall Preparations of Gram‐Positive Bacteria

M. Tanabe, S. Kusumoto, M. Nakano, 1980, Microbiology and immunology.

Chemical Synthesis of N-Acetylmuramyl Peptides with Partial Structures of Bacterial Cell Wall and Their Analogs in Relation to Immunoadjuvant Activities

S. Kusumoto, K. Ikenaka, T. Shiba, 1976 .

Effectiveness of liposomes as potential carriers of vaccines: applications to cholera toxin and human malaria sporozoite antigen.

J. Moss, R. Wirtz, C. Alving, 1986, Vaccine.

Isolation and characterization of ancovenin, a new inhibitor of angiotensin I converting enzyme, produced by actinomycetes.

T. Shiba, T. Yoshida, T. Wakamiya, 1983, The Journal of antibiotics.

Chemical synthesis of phosphorylated tetraacyl disaccharide corresponding to a biosynthetic precursor of lipid A

S. Kusumoto, M. Imoto, T. Shiba, 1984 .

Structural requirements of muramylpeptides for induction of necrosis at sites primed with Mycobacterium tuberculosis in guinea pigs

M. Kiso, A. Hasegawa, S. Kusumoto, 1987, Infection and immunity.

Liposomes as vehicles for vaccines.

C. Alving, R. Richards, J. Clements, 1980, Progress in clinical and biological research.

Antibacterial activity of palmitoyltuberactinamine N and di-beta-lysylcapreomycin IIA.

T. Yamada, T. Shiba, T. Wakamiya, 1983, The Journal of antibiotics.

Crystallization and preliminary X-ray analysis of a bacterial lysozyme produced by Streptomyces globisporus.

Y. Satow, H. Naitow, Y. Kai, 2000, Acta crystallographica. Section D, Biological crystallography.

The total structure of the antibiotic longicatenamycin.

T. Shiba, Y. Mukunoki, 1975, The Journal of antibiotics.

Vaccination of experimental monkeys against Plasmodium falciparum: a possible safe adjuvant.

S. Kusumoto, D. Taylor, T. Shiba, 1978, Science.

Mitogenic activities of synthetic lipid A analogs and suppression of mitogenicity of lipid A

K. Tanamoto, C. Galanos, S. Kusumoto, 1984, Infection and immunity.

Immunological analysis of the phosphorylation state of maize C4-form phosphoenolpyruvate carboxylase with specific antibodies raised against a synthetic phosphorylated peptide.

K. Nakajima, H. Sakakibara, T. Sugiyama, 2000, The Plant journal : for cell and molecular biology.

Biological activity of synthetic heptaacyl lipid A representing a component of Salmonella minnesota R595 lipid A.

C. Galanos, M. Freudenberg, S. Kusumoto, 1986, European journal of biochemistry.

An Inversion of Configuration of Threonine and Allothreonine in the N,O-Acyl Migration Reaction with Concentrated Sulfuric Acid

T. Shiba, T. Wakamiya, Y. Tarumi, 1974 .

Syntheses of sialic acid isomers with inhibitory activity against neuraminidase

T. Shiba, Toshihiro Yamamoto, T. Teshima, 1992 .

Synthesis of Alanyl-1-aminoethanesulfonic Acid

S. Kusumoto, T. Shiba, K. Miyoshi, 1977 .

Selective Chemical Cleavage of Threonine Peptides

S. Kusumoto, T. Shiba, T. Kaneko, 1968 .

Endotoxic properties of synthetic pentaacyl lipid A precursor Ib and a structural isomer.

C. Galanos, M. Freudenberg, S. Kusumoto, 1987, European journal of biochemistry.

CHEMICAL SYNTHESIS AND BIOLOGICAL ACTIVITY OF LIPID A ANALOGS

S. Kusumoto, T. Shiba, 1985 .

Immunopharmacological activities of a synthetic counterpart of a biosynthetic lipid A precursor molecule and of its analogs

T. Ogawa, S. Kusumoto, H. Takada, 1985, Infection and immunity.

Synthesis of sialic acid through aldol condensation of glucose with oxalacetic acid

T. Shiba, Toshihiro Yamamoto, T. Teshima, 1992 .

Quantitative measurement of caspase-3 activity in a living starfish egg.

K. Chiba, T. Shiba, T. Teshima, 2006, Biochemical and biophysical research communications.

Lipopolysaccharides: structural principles and biologic activities.

K. Tanamoto, E. Rietschel, C. Galanos, 1984, Reviews of infectious diseases.

Conversion of 3,5-diiodotyrosine to thyroxine by rattlesnake venom.

T. Shiba, H. Cahnmann, 1962, Biochimica et biophysica acta.

Adjuvant and antitumour activities of synthetic lipid A analogues.

J. Iida, I. Azuma, S. Kusumoto, 1986, Vaccine.

Stimulating effect of MDP and its adjuvant-active analogues on guinea pig fibroblasts for the production of thymocyte-activating factor

S. Kusumoto, T. Shiba, S. Kotani, 1983, The Journal of experimental medicine.

Total synthesis of an antifungal cyclic depsipeptide aureobasidin A

K. Takesako, I. Kato, T. Shiba, 1996 .

Isolation of reddish-violet peptide complex containing ferrous ion from Serratia marcescens Z-54

H. Matsunaga, Y. Kimura, T. Shiba, 1993 .

Synthetic Salmonella-type lipid A antigen with high serological specificity

S. Kusumoto, S. Arata, K. Okuda, 1986, Infection and immunity.

Somnogenic activities of synthetic lipid A

J. Krueger, S. Kusumoto, T. Shiba, 1989, Infection and immunity.

Intracellular serine-protease zymogen, factor C, from horseshoe crab hemocytes. Its activation by synthetic lipid A analogues and acidic phospholipids.

T. Kobayashi, S. Kusumoto, S. Iwanaga, 1988, European journal of biochemistry.

Chemical Studies on Tuberactinomycin. IX. Nuclear Magnetic Resonance Studies on Tuberactinomycins and Tuberactinamine N

T. Shiba, T. Wakamiya, 1975 .

Chemical studies on tuberactinomycin. II. The structure of tuberactinomycin 0

T. Noda, T. Take, K. Nakatsu, 1971 .

4-Azidobutyryl Group for Temporary Protection of Hydroxyl Functions

S. Kusumoto, K. Sakai, T. Shiba, 1986 .

Structure and synthesis of putreanine. A new amino acid isolated from mammalian brain.

T. Shiba, I. Kubota, T. Kaneko, 1970, Tetrahedron.

REDUCTION OF CARBOXYLIC ACIDS TO ALCOHOLS THROUGH 1-SUCCINIMIDYL ESTERS WITH NaBH4

J. Nikawa, T. Shiba, 1979 .

Synthetic study on peptide antibiotic nisin. IV, Synthesis of ring D-E

K. Fukase, A. Sano, T. Shiba, 1990 .

Synthesis of dehydroxymethylbulgecin a

T. Shiba, K. Yamanoi, T. Wakamiya, 1987 .

Preparation of novel pyranosyl fluorides of 3-deoxy-D--2-octulosonic acid (KDO) feasible for synthesis of KDO α-glycosides

N. Kusunose, Y. Matsuura, S. Kusumoto, 1987 .

Total synthesis of capreomycin

T. Shiba, S. Nomoto, T. Wakamiya, 1978 .

The revised structure of capreomycin.

T. Shiba, S. Nomoto, T. Wakamiya, 1977, The Journal of antibiotics.

Racemization of Amino Acid Residues Fused in Thiazoline, Oxazoline, and Imidazoline Rings

T. Shiba, K. Yonetani, Y. Hirotsu, 1975 .

Synthetic studies on bacitracin. VII. Isomerization of amino acid components of thiazoline peptides.

T. Shiba, T. Kaneko, Y. Hirotsu, 1970, Bulletin of the Chemical Society of Japan.

Total Synthesis of Antibiotic Althiomycin

T. Shiba, K. Inami, 1984 .

Synthetic studies of bacitracin. IV. Synthesis of thiazoline peptides by iminoether coupling method.

T. Shiba, T. Kaneko, Y. Hirotsu, 1967, Bulletin of the Chemical Society of Japan.

Synthesis and Stereochemistry of Hypusine, a New Amino Acid in Bovine Brain.

H. Akiyama, S. Okada, T. Shiba, 1982 .

Chemical studies on tuberactinomycin. XIV. Novel synthesis of DL-capreomycidine.

T. Ukita, T. Shiba, T. Wakamiya, 1978 .

Structure of a bitter peptide in casein hydrolyzate by bacterial proteinase

T. Shiba, K. Nunami, 1974 .

Synthetic study on peptide antibiotic nisin. V : Total synthesis of nisin

H. Fujita, K. Fukase, A. Sano, 1992 .

SYNTHESES OF FOUR STEREOISOMERS OF β-METHYLLANTHIONINE

K. Fukase, T. Shiba, Y. Oda, 1985 .

An Improved Synthesis of threo-3-Methyl-D-cysteine

K. Fukase, T. Shiba, T. Wakamiya, 1983 .

Synthesis of threo-3-Methylcysteine from Threonine

K. Nakajima, M. Neya, T. Shiba, 1982 .

Chemical Studies on Tuberactinomycin. XII. Syntheses and Antimicrobial Activities of [Ala3, Ala4]-, [Ala3]-, and [Ala4]-Tuberactinomycin O

T. Shiba, S. Nomoto, T. Wakamiya, 1977 .

Chemical studies on tuberactinomycin. XV. Total synthesis of tuberactinomycin O.

T. Shiba, S. Nomoto, T. Wakamiya, 1977, The Journal of antibiotics.

Chemical studies on tuberactinomycin. XIII. Modification of beta-ureidodehydroalanine residue in tuberactinomycin N.

T. Shiba, S. Nomoto, 1977, The Journal of antibiotics.

Chemical studies on tuberactinomycin. XI. Semisyntheses of tuberactinomycin analogs with various amino acids in branched part.

T. Shiba, T. Wakamiya, H. Sakakibara, 1977 .

Revised structure and total synthesis of capreomycin

T. Shiba, S. Nomoto, T. Wakamiya, 1976 .

Chemical studies on tuberactinomycin. VIII. Isolation of tuberactinamine N, the cyclic peptide moiety of tuberactinomycin N, and conversion of tuberactinomycin N to O.

T. Shiba, T. Wakamiya, 1975, The Journal of antibiotics.

Chemical studies on tuberactinomycin. VI. The absolute configuration of gamma-hydroxy-beta-lysine in tuberactinomycins A and N.

T. Shiba, T. Wakamiya, 1974, The Journal of antibiotics.

Chemical Studies on Tuberactinomycin. VII. Synthesis of γ-Hydroxy-β-lysine

T. Shiba, I. Kubota, T. Kaneko, 1974 .

Chemical Studies on Tuberactinomycin. V. Structures of Guanidino Amino Acids in Tuberactinomycins

T. Noda, T. Take, T. Shiba, 1973 .

Chemical Studies on Tuberactinomycin. IV. The Chemical Structure of γ-Hydroxy-β-lysine, A New Amino Acid Isolated from Tuberactinomycin A and N

T. Shiba, T. Kaneko, T. Wakamiya, 1972 .

CHEMICAL STUDIES ON TUBERACTINOMYCIN. III

T. Noda, T. Take, T. Shiba, 1972 .

Chemical studies on tuberactinomycin. I. The structure of tuberactidine, guanidino amino acid component.

T. Take, T. Shiba, T. Kaneko, 1970, Tetrahedron letters.

A new synthetic method for dehydroalanine peptides through hofmann degradation of α,β-diaminopropionyl residue

A. Sano, T. Shiba, S. Nomoto, 1979 .

Total chemical structure of streptothricin.

S. Imaoka, S. Kusumoto, T. Shiba, 1982, The Journal of antibiotics.

Synthesis of Dehydroxymethylbulgecin A (II).

T. Shiba, K. Yamanoi, T. Wakamiya, 1988 .

Synthesis of bulgecinine: a new amino acid in bulgecins

T. Shiba, K. Yamanoi, T. Wakamiya, 1985 .

Total synthesis of escherichia coli lipid A

S. Kusumoto, M. Imoto, T. Shiba, 1985 .

Chemical studies on tuberactinomycin. XVI. Synthesis of tuberactinomycin N.

T. Shiba, T. Teshima, T. Ando, 1979, The Journal of antibiotics.

Synthetic approach to bacterial lipopolysaccharide, preparation of trisaccharide part structures containing KDO and 1-dephospho lipid A

N. Kusunose, S. Kusumoto, M. Imoto, 1988 .

A new synthesis of 3-deoxy-d-manno-2-octulosonic acid (kdo) from d-mannose

M. Imoto, T. Shiba, S. Kusomoto, 1987 .

Total Synthesis of Escherichia coli Lipid A, the Endotoxically Active Principle of Cell-Surface Lipopolysaccharide

S. Kusumoto, M. Imoto, T. Shiba, 1987 .

Total synthesis of escherichia coli lipid A

S. Kusumoto, M. Imoto, T. Shiba, 1985 .

Synthetic approach to lipid A: Preparation of phosphorylated disaccharides containing (R)-3-hydroxyacyl and (R)-3-acyloxyacyl groups

S. Kusumoto, M. Imoto, T. Shiba, 1983 .

Chemical synthesis of phosphorylated fundamental structure of lipid a

S. Kusumoto, T. Shiba, M. Inage, 1981 .

Synthesis of Acyl Derivatives of -Lysine for Peptide Synthesis

T. Shiba, T. Wakamiya, T. Teshima, 1975 .

Synthesis of α-Aminophosphonic Octapeptide, Phe–Gly–Ser–Leu–AlaP–Phl–Leu–Pro, an Analog with Partial Sequence of erb B-2 Gene Product

H. Miyashita, T. Shiba, T. Teshima, 1995 .

Isolation and characterization of I5B2, a new phosphorus containing inhibitor of angiotensin I converting enzyme produced by Actinomadura sp.

T. Shiba, E. Miyagawa, T. Wakamiya, 1984, The Journal of antibiotics.

Synthesis of L-thyroxine from 3,5-diiodo-L-tyrosine by nonenzymic transamination.

M. Kajiwara, T. Shiba, T. Kaneko, 1970, Archives of biochemistry and biophysics.

Nuclear Magnetic Resonance Study of the Stereoisomeric 2-Oxazolidone and 2-Phenyl-2-oxazoline Derivatives of α-Amino-β-hydroxy Acids

T. Shiba, T. Inui, Shuji Futagawa, 1973 .

Synthesis of b-Hydroxy-a-amino Acids by Substitution Reactions of Thiazoline and Imidazoline Compounds

T. Shiba, K. Sawada, Y. Hirotsu, 1978 .

Total Synthesis of Escherichia coli Lipid A, the Endotoxically Active Principle of Cell-Surface Lipopolysaccharide.

S. Kusumoto, M. Imoto, T. Shiba, 1987 .

Synthesis and antitumor activity of lipid A analogs having a phosphonooxyethyl group with alpha- or beta-configuration at position 1.

T. Soga, S. Kusumoto, T. Kusama, 1990, Chemical & pharmaceutical bulletin.

Chemical Synthesis of a Biosynthetic Precursor of Lipid A with a Phosphorylated Tetraacyl Disaccharide Structure

S. Kusumoto, M. Imoto, T. Shiba, 1987 .

Structural determination of carnosadine, a new cyclopropyl amino acid, from red alga Grateloupia carnosa

H. Nakamoto, T. Shiba, T. Wakamiya, 1984 .

Synthetic studies of bacitracin. I. Synthesis of a protected intermediate heptapeptide (5-11).

T. Shiba, Y. Ariyoshi, T. Kaneko, 1967, Bulletin of the Chemical Society of Japan.

The structure of galantinamic acid, a new amino acid in a peptide antibiotic galantin I.

T. Shiba, T. Wakamiya, T. Teshima, 1988 .

Stimulation of the reticuloendothelial system of mice by muramyl dipeptide

S. Kusumoto, T. Shiba, S. Nagao, 1979, Infection and immunity.

Synthesis of long chain fatty acid esters of N-acetylmuramyl-L-alanyl-D-isoglutamine in relation to antitumor activity

I. Azuma, S. Kusumoto, T. Shiba, 1979 .

Synthetic low-toxicity muramyl dipeptide and monophosphoryl lipid A replace Freund complete adjuvant in inducing growth-inhibitory antibodies to the Plasmodium falciparum major merozoite surface protein, gp195

S. Kusumoto, G. Hui, T. Shiba, 1991, Infection and immunity.

Chemical structure of Escherichia coli lipid A

E. Rietschel, C. Galanos, S. Kusumoto, 1985 .

Total Synthesis of Lipid A, Active Principle of Bacterial Endotoxin

S. Kusumoto, M. Imoto, T. Shiba, 1984 .

Stimulation of nonspecific resistance to infection induced by 6-O-acyl muramyl dipeptide analogs in mice

I. Azuma, S. Kusumoto, T. Kusama, 1981, Infection and immunity.

Macrophage activation by bacterial cell walls and related synthetic compounds

S. Kusumoto, I. Yano, H. Takada, 1979, Infection and immunity.

Syntheses of Several Muramyl Peptides in Relation to Chemical Structures of Less Immunoadjuvant Bacterial Cell Walls

S. Kusumoto, K. Ikenaka, T. Shiba, 1979 .

Adjuvant activity of synthetic 6-O-"mycoloyl"-N-acetylmuramyl-L-alanyl-D-isoglutamine and related compounds

K. Sugimura, I. Azuma, S. Kusumoto, 1978, Infection and immunity.

Immunoadjuvant activities of synthetic 6-O-acyl-N-acetylmuramyl-L-alanyl-D-isoglutamine with special reference to the effect of its administration with liposomes.

S. Kusumoto, I. Morisaki, S. Okada, 1977, Biken journal.

Elucidation of stereospecificity of a selenium-containing hydrogenase from methanococcus vannielii — syntheses of (R)- and (S)-[4-2H1] 3,4-dihydro-7-hydroxy-1-hydroxyethylquinolinone

S. Yamazaki, A. Nakaji, T. Shiba, 1985 .

Chemical structure of E. Coli Lipid A: Linkage site of acyl groups in the disaccharide backbone

T. Iwashita, H. Naoki, E. Rietschel, 1983 .

Component Amino Acids of the Antibiotic Longicatenamycin. Isolation of 5-Chloro- D -tryptophan

H. Akiyama, T. Shiba, Y. Mukunoki, 1975 .

A FACILE METHOD FOR PREPARATION OF THE OPTICALLY PURE 3-HYDROXYTETRADECANOIC ACID BY AN APPLICATION OF ASYMMETRICALLY MODIFIED NICKEL CATALYST

S. Kusumoto, A. Tai, T. Shiba, 1980 .

Synthetic Studies of Bacitracin. VIII. Synthesis of Cyclohexapeptide Moiety

T. Shiba, Y. Masui, T. Kaneko, 1973 .

Synthesis and stereochemistry of carnosadine, a new cyclopropyl amino acid from red alga grateloupia carnosa

H. Fujita, T. Shiba, Y. Oda, 1986 .

A novel carbohydrate binding activity of annexin V toward a bisecting N-acetylglucosamine.

N Taniguchi, E Miyoshi, Y. Ikeda, 2000, Glycobiology.

Structure determination of lepidopteran c, self-defence substance produced by silkworm (bombyx mori)

T. Shiba, T. Nakai, Y. Ueki, 1987 .

Synthesis of Streptolidine (Roseonine, Geamine)

S. Kusumoto, T. Shiba, S. Tsuji, 1974 .

Purification and cDNA Cloning of Porcine Brain GDP-L-Fuc:N-Acetyl-β-D-Glucosaminide α1→6Fucosyltransferase*

Naoyuki Taniguchi, Eiji Miyoshi, S. Fujii, 1996, The Journal of Biological Chemistry.

A fluorescent assay method for GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha 1-6fucosyltransferase activity, involving high performance liquid chromatography.

N Taniguchi, E Miyoshi, S. Fujii, 1996, Journal of biochemistry.

Structure of de-o-acylated lipopolysaccharide from the escherichia coli re mutant strain F 515

B. Lindner, H. Naoki, E. Rietschel, 1985 .

Synthesis of ganglioside M5 from sea urchin egg

M. Hoshi, T. Shiba, Toshihiro Yamamoto, 1994 .

SYNTHESIS OF Ng-STREPTOLIDYL GULOSAMINIDE — A NEW EVIDENCE FOR THE PROPOSED STRUCTURE OF ANTIBIOTIC STREPTOTHRICIN

S. Imaoka, S. Kusumoto, T. Shiba, 1981 .

Stimulation ofNonspecific Resistance toInfection Induced by 6-0-Acyl MuramylDipeptide Analogs inMice

Kensuke Matsumoto, T. Kusama, T. Shiba, 1981 .

Immunomodulating and Related Biological Activities of Bacterial Cell Walls and Their Components, Enzymatically Prepared or Synthesized

T. Ogawa, Masahiko Kato, S. Kusumoto, 1981 .

Lipophilic derivative of muramyl dipeptide is more active than muramyl dipeptide in priming macrophages to release superoxide anion

S. Kusumoto, M. Pabst, T. Shiba, 1980, Infection and immunity.

Adjuvant Activities in Production of Reaginic Antibody by Bacterial Cell Wall Peptidoglycan or Synthetic N-Acetylmuramyl Dipeptides in Mice

S. Kusumoto, Midori Ohta, T. Shiba, 1979, Infection and immunity.

Preparation of N-Acetylmuramyl-L-[U-14C]alanyl-D-isoglutamine via a Novel Synthetic Route

S. Kusumoto, K. Ikenaka, T. Shiba, 1979 .

Synthesis of 6-O-Mycoloyl-Nacetylmuramyl-L-alanyl-D-isoglutamine with Antitumor Activity

I. Azuma, S. Kusumoto, S. Okada, 1978 .

Correlation of stereochemically specific structure in muramyl dipeptide between macrophage activation and adjuvant activity.

S. Kusumoto, T. Shiba, S. Nagao, 1977, Biochemical and biophysical research communications.

Chemical Synthesis and Biological Activities of Two Disaccharide Dipeptides Corresponding to the Repeating Units of Bacterial Peptidoglycan

S. Kusumoto, Koji Yamamoto, M. Imoto, 1986 .

Higher Immunoadjuvant Activities of N‐Acetyl‐β‐D‐glucosaminyl‐(1–4)‐N‐acetylmuramyl‐L‐alanyl‐D‐isoglutamine in Comparison with N‐Acetylmuramyl‐L‐alanyl‐D‐isoglutamine

S. Kusumoto, T. Shiba, M. Tsujimoto, 1979, Microbiology and immunology.

Selective Chemical Cleavage of Asparagine Peptides

S. Kusumoto, T. Shiba, A. Koda, 1968 .

Isolations and structures of new ureido amino acids, lividine and grateloupine, from red algae Ograteloupia c. agardh genus

T. Shiba, Y. Kobayashi, T. Wrkamiya, 1984 .

Total Synthesis of Aureobasidin A, an Antifungal Cyclic Depsipeptide.

K. Takesako, I. Kato, T. Shiba, 1993 .

Viomycin resistance: alterations of either ribosomal subunit affect the binding of the antibiotic to the pair subunit and the entire ribosome becomes resistant to the drug.

E. Choi, N. Tanaka, T. Shiba, 1979, Biochemical and biophysical research communications.

Erratum to “Key structures of bacterial peptidoglycan and lipopolysaccharide triggering the innate immune system of higher animals: Chemical synthesis and functional studies”

K. Fukase, S. Kusumoto, T. Shiba, 2010, Proceedings of the Japan Academy. Series B, Physical and Biological Sciences.

Chemical synthesis of phosphorylated tetraacyl disaccharide corresponding to a biosynthetic precursor of lipid A

S. Kusumoto, M. Imoto, T. Shiba, 1984 .

Induction of human interleukin 1 by bacterial and synthetic lipid A

H. Flad, H. Brade, S. Kusumoto, 1986, European journal of immunology.

Mitogenic and polyclonal B cell activation activities of synthetic lipid A analogues

S. Kusumoto, Y. Kumazawa, M. Matsuura, 1984, European journal of immunology.

In vitro antigenic reactivity of synthetic lipid A analogues as determined by monoclonal and conventional antibodies.

S. Kusumoto, S. Arata, K. Okuda, 1985, Biochemical and biophysical research communications.

Contractile effects of bacterial cell walls, their enzymatic digests, and muramyl dipeptides on ileal strips from guinea pigs

T. Ogawa, S. Kusumoto, T. Shiba, 1982, Infection and immunity.

Hypusine, a new amino acid occurring in bovine brain. Isolation and structural determination.

T. Shiba, T. Kaneko, Y. Kakimoto, 1971, Biochimica et biophysica acta.

Requirement of a properly acylated beta(1-6)-D-glucosamine disaccharide bisphosphate structure for efficient manifestation of full endotoxic and associated bioactivities of lipid A

T. Ogawa, M. Kiso, A. Hasegawa, 1987, Infection and immunity.

Endotoxic Properties of Chemically Synthesized Lipid A Analogs

T. Kirikae, M. Hirata, C. Galanos, 1989, Microbiology and immunology.

Characterization of monoclonal lipid A antibodies with synthetic lipid A analogues

N. Kusunose, S. Kusumoto, S. Arata, 1988 .

Immunogenicity and antigenicity of synthetic Escherichia coli lipid A

H. Brade, S. Kusumoto, E. Rietschel, 1986, Infection and immunity.

Recent developments in the organic synthesis of lipid A in relation to biologic activities.

S. Kusumoto, M. Imoto, T. Shiba, 1984, Reviews of infectious diseases.

Biological activities of synthetic lipid A analogs: pyrogenicity, lethal toxicity, anticomplement activity, and induction of gelation of Limulus amoebocyte lysate

K. Tanamoto, C. Galanos, U. Zähringer, 1984, Infection and immunity.

Biological activity of chemically synthesized analogues of lipid A. Demonstration of adjuvant effect in hapten-sensitized liposomal system.

T. Tadakuma, T. Yasuda, S. Kusumoto, 2005, European journal of biochemistry.

Endotoxic induction of prostaglandin release from macrophages by nontoxic lipid A analogs synthesized chemically

K. Tanamoto, E. Rietschel, T. Shiba, 1990, Infection and immunity.

Immunogenicity and antigenicity of natural and synthetic Escherichia coli lipid A.

H. Brade, S. Kusumoto, E. Rietschel, 1987, Progress in clinical and biological research.

Lanthiopeptin, a new peptide effective against herpes simplex virus: structural determination and comparison with Ro 09-0198, an immunopotentiating peptide

K. Fukase, M. Konishi, T. Shiba, 1988 .

Inhibitory effects of long‐chain acyl coenzyme a analogues on rat liver acetyl coenzyme a carboxylase

J. Nikawa, S. Numa, T. Tanabe, 1979, FEBS letters.

Developmental changes in localization of the main ganglioside during sea urchin embryogenesis.

K. Chiba, H. Shogomori, M. Hoshi, 2000, Glycobiology.

The structure of an antibiotic, dityromycin

S. Ōmura, Y. Iwai, T. Shiba, 1988 .

Structural specificity of synthetic peptide adjuvant for induction of experimental allergic encephalomyelitis.

S. Kusumoto, T. Shiba, T. Shimono, 1978, Cellular immunology.

Structural Requirement of Synthetic N‐Acetylmuramyl Dipeptides for Induction of Experimental Allergic Encephalomyelitis in the Rat

S. Kusumoto, A. Sumiyoshi, T. Shiba, 1980, Microbiology and immunology.

Minimum structural requirements for encephalitogen and for adjuvant in the induction of experimental allergic encephalomyelitis.

S. Kusumoto, F. Ikuta, T. Shiba, 1978, Cellular immunology.

Chemistry of Lipid A

S. Kusumoto, T. Shiba, 1988 .

tRNA binding to programmed ribosomes increases the ribosomal affinity for tuberactinomycin O

T. Shiba, T. Teshima, Takeshi Yamada, 1985, FEBS letters.

Syntheses of Althiomycin Analogs in Relation to Antibacterial Activities

T. Shiba, K. Inami, 1986 .

Total synthesis of clavamine, insecticidally active compound isolated from venom of joro spider (Nephila Clavata)

M. Yoshioka, T. Shiba, T. Wakamiya, 1990 .

Structure-activity relationship of lipid A: comparison of biological activities of natural and synthetic lipid A's with different fatty acid compositions.

T. Yasuda, K. Tanamoto, S. Kusumoto, 1986, Journal of biochemistry.

Synthesis and Antitumor Activity of Lipid A Analogs (I) Having a Phosphonooxyethyl Group with α- or β-Configuration at Position 1.

T. Soga, S. Kusumoto, T. Kusama, 1991 .

Chemical synthesis of endotoxin.

N. Kusunose, S. Kusumoto, M. Imoto, 1990, Advances in experimental medicine and biology.

Structural requirements of lipid A species in activation of clotting enzymes from the horseshoe crab, and the human complement cascade.

N. Kusunose, T. Ogawa, S. Kusumoto, 1988, European journal of biochemistry.

Granuloma formation by muramyl dipeptide associated with branched fatty acids, a structure probably essential for tubercle formation by Mycobacterium tuberculosis

S. Kusumoto, N. Shigematsu, T. Shiba, 1985, Infection and immunity.

Correlation between the immunoadjuvant activities and pyrogenicities of synthetic N-acetylmuramyl-peptides or -amino acids.

T. Shiba, T. Shimono, S. Kotani, 1976, Biken journal.

Syntheses and Properties of 2-Oxothiazolidine-4-carboxylic Acid and Its Derivatives

T. Shiba, T. Kaneko, T. Inui, 1964 .

Structural requirements of endotoxic lipopolysaccharides and bacterial cell walls in induction of interleukin-1.

S. Kusumoto, H. Takada, T. Shiba, 1988, Blood purification.

Synthesis of Specifically Iodine-131- and Carbon-14-Labeled Thyroxine1

T. Shiba, H. Cahnmann, 1962 .

Chemical synthesis of lipid for the elucidation of structure-activity relationships

S. Kusumoto, M. Imoto, T. Shiba, 1983 .

X-Neu5Ac: a novel substrate for chromogenic assay of neuraminidase activity in bacterial expression systems.

M. Kikuchi, I. Fujii, Y. Iwabuchi, 1993, Bioorganic & medicinal chemistry.

Liberation of serotonin in rabbit platelets by various bacterial cell walls, a water-soluble cell wall fragment and synthetic 6-o-mycoloyl n-acetylmuramyl tetrapeptide

S. Kusumoto, T. Shiba, S. Kotani, 1980 .

Stimulation of migration of human monocytes by bacterial cell walls and muramyl peptides

T. Ogawa, S. Kusumoto, T. Shiba, 1982, Infection and immunity.

Macrophage-stimulating effect of a synthetic muramyl dipeptide and its adjuvant-active and -inactive analogs for the production of T-cell activating monokines.

S. Kusumoto, T. Shiba, S. Kotani, 1981, Cellular immunology.

Total synthesis of nstx-3, spider toxin of nephila maculata

N. Kawai, T. Nakajima, T. Shiba, 1991 .

APPENDIX PUTREANINE, N-(4-AMINOBUTYL)-3-AMINOPROPIONIC ACID, ISOLATED FROM MAMMALIAN BRAIN

T. Shiba, T. Kaneko, 1969 .

Total Synthesis of NSTX‐3, Spider Toxin of Nephila maculata.

N. Kawai, T. Nakajima, T. Shiba, 2010 .

Characterization of binding sites for spider toxin, [3H]NSTX-3, in the rat brain

K. Mikoshiba, N. Kawai, M. Niinobe, 1990, Neuroscience Research.

Structure-activity relationship of NSTX-3, spider toxin of nephila maculata

N. Kawai, T. Nakajima, T. Shiba, 1990 .

Structure-Activity Relationship of NSTX-3, Spider Toxin of Nephila maculata.

N. Kawai, T. Nakajima, T. Shiba, 1990 .

Synthesis of lyposaccharide corresponding to fundamental structure of Salmonella-type lipid A

S. Kusumoto, T. Shiba, M. Inage, 1980 .

Chemical synthesis of 1-dephospho derivative of lipid A

S. Kusumoto, M. Imoto, T. Shiba, 1985 .

Further study of biological activities of chemically synthesized analogues of lipid A in artificial membrane vesicles.

T. Tadakuma, T. Yasuda, S. Kusumoto, 1984, European journal of biochemistry.

Interferon-inducing, pyrogenic and proclotting enzyme of horseshoe crab activation activities of chemically synthesized lipid A analogues.

S. Kusumoto, M. Matsuura, T. Shiba, 1983, European journal of biochemistry.

Immunobiological activities of synthetic lipid A analogs and related compounds as compared with those of bacterial lipopolysaccharide, re-glycolipid, lipid A, and muramyl dipeptide

T. Ogawa, S. Kusumoto, H. Takada, 1983, Infection and immunity.

Adjuvant Activity of 6-0-Acyl-Muramyldipeptides to Enhance Primary Cellular and Humoral Immune Responses in Guinea Pigs:

S. Kusumoto, T. Shiba, M. Tsujimoto, 2022 .

Key structures of bacterial peptidoglycan and lipopolysaccharide triggering the innate immune system of higher animals: Chemical synthesis and functional studies".

K. Fukase, S. Kusumoto, T. Shiba, 2010, Proceedings of the Japan Academy. Series B, Physical and biological sciences.

Binding of [14C]tuberactinomycin O, an antibiotic closely related to viomycin, to the bacterial ribosome.

N. Tanaka, T. Shiba, M. Misumi, 1978, Biochemical and Biophysical Research Communications - BBRC.

TUBERACTINO-MYCIN 0 TO RIBOSOMES FROM MYCOBACTERIUM SMEGMATIS

Takeshi Yamada, T. Shiba, T. Teshima, 2006 .

Binding of [14C]tuberactinomycin O to ribosomes from Mycobacterium smegmatis.

T. Yamada, T. Shiba, T. Teshima, 1985, The Journal of antibiotics.

The translocation inhibitor tuberactinomycin binds to nucleic acids and blocks the in vitro assembly of 50S subunits.

K. Nierhaus, T. Yamada, T. Shiba, 1980, Nucleic Acids Research.

Total synthesis of L-capreomycidine☆

T. Ukita, T. Shiba, T. Wakamiya, 1977 .

Chemical studies on tuberactinomycins. X. Total synthesis of tuberactinomycin O

T. Shiba, S. Nomoto, T. Wakamiya, 1976 .

Activity of Di-β-Lysyl-Capreomycin IIA and Palmitoyl Tuberactinamine N Against Drug-Resistant Mutants with Altered Ribosomes

T. Shiba, T. Teshima, Takeshi Yamada, 1981, Antimicrobial Agents and Chemotherapy.

IIAandPalmitoyl Tuberactinamine N Against Drug-Resistant Mutants with Altered Ribosomes

Takeshi Yamada, T. Shiba, T. Teshima, 1981 .

CHEMICAL STUDIES OF TUBERACTINOMYCINS. X. TOTAL SYNTHESIS OF TUBERACTINOMYCIN N O

T. Shiba, S. Nomoto, T. Wakamiya, 1976 .

Semisynthesis of di-beta-lysylcapreomycin IIA, a capreomycin analog effective against viomycin-resistant Mycobacterium.

T. Shiba, T. Wakamiya, 1983, Journal of antibiotics (Tokyo. 1968).

Chemical studies on tuberactinomycin. 3. The chemical structure of viomycin (tuberactinomycin B).

T. Noda, T. Take, T. Shiba, 1972, The Journal of antibiotics.

Synthesis of L-Epicapreomycidine

T. Shiba, T. Teshima, K. Konishi, 1980 .

Syntheses of capreomycin analogs in relation to their antibacterial activities.

T. Shiba, S. Nomoto, 1979 .

CHEMICAL STUDIES ON TUBERACTINOMYCIN. XII. SYNTHESES AND ANTIMICROBIAL ACTIVITIES OF (ALA3, ALA4)-, (ALA3)-, AND (ALA4)-TUBERACTINOMYCIN O

T. Shiba, S. Nomoto, T. Wakamiya, 1978 .

The chemical structure of capreomycin

T. Shiba, S. Nomoto, T. Wakamiya, 1976, Experientia.

Synthesis of N-acetylmuramyl-L- [U−14C]alanyl-D-isoglutamine

S. Kusumoto, K. Ikenaka, T. Shiba, 1977 .

Synthesis of N-acetyl-β-D-glucosaminyl-(1-4)-N-acetylmuramyl- L -alanyl-D-isoglutamine☆

S. Kusumoto, Koji Yamamoto, T. Shiba, 1978 .

Identity of a major 3-deoxyglucosone-reducing enzyme with aldehyde reductase in rat liver established by amino acid sequencing and cDNA expression.

M. Takahashi, N. Taniguchi, J. Fujii, 1993, Gene.

Increase of thromboplastin activity in bone marrow cells by synthetic lipid A analogs

M. Hirata, S. Kusumoto, Masao Yoshida, 1986 .

Chemical synthesis of 1-dephospho derivative of escherichia coli re lipopolysaccharide

N. Kusunose, S. Kusumoto, T. Shiba, 1988 .

Lanthiopeptin, a new peptide antibiotic. Production, isolation and properties of lanthiopeptin.

H. Kawaguchi, K. Fukase, M. Konishi, 1989, The Journal of antibiotics.

Synthetic studies of Bacitracin. IV. Synthesis of unprotected thiazoline peptides.

T. Shiba, T. Kaneko, Y. Hirotsu, 1970, Bulletin of the Chemical Society of Japan.

Arthritis-inducing ability of a synthetic adjuvant, N-acetylmuramyl peptides, and bacterial disaccharide peptides related to different oil vehicles and their composition

S. Kusumoto, O. Kohashi, T. Shiba, 1980, Infection and immunity.

Synergistic effect of polyriboinosinic acid:polyribocytidylic acid and either bacterial peptidoglycans or synthetic N-acetylmuramyl peptides on production of adjuvant-induced arthritis in rats

O. Kohashi, T. Shiba, S. Kotani, 1979, Infection and immunity.

Enhancement of humoral immune responses against viral vaccines by a non-pyrogenic 6-O-acylmuramyldipeptide and synthetic low toxicity analogues of lipid A.

Y. Goto, S. Kusumoto, T. Kubo, 1989, Vaccine.

Synthesis and Biological Activities of Analogs of a Lipid A Biosynthetic Precursor : 1-O-Phosphono-oxyethyl-4'-O-phosphono-disaccharides with (R)-3-Hydroxytetradecanoyl or Tetradecanoyl Groups at Positions 2, 3, 2' and 3'

T. Soga, S. Kusumoto, T. Kusama, 1991 .

Chemical syntheses of lipid X and lipid Y, acyl glucosamine 1-phosphates isolated from escherichia coli mutants

S. Kusumoto, T. Shiba, Michiharu Yamamoto, 1985 .

Synthesis and biological activities of analogs of a lipid A biosynthetic precursor: 1-O-phosphonooxyethyl-4'-O-phosphono-disaccharides with (R)-3-hydroxytetradecanoyl or tetradecanoyl groups at positions 2, 3, 2' and 3'.

T. Soga, S. Kusumoto, T. Kusama, 1991, Chemical and pharmaceutical bulletin.

Adjuvant activity of 6-O-acyl-muramyldipeptides to enhance primary cellular and humoral immune responses in guinea pigs: dose-response and local reactions observed with selected compounds

S. Kusumoto, T. Shiba, M. Tsujimoto, 1986, Infection and immunity.

Adjuvant activity of 6-O-acyl-muramyldipeptides to enhance primary cellular and humoral immune responses in guinea pigs: adaptability to various vehicles and pyrogenicity

S. Kusumoto, T. Shiba, M. Tsujimoto, 1986, Infection and immunity.

SYNTHESIS OF 6-O-MYCOLOYL-N-ACETYLMURAMYL-L-ALANYL-D-ISOGLUTAMINE WITH ANTITUMOR ACTIVITY

I. Azuma, S. Kusumoto, S. Okada, 1979 .

Muramyl Dipeptide Derivatives with Multiprenylacetyl Group. Synthesis and Immunological Activities

I. Saiki, I. Azuma, M. Fujino, 1981 .

Structure-activity relationship of lepidopteran, a self-defence peptide of bombyx moriXXX

T. Shiba, T. Nakai, M. Kitazawa, 1988 .

Synthetic and natural Escherichia coli free lipid A express identical endotoxic activities.

E. Rietschel, C. Galanos, M. Freudenberg, 1985, European journal of biochemistry.

Some aspects of the relationship between the structure of a bitter diketopiperazine and its receptor

T. Shiba, I. Kubota, Hiroshi Uratani, 1981, Biopolymers.

Synthetic studies of bacitracin. V. Synthesis of thiazoline peptides from cysteine peptides by dehydration procedure.

T. Shiba, T. Kaneko, Y. Hirotsu, 1967, Bulletin of the Chemical Society of Japan.

Synthetic studies of bacitracin. II. Synthesis of a cyclic dodecapeptide, an analogue of bacitracin A.

T. Shiba, Y. Ariyoshi, T. Kaneko, 1967, Bulletin of the Chemical Society of Japan.

Total synthesis of antibiotic streptothricin F

S. Imaoka, S. Kusumoto, T. Shiba, 1982 .

Synthetic studies of bacitracin. 3. Synthesis of (S)-2-(2-methylbutyryl)-thiazole-4-carboxylic acid and its peptide derivative.

T. Shiba, Y. Ariyoshi, T. Kaneko, 1967, Bulletin of the Chemical Society of Japan.

Nε-(carboxymethyl)-l-lysine in the acid hydrolysate of Sagittaria pygmaea

S. Kusumoto, T. Shiba, H. Matsutani, 1979 .

Endotoxic properties of chemically synthesized lipid A part structures. Comparison of synthetic lipid A precursor and synthetic analogues with biosynthetic lipid A precursor and free lipid A.

K. Tanamoto, E. Rietschel, C. Galanos, 1984, European journal of biochemistry.

SYNTHETIC STUDY ON PEPTIDE ANTIBIOTIC NISIN. I. THE SYNTHESIS OF RING A

K. Fukase, A. Sano, T. Shiba, 1983 .

A new method for the determination of optical purity of synthetic peptides

S. Kusumoto, T. Shiba, M. Matsukura, 1981 .

A NEW METHOD FOR DETERMINATION OF INTACT OPTICAL PURITY OF PEPTIDES BY USE OF MASS FRAGMENTOGRAPHY

S. Kusumoto, T. Shiba, M. Matsukura, 1981 .

Structural principles of lipopolysaccharides and biological properties of synthetic partial structures

K. Tanamoto, E. Rietschel, C. Galanos, 1983 .

[Inhibitory effect of lipopolysaccharides, natural lipid A and synthetic lipid A on growth of murine B cell lines, CYG 34 and CYG 101].

T. Kirikae, M. Yoshida, S. Kusumoto, 1988, Nihon saikingaku zasshi. Japanese journal of bacteriology.

Mitogenic effects of bacterial cell walls and their components on murine splenocytes.

S. Kusumoto, I. Yano, H. Takada, 1980, Biken journal.

Synthesis of 6-o-mycoloyl-n-acetylmuramyl-l-alanyl- D-isoglutamine with immunoadjuvant activity

I. Azuma, S. Kusumoto, S. Okada, 1976 .

Synthesis of β(1–4)-Linked Disaccharides of N-Acetylglucosamine and N-Acetylmuramic Acid by Their Direct Condensation

S. Kusumoto, M. Imoto, T. Shiba, 1986 .