Jake P. Metterville

发表

Low-level overexpression of wild type TDP-43 causes late-onset, progressive neurodegeneration and paralysis in mice

H. Cai, Jia Yu, Chunxing Yang, 2022, PloS one.

Low-level overexpression of wild type TDP-43 causes late-onset, progressive neurodegeneration and paralysis in mice

Robert H. Brown, H. Cai, Jia Yu, 2021, bioRxiv.

1 TDP-43 gains function due to perturbed autoregulation in a Tardbp knockin mouse model of ALS-FTD

Matthew A. White, L. Saksida, T. Bussey, 2019 .

Mutant Profilin 1 transgenic mice recapitulate cardinal features of motor neuron disease

Ashutosh Kumar Singh, Robert H. Brown, P. Ozdinler, 2017 .

Mutant Profilin1 transgenic mice recapitulate cardinal features of motor neuron disease

Ashutosh Kumar Singh, Robert H. Brown, P. Ozdinler, 2016, Human molecular genetics.

Low-level overexpression of wild type TDP-43 causes late-onset, progressive neurodegeneration and paralysis in mice

Robert H. Brown, H. Cai, Jia Yu, 2021, bioRxiv.

Mutant PFN1 causes ALS phenotypes and progressive motor neuron degeneration in mice by a gain of toxicity

Eric W. Danielson, Robert H. Brown, J. Landers, 2016, Proceedings of the National Academy of Sciences.

ASO5-1 C9ORF72 Manuscript – 05Feb2021 POTENT MIXED BACKBONE ANTISENSE OLIGONUCLEOTIDE SAFELY SUPPRESSES EXPRESSION OF MUTANT C9ORF72 TRANSCRIPTS AND POLYDIPEPTIDES: FIRST IN HUMAN PILOT STUDY

Robert H. Brown, R. Bowser, D. Fabris, 2021 .

Suppression of mutant C9orf72 expression by a potent mixed backbone antisense oligonucleotide

Robert H. Brown, R. Bowser, D. Fabris, 2021, Nature Medicine.

Potent Mixed Backbone Antisense Oligonucleotide Safety Suppressed Expression of Mutant C9ORF72 Transcripts and Polypeptides: First in Human Pilot Study

Robert H. Brown, R. Bowser, D. Fabris, 2021 .

Impact of guanidine-containing backbone linkages on stereopure antisense oligonucleotides in the CNS

S. Standley, C. Vargeese, K. Bowman, 2022, Nucleic acids research.

Therapeutic rAAVrh10 Mediated SOD1 Silencing in Adult SOD1G93A Mice and Nonhuman Primates

Robert H. Brown, C. Mueller, M. ElMallah, 2015, Human gene therapy.

Human C9ORF72 Hexanucleotide Expansion Reproduces RNA Foci and Dipeptide Repeat Proteins but Not Neurodegeneration in BAC Transgenic Mice

H. Horvitz, Robert H. Brown, L. Petrucelli, 2015, Neuron.

Endogenous ADAR-mediated RNA editing in non-human primates using stereopure chemically modified oligonucleotides

S. Standley, C. Vargeese, L. Apponi, 2022, Nature Biotechnology.

Loss of Sarm1 does not suppress motor neuron degeneration in the SOD1G93A mouse model of amyotrophic lateral sclerosis

Robert H. Brown, O. Peters, M. Freeman, 2018, Human molecular genetics.

Therapeutic rAAVrh 10 Mediated SOD 1 Silencing in Adult SOD 1 ( G 93 A ) Mice and Nonhuman Primates

Robert H. Brown, C. Mueller, M. ElMallah, 2017 .

Genetic diversity of axon degenerative mechanisms in models of Parkinson's disease

Robert H. Brown, O. Peters, M. Freeman, 2021, Neurobiology of Disease.

Impact of stereopure chimeric backbone chemistries on the potency and durability of gene silencing by RNA interference

P. Giangrande, C. Vargeese, Subramanian Marappan, 2023, Nucleic acids research.

TDP-43 gains function due to perturbed autoregulation in a Tardbp knock-in mouse model of ALS-FTD

Matthew A. White, L. Saksida, T. Bussey, 2018, Nature Neuroscience.

Mutant Proﬁlin1 transgenic mice recapitulate cardinal features of motor neuron disease

P. Ozdinler, A. Basnakian, J. Goellner, 2023 .