G. Hart

发表

Generation and characterization of an influenza virus neuraminidase variant with decreased sensitivity to the neuraminidase-specific inhibitor 4-guanidino-Neu5Ac2en.

P. Colman, J. Varghese, R. Bethell, 1995, Virology.

Characterization of mutants of influenza A virus selected with the neuraminidase inhibitor 4-guanidino-Neu5Ac2en

R. Webster, L. Gubareva, R. Bethell, 1996, Journal of virology.

Mutations in a Conserved Residue in the Influenza Virus Neuraminidase Active Site Decreases Sensitivity to Neu5Ac2en-Derived Inhibitors

P. Colman, J. Varghese, R. Bethell, 1998, Journal of Virology.

Evidence that pyridoxal phosphate modification of lysine residues (Lys-55 and Lys-59) causes inactivation of hydroxymethylbilane synthase (porphobilinogen deaminase).

A. Miller, C. Abell, P. Alefounder, 1989, The Biochemical journal.

Biosynthesis of porphyrins and related macrocycles. Part 53. Stereochemical studies on the enzymic formation of hydroxymethylbilane, the precursor of uroporphyrinogen III

W. Neidhart, A. Battersby, G. Hart, 1999 .

Stereochemistry of formation of the hydroxymethyl group of hydroxymethylbilane, the precursor of uro'gen-III

A. Abell, A. Battersby, G. Hart, 1987 .

Biosynthesis of the natural porphyrins: proof that hydroxymethylbilane synthase (porphobilinogen deaminase) uses a novel binding group in its catalytic action

Andrew D. Miller, F. Leeper, A. Battersby, 1987 .

Investigation of putative active-site lysine residues in hydroxymethylbilane synthase. Preparation and characterization of mutants in which (a) Lys-55, (b) Lys-59 and (c) both Lys-55 and Lys-59 have been replaced by glutamine.

C. Abell, A. Hädener, P. Alefounder, 1990, The Biochemical journal.

Evidence that the pyrromethane cofactor of hydroxymethylbilane synthase (porphobilinogen deaminase) is bound through the sulphur atom of a cysteine residue.

A. Miller, A. Battersby, G. Hart, 1988, The Biochemical journal.

Design and synthesis of pyrrolidine-5,5-trans-lactams (5-oxo-hexahydro-pyrrolo[3,2-b]pyrroles) as novel mechanism-based inhibitors of human cytomegalovirus protease. 1. The alpha-methyl-trans-lactam template.

G. Hart, T. Haley, A. Pennell, 2000, Journal of medicinal chemistry.

Design and synthesis of pyrrolidine-5,5'-trans-lactams (5-oxo-hexahydropyrrolo[3,2-b]pyrroles) as novel mechanism-based inhibitors of human cytomegalovirus protease. 4. Antiviral activity and plasma stability.

James M. Woolven, P. Ertl, N. Parry, 2003, Journal of medicinal chemistry.

Evidence that the pyrromethane cofactor of hydroxymethylbilane synthase (porphobilinogen deaminase) is bound to the protein through the sulphur atom of cysteine-242.

A. Miller, A. Battersby, G. Hart, 1988, The Biochemical journal.

Purification, N-terminal amino acid sequence and properties of hydroxymethylbilane synthase (porphobilinogen deaminase) from Escherichia coli.

C. Abell, A. Battersby, G. Hart, 1986, The Biochemical journal.

GSK256066, an Exceptionally High-Affinity and Selective Inhibitor of Phosphodiesterase 4 Suitable for Administration by Inhalation: In Vitro, Kinetic, and In Vivo Characterization

Richard Graham Knowles, R. Williamson, C. Tralau-Stewart, 2011, Journal of Pharmacology and Experimental Therapeutics.

Generation and characterization of variants of NWS/G70C influenza virus after in vitro passage in 4-amino-Neu5Ac2en and 4-guanidino-Neu5Ac2en

R. Bethell, J. McKimm-Breschkin, C. Penn, 1996, Antimicrobial agents and chemotherapy.

GSK 256066 , An Exceptionally High Affinity and Selective Inhibitor of PDE 4 Suitable for Administration by Inhalation : In vitro , Kinetic and In vivo Characterisation

Richard Graham Knowles, R. Williamson, C. Tralau-Stewart, 2011 .

Biosynthesis of porphyrins and related macrocycles. Part 35. Discovery of a novel dipyrrolic cofactor essential for the catalytic action of hydroxymethylbilane synthase (porphobilinogen deaminase)

Andrew D. Miller, F. Leeper, A. Battersby, 1990 .

Biosynthesis of porphyrins and related macrocycles. Part 21. The interaction of deaminase and its product (hydroxymethylbilane) and the relationship between deaminase and cosynthetase

C. Fookes, A. Battersby, G. Hart, 1983 .

Purification and properties of uroporphyrinogen III synthase (co-synthetase) from Euglena gracilis.

A. Battersby, G. Hart, 1985, The Biochemical journal.

Design and synthesis of pyrrolidine-5,5-trans-lactams (5-oxohexahydropyrrolo[3,2-b]pyrroles) as novel mechanism-based inhibitors of human cytomegalovirus protease. 2. Potency and chirality.

Peter Ertl, James M. Woolven, P. Ertl, 2002, Journal of medicinal chemistry.

Effects of (-)-2'-deoxy-3'-thiacytidine (3TC) 5'-triphosphate on human immunodeficiency virus reverse transcriptase and mammalian DNA polymerases alpha, beta, and gamma

J. Cameron, C. Penn, R. Boehme, 1992, Antimicrobial Agents and Chemotherapy.

Modification of hydroxymethylbilane synthase (porphobilinogen deaminase) by pyridoxal 5'-phosphate. Demonstration of an essential lysine residue.

F. Leeper, A. Battersby, G. Hart, 1984, The Biochemical journal.

Inhibition of herpes simplex virus type 1 DNA polymerase activity by peptides from the UL42 accessory protein is largely nonspecific

H. Marsden, M. Challberg, A. Owsianka, 1993, Journal of virology.

Dimeric zanamivir conjugates with various linking groups are potent, long-lasting inhibitors of influenza neuraminidase including H5N1 avian influenza.

Stephanie Hamilton, Rachel Cameron, Simon J F Macdonald, 2005, Journal of medicinal chemistry.

Potent and Long-Acting Dimeric Inhibitors of Influenza Virus Neuraminidase Are Effective at a Once-Weekly Dosing Regimen

H. T. Jones, Andy M Mason, S. Tucker, 2004, Antimicrobial Agents and Chemotherapy.

The effect of the UL42 protein on the DNA polymerase activity of the catalytic subunit of the DNA polymerase encoded by herpes simplex virus type 1

R. Boehme, G. Hart, 1992, FEBS letters.

Synthesis of (11S)- and (11R)-[11-2H1]porphobilinogen; stereochemical studies on hydroxymethylbilane synthase (PBG deaminase)

W. Neidhart, A. Battersby, G. Hart, 1985 .

Biochemical Methods for the Characterization of Influenza Viruses with Reduced Sensitivity to 4-Guanidino-Neu5Ac2en.

R. Bethell, J. McKimm-Breschkin, T. Blick, 2000, Methods in molecular medicine.

Biosynthesis of porphyrins and related macrocycles. Part 40. Synthesis of a spiro-lactam related to the proposed spiro-intermediate for porphyrin biosynthesis: inhibition of cosynthetase

J. Lewis, C. Hawker, F. Leeper, 1993 .

Synthetic studies on the proposed spiro intermediate for biosynthesis of the natural porphyrins: inhibition of cosynthetase

W. Stark, A. Battersby, G. Hart, 1986 .