H. Seidel

发表

Phosphonate biosynthesis: isolation of the enzyme responsible for the formation of a carbon–phosphorus bond

J. Knowles, H. Seto, S. Freeman, 1988, Nature.

Exons as microgenes?

J. Knowles, D. Pompliano, H. Seidel, 1992, Science.

(R)-2-Phenylpyrrolidine Substituted Imidazopyridazines: A New Class of Potent and Selective Pan-TRK Inhibitors.

Nanxin Li, Jennifer L. Harris, Jianwei Che, 2015, ACS medicinal chemistry letters.

Discovery of GNF-5837, a Selective TRK Inhibitor with Efficacy in Rodent Cancer Tumor Models.

Nanxin Li, A. Kreusch, Shenlin Huang, 2012, ACS medicinal chemistry letters.

Characterization of a novel, brain-penetrating CB1 receptor inverse agonist: metabolic profile in diet-induced obese models and aspects of central activity

P. McNamara, J. Gromada, S. Commerford, 2011, Naunyn-Schmiedeberg's Archives of Pharmacology.

Rapid activation of the STAT3 transcription factor by granulocyte colony-stimulating factor

P. Lamb, H. Seidel, S. Tian, 1994 .

Inhibition of the Inositol Kinase Itpkb Augments Calcium Signaling in Lymphocytes and Reveals a Novel Strategy to Treat Autoimmune Disease

Paul J. Groot-Kormelink, Daniel R. Beisner, M. Cooke, 2015, PloS one.

Discovery of trifluoromethyl(pyrimidin-2-yl)azetidine-2-carboxamides as potent, orally bioavailable TGR5 (GPBAR1) agonists: structure-activity relationships, lead optimization, and chronic in vivo efficacy.

P. McNamara, Chun Xing Li, Yang Yang, 2014, Journal of medicinal chemistry.

Peptide Binding Identifies an ERα Conformation That Generates Selective Activity in Multiple In Vitro Assays

A. Negro-Vilar, C. Larson, H. Seidel, 2005, Journal of biomolecular screening.

Hepatobiliary and Cardiovascular Effects Limit

P. McNamara, J. Markovits, S. Chandra, 2017 .

NMR Structural Studies of Interactions of a Small, Nonpeptidyl Tpo Mimic with the Thrombopoietin Receptor Extracellular Juxtamembrane and Transmembrane Domains*

S. Opella, S. H. Park, T. Marsilje, 2007, Journal of Biological Chemistry.

Discovery of Pyridinyl Acetamide Derivatives as Potent, Selective, and Orally Bioavailable Porcupine Inhibitors.

Jennifer L. Harris, S. Kasibhatla, D. Han, 2016, ACS medicinal chemistry letters.

Nidufexor (LMB763), a Novel FXR Modulator for the Treatment of Nonalcoholic Steatohepatitis (NASH).

I. Sancho-Martinez, P. McNamara, S. Joseph, 2020, Journal of medicinal chemistry.

新規PPARδ作動薬としての3,4,5‐三置換イソオキサゾール:1部

Xie Yongping, H. Seidel, E. Robert, 2006 .

Discovery of Tropifexor (LJN452), a Highly Potent Non-bile Acid FXR Agonist for the Treatment of Cholestatic Liver Diseases and Nonalcoholic Steatohepatitis (NASH).

P. McNamara, S. Joseph, B. Laffitte, 2017, Journal of medicinal chemistry.

Spacing of palindromic half sites as a determinant of selective STAT (signal transducers and activators of transcription) DNA binding and transcriptional activity.

J. Darnell, J. Rosen, P. Lamb, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Novel tricyclic pyrazolopyrimidines as potent and selective GPR119 agonists.

P. McNamara, S. Joseph, R. Epple, 2014, Bioorganic & medicinal chemistry letters.

Discovery of pyrimidine benzimidazoles as Src-family selective Lck inhibitors. Part II.

N. Gray, Jianwei Che, P. Ren, 2009, Bioorganic & medicinal chemistry letters.

Pharmacological inhibition of porcupine induces regression of experimental skin fibrosis by targeting Wnt signalling

C. Maier, Jennifer L. Harris, G. Schett, 2017, Annals of the rheumatic diseases.

Rapid activation of proteins that interact with the interferon gamma activation site in response to multiple cytokines

J. Rosen, D. Levy, R. Stein, 1994 .

Novel bisaryl substituted thiazoles and oxazoles as highly potent and selective peroxisome proliferator-activated receptor delta agonists.

J. Wityak, E. Saez, R. Epple, 2010, Journal of medicinal chemistry.

Optimization of small molecule agonists of the thrombopoietin (Tpo) receptor derived from a benzo[a]carbazole hit scaffold.

J. Lao, D. Chow, T. Marsilje, 2008, Bioorganic & medicinal chemistry letters.

Discovery and biological evaluation of benzo[a]carbazole-based small molecule agonists of the thrombopoietin (Tpo) receptor.

J. Lao, A. Chatterjee, T. Tuntland, 2008, Bioorganic & medicinal chemistry letters.

Synthesis of 24-heteroatom-substituted cholestanols.

R. Pascal, H. Seidel, M. D. Rahman, 1988, Journal of lipid research.

Targeting the NLRP3 inflammasome in inflammatory diseases

E. Latz, E. Olhava, G. Glick, 2018, Nature Reviews Drug Discovery.

Phosphonate biosynthesis: molecular cloning of the gene for phosphoenolpyruvate mutase from Tetrahymena pyriformis and overexpression of the gene product in Escherichia coli.

J. Knowles, D. Pompliano, H. Seidel, 1992, Biochemistry.

Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974

W. Sellers, P. Schultz, Jennifer L. Harris, 2013, Proceedings of the National Academy of Sciences.

Design of Conditionally Active STATs: Insights into STAT Activation and Gene Regulatory Function

H. Seidel, Lawrence H. Milocco, Jennifer A. Haslam, 1999, Molecular and Cellular Biology.

Regulatory Function Insights into STAT Activation and Gene Design of Conditionally Active STATs :

H. Seidel, J. Rosen, L. Milocco, 1999 .

Rapid activation of the interferon-gamma signal transduction pathway by inhibitors of tyrosine phosphatases.

J. Rosen, P. Lamb, L. Kessler, 1994, Journal of interferon research.

Ligand-Dependent Degradation of Retinoid X Receptors Does Not Require Transcriptional Activity or Coactivator Interactions

I. Schulman, G. Shao, H. Seidel, 2001, Molecular and Cellular Biology.

Pharmaceutical intervention in the JAK/STAT signaling pathway

P. Lamb, H. Seidel, J. Rosen, 2000, Oncogene.

Synthesis, structure-activity relationships, and in vivo efficacy of the novel potent and selective anaplastic lymphoma kinase (ALK) inhibitor 5-chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (LDK378) currently in phase 1 and phase 2

Sungjoon Kim, Nanxin Li, M. Warmuth, 2013, Journal of medicinal chemistry.

Chapter 27. The Role of JAKs and STATs in Transcriptional Regulation by Cytokines

P. Lamb, H. Seidel, R. Stein, 1996 .

Targeting the NLRP3 inflammasome in inflammatory diseases

E. Latz, E. Olhava, G. Glick, 2018, Nature Reviews Drug Discovery.

Drug Discovery Approaches Targeting the JAK/STAT Pathway

H. Seidel, J. Rosen, 2003 .

Rapid Activation of the STAT 3 Transcription Factor by Granulocyte Colony-Stimulating Factor

Robert, P. Lamb, H. Seidel, 2002 .

Rapid activation of proteins that interact with the interferon gamma activation site in response to multiple cytokines.

J. Rosen, D. Levy, P. Lamb, 1994, Blood.

Introns and the origin of protein-coding genes.

J. Knowles, H. Seidel, B. Bertolaet, 1995, Science.

STAT protein complexes activated by interferon-gamma and gp130 signaling molecules differ in their sequence preferences and transcriptional induction properties.

J. Rosen, P. Lamb, L. Kessler, 1995, Nucleic acids research.

Rapid activation of the STAT3 transcription factor by granulocyte colony-stimulating factor.

P. Lamb, H. Seidel, S. Tian, 1994, Blood.

Poly I:CLC induction of the interferon system in mice: an initial study of four detection methods.

S. Baron, H. Seidel, H. Levy, 2002, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

N-Acylthiadiazolines, a new class of liver X receptor agonists with selectivity for LXRbeta.

Peter Tontonoz, Tove Tuntland, Ansgar Brock, 2007, Journal of medicinal chemistry.

Phosphonate biosynthesis: the stereochemical course of phosphoenolpyruvate phosphomutase

J. Knowles, S. Freeman, H. Seidel, 1989 .

Interaction of inhibitors with phosphoenolpyruvate mutase: implications for the reaction mechanism and the nature of the active site.

J. Knowles, H. Seidel, 1994, Biochemistry.