J. Janson

发表

β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes

Robert A. Rizza, R. Rizza, S. Bonner-Weir, 2003, Diabetes.

Spontaneous diabetes mellitus in transgenic mice expressing human islet amyloid polypeptide.

W. Soeller, P. Roche, P. Butler, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Neuronal calcium sensor-1 potentiates glucose-dependent exocytosis in pancreatic β cells through activation of phosphatidylinositol 4-kinase β

A. Jeromin, K. Smidt, J. Gromada, 2005 .

Robust LC-MS/MS methods for analysis of heparan sulfate levels in CSF and brain for application in studies of MPS IIIA.

P. Edlund, J. Janson, T. Andersson, 2019, Bioanalysis.

Capillary microsampling and analysis of 4-µl blood, plasma and serum samples to determine human α-synuclein elimination rate in mice.

O. Jonsson, Ann-Charlott Steffen, J. Janson, 2013, Bioanalysis.

Discovery of AZD3839, a potent and selective BACE1 clinical candidate for the treatment of Alzheimer’s Disease*

B. Ploeger, S. Eketjäll, B. Swahn, 2012 .

Tomosyn is expressed in β-cells and negatively regulates insulin exocytosis

K. Smidt, J. Gromada, Wei Zhang, 2006 .

Accelerated Apoptosis Overcomes Increased Replication To Cause β-Cell Loss in Diabetes in Mice Transgenic for h-IAPP

W. Soeller, P. Butler, C. Sultana, 2002 .

Discovery of AZD3839, a Potent and Selective BACE1 Inhibitor Clinical Candidate for the Treatment of Alzheimer Disease*

Britt-Marie Swahn, Bart Ploeger, Tjerk Bueters, 2012, The Journal of Biological Chemistry.

Sulfonimidamides as Sulfonamides Bioisosteres: Rational Evaluation through Synthetic, in Vitro, and in Vivo Studies with γ‐Secretase Inhibitors

J. Holenz, P. Arvidsson, J. Lundkvist, 2012, ChemMedChem.

New aminoimidazoles as β-secretase (BACE-1) inhibitors showing amyloid-β (Aβ) lowering in brain.

S. Eketjäll, B. Swahn, K. Kolmodin, 2012, Journal of medicinal chemistry.

Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes.

Robert A Rizza, R. Rizza, S. Bonner-Weir, 2003, Diabetes.

The mechanism of islet amyloid polypeptide toxicity is membrane disruption by intermediate-sized toxic amyloid particles.

D. Harrison, P. Butler, R. Ashley, 1999, Diabetes.

Tomosyn is expressed in beta-cells and negatively regulates insulin exocytosis.

K. Smidt, J. Gromada, Wei Zhang, 2006, Diabetes.

Increased risk of type 2 diabetes in Alzheimer disease.

Ronald C Petersen, Peter O'Brien, Joseph E Parisi, 2004, Diabetes.

Impact of chemical modification of sulfamidase on distribution to brain interstitial fluid and to CSF after an intravenous administration in awake, freely-moving rats

J. Janson, J. Folgering, M. Eriksson, 2019, Molecular genetics and metabolism reports.

Intravenous delivery of a chemically modified sulfamidase efficiently reduces heparan sulfate storage and brain pathology in mucopolysaccharidosis IIIA mice

J. Janson, T. Andersson, C. Ekholm, 2019, Molecular genetics and metabolism reports.

AZD3293: A Novel, Orally Active BACE1 Inhibitor with High Potency and Permeability and Markedly Slow Off-Rate Kinetics

S. Haeberlein, S. Eketjäll, J. Janson, 2016, Journal of Alzheimer's disease : JAD.

Sustained peripheral depletion of amyloid-β with a novel form of neprilysin does not affect central levels of amyloid-β

S. Fowler, L. Jermutus, P. Freskgård, 2013, Brain : a journal of neurology.

Increased beta-cell apoptosis prevents adaptive increase in beta-cell mass in mouse model of type 2 diabetes: evidence for role of islet amyloid formation rather than direct action of amyloid.

W. Soeller, P. Butler, Peter C Butler, 2003, Diabetes.

AZ-4217: A High Potency BACE Inhibitor Displaying Acute Central Efficacy in Different In Vivo Models and Reduced Amyloid Deposition in Tg2576 Mice

S. Eketjäll, B. Swahn, K. Kolmodin, 2013, The Journal of Neuroscience.

An Ancient Duplication of Exon 5 in the Snap25 Gene Is Required for Complex Neuronal Development/Function

M. Wikström, T. Hökfelt, Jesper Ericsson, 2008, PLoS genetics.

Population PKPD Modeling of BACE1 Inhibitor-Induced Reduction in Aβ Levels In Vivo and Correlation to In Vitro Potency in Primary Cortical Neurons from Mouse and Guinea Pig

S. Visser, S. Eketjäll, J. Janson, 2014, Pharmaceutical Research.

Islet amyloid-associated diabetes in obese A(vy)/a mice expressing human islet amyloid polypeptide.

M. Carty, W. Soeller, P. Butler, 1998, Diabetes.

Design and synthesis of β-site amyloid precursor protein cleaving enzyme (BACE1) inhibitors with in vivo brain reduction of β-amyloid peptides.

Britt-Marie Swahn, Johan Lindström, Stefan Berg, 2012, Journal of medicinal chemistry.

Neuronal calcium sensor-1 potentiates glucose-dependent exocytosis in pancreatic beta cells through activation of phosphatidylinositol 4-kinase beta.

A. Jeromin, K. Smidt, J. Gromada, 2005, Proceedings of the National Academy of Sciences of the United States of America.

New aminoimidazoles as beta-secretase (BACE-1) inhibitors showing amyloid-beta (A beta ) lowering in brain.

S. Eketjäll, B. Swahn, K. Strömberg, 2012 .

Capillary microsampling and analysis of 4-µl blood, plasma and serum samples to determine human α-synuclein elimination rate in mice.

Ann-Charlott Steffen, J. Janson, S. Martinsson, 2013, Bioanalysis.