S. Ro

发表

Structural chemoproteomics and drug discovery

Y. Hyun, D. Shin, Y. Heo, 2005, Biopolymers.

Design and synthesis of 7-hydroxy-1H-benzoimidazole derivatives as novel inhibitors of glycogen synthase kinase-3beta.

Yong Eun Kim, Yong-Soon Cho, Y. Hyun, 2007, Bioorganic & medicinal chemistry letters.

Molecular Basis for the Local Conformational Rearrangement of Human Phosphoserine Phosphatase*

Sam-Yong Park, J. Moon, K. Hwang, 2002, The Journal of Biological Chemistry.

A novel class of highly potent, selective, and non-peptidic inhibitor of Ras farnesyltransferase (FTase).

Y. Shin, J. Kim, H. Lee, 2001, Bioorganic & medicinal chemistry letters.

3-Aryl-4-aryloyl-1-(1H-imidazol-5-yl)methylpyrrole, a novel class of farnesyltransferase inhibitors.

Y. Shin, J. Kim, H. Lee, 2001, Bioorganic & medicinal chemistry letters.

In Vitro Activities of CG400549, a Novel FabI Inhibitor, against Recently Isolated Clinical Staphylococcal Strains in Korea

Chang Ki Kim, D. Yong, Y. Chong, 2007, Antimicrobial Agents and Chemotherapy.

CG0009, a Novel Glycogen Synthase Kinase 3 Inhibitor, Induces Cell Death through Cyclin D1 Depletion in Breast Cancer Cells

S. Jang, Jene Choi, Choung-Soo Kim, 2013, PloS one.

In vitro evaluation of histone deacetylase inhibitors as combination agents for colorectal cancer.

Seon-Young Kim, J. Kim, Tae Won Kim, 2009, Anticancer research.

Evaluation of novel histone deacetylase inhibitors as therapeutic agents for colorectal adenocarcinomas compared to established regimens with the histoculture drug response assay

Seon-Young Kim, Y. S. Kim, J. Kim, 2009, International Journal of Colorectal Disease.

Discovery of novel 2-[2-(3-hydroxy-pyridin-2-yl)-thiazol-4-yl]-acetamide derivatives as HIF prolyl 4-hydroxylase inhibitors; SAR, synthesis and modeling evaluation.

S. Ro, Y. Jung, J. Cho, 2014, Bioorganic & medicinal chemistry letters.

[(4-Hydroxyl-benzo[4,5]thieno[3,2-c]pyridine-3-carbonyl)-amino]-acetic acid derivatives; HIF prolyl 4-hydroxylase inhibitors as oral erythropoietin secretagogues.

S. Ro, Y. Jung, Seung-Chul Lee, 2013, Bioorganic & medicinal chemistry letters.

A novel histone deacetylase inhibitor, CG0006, induces cell death through both extrinsic and intrinsic apoptotic pathways

S. Jang, Jene Choi, Choung-Soo Kim, 2009, Anti-cancer drugs.

HDAC inhibitors synergize antiproliferative effect of sorafenib in renal cell carcinoma cells.

Dong Eun Kim, S. Jang, Jene Choi, 2012, Anticancer research.

CG0006, a novel histone deacetylase inhibitor, induces breast cancer cell death via histone-acetylation and chaperone-disrupting pathways independent of ER status

S. Jang, Jene Choi, Choung-Soo Kim, 2011, Breast Cancer Research and Treatment.

Effects of the HDAC inhibitor CG2 in combination with irinotecan, 5-fluorouracil, or oxaliplatin on HCT116 colon cancer cells and xenografts.

J. Kim, Tae Won Kim, D. Jin, 2010, Oncology reports.

Topochemical analysis of morphiceptin and dermorphin bioactivities.

T. Yamazaki, M. Goodman, S. Ro, 1991, Biochemical and biophysical research communications.

The utility of 2-hydroxypropyl-beta-cyclodextrin as a vehicle for the intracerebral and intrathecal administration of drugs.

T. Yaksh, M. Goodman, Y. Nishiuchi, 1991, Life sciences.

Structure of the catalytic domain of human phosphodiesterase 5 with bound drug molecules

Jin Hwan Kim, Tae Gyu Lee, Young Ho Jeon, 2003, Nature.

Solid phase synthesis of hydantoin library using a novel cyclization and traceless cleavage step

Jinho Lee, S. Ro, Sang Wong Kim, 1997 .

Solid phase synthesis of benzamidine and butylamine-derived hydantoin libraries

S. Ro, Sang Wong Kim, J. Koh, 1997, Molecular Diversity.

Solution and solid phase combinatorial synthesis of peptidomimetic library containing diversified alpha-methylated amino acids.

S. Ro, S. Kim, Y. S. Shin, 1998, Bioorganic & medicinal chemistry letters.

Phosphodiesterase: overview of protein structures, potential therapeutic applications and recent progress in drug development

Y. Jeon, Y. Hyun, Y. Heo, 2005, Cellular and Molecular Life Sciences CMLS.

Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125

Sam-Yong Park, K. Hwang, Chul-hak Yang, 2004, The EMBO journal.

Growth arrest and forced differentiation of human primary glioblastoma multiforme by a novel small molecule

K. Kang, Tae-Wook Kang, S. Choi, 2014, Scientific Reports.

A topochemical approach to explain morphiceptin bioactivity.

T. Yamazaki, P. Schiller, N. N. Chung, 1993, Journal of medicinal chemistry.

First-in-human study of the toxicity, pharmacokinetics, and pharmacodynamics of CG200745, a pan-HDAC inhibitor, in patients with refractory solid malignancies

Tae Won Kim, Jae-Lyun Lee, K. Bae, 2015, Investigational New Drugs.

A Newly Identified CG301269 Improves Lipid and Glucose Metabolism Without Body Weight Gain Through Activation of Peroxisome Proliferator–Activated Receptor α and γ

K. Park, Hyo‐Soo Kim, J. B. Kim, 2011, Diabetes.

Crystal structure of the biotin carboxylase domain of human acetyl‐CoA carboxylase 2

Yong Eun Kim, Sam-Yong Park, Yong-Soon Cho, 2007, Proteins.

A novel histone deacetylase inhibitor, CG200745, potentiates anticancer effect of docetaxel in prostate cancer via decreasing Mcl-1 and Bcl-XL

S. Jang, Jene Choi, Choung-Soo Kim, 2012, Investigational New Drugs.

A novel HDAC inhibitor, CG200745, inhibits pancreatic cancer cell growth and overcomes gemcitabine resistance

H. Lee, S. Kim, S. Ro, 2017, Scientific Reports.

The energetically favorable cis peptide bond for the azaglycine-containing peptide: For-AzGly-NH2 model

Young-Sang Choi, Jong-Won Song, Ho-Jin Lee, 2001 .

An MG53-IRS1-interaction disruptor ameliorates insulin resistance

Jae-Seon Lee, Bong-Woo Kim, Y. Ko, 2018, Experimental & Molecular Medicine.

Histone deacetylase inhibitor, CG200745, attenuates cardiac hypertrophy and fibrosis in DOCA-induced hypertensive rats

Seol-Hee Kang, Hae-Ahm Lee, Mina Kim, 2016, The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology.

Structure of human PRL‐3, the phosphatase associated with cancer metastasis

Weontae Lee, J. Jee, Chulhyun Lee, 2004, FEBS letters.

Novel histone deacetylase inhibitor CG200745 induces clonogenic cell death by modulating acetylation of p53 in cancer cells

H. Park, E. Choi, E. Oh, 2012, Investigational New Drugs.

A Nonthiazolidinedione Peroxisome Proliferator-Activated Receptor α/γ Dual Agonist CG301360 Alleviates Insulin Resistance and Lipid Dysregulation in db/db Mice

J. H. Lee, J. B. Kim, Sung-Hee Choi, 2010, Molecular Pharmacology.

A NON-TZD PPARα/γ DUAL AGONIST CG301360 ALLEVIATES INSULIN RESISTANCE AND LIPID DYSREGULATION IN db/db MICE

R. Kim, J. H. Lee, J. B. Kim, 2010 .

Comparison between Therapeutic Efficacies of Histone Deacetylase Inhibitors and Established Drug Regimens Against Breast Cancer Cells using the Histoculture Drug Response Assay.

S. Ahn, Seon-Young Kim, Tae Won Kim, 2009 .

3D Quantitative and Qualitative Structure-Activity Relationships of the δ-Opioid Receptor Antagonists

K. Jeong, Yangmee Kim, Jee-Young Lee, 2008 .

Proton Magnetic Resonance Study of the Amino Group of Thioacetamide (TA) I. Quadrupole Relaxation Effects in NH$_2$ of Thioacetamide

S. Ro, C. Yoon, Young-Sang Choi, 1987 .

Highly potent side chain–main chain cyclized dermorphin–deltorphin analogues: An integrated approach including synthesis, bioassays, NMR spectroscopy and molecular modelling

A. Malmberg, T. Burks, T. Yaksh, 1995, Journal of peptide science : an official publication of the European Peptide Society.

In vitro chemosensitivity of gastric adenocarcinomas to histone deacetylase inhibitors, compared to established drugs.

Seon-Young Kim, Y. S. Kim, S. Roh, 2010, Hepato-gastroenterology.

Combination treatment of renal cell carcinoma with belinostat and 5-fluorouracil: a role for oxidative stress induced DNA damage and HSP90 regulated thymidine synthase.

E. Choi, Choung-Soo Kim, J. Hwang, 2015, The Journal of urology.

Structural basis of triclosan resistance.

Han Myoung Lee, Kwang S. Kim, H. Lee, 2011, Journal of structural biology.

Evaluation of preventive and therapeutic activity of novel non-steroidal anti-inflammatory drug, CG100649, in colon cancer: Increased expression of TNF-related apoptosis-inducing ligand receptors enhance the apoptotic response to combination treatment with TRAIL.

S. Oh, J. Woo, Ju-Hee Kang, 2015, Oncology reports.