M. Goto

发表

Design, synthesis and biological evaluation of novel indolin-2-ones as potent anticancer compounds.

K. Lee, Lei Yan, Fang-fang Lai, 2017, Bioorganic & medicinal chemistry letters.

Phenylethylchromones with In Vitro Antitumor Promoting Activity from Aquilaria filaria

H. Tokuda, N. Suzuki, E. Ichiishi, 2016, Planta Medica.

SAR study on N2,N4-disubstituted pyrimidine-2,4-diamines as effective CDK2/CDK9 inhibitors and antiproliferative agents

K. Lee, Zhiyan Xiao, M. Goto, 2018, RSC advances.

Biologically active quinoline and quinazoline alkaloids part I

K. Lee, S. Morris-Natschke, Ying-Qian Liu, 2018, Medicinal research reviews.

5'-Chloro-2,2'-dihydroxychalcone and related flavanoids as treatments for prostate cancer.

K. Izumi, A. Mizokami, Yohei Saito, 2018, European journal of medicinal chemistry.

Bicyclic Chalcones as Mitotic Inhibitors for Overcoming Androgen Receptor-Independent and Multidrug-Resistant Prostate Cancer

Kyoko Takahashi, K. Izumi, A. Mizokami, 2021, ACS omega.

Bioactivity inspired C19-diterpenoid alkaloids for overcoming multidrug-resistant cancer

H. Yamashita, K. Lee, M. Goto, 2022, Journal of Natural Medicines.

Structure–activity relationships and evaluation of esterified diterpenoid alkaloid derivatives as antiproliferative agents

H. Yamashita, K. Lee, M. Goto, 2019, Journal of Natural Medicines.

Mechanism of action of cytotoxic compounds from the seeds of Euphorbia lathyris.

K. Lee, S. Morris-Natschke, Yu Zhang, 2018, Phytomedicine : international journal of phytotherapy and phytopharmacology.

Biologically active quinoline and quinazoline alkaloids part II

Jiyu Zhang, K. Lee, S. Morris-Natschke, 2018, Medicinal research reviews.

Novel furoquinolinones from an Indonesian Plant, Lunasia amara

S. Fukuyoshi, Yohei Saito, A. Rahim, 2020 .

Design, Synthesis, Mechanisms of Action, and Toxicity of Novel 20(S)-Sulfonylamidine Derivatives of Camptothecin as Potent Antitumor Agents

Jai-Sing Yang, Y. Wu, S. Kuo, 2014, Journal of medicinal chemistry.

Antitumor Agents. 282. 2'-(R)-O-acetylglaucarubinone, a quassinoid from Odyendyea gabonensis as a potential anti-breast and anti-ovarian cancer agent.

M. Hung, D. Newman, G. Cragg, 2010, Journal of natural products.

Cytotoxic diterpenoid alkaloid from Aconitum japonicum subsp. subcuneatum

H. Yamashita, K. Lee, M. Goto, 2019, Journal of Natural Medicines.

Four new C19-diterpenoid alkaloids from Delphinium elatum.

H. Yamashita, K. Lee, M. Goto, 2015, Phytochemistry letters.

Evaluation of Aconitum diterpenoid alkaloids as antiproliferative agents.

K. Lee, S. Morris-Natschke, M. Goto, 2015, Bioorganic & medicinal chemistry letters.

Synthesis of novel spin-labeled derivatives of 5-FU as potential antineoplastic agents

Zhi‐Jun Zhang, K. Lee, S. Morris-Natschke, 2014, Medicinal Chemistry Research.

A new flavonoid derivative exerts antitumor effects against androgen‐sensitive to cabazitaxel‐resistant prostate cancer cells

H. Yaegashi, K. Izumi, A. Mizokami, 2021, The Prostate.

Discovery of C20-Diterpenoid Alkaloid Kobusine Derivatives Exhibiting Sub-G1 Inducing Activity

K. Lee, M. Goto, K. Wada, 2022, ACS omega.

Tabercorymines A and B, Two Vobasinyl-Ibogan-Type Bisindole Alkaloids from Tabernaemontana corymbosa.

K. Lee, X. Hao, S. Morris-Natschke, 2017, Organic letters.

(-)-Neocaryachine, an Antiproliferative Pavine Alkaloid from Cryptocarya laevigata, Induces DNA Double-Strand Breaks.

D. Newman, K. Lee, B. O’Keefe, 2017, Journal of natural products.

Design and synthesis of novel spin-labeled camptothecin derivatives as potent cytotoxic agents.

K. Lee, S. Morris-Natschke, Dan Wu, 2014, Bioorganic & medicinal chemistry.

Discovery of novel andrographolide derivatives as cytotoxic agents.

K. Lee, H. Hua, Zhiyan Xiao, 2013, Bioorganic & medicinal chemistry letters.

Discovery of an Oleanolic Acid/Hederagenin-Nitric Oxide Donor Hybrid as an EGFR Tyrosine Kinase Inhibitor for Non-Small-Cell Lung Cancer.

Xiaoqin Tong, Pan‐Chyr Yang, Yan-li Liu, 2019, Journal of natural products.

Antitumor agents. 284. New desmosdumotin B analogues with bicyclic B-ring as cytotoxic and antitubulin agents.

Liying Zhang, Hao Zhu, K. Lee, 2011, Journal of medicinal chemistry.

Ochrocephalamine A, a new quinolizidine alkaloid from Oxytropis ochrocephala Bunge.

K. Lee, S. Morris-Natschke, M. Goto, 2016, Tetrahedron letters.

(+)‐(14β)‐14‐Ethylmatridin‐15‐one, a New Quinolizidine Alkaloid from the Poisonous Plant Oxytropis ochrocephala Bunge

K. Lee, S. Morris-Natschke, M. Goto, 2016 .

Alkaloids from Oxytropis ochrocephala and antiproliferative activity of sophoridine derivatives against cancer cell lines.

K. Lee, S. Morris-Natschke, M. Goto, 2016, Bioorganic & medicinal chemistry letters.

Dual-functional abeo-taxane derivatives destabilizing microtubule equilibrium and inhibiting NF-κB activation.

Z. Yao, K. Lee, Yan Li, 2013, Journal of medicinal chemistry.

Fluorinated Modification of Neo-Tanshinlactone and Antiproliferative Activity Evaluation

K. Lee, M. Goto, Kaixin Zhang, 2022, Chemistry of Natural Compounds.

Selectfluor-Enabled C(sp3)-H Alkoxylation of 3-Methylfuranocoumarins.

K. Lee, M. Goto, Kaixin Zhang, 2021, The Journal of organic chemistry.

Design and synthesis of novel PEG-conjugated 20(S)-camptothecin sulfonylamidine derivatives with potent in vitro antitumor activity via Cu-catalyzed three-component reaction.

K. Lee, S. Morris-Natschke, Ying-Qian Liu, 2015, Bioorganic & medicinal chemistry letters.

Kleinhospitine E and Cycloartane Triterpenoids from Kleinhovia hospita.

Chin-Ho Chen, K. Lee, S. Morris-Natschke, 2018, Journal of natural products.

Prenylated Acetophloroglucinol Dimers from Acronychia trifoliolata: Structure Elucidation and Total Synthesis.

D. Newman, K. Lee, B. O’Keefe, 2019, Journal of natural products.

Acetophenone Monomers from Acronychia trifoliolata.

D. Newman, K. Lee, B. O’Keefe, 2016, Journal of natural products.

Design, Synthesis and Structure-Activity Relationships of (±)-Isochaihulactone Derivatives.

H. Harn, K. Lee, S. Morris-Natschke, 2017, MedChemComm.

Antiproliferative Aspidosperma-Type Monoterpenoid Indole Alkaloids from Bousigonia mekongensis Inhibit Tubulin Polymerization

A. Oda, K. Lee, X. Hao, 2019, Molecules.

Kalshiolin A, new lignan from Kalimeris shimadai

G. Wang, N. Zhang, K. Lee, 2019, Journal of Asian natural products research.

Total Synthesis of Antiproliferative Parvifloron F.

Yohei Saito, M. Goto, Kyoko Nakagawa-Goto, 2018, Organic letters.

Isolation, Structure Elucidation, and Antiproliferative Activity of Butanolides and Lignan Glycosides from the Fruit of Hernandia nymphaeifolia

S. Fukuyoshi, D. Newman, K. Lee, 2019, Molecules.

Optimization of N-aryl-6-methoxy-1,2,3,4-tetrahydroquinolines as tubulin polymerization inhibitors.

Xiao‐Feng Wang, K. Lee, S. Morris-Natschke, 2015, Bioorganic & medicinal chemistry.

Biologically active isoquinoline alkaloids covering 2014–2018

Xiao Guo, Jiyu Zhang, K. Lee, 2020, Medicinal research reviews.

Palladium (II), platinum (II) and silver (I) complexes with oxazolines: Their synthesis, characterization, DFT calculation, molecular docking and antitumour effects.

K. Lee, S. Morris-Natschke, Lan Xie, 2022, Journal of inorganic biochemistry.

Synthesis of 4- epi-Parviflorons A, C, and E: Structure-Activity Relationship Study of Antiproliferative Abietane Derivatives.

Yohei Saito, M. Goto, Kyoko Nakagawa-Goto, 2019, The Journal of organic chemistry.

Salvisertin A, a New Hexacyclic Triterpenoid, and Other Bioactive Terpenes from Salvia deserta Root

K. Lee, S. Morris-Natschke, Shu‐Ming Li, 2018, Chemistry & biodiversity.

Design, synthesis and evaluation of antiproliferative activity of fluorinated betulinic acid.

Stephen J. Capuzzi, K. Lee, Ling-Chu Chang, 2019, Bioorganic & medicinal chemistry.

Fluorinated betulinic acid derivatives and evaluation of their anti-HIV activity.

Li Huang, Chin-Ho Chen, K. Lee, 2016, Bioorganic & medicinal chemistry letters.

Selective cytotoxic eremophilane-type sesquiterpenes from Penicillium citreonigrum

Bo Yuan, K. Lee, S. Morris-Natschke, 2015, Journal of Asian natural products research.

Chemical Space Expansion of Flavonoids: Induction of Mitotic Inhibition by Replacing Ring B with a 10π-Electron System, Benzo[b]thiophene.

Yohei Saito, M. Goto, Kyoko Nakagawa-Goto, 2022, Journal of natural products.

New Phorbol Ester Derivatives as Potent Anti-HIV Agents.

Chin-Ho Chen, K. Lee, Lei Zhao, 2021, Bioorganic & medicinal chemistry letters.

Antitumor agents. 293. Nontoxic dimethyl-4,4'-dimethoxy-5,6,5',6'-dimethylenedioxybiphenyl-2,2'-dicarboxylate (DDB) analogues chemosensitize multidrug-resistant cancer cells to clinical anticancer drugs.

K. Lee, M. Goto, K. Bastow, 2012, Journal of medicinal chemistry.

A novel derivative of betulinic acid, SYK023, suppresses lung cancer growth and malignancy

M. Lai, Ying-Jung Chen, J. Hung, 2015, Oncotarget.

Triethylated chromones with substituted naphthalenes as tubulin inhibitors.

A. Oda, K. Lee, E. Hamel, 2016, Bioorganic & medicinal chemistry.

Taburnaemines A-I, Cytotoxic Vobasinyl-Iboga-Type Bisindole Alkaloids from Tabernaemontana corymbosa.

K. Lee, X. Hao, S. Morris-Natschke, 2018, Journal of natural products.

Corymbulosins D-H, 2-Hydroxy- and 2-Oxo-clerodane Diterpenes from the Bark of Laetia corymbulosa.

S. Fukuyoshi, D. Newman, K. Lee, 2017, Journal of natural products.

Design, semisynthesis and potent cytotoxic activity of novel 10-fluorocamptothecin derivatives.

K. Lee, S. Morris-Natschke, Ying-Qian Liu, 2017, Bioorganic & medicinal chemistry letters.

Design, synthesis and potent cytotoxic activity of novel 7-(N-[(substituted-sulfonyl)piperazinyl]-methyl)-camptothecin derivatives.

N. Zhang, K. Lee, S. Morris-Natschke, 2017, Bioorganic & medicinal chemistry letters.

Design and synthesis of new 7-(N-substituted-methyl)-camptothecin derivatives as potent cytotoxic agents.

K. Lee, S. Morris-Natschke, Dan Wu, 2014, Bioorganic & medicinal chemistry letters.

Multidrug resistance-selective antiproliferative activity of Piper amide alkaloids and synthetic analogues.

K. Lee, S. Morris-Natschke, Chun-lin Long, 2014, Bioorganic & medicinal chemistry letters.

1-(3,4,5-Trimethoxyphenyl)ethane-1,2-diyl esters, a novel compound class with potent chemoreversal activity.

K. Lee, M. Goto, Kyoko Nakagawa-Goto, 2012, Bioorganic & medicinal chemistry letters.

Design and synthesis of novel 7-[(N-substituted-thioureidopiperazinyl)-methyl]-camptothecin derivatives as potential cytotoxic agents

Zhi‐Jun Zhang, K. Lee, S. Morris-Natschke, 2019, Natural product research.

Design, synthesis, cytotoxic activity and molecular docking studies of new 20(S)-sulfonylamidine camptothecin derivatives.

Lanlan Li, K. Lee, S. Morris-Natschke, 2016, European journal of medicinal chemistry.

Design, synthesis, and cytotoxic activity of novel 7-substituted camptothecin derivatives incorporating piperazinyl-sulfonylamidine moieties.

K. Lee, S. Morris-Natschke, Ying-Qian Liu, 2017, Bioorganic & medicinal chemistry letters.

Novel curcumin analogs to overcome EGFR-TKI lung adenocarcinoma drug resistance and reduce EGFR-TKI-induced GI adverse effects.

Pan‐Chyr Yang, S. Kuo, Jen-Yi Lee, 2015, Bioorganic & medicinal chemistry.

Antitumor agents 290. Design, synthesis, and biological evaluation of new LNCaP and PC-3 cytotoxic curcumin analogs conjugated with anti-androgens.

K. Lee, S. Morris-Natschke, M. Goto, 2012, Bioorganic & medicinal chemistry.

Antiproliferative and Chemosensitizing Effects of Diarylheptanoids on Intractable Tumor Cells

Yohei Saito, M. Goto, Kyoko Nakagawa-Goto, 2019, ACS Omega.

In Vivo and Mechanistic Studies on Antitumor Lead 7-Methoxy-4-(2-methylquinazolin-4-yl)-3,4-dihydroquinoxalin-2(1H)-one and Its Modification as a Novel Class of Tubulin-Binding Tumor-Vascular Disrupting Agents.

K. Lee, S. Morris-Natschke, E. Hamel, 2017, Journal of medicinal chemistry.

A Novel Clerodane Diterpene from Vitex cofassus.

S. Fukuyoshi, Yohei Saito, Y. Sasaki, 2017, Chemical & pharmaceutical bulletin.

Four new diterpenoid alkaloids from Aconitum japonicum subsp. subcuneatum

H. Yamashita, Shota Suzuki, K. Lee, 2017, Journal of Natural Medicines.

α-Trifluoromethyl Chalcones as Potent Anticancer Agents for Androgen Receptor-Independent Prostate Cancer

K. Izumi, A. Mizokami, Yohei Saito, 2021, Molecules.

Development of a novel class of tubulin inhibitor from desmosdumotin B with a hydroxylated bicyclic B-ring.

A. Oda, K. Lee, E. Hamel, 2015, Journal of medicinal chemistry.

Paliasanines A-E, 3,4-Methylenedioxyquinoline Alkaloids Fused with a Phenyl-14-oxabicyclo[3.2.1]octane Unit from Melochia umbellata var. deglabrata.

S. Fukuyoshi, Chin-Ho Chen, K. Lee, 2020, Journal of natural products.

Synthesis of Thio-lignan Analogues, Bioequivalent Salvinal without Unfavored Aldehyde.

Yohei Saito, M. Goto, Kyoko Nakagawa-Goto, 2021, The Journal of organic chemistry.

Scaffold Hopping-Driven Optimization of 4-(Quinazolin-4-yl)-3,4-dihydroquinoxalin-2(1H)-ones as Novel Tubulin Inhibitors.

K. Lee, S. Morris-Natschke, L. Jiang, 2019, ACS Medicinal Chemistry Letters.

Four New Triterpenoids from the Bark of Euonymus alatus forma ciliato-dentatus.

H. Yamashita, K. Lee, T. Shibata, 2019, Phytochemistry letters.

Novel seco-phenanthroquinolizidine alkaloids from Indonesian Boehmeria virgata

Yohei Saito, A. Rahim, M. Goto, 2021 .

Identification of 3, 4-disubstituted pyridine derivatives as novel CDK8 inhibitors.

K. Lee, Xiaoguang Chen, Zhiyan Xiao, 2021, European journal of medicinal chemistry.

Corymbulosins I-W, Cytotoxic Clerodane Diterpenes from the Bark of Laetia corymbulosa.

S. Fukuyoshi, D. Newman, K. Lee, 2018, The Journal of organic chemistry.

Antiproliferative Alkaloids from Alangium longiflorum, an Endangered Tropical Plant Species.

D. Newman, K. Lee, B. O’Keefe, 2018, Journal of natural products.

First Total Synthesis of the Pavine Alkaloid (±)-Neocaryachine and Its Optical Resolution.

Y. Miura, Yohei Saito, M. Goto, 2020, Chemical and pharmaceutical bulletin.

Eleven new C19-diterpenoid alkaloids from Delphinium elatum cv. Pacific Giant

K. Lee, M. Goto, K. Wada, 2021, Journal of Natural Medicines.

Six new norditerpenoid alkaloids from Delphinium elatum

H. Yamashita, K. Lee, M. Goto, 2015 .

Synthesis, biological evaluation, and physicochemical property assessment of 4-substituted 2-phenylaminoquinazolines as Mer tyrosine kinase inhibitors.

Xiao‐Feng Wang, K. Lee, S. Morris-Natschke, 2016, Bioorganic & medicinal chemistry.