Kevin Blades

发表

Imidazole pyrimidine amides as potent, orally bioavailable cyclin-dependent kinase inhibitors.

D. M. Andrews, A. Barker, Kate F. Byth, 2008, Bioorganic & medicinal chemistry letters.

Discovery of 4-{4-[(3R)-3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}-1H-indole (AZ20): a potent and selective inhibitor of ATR protein kinase with monotherapy in vivo antitumor activity.

X. Jacq, J. Nissink, I. Hickson, 2013, Journal of medicinal chemistry.

Expedient synthesis of biologically important sulfonylmethyl pyrimidines

L. Hassall, E. Williams, T. McGuire, 2014 .

Small molecule binding sites on the Ras:SOS complex can be exploited for inhibition of Ras activation.

Malcolm Anderson, Jason G Kettle, Alexander L Breeze, 2015, Journal of medicinal chemistry.

Discovery of Pyrazolo[1,5-a]pyrimidine B-Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors.

Matthew Grist, C. Chuaqui, Qing Cao, 2017, Journal of medicinal chemistry.

Optimization of Highly Kinase Selective Bis-anilino Pyrimidine PAK1 Inhibitors.

E. Hennessy, C. Chuaqui, A. Ferguson, 2016, ACS medicinal chemistry letters.

Discovery and structure-activity relationships of a novel oxazolidinone class of bacterial type II topoisomerase inhibitors.

R. Newman, C. Charrier, M. Craighead, 2022, Bioorganic & medicinal chemistry letters.

Facile [2,3]-rearrangements of difluoroallylic alcohols with CP and CS bond formation

R. Wilkes, J. Percy, Kevin Blades, 1996 .

Synthesis of the Novel Tetrahydropyrazolo[3,4‐c]pyridin‐5‐one Scaffold.

G. Lamont, Kevin Blades, N. Howe, 2015 .

A reproducible and high-yielding cerium-mediated route to α,α-difluoro-β-ketophosphonates

J. Percy, Kevin Blades, T. Lequeux, 1997 .

Synthesis of 3-(hetero)aryl tetrahydropyrazolo[3,4-c]pyridines by Suzuki-Miyaura cross-coupling methodology.

G. Lamont, Matthew R. Box, P. Kemmitt, 2014, The Journal of organic chemistry.

Directed dihydroxylation of cyclic allylic alcohols and trichloroacetamides using OsO4/TMEDA.

M. Waring, T. Donohoe, G. Stemp, 2002, The Journal of organic chemistry.

The synthesis of (+)-pericosine B

M. Waring, T. Donohoe, N. Newcombe, 1998 .

A syn selective dihydroxylation of cyclic allylic trichloroacetamides using catalytic osmium tetroxide

T. Donohoe, G. Stemp, Kevin Blades, 2000 .

Synthesis of amino-sugars using the directed dihydroxylation reaction

T. Donohoe, M. Helliwell, Kevin Blades, 1999 .

Directed Dihydroxylation of Allylic Trichloroacetamides.

T. Donohoe, G. Stemp, M. Helliwell, 1999, The Journal of organic chemistry.

A conjugate addition/sulfoxide elimination route to allylic difluorophosphonates

J. Percy, Kevin Blades, 1998 .

Conjugate addition reactions of a (diethoxyphosphinoyl)difluoromethyl anion equivalent to acyclic and cyclic vinyl sulfones

J. Percy, Kevin Blades, D. Lapôtre, 1997 .

A DAST-free route to aryl(difluoromethyl)phosphonic esters

J. Percy, G. S. Cockerill, Kevin Blades, 1996 .

Reactive dienophiles containing a difluoromethylenephosphonato group

J. Percy, Kevin Blades, T. Lequeux, 1996 .

The discovery of AZD5597, a potent imidazole pyrimidine amide CDK inhibitor suitable for intravenous dosing.

D. M. Andrews, A. Barker, Catherine Geh, 2008, Bioorganic & medicinal chemistry letters.

Discovery of AZD3147: a potent, selective dual inhibitor of mTORC1 and mTORC2.

C. A. Roberts, J. Culshaw, G. Currie, 2015, Journal of medicinal chemistry.

The discovery of benzanilides as c-Met receptor tyrosine kinase inhibitors by a directed screening approach.

Andrew G. Leach, J. Major, D. Buttar, 2011, Bioorganic & medicinal chemistry letters.

Discovery and Characterization of AZD6738, a Potent Inhibitor of Ataxia Telangiectasia Mutated and Rad3 Related (ATR) Kinase with Application as an Anticancer Agent.

J. Nissink, A. Lau, P. Jewsbury, 2018, Journal of medicinal chemistry.

Identification and optimisation of 7-azaindole PAK1 inhibitors with improved potency and kinase selectivity

E. Hennessy, C. Chuaqui, A. Ferguson, 2014 .

Abstract 2348: Discovery of AZD6738, a potent and selective inhibitor with the potential to test the clinical efficacy of ATR kinase inhibition in cancer patients.

S. Guichard, P. Jewsbury, R. Odedra, 2013 .

In Vitro Activity of Novel Topoisomerase Inhibitors against Francisella tularensis and Burkholderia pseudomallei

M. Craighead, A. Lyons, A. Whelan, 2023, Antibiotics.