E. Goedken

发表

Divalent metal cofactor binding in the kinetic folding trajectory of Escherichia coli ribonuclease HI

J M Berger, J. Berger, S. Marqusee, 2000, Protein science : a publication of the Protein Society.

Discovery and characterization of non-ATP site inhibitors of the mitogen activated protein (MAP) kinases.

Hua Tang, Bo Liu, Gang Liu, 2011, ACS chemical biology.

Analysis of the role of PCNA-DNA contacts during clamp loading

J. Kuriyan, M. O’Donnell, G. Bowman, 2010, BMC Structural Biology.

Small Molecule and Pooled CRISPR Screens Investigating IL17 Signaling Identify BRD2 as a Novel Contributor to Keratinocyte Inflammatory Responses.

D. Donnelly-roberts, Charles Lu, Namjin Chung, 2019, ACS chemical biology.

Functional comparison of recombinant acidic mammalian chitinase with enzyme from murine bronchoalveolar lavage.

P. Richardson, J. Mankovich, A. Cherniack, 2011, Protein expression and purification.

THU0127 Pharmacodynamics of A Novel JAK1 Selective Inhibitor in Rat Arthritis and Anemia Models and in Healthy Human Subjects

L. Olson, M. Friedman, N. Wishart, 2014 .

Identification and structure-based drug design of cell-active inhibitors of interleukin 17A at a novel C-terminal site

Justin D Dietrich, A. Petros, P. Richardson, 2022, Scientific Reports.

Domain-level stability of an antibody monitored by reduction, differential alkylation, and mass spectrometry analysis.

Hongcheng Liu, G. Gaza-Bulseco, E. Goedken, 2010, Analytical biochemistry.

Folding the ribonuclease H domain of Moloney murine leukemia virus reverse transcriptase requires metal binding or a short N‐terminal extension

S. Marqusee, E. Goedken, 1998, Proteins.

Merits and Pitfalls in the Characterization of Covalent Inhibitors of Bruton’s Tyrosine Kinase

Noel S. Wilson, Christopher M. Harris, E. Goedken, 2018, SLAS discovery : advancing life sciences R & D.

HTRF-Based Assay for Microsomal Prostaglandin E

Junjian Liu, E. Goedken, A. Burchat, 2013 .

HTRF-Based Assay for Microsomal Prostaglandin E2 Synthase-1 Activity

Junjian Liu, E. Goedken, M. Tomlinson, 2008, Journal of biomolecular screening.

Design and synthesis of tricyclic cores for kinase inhibition.

Brian J. Kotecki, Philip J. Merta, S. Shekhar, 2013, Bioorganic & medicinal chemistry letters.

Co-crystal of Escherichia coli RNase HI with Mn2+ Ions Reveals Two Divalent Metals Bound in the Active Site*

S. Marqusee, E. Goedken, Eric R. Goedken, 2001, The Journal of Biological Chemistry.

Activation/Attenuation Model for RNase H

S. Marqusee, J. Keck, E. Goedken, 1998, The Journal of Biological Chemistry.

Mapping the interaction of DNA with the Escherichia coli DNA polymerase clamp loader complex

S. Kazmirski, J. Kuriyan, M. O’Donnell, 2005, Nature Structural &Molecular Biology.

Fluorescence measurements on the E.coli DNA polymerase clamp loader: implications for conformational changes during ATP and clamp binding.

John Kuriyan, Mike O'Donnell, Carlos Bustamante, 2004, Journal of molecular biology.

Tricyclic Covalent Inhibitors Selectively Target Jak3 through an Active Site Thiol*

Christopher M Harris, A. Hobson, D. Ihle, 2014, The Journal of Biological Chemistry.

Enabling structure-based drug design of Tyk2 through co-crystallization with a stabilizing aminoindazole inhibitor

R. Dixon, D. Borhani, R. Talanian, 2012, BMC Structural Biology.

ABBV-105, a selective and irreversible inhibitor of Bruton’s tyrosine kinase, is efficacious in multiple preclinical models of inflammation

Christian Goess, S. Mathieu, E. Sampson, 2018, Modern rheumatology.

Native-state energetics of a thermostabilized variant of ribonuclease HI.

S. Marqusee, E. Goedken, 2001, Journal of molecular biology.

The Mechanism of ATP-Dependent Primer-Template Recognition by a Clamp Loader Complex

S. Kazmirski, J. Kuriyan, M. O’Donnell, 2009, Cell.

Crystal structure of a DNA polymerase sliding clamp from a Gram-positive bacterium

J. Kuriyan, M. O’Donnell, I. Bruck, 2006, BMC Structural Biology.

Sliding Clamps in DNA Replication: E. coli β-Clamp and PCNA Structure

J. Kuriyan, E. Goedken, 2004 .

The crystal structure of adenylosuccinate lyase from Pyrobaculum aerophilum reveals an intracellular protein with three disulfide bonds.

T. Yeates, S. Marqusee, C. Worby, 2000, Journal of molecular biology.

DNA polymerase clamp loaders and DNA recognition

John Kuriyan, Mike O'Donnell, S. Kazmirski, 2005, FEBS letters.

In Vivo Characterization Of ABT-308, A Potent Anti-IL-13 Antibody For The Treatment Of Asthma

C. Cuff, E. Goedken, Chengbin Wu, 2010, ATS 2010.

Structure activity optimization of 6H-pyrrolo[2,3-e][1,2,4]triazolo[4,3-a]pyrazines as Jak1 kinase inhibitors.

Ana L. Aguirre, E. Tarcsa, Bin Li, 2015, Bioorganic & Medicinal Chemistry Letters.

Minimum Significant Ratio of Selectivity Ratios (MSRSR) and Confidence in Ratio of Selectivity Ratios (CRSR)

Viswanath Devanarayan, Christopher M Harris, V. Devanarayan, 2012, Journal of biomolecular screening.

Metal binding and activation of the ribonuclease H domain from moloney murine leukemia virus.

S. Marqusee, E. Goedken, 1999, Protein engineering.

Importance of the C-terminal helix to the stability and enzymatic activity of Escherichia coli ribonuclease H.

S. Marqusee, T. M. Raschke, E. Goedken, 1997, Biochemistry.

ACT1 is required for murine IL-23-induced psoriasiform inflammation potentially independent of E3 ligase activity.

A. Lipovsky, S. Gauld, P. Slivka, 2021, The Journal of investigative dermatology.

Domain-level stability of an antibody monitored by reduction, differential alkylation, and mass spectrometry analysis.

Hongcheng Liu, G. Gaza-Bulseco, E. Goedken, 2010, Analytical biochemistry.

Importance of PLD2 in an IL‐23 driven psoriasiform dermatitis model and potential link to human psoriasis

Kathleen M. Smith, A. Lipovsky, P. Honore, 2023, The Journal of dermatology.

Decreased expression of carboxypeptidase E protein is correlated to estrogen-induction of rat pituitary tumors

J. Gorski, D. Gregg, E. Goedken, 1996, Molecular and Cellular Endocrinology.