Qi Gao

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The alkylation of isatin‐derived oximes: Spectroscopic and X‐ray crystallographic structural characterization of oxime and nitrone products

Stella Huang, N. Meanwell, R. Dalterio, 2009 .

Inhibitors of human immunodeficiency virus type 1 (HIV-1) attachment. 12. Structure-activity relationships associated with 4-fluoro-6-azaindole derivatives leading to the identification of 1-(4-benzoylpiperazin-1-yl)-2-(4-fluoro-7-[1,2,3]triazol-1-yl-1h-pyrrolo[2,3-c]pyridin-3-yl)ethane-1,2-dione (B

N. Meanwell, D. Langley, R. Colonno, 2013, Journal of medicinal chemistry.

Diastereoselective addition of Grignard reagents to azetidine-2,3-dione: Synthesis of novel Taxol® analogues

Stella Huang, D. Langley, C. Fairchild, 1996 .

Design and applications of bifunctional cinnamide derivatives as potential antimycobacterial agents with few hepatotoxic effects

Zhengrong Wu, Qi Gao, Yan-Fang Bao, 2014, Medicinal Chemistry Research.

2,3-Benzodiazepin-1,4-diones as peptidomimetic inhibitors of γ-secretase

David W. Smith, D. Barten, C. Polson, 2004 .

Solubility Measurement and Correlation of 2-Oxindole in 12 Pure Organic Solvents

Li Ji, Qi Gao, Jin-Qiang Liu, 2019, Journal of Chemical & Engineering Data.

Novel stilbenes isolated from the root bark of Ekebergia benguelensis

G. Cordell, J. Pezzuto, A. Kinghorn, 2001 .

Cytotoxic Constituents of the Roots of Exostema acuminatum

G. Cordell, J. Pezzuto, A. Kinghorn, 2000 .

Conformationally constrained ortho-anilino diaryl ureas: discovery of 1-(2-(1'-neopentylspiro[indoline-3,4'-piperidine]-1-yl)phenyl)-3-(4-(trifluoromethoxy)phenyl)urea, a potent, selective, and bioavailable P2Y1 antagonist.

Steven A. Spronk, P. Lam, D. Schnur, 2013, Journal of medicinal chemistry.

Discovery of 6-chloro-2-trifluoromethyl-7-aryl-7H-imidazo[1,2-a]imidazol-3-ylmethylamines, a novel class of corticotropin-releasing factor receptor type 1 (CRF1R) antagonists.

J. Macor, D. Zuev, G. Dubowchik, 2010, Bioorganic & medicinal chemistry letters.

(R)-2-(4-Phenylbutyl)dihydrobenzofuran derivatives as melatoninergic agents.

S. Bertenshaw, C. D. Mahle, K. Takaki, 2005, Bioorganic & medicinal chemistry letters.

Crystal Structure of 2-Debenzoyl, 2-Acetoxy Paclitaxel (Taxol®): Conformation of the Paclitaxel Side-Chain

Qi Gao, Jian Wei, Shu‐Hui Chen, 1995, Pharmaceutical Research.

Indanyl piperazines as melatonergic MT2 selective agents.

R. Mattson, C. D. Mahle, F. Yocca, 2003, Bioorganic & medicinal chemistry letters.

Discovery of a Potent Acyclic, Tripeptidic, Acyl Sulfonamide Inhibitor of Hepatitis C Virus NS3 Protease as a Back-up to Asunaprevir with the Potential for Once-Daily Dosing.

L. Mueller, K. Kish, H. Klei, 2016, Journal of medicinal chemistry.

Synthesis and structure-activity relationships of 3-aryloxindoles: a new class of calcium-dependent, large conductance potassium (maxi-K) channel openers with neuroprotective properties.

V. Gribkoff, Stella Huang, N. Meanwell, 2002, Journal of medicinal chemistry.

Discovery of a cyclopentylamine as an orally active dual NK1 receptor antagonist-serotonin reuptake transporter inhibitor.

J. Macor, R. Westphal, R. Bertekap, 2014, Bioorganic & medicinal chemistry letters.

Synthesis of HIV-Maturation Inhibitor BMS-955176 from Betulin by an Enabling Oxidation Strategy.

Qi Gao, Matthew W. Haley, Zhongmin Xu, 2017, The Journal of organic chemistry.

Cytotoxic constituents from the stem bark of Dichapetalum gelonioides collected in the Philippines.

G. Cordell, J. Pezzuto, A. Kinghorn, 2006, Journal of Natural Products.

Surprising selectivity in the transformation of dimethoxy azaindoles

J. Castoro, Feng Xu, C. Pathirana, 2007 .

Catalytic asymmetric syntheses of tyrosine surrogates.

J. Macor, G. Dubowchik, Qi Gao, 2008, The Journal of organic chemistry.

Inhibitors of human immunodeficiency virus type 1 (HIV-1) attachment. 5. An evolution from indole to azaindoles leading to the discovery of 1-(4-benzoylpiperazin-1-yl)-2-(4,7-dimethoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)ethane-1,2-dione (BMS-488043), a drug candidate that demonstrates antiviral activity

N. Meanwell, R. Colonno, J. Kadow, 2009, Journal of medicinal chemistry.

Regioselective Synthesis of 3-(Heteroaryl)-iminothiazolidin-4-ones

M. Serrano-Wu, D. Laurent, Qi Gao, 2004 .

Discovery and early clinical evaluation of BMS-605339, a potent and orally efficacious tripeptidic acylsulfonamide NS3 protease inhibitor for the treatment of hepatitis C virus infection.

A. Good, H. Klei, A. Cocuzza, 2014, Journal of medicinal chemistry.

Identification of a potent and selective 5-HT(6) antagonist: one-step synthesis of (E)-3-(benzenesulfonyl)-2- (methylsulfanyl)pyrido[1,2-a]pyrimidin-4-ylidenamine from 2-(benzenesulfonyl)-3,3-bis(methylsulfanyl)acrylonitrile.

R. Westphal, P. Scola, R. Bertekap, 2003, Journal of medicinal chemistry.

The impact of palladium(II) reduction pathways on the structure and activity of palladium(0) catalysts.

Qi Gao, Jacob Albrecht, Srinivas Tummala, 2013, Angewandte Chemie.

Inhibitors of HIV-1 attachment. Part 7: indole-7-carboxamides as potent and orally bioavailable antiviral agents.

N. Meanwell, P. Shi, K. Yeung, 2013, Bioorganic & medicinal chemistry letters.

Conformationally restricted homotryptamines. 2. Indole cyclopropylmethylamines as selective serotonin reuptake inhibitors.

B. Beno, M. Cunningham, T. Molski, 2005, Journal of medicinal chemistry.

Conformationally restricted homotryptamines. Part 7: 3-cis-(3-aminocyclopentyl)indoles as potent selective serotonin reuptake inhibitors.

B. Beno, J. Macor, T. Molski, 2010, Journal of medicinal chemistry.

Ligand conformation has a definitive effect on 5-HT1A and serotonin reuptake affinity.

R. Mattson, J. Yevich, M. Dee, 2004, Bioorganic & medicinal chemistry letters.

The “hydrophobic collapse” conformation of paclitaxel (Taxol®) has been observed in a non-aqueous environment: Crystal structure of 10-deacetyl-7-epitaxol

Qi Gao, W. Parker, 1996 .

The discovery of asunaprevir (BMS-650032), an orally efficacious NS3 protease inhibitor for the treatment of hepatitis C virus infection.

Qi Gao, Huabin Sun, Hong Shi, 2014, Journal of medicinal chemistry.

Terpestacin, a novel syncytium formation inhibitor, isolated from Arthrinium species

S. Iimura, T. Oki, M. Konishi, 1993 .

Discovery and preclinical characterization of the cyclopropylindolobenzazepine BMS-791325, a potent allosteric inhibitor of the hepatitis C virus NS5B polymerase.

Chong-Hwan Chang, M. Witmer, B. Beno, 2014, Journal of medicinal chemistry.

The synthesis and characterization of BMS-204352 (MaxiPost) and related 3-fluorooxindoles as openers of maxi-K potassium channels.

V. Gribkoff, R. Perrone, N. Meanwell, 2002, Bioorganic & medicinal chemistry letters.

Novel Stilbenes Isolated from the Root Bark of Ekebergia benguelensis.

G. Cordell, J. Pezzuto, A. Kinghorn, 2001 .

Amorphous drug-PVP dispersions: application of theoretical, thermal and spectroscopic analytical techniques to the study of a molecule with intermolecular bonds in both the crystalline and pure amorphous state.

Y. Khimyak, P. Timmins, John F. Gamble, 2009, Journal of pharmaceutical sciences.

Phosphonooxymethyl prodrugs of the broad spectrum antifungal azole, ravuconazole: synthesis and biological properties.

Qi Gao, Mandar Dali, Srini Venkatesh, 2003, Bioorganic & medicinal chemistry letters.

Identification of a broad-spectrum azasordarin with improved pharmacokinetic properties.

C. Mazzucco, A. Marinier, M. Serrano-Wu, 2003, Bioorganic & medicinal chemistry letters.

Design and applications of bifunctional cinnamide derivatives as potential antimycobacterial agents with few hepatotoxic effects

Qi Gao, Yan-Fang Bao, De-Juan Zhi, 2014, Medicinal Chemistry Research.

Synthesis and hSERT activity of homotryptamine analogs. Part 6: [3+2] dipolar cycloaddition of 3-vinylindoles.

T. Molski, R. Mattson, N. Lodge, 2010, Bioorganic & medicinal chemistry letters.

Inhibitors of HIV-1 attachment. Part 4: A study of the effect of piperazine substitution patterns on antiviral potency in the context of indole-based derivatives.

T. Spicer, N. Meanwell, P. Shi, 2009, Bioorganic & medicinal chemistry letters.

3-[(5-Chloro-2-hydroxyphenyl)methyl]-5-[4-(trifluoromethyl)phenyl ]-1,3,4-oxadiazol-2(3H)-one, BMS-191011: opener of large-conductance Ca(2+)-activated potassium (maxi-K) channels, identification, solubility, and SAR.

Astrid A. Ortiz, V. Gribkoff, J. Starrett, 2007, Journal of medicinal chemistry.

Novel bioactive phenanthrene derivatives from Domohinea perrieri

G. Cordell, J. Pezzuto, A. Kinghorn, 1997 .

Conformationally restricted homotryptamines. Part 6: indole-5-cycloalkyl methylamines as selective serotonin reuptake inhibitors.

J. Macor, T. Molski, R. Mattson, 2013, Bioorganic & medicinal chemistry letters.

2-arylaminothiazoles as high-affinity corticotropin-releasing factor 1 receptor (CRF1R) antagonists: synthesis, binding studies and behavioral efficacy.

K. Browman, D. Zuev, P. Scola, 2003, Bioorganic & medicinal chemistry letters.

Discovery of a Hepatitis C Virus NS5B Replicase Palm Site Allosteric Inhibitor (BMS-929075) Advanced to Phase 1 Clinical Studies.

Qi Gao, Min Gao, Steven Sheriff, 2017, Journal of medicinal chemistry.

(+)-Dinapsoline: an efficient synthesis and pharmacological profile of a novel dopamine agonist.

T. Verdoorn, T. Molski, H. Wong, 2002, Journal of medicinal chemistry.

Synthesis of fluorinated 1-(3-morpholin-4-yl-phenyl)-ethylamines.

Yong-Jin Wu, Qi Gao, Huan He, 2003, Bioorganic & medicinal chemistry letters.

Studies on the photochemistry of taxol

Stella Huang, T. Doyle, V. Farina, 1994 .

The Chemistry of Taxanes: Skeletal Rearrangements of Baccatin Derivatives via Radical Intermediates.

Stella Huang, V. Farina, J. Golik, 1994 .

A Divergent Nickel-Catalyzed Synthesis of Quinazolinediones and Benzoxazinone Imines

E. Simmons, G. Beutner, Qi Gao, 2018, Synthesis.

Development of a presynaptic 5-HT1A antagonist.

R. B. Carter, R. Mattson, C. D. Mahle, 2003, Bioorganic & medicinal chemistry letters.

Potent Inhibitors of Hepatitis C Virus NS3 Protease: Employment of a Difluoromethyl Group as a Hydrogen-Bond Donor.

A. Good, K. Kish, H. Klei, 2018, ACS medicinal chemistry letters.

Synthesis and KCNQ2 opener activity of N-(1-benzo[1,3]dioxol-5-yl-ethyl, N-[1-(2,3-dihydro-benzofuran-5-yl)-ethyl, and N-[1-(2,3-dihydro-1H-indol-5-yl)-ethyl acrylamides.

Qi Gao, Jie Chen, Huan He, 2004, Bioorganic & medicinal chemistry letters.

(S)-N-[1-(4-cyclopropylmethyl-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-ethyl]-3-(2-fluoro-phenyl)-acrylamide is a potent and efficacious KCNQ2 opener which inhibits induced hyperexcitability of rat hippocampal neurons.

Qi Gao, Jie Chen, Huan He, 2004, Bioorganic & medicinal chemistry letters.

Imaging dehydration kinetics of a channel hydrate form of the HIV-1 attachment inhibitor prodrug BMS-663068.

Qi Gao, Clive J Roberts, Andrew Parker, 2013, Journal of pharmaceutical sciences.

Discovery of (S)-2-((S)-2-(3,5-difluorophenyl)-2-hydroxyacetamido)-N-((S,Z)-3-methyl-4-oxo-4,5-dihydro-3H-benzo[d][1,2]diazepin-5-yl)propanamide (BMS-433796): a gamma-secretase inhibitor with Abeta lowering activity in a transgenic mouse model of Alzheimer's disease.

David W. Smith, J. Hendrick, D. Barten, 2007, Bioorganic & medicinal chemistry letters.

4,5-diphenyltriazol-3-ones: openers of large-conductance Ca(2+)-activated potassium (maxi-K) channels.

Qi Gao, Nicholas A Meanwell, Yi Li, 2002, Journal of medicinal chemistry.

Sulfated modification, basic characterization, antioxidant and anticoagulant potentials of polysaccharide from Sagittaria trifolia

Qi Gao, Jiahao Xu, Yihui Liu, 2023, Arabian Journal of Chemistry.

Crystallographic Determination of the Stereochemistry of C‐6,7 Epoxy Paclitaxel.

J. Kadow, M. Wittman, Qi Gao, 1998 .

An unprecedented side chain conformation of paclitaxel (Taxol®): Crystal structure of 7-Mesylpaclitaxel

Qi Gao, Shuhui Chen, 1996 .

Potential CRF1R PET imaging agents: N-fluoroalkyl-8-(6-methoxy-2-methylpyridin-3-yl)-2,7-dimethyl-N-alkylpyrazolo[1,5-a][1,3,5]triazin-4-amines.

J. Macor, D. Zuev, R. Mattson, 2011, Bioorganic & medicinal chemistry letters.

Discovery of a Novel Class of Bicyclo[3.1.0]hexanylpiperazines as Noncompetitive Neuropeptide Y Y1 Antagonists.

Astrid A. Ortiz, O. Flint, M. Deshpande, 2012, ACS medicinal chemistry letters.

Combining an In Vitro Kinetic Model with a Physiologically-Based Pharmacokinetic Model to Assess the Potential In Vivo Fate of Polyvinyl Pyrrolidone-Vinyl Acetate Copolymers

Qi Gao, Joshua D. Engstrom, Daniel S. Hsieh, 2018, Pharmaceutical Research.

Stereoselective synthesis of new conformationally restricted analogues of a potent CGRP receptor antagonist.

B. Beno, J. Macor, D. Zuev, 2005, Organic letters.

Design and synthesis of uracil urea derivatives as potent and selective fatty acid amide hydrolase inhibitors

Jie Ren, Canzhong Lu, Qi Gao, 2017 .

A facile construction of 4-hydroxymethylbenzisothiazolone-1,1-dioxide

N. Meanwell, K. Yeung, Qi Gao, 1998 .

Atropisomeric 3-(beta-hydroxyethyl)-4-arylquinolin-2-ones as Maxi-K potassium channel openers.

V. Gribkoff, S. Dworetzky, C. Boissard, 2007, Journal of medicinal chemistry.

Enantioselective Synthesis of a Highly Potent Selective Serotonin Reuptake Inhibitor. An Application of Imidazolidinone Catalysis to the Alkylation of Indoles with an α,β-Disubstituted α,β-Unsaturated Aldehyde

J. Macor, R. Mattson, Qi Gao, 2005 .

The impact of palladium(II) reduction pathways on the structure and activity of palladium(0) catalysts.

Martin D. Eastgate, S. Tummala, O. Soltani, 2013, Angewandte Chemie.

Conformationally restricted homotryptamines. Part 5: 3-(trans-2-aminomethylcyclopentyl)indoles as potent selective serotonin reuptake inhibitors.

J. Macor, T. Molski, R. Mattson, 2009, Bioorganic & medicinal chemistry letters.

Conformationally restricted homotryptamines 3. Indole tetrahydropyridines and cyclohexenylamines as selective serotonin reuptake inhibitors.

B. Beno, T. Molski, R. Mattson, 2007, Bioorganic & Medicinal Chemistry Letters.

Discovery and early clinical evaluation of BMS-605339, a potent and orally efficacious tripeptidic acylsulfonamide NS3 protease inhibitor for the treatment of hepatitis C virus infection.

A. Good, H. Klei, A. Cocuzza, 2014, Journal of medicinal chemistry.

Synthesis and hSERT activity of homotryptamine analogs. Part 6: [3+2] dipolar cycloaddition of 3-vinylindoles.

T. Molski, R. Mattson, N. Lodge, 2010, Bioorganic & medicinal chemistry letters.