W. Nomura

发表

Synthesis and Evaluation of Dimeric Derivatives of Diacylglycerol-Lactones as Protein Kinase C Ligands.

P. Blumberg, H. Tamamura, N. Lewin, 2017, Bioconjugate chemistry.

[Application and potential of genome engineering by artificial enzymes].

W. Nomura, 2015, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

The hepatokine FGF21 is crucial for peroxisome proliferator-activated receptor-α agonist-induced amelioration of metabolic disorders in obese mice

S. Seno, H. Matsuda, R. Yu, 2017, The Journal of Biological Chemistry.

CD4 mimics targeting the mechanism of HIV entry.

S. Matsushita, T. Narumi, H. Tamamura, 2010, Bioorganic & medicinal chemistry letters.

Development of crosslink-type tag-probe pairs for fluorescent imaging of proteins.

T. Narumi, H. Tamamura, H. Tsutsumi, 2010, Biopolymers.

Fluorogenically active leucine zipper peptides as tag-probe pairs for protein imaging in living cells.

K. Akiyoshi, H. Tamamura, K. Ohba, 2009, Angewandte Chemie.

A minimally cytotoxic CD4 mimic as an HIV entry inhibitor.

S. Matsushita, T. Narumi, H. Tamamura, 2016, Bioorganic & medicinal chemistry letters.

Small‐Molecule CD4 Mimics Containing Mono‐cyclohexyl Moieties as HIV Entry Inhibitors

S. Matsushita, H. Tamamura, N. Ohashi, 2016, ChemMedChem.

A Synthetic C34 Trimer of HIV‐1 gp41 Shows Significant Increase in Inhibition Potency

T. Narumi, H. Tamamura, Kosuke Miyauchi, 2012, ChemMedChem.

Chemogenetic Approach Using Ni(II) Complex–Agonist Conjugates Allows Selective Activation of Class A G-Protein-Coupled Receptors

I. Hamachi, S. Kiyonaka, W. Nomura, 2018, ACS central science.

Anti-Inflammatory and Antioxidative Properties of Isoflavones Provide Renal Protective Effects Distinct from Those of Dietary Soy Proteins Against Diabetic Nephropathy.

S. Seno, H. Matsuda, K. Hayashi, 2020, Molecular nutrition & food research.

Green Tea Polyphenols Function as Prooxidants To Activate Oxidative-Stress-Responsive Transcription Factors in Yeasts

Y. Inoue, Yoshifumi Takatsume, W. Nomura, 2006, Applied and Environmental Microbiology.

Release of thioredoxin from Saccharomyces cerevisiae with environmental stimuli: solubilization of thioredoxin with ethanol

H. Masutani, J. Yodoi, Y. Inoue, 2007, Applied Microbiology and Biotechnology.

Methylglyoxal attenuates isoproterenol-induced increase in uncoupling protein 1 expression through activation of JNK signaling pathway in beige adipocytes

T. Kawada, Kazuo Inoue, T. Goto, 2021, Biochemistry and biophysics reports.

The dipeptidyl peptidase‐4 (DPP‐4) inhibitor teneligliptin enhances brown adipose tissue function, thereby preventing obesity in mice

S. Seno, H. Matsuda, T. Ara, 2018, FEBS open bio.

Comparative Analysis of the Preventive Effects of Canagliflozin, a Sodium-Glucose Co-Transporter-2 Inhibitor, on Body Weight Gain Between Oral Gavage and Dietary Administration by Focusing on Fatty Acid Metabolism

T. Kawada, Kazuo Inoue, T. Goto, 2020, Diabetes, metabolic syndrome and obesity : targets and therapy.

Soy hydrolysate enhances the isoproterenol-stimulated lipolytic pathway through an increase in β-adrenergic receptor expression in adipocytes

Tetsuro Ito, T. Ara, T. Kawada, 2019, Bioscience, biotechnology, and biochemistry.

The Mevalonate Pathway Is Indispensable for Adipocyte Survival

T. Ara, T. Kawada, T. Goto, 2018, iScience.

Development of a traceable linker containing a thiol-responsive amino acid for the enrichment and selective labelling of target proteins.

A. Otaka, H. Tamamura, A. Yamauchi, 2014, Organic & biomolecular chemistry.

Development of a fluoride-responsive amide bond cleavage device that is potentially applicable to a traceable linker

A. Otaka, H. Tamamura, A. Yamauchi, 2014 .

Synthesized enone fatty acids resembling metabolites from gut microbiota suppress macrophage-mediated inflammation in adipocytes.

R. Yu, T. Kawada, S. Kishino, 2017, Molecular nutrition & food research.

Lactobacillus helveticus-MIKI-020 enhances hepatic FGF21 expression and decreases the core body temperature during sleep in mice

T. Ara, T. Kawada, T. Goto, 2019, Journal of Functional Foods.

Intense Blue Fluorescence in a Leucine Zipper Assembly

W. Nomura, Hiroshi Tsutsumi , Seiichiro Abe , 2011, Chembiochem : a European journal of chemical biology.

CD4 mimics as HIV entry inhibitors: lead optimization studies of the aromatic substituents.

S. Matsushita, T. Narumi, H. Tamamura, 2013, Bioorganic & medicinal chemistry.

Suksdorfin Promotes Adipocyte Differentiation and Improves Abnormalities in Glucose Metabolism via PPARγ Activation

R. Yu, T. Kawada, T. Goto, 2017, Lipids.

10-oxo-12(Z)-octadecenoic acid, a linoleic acid metabolite produced by gut lactic acid bacteria, potently activates PPARγ and stimulates adipogenesis.

R. Yu, T. Kawada, S. Kishino, 2015, Biochemical and biophysical research communications.

Utilization of the Heavy Atom Effect for the Development of a Photosensitive 8-Azacoumarin-Type Photolabile Protecting Group.

T. Narumi, H. Tamamura, T. Furuta, 2015, Organic letters.

Development of the 8-aza-3-bromo-7-hydroxycoumarin-4-ylmethyl group as a new entry of photolabile protecting groups

T. Narumi, H. Tamamura, T. Furuta, 2014 .

TOR Signaling in Budding Yeast

Y. Inoue, W. Nomura, 2018 .

Contribution of phosphatidylserine to Rho1- and Pkc1-related repolarization of the actin cytoskeleton under stressed conditions in Saccharomyces cerevisiae

Y. Inoue, W. Nomura, 2019, Small GTPases.

Fluorophore labeling enables imaging and evaluation of specific CXCR4-ligand interaction at the cell membrane for fluorescence-based screening.

H. Tamamura, K. Ohba, H. Tsutsumi, 2008, Bioconjugate chemistry.

Activation of TOR Signaling by Metabolic Stress

Y. Inoue, W. Nomura, 2016 .

Design and synthesis of artificial zinc finger proteins.

Y. Sugiura, W. Nomura, 2007, Methods in molecular biology.

Influence of TFIIIA-type linker at the N- or C-terminal of nine-zinc finger protein on DNA-binding site.

Y. Sugiura, W. Nomura, Y. Shiraishi, 2003, Biochemical and biophysical research communications.

Significant effect of linker sequence on DNA recognition by multi-zinc finger protein.

Y. Sugiura, W. Nomura, Y. Shiraishi, 2001, Biochemical and biophysical research communications.

Multimerized HIV‐gp41‐derived peptides as fusion inhibitors and vaccines

H. Tamamura, W. Nomura, Takaaki Mizuguchi, 2016, Biopolymers.

A CD4 mimic as an HIV entry inhibitor: pharmacokinetics.

S. Matsushita, T. Narumi, H. Tamamura, 2013, Bioorganic & medicinal chemistry.

CD4 mimics targeting the HIV entry mechanism and their hybrid molecules with a CXCR4 antagonist.

S. Matsushita, T. Narumi, H. Tamamura, 2010, Bioorganic & medicinal chemistry letters.

Evaluation of a synthetic C34 trimer of HIV-1 gp41 as AIDS vaccines.

T. Narumi, H. Tamamura, Kosuke Miyauchi, 2012, Bioorganic & medicinal chemistry.

A future perspective on the development of chemokine receptor CXCR4 antagonists

H. Tamamura, N. Fujii, H. Tsutsumi, 2008, Expert opinion on drug discovery.

Remodeling of dynamic structures of HIV-1 envelope proteins leads to synthetic antigen molecules inducing neutralizing antibodies.

T. Narumi, H. Tamamura, K. Ohba, 2010, Bioconjugate chemistry.

Effects of linking 15-zinc finger domains on DNA binding specificity and multiple DNA binding modes.

Y. Sugiura, M. Imanishi, W. Nomura, 2005, Bioorganic & medicinal chemistry letters.

Low‐Molecular‐Weight CXCR4 Ligands with Variable Spacers

T. Narumi, H. Tamamura, T. Murakami, 2013, ChemMedChem.

Pharmacophore-based small molecule CXCR4 ligands.

T. Narumi, H. Tamamura, T. Murakami, 2012, Bioorganic & medicinal chemistry letters.

Azamacrocyclic Metal Complexes as CXCR4 Antagonists

T. Narumi, H. Tamamura, T. Ozaki, 2011, ChemMedChem.

Structure-activity relationship study on artificial CXCR4 ligands possessing the cyclic pentapeptide scaffold: the exploration of amino acid residues of pentapeptides by substitutions of several aromatic amino acids.

T. Narumi, H. Tamamura, N. Fujii, 2009, Organic & biomolecular chemistry.

Structure-activity relationship study of CXCR4 antagonists bearing the cyclic pentapeptide scaffold: identification of the new pharmacophore.

H. Tamamura, N. Fujii, K. Ohba, 2008, Organic & biomolecular chemistry.

Toxicity of dihydroxyacetone is exerted through the formation of methylglyoxal in Saccharomyces cerevisiae: effects on actin polarity and nuclear division.

Y. Inoue, W. Nomura, M. Aoki, 2018, The Biochemical journal.

Metabolomics reveals inosine 5′-monophosphate is increased during mice adipocyte browning

Tetsuro Ito, T. Ara, T. Kawada, 2022, The Journal of biological chemistry.

Glyoxalase system in yeasts: structure, function, and physiology.

Y. Inoue, W. Nomura, Kazuhiro Maeta, 2011, Seminars in cell & developmental biology.

Conjugation of cell-penetrating peptides leads to identification of anti-HIV peptides from matrix proteins.

T. Narumi, Shintaro Suzuki, H. Tamamura, 2012, Bioorganic & medicinal chemistry.

Metabolome analysis revealed that soybean–Aspergillus oryzae interaction induced dynamic metabolic and daidzein prenylation changes

Yusuke Shinyama, T. Kawada, T. Goto, 2021, PloS one.

Microwave-Assisted Synthesis of Azacoumarin Fluorophores and the Fluorescence Characterization.

T. Narumi, H. Tamamura, W. Nomura, 2017, The Journal of organic chemistry.

Anti‐HIV‐1 Peptide Derivatives Based on the HIV‐1 Co‐receptor CXCR4

T. Narumi, H. Tamamura, M. Fujino, 2013, ChemMedChem.

Trivalent ligands for CXCR4 bearing polyproline linkers show specific recognition for cells with increased CXCR4 expression.

H. Tamamura, N. Ohashi, W. Nomura, 2015, Organic & biomolecular chemistry.

An in-cell fluorogenic Tag-probe system for protein dynamics imaging enabled by cell-penetrating peptides.

H. Tamamura, N. Ohashi, W. Nomura, 2015, Bioconjugate chemistry.

Efficient Extraction of Thioreodoxin from Saccharomyces cerevisiae by Ethanol

H. Masutani, J. Yodoi, Y. Inoue, 2007, Applied and Environmental Microbiology.

The successes and failures of HIV drug discovery

T. Narumi, H. Tamamura, W. Nomura, 2011, Expert opinion on drug discovery.

Calcineurin/Crz1 destabilizes Msn2 and Msn4 in the nucleus in response to Ca(2+) in Saccharomyces cerevisiae.

Y. Inoue, Yoshifumi Takatsume, W. Nomura, 2010, The Biochemical journal.

Molecular Switch Engineering for Precise Genome Editing.

Daisuke Matsumoto, W. Nomura, 2021, Bioconjugate chemistry.

Development of Toolboxes for Precision Genome/Epigenome Editing and Imaging of Epigenetics.

Wataru Nomura, W. Nomura, 2018, Chemical record.

Endoplasmic Reticulum Stress Impaired Uncoupling Protein 1 Expression via the Suppression of Peroxisome Proliferator-Activated Receptor γ Binding Activity in Mice Beige Adipocytes

T. Ara, T. Kawada, T. Goto, 2019, International journal of molecular sciences.

β-adrenergic Receptor Stimulation Revealed a Novel Regulatory Pathway via Suppressing Histone Deacetylase 3 to Induce Uncoupling Protein 1 Expression in Mice Beige Adipocyte

T. Ara, T. Kawada, T. Goto, 2018, International journal of molecular sciences.

Long non-coding RNA 2310069B03Rik functions as a suppressor of Ucp1 expression under prolonged cold exposure in murine beige adipocytes

S. Seno, H. Matsuda, N. Osato, 2020, Bioscience, biotechnology and biochemistry.

A new mouse model for noninvasive fluorescence‐based monitoring of mitochondrial UCP1 expression

T. Ara, R. Yu, T. Kawada, 2019, FEBS letters.

Phosphatidylinositol 3,5-bisphosphate is involved in methylglyoxal-induced activation of the Mpk1 mitogen-activated protein kinase cascade in Saccharomyces cerevisiae

Y. Inoue, W. Nomura, Kazuhiro Maeta, 2017, The Journal of Biological Chemistry.

Inhibition of EGFR Activation by Bivalent Ligands Based on a Cyclic Peptide Mimicking the Dimerization Arm Structure of EGFR.

H. Tamamura, W. Nomura, Takuya Kobayakawa, 2018, Chemical & pharmaceutical bulletin.

H. Mitsuya, S. Oka, K. Maeda, 2018, The Journal of Biological Chemistry.

Effects of DNA binding of the zinc finger and linkers for domain fusion on the catalytic activity of sequence-specific chimeric recombinases determined by a facile fluorescent system.

A. Ryo, N. Ito, H. Tamamura, 2012, Biochemistry.

A cell cycle-dependent CRISPR-Cas9 activation system based on an anti-CRISPR protein shows improved genome editing accuracy

H. Tamamura, Daisuke Matsumoto, W. Nomura, 2020, Communications Biology.

Methylglyoxal inhibits nuclear division through alterations in vacuolar morphology and accumulation of Atg18 on the vacuolar membrane in Saccharomyces cerevisiae

Y. Inoue, W. Nomura, M. Aoki, 2020, Scientific Reports.

Multiconnection of identical zinc finger: implication for DNA binding affinity and unit modulation of the three zinc finger domain.

Y. Hori, Y. Sugiura, M. Imanishi, 2001, Biochemistry.

Functional evaluation of fluorescein-labeled derivatives of a peptide inhibitor of the EGF receptor dimerization.

H. Tamamura, W. Nomura, K. Toyama, 2016, Bioorganic & medicinal chemistry.

Methylglyoxal activates Gcn2 to phosphorylate eIF2α independently of the TOR pathway in Saccharomyces cerevisiae

Y. Inoue, W. Nomura, K. Kita, 2010, Applied Microbiology and Biotechnology.

Role of Gcn4 for adaptation to methylglyoxal in Saccharomyces cerevisiae: methylglyoxal attenuates protein synthesis through phosphorylation of eIF2alpha.

Y. Inoue, W. Nomura, K. Kita, 2008, Biochemical and biophysical research communications.

Role of RhoGAP Rgd1 in Pkc1 signaling-related actin repolarization under heat shock stress in Saccharomyces cerevisiae.

Y. Inoue, Ryota Futamata, W. Nomura, 2021, Biochimica et biophysica acta. General subjects.

Role of phosphatidylserine in the activation of Rho1-related Pkc1 signaling in Saccharomyces cerevisiae.

Yusuke Ito, Y. Inoue, W. Nomura, 2017, Cellular signalling.

Methylglyoxal Activates the Target of Rapamycin Complex 2-Protein Kinase C Signaling Pathway in Saccharomyces cerevisiae

Y. Inoue, W. Nomura, 2015, Molecular and Cellular Biology.

Mevalonate biosynthesis pathway regulates the development and survival of brown adipocytes

R. Yu, T. Kawada, S. Matsumura, 2023, iScience.

Synthesis of a Chloroalkene Dipeptide Isostere-Containing Peptidomimetic and Its Biological Application.

H. Tamamura, M. Nomizu, W. Nomura, 2018, ACS medicinal chemistry letters.

Combined treatment with teneligliptin and canagliflozin additively suppresses high-fat diet-induced body weight gain in mice with modulation of lipid metabolism-related gene expression.

T. Kawada, T. Goto, W. Nomura, 2023, European journal of pharmacology.

Reduction of Glucose Uptake through Inhibition of Hexose Transporters and Enhancement of Their Endocytosis by Methylglyoxal in Saccharomyces cerevisiae*

Y. Inoue, W. Nomura, S. Izawa, 2011, The Journal of Biological Chemistry.

Delivery of a Proapoptotic Peptide to EGFR-Positive Cancer Cells by a Cyclic Peptide Mimicking the Dimerization Arm Structure of EGFR.

H. Tamamura, W. Nomura, Takuya Kobayakawa, 2018, Bioconjugate chemistry.

Glycerol kinase stimulates uncoupling protein 1 expression by regulating fatty acid metabolism in beige adipocytes

S. Seno, H. Matsuda, N. Osato, 2020, The Journal of Biological Chemistry.

Discovery of a Macropinocytosis‐Inducing Peptide Potentiated by Medium‐Mediated Intramolecular Disulfide Formation

S. Futaki, A. Otaka, K. Sonomura, 2021, Angewandte Chemie.

Discovery of a Macropinocytosis-Inducing Peptide Potentiated by Medium-Mediated Intramolecular Disulfide Formation.

S. Futaki, A. Otaka, K. Sonomura, 2021, Angewandte Chemie.

Bivalent ligands of CXCR4 with rigid linkers for elucidation of the dimerization state in cells.

T. Narumi, H. Tamamura, W. Nomura, 2010, Journal of the American Chemical Society.

Exploration of labeling by near infrared dyes of the polyproline linker for bivalent-type CXCR4 ligands.

H. Tamamura, W. Nomura, Takaaki Mizuguchi, 2015, Bioorganic & medicinal chemistry.

Design, synthesis and biological evaluation of low molecular weight CXCR4 ligands.

T. Narumi, H. Tamamura, M. Fujino, 2019, Bioorganic & medicinal chemistry.

Exploratory Studies on Development of the Chemokine Receptor CXCR4 Antagonists Toward Downsizing

H. Tamamura, N. Fujii, H. Tsutsumi, 2008, Perspectives in medicinal chemistry.

Multimerized CHR-derived peptides as HIV-1 fusion inhibitors.

H. Tamamura, M. Fujino, T. Murakami, 2013, Bioorganic & medicinal chemistry.

4-Hydroxyderricin, as a PPARγ Agonist, Promotes Adipogenesis, Adiponectin Secretion, and Glucose Uptake in 3T3-L1 Cells

T. Kawada, T. Goto, N. Takahashi, 2016, Lipids.

Synthetic Caged DAG‐lactones for Photochemically Controlled Activation of Protein Kinase C

T. Narumi, P. Blumberg, H. Tamamura, 2011, Chembiochem : a European journal of chemical biology.

Effects of length and position of an extended linker on sequence-selective DNA recognition of zinc finger peptides.

Y. Sugiura, W. Nomura, 2003, Biochemistry.

Bivalent 14‐mer peptide ligands of CXCR4 with polyproline linkers with anti‐chemotactic activity against Jurkat cells

H. Tamamura, W. Nomura, Tomohiro Tanaka, 2017, Journal of peptide science : an official publication of the European Peptide Society.

Peptidic HIV integrase inhibitors derived from HIV gene products: structure-activity relationship studies.

Y. Pommier, T. Narumi, H. Tamamura, 2010, Bioorganic & medicinal chemistry.

Peptide HIV-1 integrase inhibitors from HIV-1 gene products.

Y. Pommier, W. Sugiura, T. Narumi, 2010, Journal of medicinal chemistry.

Small molecular CD4 mimics as HIV entry inhibitors.

S. Matsushita, T. Narumi, H. Tamamura, 2011, Bioorganic & medicinal chemistry.

Dimeric C34 Derivatives Linked through Disulfide Bridges as New HIV‐1 Fusion Inhibitors

H. Tamamura, M. Fujino, T. Murakami, 2019, Chembiochem : a European journal of chemical biology.

Development of anti‐HIV peptides based on a viral capsid protein

H. Tamamura, Daichi Matsumoto, T. Murakami, 2017, Biopolymers.

Anti-HIV screening for cell-penetrating peptides using chloroquine and identification of anti-HIV peptides derived from matrix proteins.

H. Tamamura, T. Murakami, N. Yamamoto, 2015, Bioorganic & medicinal chemistry.

Cell-permeable stapled peptides based on HIV-1 integrase inhibitors derived from HIV-1 gene products.

Y. Pommier, T. Narumi, H. Tamamura, 2013, ACS chemical biology.

Peptide-based ligand screening and functional analysis of protein kinase C.

T. Narumi, H. Tamamura, N. Ohashi, 2013, Biopolymers.

Fluorescence-quenching screening of protein kinase C ligands with an environmentally sensitive fluorophore.

N. Ito, T. Narumi, T. Ikura, 2011, Bioconjugate chemistry.

Fluorescent-responsive synthetic C1b domains of protein kinase Cδ as reporters of specific high-affinity ligand binding.

T. Narumi, P. Blumberg, H. Tamamura, 2011, Bioconjugate chemistry.

TALEN-based chemically inducible, dimerization-dependent, sequence-specific nucleases.

H. Tamamura, Daisuke Matsumoto, W. Nomura, 2020, Biochemistry.

Fluorescence resonance energy transfer-based screening for protein kinase C ligands using 6-methoxynaphthalene-labeled 1,2-diacylglycerol-lactones.

H. Tamamura, T. Ishii, N. Ohashi, 2021, Organic & biomolecular chemistry.

Efficient and Orthogonal Transcription Regulation by Chemically Inducible Artificial Transcription Factors.

H. Tamamura, Daisuke Matsumoto, W. Nomura, 2018, Biochemistry.

In vivo site-specific DNA methylation with a designed sequence-enabled DNA methylase.

Wataru Nomura, C. Barbas, Carlos F Barbas, 2007, Journal of the American Chemical Society.

Screening of flavor compounds using Ucp1-luciferase reporter beige adipocytes identified 5-methylquinoxaline as a novel UCP1-inducing compoundsss.

T. Kawada, T. Goto, W. Nomura, 2021, Bioscience, biotechnology and biochemistry.

Bivalent ligands of CXCR4 with rigid linkers for elucidation of the dimerization state in cells.

T. Narumi, H. Tamamura, W. Nomura, 2010, Journal of the American Chemical Society.

Synthesis of protein kinase Cδ C1b domain by native chemical ligation methodology and characterization of its folding and ligand binding

T. Narumi, P. Blumberg, H. Tamamura, 2009, Journal of peptide science : an official publication of the European Peptide Society.

Functional evaluation of fluorescein-labeled derivatives of a peptide inhibitor of the EGF receptor dimerization.

H. Tamamura, W. Nomura, K. Toyama, 2016, Bioorganic & medicinal chemistry.

Small‐Molecule CD4 Mimics Containing Mono‐cyclohexyl Moieties as HIV Entry Inhibitors

S. Matsushita, H. Tamamura, N. Ohashi, 2016, ChemMedChem.

Screening for protein kinase C ligands using fluorescence resonance energy transfer.

H. Tamamura, N. Ohashi, W. Nomura, 2014, Chemical & pharmaceutical bulletin.

Effect of Two-Photon Excitation to 8-Azacoumarin Derivatives as Photolabile Protecting Groups

N. Ohashi, W. Nomura, Takuya Kobayakawa, 2024, Chemical and Pharmaceutical Bulletin.

Synthesis of hydrophilic caged DAG-lactones for chemical biology applications.

H. Tamamura, T. Furuta, T. Ishii, 2020, Organic & biomolecular chemistry.