S. Da Cruz

发表

Wild type human TDP-43 potentiates ALS-linked mutant TDP-43 driven progressive motor and cortical neuron degeneration with pathological features of ALS

T. Hortobágyi, C. Shaw, C. Vance, 2015, Acta neuropathologica communications.

Reduced C9ORF72 function exacerbates gain of toxicity from ALS/FTD-causing repeat expansion in C9orf72

L. Petrucelli, Huaxi Xu, A. L. La Spada, 2020, Nature Neuroscience.

Overriding FUS autoregulation in mice triggers gain-of-toxic 1 dysfunctions in RNA metabolism and autophagy-lysosome axis 2 3

Debbie, Shuying, Gene W. Yeo, 2022 .

ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43

Gene W. Yeo, C. Shaw, L. Tessarollo, 2013, Proceedings of the National Academy of Sciences.

SLP-2 interacts with prohibitins in the mitochondrial inner membrane and contributes to their stability.

Jean-Claude Martinou, Manfredo Quadroni, Philippe Gonzalo, 2008, Biochimica et biophysica acta.

SLP-2 negatively modulates mitochondrial sodium-calcium exchange.

J. Martinou, N. Demaurex, M. Frieden, 2010, Cell calcium.

Polo-like kinase 4 controls centriole duplication but does not directly regulate cytokinesis

I. Verma, Quan-sheng Zhu, M. Bettencourt-Dias, 2012, Molecular biology of the cell.

Building the mitochondrial proteome

J. Martinou, S. Da Cruz, P. Parone, 2005, Expert review of proteomics.

Membralin deficiency dysregulates astrocytic glutamate homeostasis leading to ALS-like impairment.

Huaxi Xu, Timothy Y. Huang, D. Cleveland, 2019, The Journal of clinical investigation.

Fused in Sarcoma (FUS) Protein Lacking Nuclear Localization Signal (NLS) and Major RNA Binding Motifs Triggers Proteinopathy and Severe Motor Phenotype in Transgenic Mice

V. Buchman, O. Peters, A. Deykin, 2013, The Journal of Biological Chemistry.

Inhibiting the Mitochondrial Fission Machinery Does Not Prevent Bax/Bak-Dependent Apoptosis

J. Martinou, O. Donzé, Yves Mattenberger, 2006, Molecular and Cellular Biology.

Enhancing Mitochondrial Calcium Buffering Capacity Reduces Aggregation of Misfolded SOD1 and Motor Neuron Cell Death without Extending Survival in Mouse Models of Inherited Amyotrophic Lateral Sclerosis

D. Cleveland, Joo Seok Han, S. Da Cruz, 2013, The Journal of Neuroscience.

Preventing Mitochondrial Fission Impairs Mitochondrial Function and Leads to Loss of Mitochondrial DNA

J. Martinou, Yves Mattenberger, S. Da Cruz, 2008, PloS one.

SLP‐2 is required for stress‐induced mitochondrial hyperfusion

Jean-Claude Martinou, Christiane Alexander, Alexis A. Jourdain, 2009, The EMBO journal.

Proteomic Analysis of the Mouse Liver Mitochondrial Inner Membrane*

Jean-Claude Martinou, Ioannis Xenarios, I. Xenarios, 2003, Journal of Biological Chemistry.

Phenotypic Suppression of ALS/FTD-Associated Neurodegeneration Highlights Mechanisms of Dysfunction

D. A. Bosco, Nicole F. Liachko, C. Lagier-Tourenne, 2019, The Journal of Neuroscience.

An endogenous peptide marker differentiates SOD1 stability and facilitates pharmacodynamic monitoring in SOD1 amyotrophic lateral sclerosis.

M. Benatar, J. Wuu, F. Rigo, 2019, JCI insight.

ALS/FTD-Linked Mutation in FUS Suppresses Intra-axonal Protein Synthesis and Drives Disease Without Nuclear Loss-of-Function of FUS

C. Shaw, Xiang-Dong Fu, G. Hicks, 2018, Neuron.

Premature polyadenylation-mediated loss of stathmin-2 is a hallmark of TDP-43-dependent neurodegeneration

F. Rigo, Nianwei Lin, C. Bennett, 2018, Nature Neuroscience.

Spinal subpial delivery of AAV9 enables widespread gene silencing and blocks motoneuron degeneration in ALS

Shang Gao, Shawn P. Driscoll, Samuel L. Pfaff, 2019, Nature Medicine.

Premature polyadenylation-mediated loss of stathmin-2 is a hallmark of TDP-43-dependent neurodegeneration

F. Rigo, Nianwei Lin, C. Bennett, 2018, Nature Neuroscience.

Therapeutically viable generation of neurons with antisense oligonucleotide suppression of PTB

A. Muotri, T. Hnasko, F. Rigo, 2021, Nature Neuroscience.

Lost in local translation: TDP-43 and FUS in axonal/neuromuscular junction maintenance and dysregulation in amyotrophic lateral sclerosis

S. Da Cruz, D. Piol, Tessa Robberechts, 2023, Neuron.

HSP70 chaperones RNA-free TDP-43 into anisotropic intranuclear liquid spherical shells

J. Yates, E. Villa, J. Newby, 2020, Science.

Mutant TDP-43 within motor neurons drives disease onset but not progression in amyotrophic lateral sclerosis

D. Pizzo, Kevin Drenner, D. Cleveland, 2017, Acta Neuropathologica.

Elevated PGC-1α activity sustains mitochondrial biogenesis and muscle function without extending survival in a mouse model of inherited ALS.

B. Spiegelman, C. Lillo, David S. Williams, 2012, Cell metabolism.

Molecular Convergence of Bacterial and Eukaryotic Surface Order*

M. A. Surma, D. Lingwood, V. Müller, 2011, The Journal of Biological Chemistry.

TDP-43 and HSP70 phase separate into anisotropic, intranuclear liquid spherical annuli

J. Yates, E. Villa, J. Newby, 2020, bioRxiv.

ALS/FTD-Linked Mutation in FUS Suppresses Intra-axonal Protein Synthesis and Drives Disease Without Nuclear Loss-of-Function of FUS

C. Shaw, Xiang-Dong Fu, G. Hicks, 2020, Neuron.

Overriding FUS autoregulation in mice triggers gain-of-toxic dysfunctions in RNA metabolism and autophagy-lysosome axis

Gene W. Yeo, C. Shaw, G. Tucker-Kellogg, 2019, eLife.

Membralin deficiency dysregulates astrocytic glutamate homeostasis leading to ALS-like impairment.

Huaxi Xu, Timothy Y. Huang, D. Cleveland, 2019, The Journal of clinical investigation.