H. N. Bramson

发表

Oxindole-based inhibitors of cyclin-dependent kinase 2 (CDK2): design, synthesis, enzymatic activities, and X-ray crystallographic analysis.

P. A. Harris, L. Kuyper, S. Frye, 2001, Journal of medicinal chemistry.

6‐Azasteroids: Structure‐Activity Relationships for Inhibition of Type 1 and 2 Human 5α‐Reductase and Human Adrenal 3β‐Hydroxy‐. delta.5‐steroid Dehydrogenase/3‐Keto‐δ5‐steroid Isomerase.

Stephanie L. Schweiker, Patrick Maloney, John A. Ray, 1994 .

An antipeptide antibody that specifically inhibits insulin receptor autophosphorylation and protein kinase activity.

O. Rosen, E. Kaiser, R. Herrera, 1985, Proceedings of the National Academy of Sciences of the United States of America.

In vitro enzymatic assays for Ser/Thr-selective protein kinases.

H. N. Bramson, 2003, Current protocols in pharmacology.

The amino terminus of the putative Drosophila choline acetyltransferase precursor is cleaved to yield the 67 kDa enzyme.

J. Slemmon, H. N. Bramson, G. Campbell, 1991, Brain research. Molecular brain research.

Discovery and development of GG745, a potent inhibitor of both isozymes of 5 alpha-reductase.

S. Frye, D. Hermann, H. N. Bramson, 1998, Pharmaceutical biotechnology.

Pharmacokinetic parameters and mechanisms of inhibition of rat type 1 and 2 steroid 5alpha-reductases: determinants for different in vivo activities of GI198745 and finasteride in the rat.

J. D. Stuart, T. Kost, T. Tippin, 2001, Biochemical pharmacology.

17 beta-(N-tert-butylcarbamoyl)-4-aza-5 alpha-androstan-1-en-3-one is an active site-directed slow time-dependent inhibitor of human steroid 5 alpha-reductase 1.

J. D. Stuart, T. Kost, R. Mook, 1994, Biochemistry.

Nuclear Overhauser effect studies of the conformations of tetraamminecobalt(III)-adenosine 5'-triphosphate free and bound to bovine heart protein kinase.

P. Rosevear, A. Mildvan, E. Kaiser, 1983, Biochemistry.

Role of enzyme-peptide substrate backbone hydrogen bonding in determining protein kinase substrate specificities.

W. Miller, E. Kaiser, H. N. Bramson, 1987, Biochemistry.

Unique preclinical characteristics of GG745, a potent dual inhibitor of 5AR.

M. K. James, S. Frye, D. Hermann, 1997, The Journal of pharmacology and experimental therapeutics.

A kinetic study of interactions of (Rp)- and (Sp)-adenosine cyclic 3',5'-phosphorothioates with type II bovine cardiac muscle adenosine cyclic 3',5'-phosphate dependent protein kinase.

W. Stec, E. Kaiser, S. Roczniak, 1982, Biochemistry.

Magnetic resonance measurements of intersubstrate distances at the active site of protein kinase using substitution-inert cobalt(III) and chromium(III) complexes of adenosine 5'-(beta, gamma-methylenetriphosphate).

A. Mildvan, E. Kaiser, H. N. Bramson, 1980, Biochemistry.

The use of N-methylated peptides and depsipeptides to probe the binding of heptapeptide substrates to cAMP-dependent protein kinase.

E. Kaiser, H. N. Bramson, N. Thomas, 1985, The Journal of biological chemistry.

Biotin analogs activate guanylate cyclase

D. vesely, H. N. Bramson, H. Wormser, 2004, Molecular and Cellular Biochemistry.

6-Azasteroids: potent dual inhibitors of human type 1 and 2 steroid 5 alpha-reductase.

S. Frye, R. Mook, P. Maloney, 1993, Journal of medicinal chemistry.

6-Azasteroids: Potent Dual Inhibitors of Human Type 1 and 2 Steroid 5. alpha.-Reductase.

M. K. James, S. Frye, T. Tippin, 1994 .

Modification of the catalytic subunit of bovine heart cAMP-dependent protein kinase with affinity labels related to peptide substrates.

S. Taylor, E. Kaiser, N. C. Nelson, 1982, The Journal of biological chemistry.

Carbon-13 enriched S-methyl probe at the active site of an enzyme: [S-[13C]methylmethionine-192]-.alpha.-chymotrypsin (MSMC)

W. DeGrado, H. N. Bramson, M. Russo, 1980 .

Stereochemical course of the phospho group transfer catalyzed by cAMP-dependent protein kinase

J. Knowles, E. Kaiser, H. N. Bramson, 1988 .

Stereochemical and kinetic studies on the action of the catalytic subunit of bovine cardiac muscle adenosine 3',5'-monophosphate dependent protein kinase using metal ion complexes of ATP beta S.

D. W. Bolen, E. Kaiser, H. N. Bramson, 1980, Biochemistry.

Mechanistic studies of cAMP-dependent protein kinase action.

A. Mildvan, E. Kaiser, H. N. Bramson, 1984, CRC critical reviews in biochemistry.

Prevention of chemotherapy-induced alopecia in rats by CDK inhibitors.

B G Benson, A M Hassell, P. A. Harris, 2001, Science.

Conformation of Leu-Arg-Arg-Ala-Ser-Leu-Gly bound in the active site of adenosine cyclic 3',5'-phosphate dependent protein kinase.

A. Mildvan, W. Miller, D. Fry, 1987, Biochemistry.

Nuclear magnetic resonance studies of the conformation and kinetics of the peptide-substrate at the active site of bovine heart protein kinase.

A. Mildvan, E. Kaiser, H. N. Bramson, 1981, Biochemistry.

Development of a convenient spectrophotometric assay for peptide phosphorylation catalyzed by adenosine 3',5'-monophosphate dependent protein kinase

W. DeGrado, E. Kaiser, H. N. Bramson, 1980 .

Distinguishing among protein kinases by substrate specificities.

P. Greengard, A. Nairn, A. Mildvan, 1987, Biochemistry.

Pharmacokinetic parameters and mechanisms of inhibition of rat type 1 and 2 steroid 5α-reductases: determinants for different in vivo activities of GI198745 and finasteride in the rat

T. Kost, T. Tippin, S. Kadwell, 2001 .

Synthetic fragments of the CD4 receptor cytoplasmic domain and large polycations alter the activities of the pp56lck tyrosine protein kinase.

J. Casnellie, C. Sommers, H. N. Bramson, 1991, The Journal of biological chemistry.

Structure-activity relationships for inhibition of type 1 and 2 human 5 alpha-reductase and human adrenal 3 beta-hydroxy-delta 5-steroid dehydrogenase/3-keto-delta 5-steroid isomerase by 6-azaandrost-4-en-3-ones: optimization of the C17 substituent.

S. Frye, P. Maloney, S V Frye, 1995, Journal of medicinal chemistry.