Youn-bok Lee

发表

Cytoplasmic TDP-43 is involved in cell fate during stress recovery

C. Shaw, C. Troakes, B. Rogelj, 2021, Human molecular genetics.

Nuclear RNA foci from C9ORF72 expansion mutation form paraspeckle-like bodies

C. Shaw, H. Motaln, B. Rogelj, 2019, Journal of Cell Science.

Allele-Specific Knockdown of ALS-Associated Mutant TDP-43 in Neural Stem Cells Derived from Induced Pluripotent Stem Cells

T. Maniatis, C. Shaw, M. Carrasco, 2014, PloS one.

Phosphorylation of C-terminal tyrosine residue 526 in FUS impairs its nuclear import

C. Shaw, G. Guncar, B. Rogelj, 2015, Journal of Cell Science.

Hexanucleotide Repeats in ALS/FTD Form Length-Dependent RNA Foci, Sequester RNA Binding Proteins, and Are Neurotoxic

J. Ule, C. Shaw, C. Troakes, 2013, Cell reports.

C9orf72 poly GA RAN-translated protein plays a key role in amyotrophic lateral sclerosis via aggregation and toxicity

L. Petrucelli, C. Shaw, C. Troakes, 2017, Human molecular genetics.

Disease Mechanisms and Therapeutic Approaches in C9orf72 ALS-FTD

C. Shaw, Youn-bok Lee, Keith Mayl, 2021, Biomedicines.

Edinburgh Explorer Allele-Specific Knockdown of ALS-Associated Mutant TDP-43 in Neural Stem Cells Derived from Induced Pluripotent Stem Cells

T. Maniatis, C. Shaw, M. Carrasco, 2018 .

Interactome screening of C9orf72 dipeptide repeats reveals VCP sequestration and functional impairment by polyGA

E. Aronica, H. Motaln, A. Thompson, 2021, Brain : a journal of neurology.

Dipeptide repeat protein inclusions are rare in the spinal cord and almost absent from motor neurons in C9ORF72 mutant amyotrophic lateral sclerosis and are unlikely to cause their degeneration

C. Shaw, C. Troakes, S. Al-Sarraj, 2015, Acta Neuropathologica Communications.

Regulation of Synapse Weakening through Interactions of the Microtubule Associated Protein Tau with PACSIN1

Kwangwook Cho, Youn-bok Lee, P. Regan, 2021, The Journal of Neuroscience.

C9ORF72 repeat expansion causes vulnerability of motor neurons to Ca2+-permeable AMPA receptor-mediated excitotoxicity

P. Kind, C. Shaw, Colin Smith, 2018, Nature Communications.

RNA Misprocessing in C9orf72-Linked Neurodegeneration

C. Shaw, J. Gallo, Youn-bok Lee, 2017, Front. Cell. Neurosci..

RNA Misprocessing in C9orf72-Linked Neurodegeneration

C. Shaw, J. Gallo, Youn-bok Lee, 2017, Front. Cell. Neurosci..

Disruption of ER‐mitochondria tethering and signalling in C9orf72‐associated amyotrophic lateral sclerosis and frontotemporal dementia

C. Shaw, W. Noble, Jacqueline C Mitchell, 2022, Aging cell.

Differential roles of the ubiquitin proteasome system and autophagy in the clearance of soluble and aggregated TDP-43 species

D. Rubinsztein, C. Shaw, C. Vance, 2014, Journal of Cell Science.

A serum microRNA signature for amyotrophic lateral sclersosis reveals convergent RNA processing defects and identifies presymptomatic mutation carriers.

C. Shaw, B. Rogelj, Youn-bok Lee, 2014, Brain : a journal of neurology.

Retention of hexanucleotide repeat-containing intron in C9orf72 mRNA: implications for the pathogenesis of ALS/FTD

C. Shaw, C. Troakes, S. Al-Sarraj, 2016, Acta Neuropathologica Communications.

Expanded G4C2 repeats linked to C9ORF72 ALS and FTD form length-dependent RNA foci, sequester RNA binding proteins and are neurotoxic

C. Shaw, C. Troakes, C. Vance, 2013, Molecular Neurodegeneration.

The C9ORF72 expansion mutation is a common cause of ALS+/−FTD in Europe and has a single founder

Michelle K. Lupton, T. Hortobágyi, Robert H. Brown, 2012, European Journal of Human Genetics.

A feedback loop between dipeptide-repeat protein, TDP-43 and karyopherin-α mediates C9orf72-related neurodegeneration

T. Hortobágyi, C. Shaw, C. Troakes, 2018, Brain : a journal of neurology.

Dipeptide repeat protein inclusions are rare in the spinal cord and almost absent from motor neurons in C9ORF72 mutant amyotrophic lateral sclerosis and are unlikely to cause their degeneration

C. Shaw, C. Troakes, S. Al-Sarraj, 2015, Acta neuropathologica communications.

C9ORF72 repeat expansion causes vulnerability of motor neurons to Ca2+-permeable AMPA receptor-mediated excitotoxicity

P. Kind, C. Shaw, S. Chandran, 2018, Nature Communications.

C9orf72 poly GA RAN-translated protein plays a key role in amyotrophic lateral sclerosis via aggregation and toxicity.

L. Petrucelli, C. Shaw, C. Troakes, 2020, Human molecular genetics.

A serum microRNA signature for amyotrophic lateral sclersosis reveals convergent RNA processing defects and identifies presymptomatic mutation carriers.

C. Shaw, B. Rogelj, Youn-bok Lee, 2014, Brain : a journal of neurology.