Sarah R Pickles

发表

Truncated stathmin-2 is a marker of TDP-43 pathology in frontotemporal dementia.

Anna L. Brown, L. Petrucelli, E. Thompson, 2020, The Journal of clinical investigation.

Misfolded SOD1 and ALS: Zeroing in on mitochondria

Sarah R Pickles, C. Vande Velde, 2012, Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases.

TAR DNA-binding protein 43 (TDP-43) regulates stress granule dynamics via differential regulation of G3BP and TIA-1.

G. Rouleau, W. Camu, A. Aulas, 2011, Human molecular genetics.

TNF receptor associated factor 6 interacts with ALS-linked misfolded superoxide dismutase 1 and promotes aggregation

H. McBride, E. Meiering, S. Plotkin, 2020 .

Poly(GR) impairs protein translation and stress granule dynamics in C9orf72-associated frontotemporal dementia and amyotrophic lateral sclerosis

Mark T. W. Ebbert, L. Petrucelli, D. Dickson, 2018, Nature Medicine.

Characterization of lipid binding specificities of dysferlin C2 domains reveals novel interactions with phosphoinositides.

M. Sinnreich, Sarah R Pickles, C. Therrien, 2009, Biochemistry.

Evidence of cerebellar TDP-43 loss of function in FTLD-TDP

L. Petrucelli, E. Thompson, J. Kachergus, 2022, Acta neuropathologica communications.

ALS-linked misfolded SOD1 species have divergent impacts on mitochondria

Helen R. Broom, E. Meiering, N. Cashman, 2016, Acta Neuropathologica Communications.

Mitochondrial damage revealed by immunoselection for ALS-linked misfolded SOD1

J. Julien, G. Rouleau, Sarah R Pickles, 2013, Molecular Neurodegeneration.

CRISPR expands insight into the mechanisms of ALS and FTD

L. Petrucelli, Sarah R Pickles, 2018, Nature Reviews Neurology.

Mitophagy and Quality Control Mechanisms in Mitochondrial Maintenance

R. Youle, Sarah R Pickles, P. Vigié, 2018, Current Biology.

Mitochondrial fission facilitates the selective mitophagy of protein aggregates

R. Youle, Chunxin Wang, J. Hammer, 2017, The Journal of cell biology.

Uncovering the role of misfolded SOD1 in the pathogenesis of Amyotrophic Lateral Sclerosis

Sarah R Pickles, 2015 .

TDP-43 represses cryptic exon inclusion in the FTD–ALS gene UNC13A

Caitlin M. Rodriguez, Beryl B. Cummings, Laura R. Ganser, 2021, Nature.

Heterochromatin anomalies and double-stranded RNA accumulation underlie C9orf72 poly(PR) toxicity

L. Petrucelli, D. Dickson, Connor H. Ludwig, 2019, Science.

The E3 ubiquitin ligase TRAF6 is a novel interacting protein of amyotrophic lateral sclerosis-linked misfolded SOD1

Thomas M. Durcan, H. McBride, E. Meiering, 2019, bioRxiv.

TNF receptor–associated factor 6 interacts with ALS-linked misfolded superoxide dismutase 1 and promotes aggregation

Thomas M. Durcan, H. McBride, E. Meiering, 2020, The Journal of Biological Chemistry.

Poly(GR) impairs protein translation and stress granule dynamics in C9orf72-associated frontotemporal dementia and amyotrophic lateral sclerosis

L. Petrucelli, D. Dickson, A. Gitler, 2018, Nature Medicine.

TDP-43 and other hnRNPs regulate cryptic exon inclusion of a key ALS/FTD risk gene, UNC13A

L. Petrucelli, D. Dickson, C. Cook, 2023, PLoS biology.

Disruption of CLPB is associated with congenital microcephaly, severe encephalopathy and 3-methylglutaconic aciduria

C. Fallet-Bianco, D. Labuda, E. Brustein, 2015, Journal of Medical Genetics.

ALS-linked misfolded SOD1 species have divergent impacts on mitochondria

Helen R. Broom, E. Meiering, N. Cashman, 2016, Acta neuropathologica communications.

Mitochondrial damage revealed by immunoselection for ALS-linked misfolded SOD1

J. Julien, G. Rouleau, Sarah R Pickles, 2013, Molecular Neurodegeneration.

Mis-spliced transcripts generate de novo proteins in TDP-43-related ALS/FTD

M. Nalls, N. Staff, L. Petrucelli, 2023, bioRxiv.

Endo-MitoEGFP Mice: A Novel Transgenic Mouse with Fluorescently Marked Mitochondria in Microvascular Endothelial Cells

P. Cossette, A. Prat, Marc-André Lécuyer, 2013, PloS one.

CRISPR interference to evaluate modifiers of C9ORF72-mediated toxicity in FTD

L. Petrucelli, B. Boeve, D. Dickson, 2023, Frontiers in cell and developmental biology.

Immunodetection of outer membrane proteins by flow cytometry of isolated mitochondria.

Sarah R Pickles, C. Vande Velde, N. Arbour, 2014, Journal of visualized experiments : JoVE.

Mitochondrial damage revealed by immunoselection for ALS-linked misfolded SOD1

J. Julien, G. Rouleau, Sarah R Pickles, 2013, Molecular Neurodegeneration.

Truncated stathmin-2 is a marker of TDP-43 pathology in Truncated stathmin-2 is a marker of TDP-43 pathology in frontotemporal dementia. frontotemporal dementia.

L. Petrucelli, J. Kachergus, D. Knopman, 2022 .

Mis-spliced transcripts generate de novo proteins in TDP-43–related ALS/FTD

J. Ule, N. Staff, L. Petrucelli, 2024, Science Translational Medicine.

Characterization of lipid binding specificities of dysferlin C2 domains reveals novel interactions with phosphoinositides.

M. Sinnreich, Sarah R Pickles, C. Therrien, 2009, Biochemistry.