S. Jaken

B. van de Water, L. Dong, J. Stevens, 1998, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

Protein kinase C isozymes and substrates.

S. Jaken, 1996, Current opinion in cell biology.

Protein kinase C signaling and oxidative stress.

R Gopalakrishna, S Jaken, R. Gopalakrishna, 2000, Free radical biology & medicine.

Intracellular targeting of protein kinase C isoenzymes: functional implications.

P. Parker, R. Whelan, S. Kiley, 1995, Biochemical Society transactions.

Protein kinase C and tumor promoters.

S. Jaken, 1990, Current opinion in cell biology.

Differences in the isoelectric focusing patterns of gamma-glutamyl transpeptidase from normal and cancerous rat mammary tissue.

S. Jaken, M. Mason, 1978, Proceedings of the National Academy of Sciences of the United States of America.

Development and Validation of a Drug Activity Biomarker that Shows Target Inhibition in Cancer Patients Receiving Enzastaurin, a Novel Protein Kinase C-β Inhibitor

R. Herbst, M. Carducci, C. Britten, 2006, Clinical Cancer Research.

Human multidrug resistant KB cells overexpress protein kinase C: involvement in drug resistance.

M. Morin, E. McKeegan, T. Tritton, 1989, Cancer communications.

Protein kinase C isozymes and substrates in mammary carcinogenesis

J. Welsh, S. Kiley, S. Jaken, 1996, Journal of Mammary Gland Biology and Neoplasia.

Protein kinase C heterogeneity in GH4C1 rat pituitary cells. Characterization of a Ca2(+)-independent phorbol ester receptor.

P. Parker, S. Kiley, L. Hsieh, 1990, The Journal of biological chemistry.

Overexpression of the alpha-type protein kinase (PK) C in LLC-PK1 cells does not lead to a proportional increase in the induction of two 12-O-tetradecanoylphorbol-13-acetate-inducible genes.

D. Fabbro, Y. Nagamine, P. Parker, 1991, Cell regulation.

Purification and characterization of three types of protein kinase C from rabbit brain cytosol.

S. Kiley, S. Jaken, 1987, Proceedings of the National Academy of Sciences of the United States of America.

Measurement of phorbol ester receptors in intact cells and subcellular fractions.

S. Jaken, 1987, Methods in enzymology.

Intracellular Ca2+-dependent protein kinase C activation mimics delayed effects of thyrotropin-releasing hormone on clonal pituitary cell excitability.

J. Barker, B. Dufy, S. Jaken, 1987, Endocrinology.

Initial events in phorbol ester binding to GH4C1 rat pituitary cells.

S. Jaken, 1985, Endocrinology.

Increased diacylglycerol content with phospholipase C or hormone treatment: inhibition of phorbol ester binding and induction of phorbol ester-like biological responses.

S. Jaken, 1985, Endocrinology.

Structural and chemical specificity of diradylglycerols for protein kinase C activation

M. Cabot, S. Jaken, 1984 .

Regulation of plasminogen activator in 3T3 cells: effect of phorbol myristate acetate on subcellular distribution and molecular weight

P. Black, S. Jaken, 1981, The Journal of cell biology.

Differential regulation of protein kinase C isozymes by thyrotropin-releasing hormone in GH4C1 cells.

S. Kiley, S. Jaken, P. Parker, 1991, The Journal of biological chemistry.

Relationship between biological responsiveness to phorbol esters and receptor levels in GH4C1 rat pituitary cells.

P. Blumberg, A. Tashjian, S. Jaken, 1981, Cancer research.

Hormone- and phorbol ester-activated protein kinase C isozymes mediate a reorganization of the actin cytoskeleton associated with prolactin secretion in GH4C1 cells.

D. Fabbro, P. Parker, S. Kiley, 1992, Molecular endocrinology.

Dexamethasone inhibition and phorbol myristate acetate stimulation of plasminogen activator in human embryonic lung cells.

P. Black, S. Jaken, C. Geffen, 1981, Biochemical and biophysical research communications.

Biochemical and immunological characterization of renal protein kinase C.

L. Dong, J. Stevens, S. Jaken, 1991, The American journal of physiology.

35H, a Sequence Isolated as a Protein Kinase C Binding Protein, Is a Novel Member of the Adducin Family (*)

K. Ramsay, L. Dong, J. Stevens, 1995, The Journal of Biological Chemistry.

Effect of alpha-protein kinase C neutralizing antibodies and the pseudosubstrate peptide on phosphorylation, migration, and growth of REF52 cells.

S. Jaken, L. Liao, 1993, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

PHORBOL ESTER RECEPTORS AND THE IN VITRO EFFECTS OF TUMOR PROMOTERS

K. Leach, P. Blumberg, K. B. Delclos, 1983, Annals of the New York Academy of Sciences.

Phorbol ester and interferon-gamma modulation of epidermal growth factor receptors on human amniotic (WISH) cells.

K. Zoon, Y. Karasaki, A. Komoriya, 1989, The Journal of biological chemistry.

Phase I trial of 72-hour continuous infusion UCN-01 in patients with refractory neoplasms.

E. Sausville, S. Arbuck, A. Senderowicz, 2001, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Transformation-sensitive localization of alpha-protein kinase C at cell-cell contacts in rat renal proximal tubule epithelial cells.

L. Dong, J. Stevens, S. Jaken, 1993, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

Association of type 3 protein kinase C with focal contacts in rat embryo fibroblasts

K. Leach, T. Klauck, S. Jaken, 1989, The Journal of cell biology.

Characterization of phorbol ester receptors and their down-modulation in GH4C1 rat pituitary cells.

P. Blumberg, A. Tashjian, S. Jaken, 1981, Cancer research.

Mechanism of action of the phorbol ester tumor promoters: specific receptors for lipophilic ligands.

K. Leach, P. Blumberg, A. Jeng, 1984, Biochemical pharmacology.

Tissue and species specificity for phorbol ester receptors.

P. Blumberg, K. B. Delclos, S. Jaken, 1983, Basic life sciences.

Relationship between mezerein-mediated biological responses and phorbol ester receptor occupancy.

P. Blumberg, A. Tashjian, M. Shupnik, 1983, Cancer research.

Specific binding of phorbol ester tumor promoters to mouse tissues and cultured cells.

P. Blumberg, W. Dunphy, K. B. Delclos, 1982, Carcinogenesis; a comprehensive survey.

Interferon inhibits the release of plasminogen activator from SV3T3 cells

P. Black, S. Jaken, E. Schroder, 1978, Nature.

Immunocytochemical Localization of Protein Kinase C

S. L. Hyatt, S. Kiley, T. Klauck, 1990 .

Protein kinase C is localized in focal contacts of normal but not transformed fibroblasts

S. L. Hyatt, T. Klauck, S. Jaken, 1990, Molecular carcinogenesis.

Type 3 protein kinase C localization to the nuclear envelope of phorbol ester-treated NIH 3T3 cells

S. Kaufmann, K. Leach, S. Kaufmann, 1989, The Journal of cell biology.

M. Ueffing, I. Weinstein, P. Parker, 1995, The Journal of Biological Chemistry.

Correlation between a specific molecular weight form of plasminogen activator and metabolic activity of 3T3 cells

P. Black, S. Jaken, Susan Aken, 1981, The Journal of cell biology.

Purification and comparison of several catalytic parameters of the gamma-glutamyltranspeptidase of rat mammary adenocarcinoma (13762) and of normal rat mammary gland.

S. Jaken, M. Mason, 1979, Biochimica et biophysica acta.

Signal Transduction for Proliferation and Differentiation in Keratinocytes

D. Roop, S. Yuspa, R. Tucker, 1988, Annals of the New York Academy of Sciences.

The Cultured Murine Epidermal Keratinocyte and Studies of Differentiation

D. Roop, S. Yuspa, R. Tucker, 1988 .

Cleavage of the Actin-capping Protein α-Adducin at Asp-Asp-Ser-Asp633-Ala by Caspase-3 Is Preceded by Its Phosphorylation on Serine 726 in Cisplatin-induced Apoptosis of Renal Epithelial Cells*

B. van de Water, I. Tijdens, G. Mulder, 2000, The Journal of Biological Chemistry.

Specific desensitization to tumor-promoting phorbol esters in mouse pituitary cells. Evidence that desensitization is a two-step process.

M. Phillips, S. Jaken, 1983, The Journal of biological chemistry.

Protein kinase C isozymes in progressively transformed rat embryo fibroblasts.

K. Ramsay, S. Jaken, L. Liao, 1994, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

Consequences of exposure to initiating levels of carcinogens in vitro and in vivo: altered differentiation and growth, mutations, and transformation.

D. Roop, S. Yuspa, R. Tucker, 1989, Progress in clinical and biological research.

Early signals for keratinocyte differentiation: role of Ca2+-mediated inositol lipid metabolism in normal and neoplastic epidermal cells.

S. Yuspa, S. Jaken, 1988, Carcinogenesis.

LY3009120, a panRAF inhibitor, has significant anti-tumor activity in BRAF and KRAS mutant preclinical models of colorectal cancer

Xiu-juan Yuan, J. Manro, Sheng-Bin Peng, 2016, Oncotarget.

Monoclonal antibodies specific for type 3 protein kinase C recognize distinct domains of protein kinase C and inhibit in vitro functional activity.

K. Leach, S. Kiley, L. Dong, 1988, The Journal of biological chemistry.

Differences in intracellular distribution of plasminogen activator in growing, confluent, and transformed 3T3 cells.

P. Black, S. Jaken, 1979, Proceedings of the National Academy of Sciences of the United States of America.

Novel Phenotypic Outcomes Identified for a Public Collection of Approved Drugs from a Publicly Accessible Panel of Assays

Ruili Huang, Paul Shinn, Anton Simeonov, 2015, PloS one.

Proto-Oncogene Expression in Mesothelial Cells jun and c-fos Inhibition of Protein Kinase C Prevents Asbestos-induced c-Updated Version

N. Heintz, D. Taatjes, B. Mossman, 2006 .

Advances in Brief Inhibition of Protein Kinase C Prevents Asbestos-induced c-fos and c-jun Proto Oncogene Expression in Mesothelial Cells 1

N. Heintz, D. Taatjes, B. Mossman, 2006 .

Inhibition of protein kinase C prevents asbestos-induced c-fos and c-jun proto-oncogene expression in mesothelial cells.

N. Heintz, D. Taatjes, B. Mossman, 1997, Cancer research.

The Novel IKK 2 Inhibitor LY 2409881 Potently Synergizes with Histone Deacetylase Inhibitors in Preclinical Models of Lymphoma through the Downregulation of NFk B

W. Tsai, C. Deng, O. O’Connor, 2014 .

Title: the Novel Ikk2 Inhibitor Ly2409881 Potently Synergizes with Histone Deacetylase Inhibitors in Preclinical Models of Lymphoma through the Downregulation of Nf-kb Authors and Affiliations

W. Tsai, Christine, C. Deng, 2022 .

Activated phosphoinositide 3-kinase associates with membrane skeleton in thrombin-exposed platelets.

M. Waterfield, J. Zhang, J. Fox, 1992, The Journal of biological chemistry.

Chapter 25. Isozymes of Protein Kinase C

K. Leach, S. Jaken, 1988 .

Identification and characterization of alpha-protein kinase C binding proteins in normal and transformed REF52 cells.

S. L. Hyatt, L. Liao, S. Jaken, 1994, Biochemistry.

Protein Kinase C δ Involvement in Mammary Tumor Cell Metastasis

S. Kiley, D. Welch, S. Jaken, 1999 .

Identification of a Major Protein Kinase C-binding Protein and Substrate in Rat Embryo Fibroblasts

S. Kiley, B. Mousseau, S. Jaken, 1996, The Journal of Biological Chemistry.

Correlation between protein kinase C binding proteins and substrates in REF52 cells.

S. L. Hyatt, A. Nairn, A. Aderem, 1994, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

Correlation between Protein Kinase C Binding Proteins and Substrates

A. Nairn, A. Aderem, S. Jaken, 1994 .

Activation of alpha-protein kinase C leads to association with detergent-insoluble components of GH4C1 cells.

S. Kiley, S. Jaken, 1990, Molecular endocrinology.

Protein kinase C and mammary cell differentiation: involvement of protein kinase C alpha in the induction of beta-casein expression.

D. Fabbro, T. Meyer, N. Hynes, 1994, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

Development and validation of a drug activity biomarker that shows target inhibition in cancer patients receiving enzastaurin, a novel protein kinase C-beta inhibitor.

R. Herbst, M. Carducci, C. Britten, 2006, Clinical cancer research : an official journal of the American Association for Cancer Research.

Protein kinase C: interactions and consequences.

S. Kiley, S. Jaken, Susan Jaken, 1994, Trends in cell biology.

Characterization of Protein Kinase C in Photoreceptor Outer Segments

A. Newton, C. L. Schlamp, S. Jaken, 1997, Journal of neurochemistry.

Variation with embryonic development and regional localization of specific [3H]phorbol 12,13-dibutyrate binding to brain.

P. Blumberg, S. Jaken, M. Castagna, 1981, Cancer research.

Coordination of Three Signaling Enzymes by AKAP79, a Mammalian Scaffold Protein

L. Langeberg, John D. Scott, M. Faux, 1996, Science.

Interaction cloning of protein kinase C substrates.

K. Ramsay, T. Klauck, S. Jaken, 1993, The Journal of biological chemistry.

The Novel IKK2 Inhibitor LY2409881 Potently Synergizes with Histone Deacetylase Inhibitors in Preclinical Models of Lymphoma through the Downregulation of NF-κB

W. Tsai, C. Deng, O. O’Connor, 2014, Clinical Cancer Research.

Protein kinase C binding partners.

P. Parker, S. Jaken, 2000, BioEssays : news and reviews in molecular, cellular and developmental biology.

Mechanism of the nephrogenic repair response. Studies on proliferation and vimentin expression after 35S-1,2-dichlorovinyl-L-cysteine nephrotoxicity in vivo and in cultured proximal tubule epithelial cells.

A Wallin, J. Stevens, S Jaken, 1992, Laboratory investigation; a journal of technical methods and pathology.

Targeting of Protein Kinase Cα to Caveolae

Richard G. W. Anderson, C. Mineo, Y. Ying, 1998, The Journal of cell biology.

Structural and chemical specificity of diacylglycerols for protein kinase C activation.

M. Cabot, S. Jaken, 1984, Biochemical and biophysical research communications.

Redistribution and enhanced protein kinase C-mediated phosphorylation of alpha- and gamma-adducin during renal tumor progression.

J. Everitt, J. Stevens, S. Jaken, 1998, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

Regulation of protein kinase C isozymes in kidney regeneration.

D. Fabbro, L. Dong, J. Stevens, 1993, Cancer research.

Protein kinase C domains involved in interactions with other proteins.

S. L. Hyatt, S. Jaken, C. Chapline, 1994, Biochemistry.

Calpain-induced downregulation of activated protein kinase C-alpha affects lung epithelial cell morphology.

A. Malkinson, S. Jaken, A. Miller, 1994, The American journal of physiology.

Protein kinase C isozyme expression and down-modulation in growing, quiescent, and transformed renal proximal tubule epithelial cells.

D. Fabbro, L. Dong, J. Stevens, 1994, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

Association of phorbol ester receptor down modulation with a cryptic receptor state.

P. Blumberg, A. Tashjian, H. Feldman, 1983, Cancer research.

Regulation of motility in bovine brain endothelial cells

M. Bhargava, E. Rosen, I. Goldberg, 1991, Journal of cellular physiology.

Abstract 4973: Discovery of LY3214996, a selective and novel ERK1/2 inhibitor with potent antitumor activities in cancer models with MAPK pathway alterations

J. Manro, Sheng-Bin Peng, W. Mcmillen, 2017 .

Immunocytochemical localization of phospholipase C-gamma in rat embryo fibroblasts.

S. Jaken, K. McBride, S. G. Rhee, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Protein kinase C isozyme expression and down-modulation in growing, quiescent, and transformed renal proximal tubule epithelial cells.

S. Jaken, Liqun Dong, James L. Stevens, 1994, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

Association of type 3 protein kinase C with focal contacts in rat embryo fibroblasts

T. Klauck, S. Jaken, Karen L. Leach, 1989, The Journal of cell biology.