H. Grasberger

发表

Genetic Complexity of Crohn’s Disease in Two Large Ashkenazi Jewish Families

J. Barrett, L. Jostins, V. Plagnol, 2016, Gastroenterology.

H. Grasberger, O. Janssen, C. Buettner, 1999, The Journal of Biological Chemistry.

Aim2-Mediated/IFN-β-Independent Regulation of Gastric Metaplastic Lesions via CD8+ T Cells.

Henry R. Haley, G. Luker, M. Cascalho, 2020, JCI insight.

Identification of thyroxine-binding globulin-San Diego in a family from Houston and its characterization by in vitro expression using Xenopus oocytes.

S. Refetoff, S. Astner, H. Grasberger, 2000, The Journal of clinical endocrinology and metabolism.

Characterization of the thyroxine-binding site of thyroxine-binding globulin by site-directed mutagenesis.

H. Grasberger, O. Janssen, C. Buettner, 1999, Molecular endocrinology.

Loss-of-function mutations in the thyrotropin receptor gene as a major determinant of hyperthyrotropinemia in a consanguineous community.

S. Refetoff, H. Grasberger, L. Montanelli, 2009, The Journal of clinical endocrinology and metabolism.

Resistance to thyrotropin.

S. Refetoff, H. Grasberger, 2017, Best practice & research. Clinical endocrinology & metabolism.

Chemotaxis Allows Bacteria To Overcome Host-Generated Reactive Oxygen Species That Constrain Gland Colonization

K. Ottemann, J. Kao, Shuai Hu, 2017, Infection and Immunity.

Missense mutations of dual oxidase 2 (DUOX2) implicated in congenital hypothyroidism have impaired trafficking in cells reconstituted with DUOX2 maturation factor.

F. Miot, S. Refetoff, X. de Deken, 2007, Molecular endocrinology.

DUOX2-derived reactive oxygen species are effectors of NOD2-mediated antibacterial responses

P. Rosenstiel, A. Arlt, A. Till, 2009, Journal of Cell Science.

Indoleamine 2,3-Dioxygenase 1, Increased in Human Gastric Pre-Neoplasia, Promotes Inflammation and Metaplasia in Mice and Is Associated With Type II Hypersensitivity/Autoimmunity.

A. Bass, R. Bowlby, W. Leung, 2018, Gastroenterology.

Biallelic inactivation of the dual oxidase maturation factor 2 (DUOXA2) gene as a novel cause of congenital hypothyroidism.

L. Persani, S. Mora, S. Refetoff, 2008, The Journal of clinical endocrinology and metabolism.

Characterization of T(4)-binding globulin cleaved by human leukocyte elastase.

K. Mann, S. Refetoff, H. Golcher, 2002, The Journal of clinical endocrinology and metabolism.

Dual oxidases control release of hydrogen peroxide by the gastric epithelium to prevent Helicobacter felis infection and inflammation in mice.

J. Merchant, D. Dang, H. Grasberger, 2013, Gastroenterology.

Dual oxidase 2 bidirectional promoter polymorphisms confer differential immune responses in airway epithelia.

R. Harper, A. Linderholm, Changhong Xu, 2012, American journal of respiratory cell and molecular biology.

Dual oxidase regulates neutrophil recruitment in allergic airways.

R. Harper, A. Linderholm, N. Kenyon, 2013, Free radical biology & medicine.

A familial thyrotropin (TSH) receptor mutation provides in vivo evidence that the inositol phosphates/Ca2+ cascade mediates TSH action on thyroid hormone synthesis.

S. Refetoff, J. van Sande, H. Grasberger, 2007, The Journal of clinical endocrinology and metabolism.

Pituitary-thyroid setpoint and thyrotropin receptor expression in consomic rats.

R. Weiss, L. Moeller, S. Refetoff, 2007, Endocrinology.

Activation of Dual Oxidases Duox1 and Duox2

J. Dumont, F. Miot, B. Corvilain, 2009, Journal of Biological Chemistry.

Thyroid transcription factor 1 rescues PAX8/p300 synergism impaired by a natural PAX8 paired domain mutation with dominant negative activity.

M. Abramowicz, G. Vassart, S. Refetoff, 2005, Molecular endocrinology.

Mice deficient in dual oxidase maturation factors are severely hypothyroid.

S. Refetoff, X. Liao, H. Grasberger, 2012, Molecular endocrinology.

A somatic gain-of-function mutation in the thyrotropin receptor gene producing a toxic adenoma in an infant.

B. Kohn, S. Refetoff, H. Grasberger, 2009, Thyroid : official journal of the American Thyroid Association.

Effects of growth hormone replacement therapy on levels of cortisol and cortisol-binding globulin in hypopituitary adults.

M. Tschöp, C. Strasburger, K. Morrison, 2000, European journal of endocrinology.

Mutations in the NKX2.5 gene and the PAX8 promoter in a girl with thyroid dysgenesis.

S. Refetoff, H. Grasberger, J. Pohlenz, 2011, The Journal of clinical endocrinology and metabolism.

Increased Expression of DUOX2 Is an Epithelial Response to Mucosal Dysbiosis Required for Immune Homeostasis in Mouse Intestine.

J. Merchant, A. Shreiner, J. Kao, 2015, Gastroenterology.

Dual NADPH oxidases DUOX1 and DUOX2 synthesize NAADP and are necessary for Ca2+ signaling during T cell activation

K. Krause, D. Lodygin, A. Bowie, 2021, Science Signaling.

Tryptophan Catabolism Restricts IFN-γ–Expressing Neutrophils and Clostridium difficile Immunopathology

R. Lutter, V. Young, G. Huffnagle, 2014, The Journal of Immunology.

Dietary L-serine confers a competitive fitness advantage to Enterobacteriaceae in the inflamed gut

A. Hirayama, N. Barnich, C. Alteri, 2019, Nature Microbiology.

Defects of thyroidal hydrogen peroxide generation in congenital hypothyroidism

H. Grasberger, 2010, Molecular and Cellular Endocrinology.

Autosomal dominant resistance to thyrotropin as a distinct entity in five multigenerational kindreds: clinical characterization and exclusion of candidate loci.

P. Macchia, M. Abramowicz, G. Vassart, 2005, The Journal of clinical endocrinology and metabolism.

Characterization and primary structures of bovine and porcine thyroxine-binding globulin

S. A. Spring, R. Einspanier, K. Mann, 2002, Molecular and Cellular Endocrinology.

DUOX2 variants associate with preclinical disturbances in microbiota-immune homeostasis and increased inflammatory bowel disease risk.

A. Magis, G. Omenn, M. Conomos, 2021, The Journal of clinical investigation.

Chapter 7 – Congenital Defects of Thyroid Hormone Synthesis

S. Refetoff, H. Grasberger, 2016 .

Genetic causes of congenital hypothyroidism due to dyshormonogenesis

S. Refetoff, H. Grasberger, 2011, Current opinion in pediatrics.

Congenital Defects of Thyroid Hormone Synthesis

S. Refetoff, H. Grasberger, 2010 .

The effect of CT26 tumor-derived TGF-β on the balance of tumor growth and immunity.

J. Kao, H. Grasberger, Min F Zhang, 2017, Immunology letters.

CD4+ tissue-resident memory T-cells expand and are a major source of mucosal tumor necrosis factor α in active Crohn's Disease.

P. Higgins, W. Zou, J. Kao, 2019, Journal of Crohn's & colitis.

Functional Characterization of Inflammatory Bowel Disease–Associated Gut Dysbiosis in Gnotobiotic Mice

P. Higgins, A. Hirayama, V. Young, 2016, Cellular and molecular gastroenterology and hepatology.

Peroxidasin-mediated crosslinking of collagen IV is independent of NADPH oxidases

M. Geiszt, Ágnes Donkó, E. Lázár, 2018, Redox biology.

Dual promoter structure of ZFP106: regulation by myogenin and nuclear respiratory factor-1.

G. Bell, H. Mashima, Honggang Ye, 2005, Gene.

Repulsive separation of the cytoplasmic ends of transmembrane helices 3 and 6 is linked to receptor activation in a novel thyrotropin receptor mutant (M626I).

J. van Durme, R. Weiss, S. Refetoff, 2006, Molecular endocrinology.

Effects of Anti-Helicobacter pylori Therapy on Incidence of Autoimmune Diseases, Including Inflammatory Bowel Diseases.

Deng-Chyang Wu, A. Waljee, J. Kao, 2019, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

Essential Role of NADPH Oxidase–Dependent Production of Reactive Oxygen Species in Maintenance of Sustained B Cell Receptor Signaling and B Cell Proliferation

T. Tsubata, H. Grasberger, Y. Matsumura, 2019, The Journal of Immunology.

Increased risk for inflammatory bowel disease in congenital hypothyroidism supports the existence of a shared susceptibility factor

A. Waljee, J. Kao, J. Adler, 2018, Scientific Reports.

Identification of the Maturation Factor for Dual Oxidase

S. Refetoff, H. Grasberger, 2006, Journal of Biological Chemistry.

Ceftriaxone-Associated Nephrolithiasis

H. Grasberger, K. Loeschke, Bärbel Otto, 2000, The Annals of pharmacotherapy.

Subcellular recruitment by TSG118 and TSPYL implicates a role for zinc finger protein 106 in a novel developmental pathway.

G. Bell, H. Grasberger, 2005, The international journal of biochemistry & cell biology.

Endoplasmic reticulum stress in the intestinal epithelium initiates purine metabolite synthesis and promotes Th17 cell differentiation in the gut.

U. Sauer, A. Kaser, P. Rosenstiel, 2023, Immunity.

Resistance to thyroid hormone in a patient with thyroid dysgenesis.

S. Refetoff, M. Croxson, H. Grasberger, 2005, Thyroid : official journal of the American Thyroid Association.

Two cases of thyroid dysgenesis caused by different novel PAX8 mutations in the DNA-binding region: in vitro studies reveal different pathogenic mechanisms.

H. Dörr, S. Refetoff, H. Grasberger, 2012, Thyroid : official journal of the American Thyroid Association.

Identification of a locus for nongoitrous congenital hypothyroidism on chromosome 15q25.3-26.1

P. Froguel, M. Vaxillaire, V. Vatin, 2005, Human Genetics.

Deficiency in Duox2 activity alleviates ileitis in GPx1- and GPx2-knockout mice without affecting apoptosis incidence in the crypt epithelium

J. Doroshow, F. Chu, T. Leto, 2016, Redox biology.

ZBP-89 regulates expression of tryptophan hydroxylase I and mucosal defense against Salmonella typhimurium in mice.

J. Merchant, D. J. Law, M. Saqui-Salces, 2013, Gastroenterology.

The tumour necrosis factor-alpha induced vascular permeability is associated with a reduction of VE-cadherin expression.

R. Landgraf, M. Bidlingmaier, S. Hofmann, 2002, European journal of medical research.

A novel thyroid hormone receptor-beta mutation that fails to bind nuclear receptor corepressor in a patient as an apparent cause of severe, predominantly pituitary resistance to thyroid hormone.

R. Weiss, S. Refetoff, J. Noel, 2006, The Journal of clinical endocrinology and metabolism.

A single copy of the recently identified dual oxidase maturation factor (DUOXA) 1 gene produces only mild transient hypothyroidism in a patient with a novel biallelic DUOXA2 mutation and monoallelic DUOXA1 deletion.

S. Refetoff, S. Heger, H. Grasberger, 2011, The Journal of clinical endocrinology and metabolism.

Probiotic-Mediated Protection Against Chronic Water-Avoidance Stress Enteritis in Mice is Associated with Lamina Propria Plasmacytoid Dendritic Cell Infiltration

J. Kao, H. Grasberger, Yundong Sun, 2017 .

Helicobacter pylori Antimicrobial Susceptibility Testing-Guided Salvage Therapy in the USA: A Real Life Experience

J. Kao, S. Bishu, H. Grasberger, 2018, Digestive Diseases and Sciences.

Dendritic cell‐derived TGF‐β mediates the induction of mucosal regulatory T‐cell response to Helicobacter infection essential for maintenance of immune tolerance in mice

J. Kao, Min Zhang, S. Bishu, 2020, Helicobacter.

Novel Mutations in the NKX2.1 gene and the PAX8 gene in a Boy with Brain-Lung-Thyroid Syndrome

S. Refetoff, H. Grasberger, J. Pohlenz, 2017, Experimental and Clinical Endocrinology & Diabetes.

Citrobacter rodentium Induces Tissue-Resident Memory CD4+ T Cells

P. Higgins, W. Zou, J. Kao, 2019, Infection and Immunity.

C-terminal amino acid alteration rather than late termination causes complete deficiency of thyroxine-binding globulin CD-NeuIsenburg.

K. Mann, L. Moeller, B. Weimer, 2006, The Journal of clinical endocrinology and metabolism.

Aberrant Cerebellar Development in Mice Lacking Dual Oxidase Maturation Factors.

N. Koibuchi, S. Refetoff, T. Iwasaki, 2016, Thyroid : official journal of the American Thyroid Association.

Identification of a Functional TPH1 Polymorphism Associated With Irritable Bowel Syndrome Bowel Habit Subtypes

W. Shih, A. Presson, E. Mayer, 2013, The American Journal of Gastroenterology.

Loop variants of the serpin thyroxine-binding globulin: implications for hormone release upon limited proteolysis.

H. Golcher, H. Grasberger, O. Janssen, 2002, The Biochemical journal.

Increased risk for inflammatory bowel disease in congenital hypothyroidism supports the existence of a shared susceptibility factor

A. Waljee, J. Kao, J. Adler, 2018, Scientific Reports.

The Cxcr2+ subset of the S100a8+ gastric granylocytic myeloid-derived suppressor cell population (G-MDSC) regulates gastric pathology

H. Grasberger, M. El-zaatari, Krystal D. Kao, 2023, Frontiers in immunology.

Mutations in the NKX2.5 gene and the PAX8 promoter in a girl with thyroid dysgenesis.

S. Refetoff, H. Grasberger, J. Pohlenz, 2011, The Journal of clinical endocrinology and metabolism.