T. Pfeifer

发表

Reversal of the cardiotonic and action‐potential prolonging effects of DPI 201–106 by BDF 8784, a methyl‐indol derivative

U. Ravens, Benjamin I. Armah, T. Pfeifer, 1989, British journal of pharmacology.

Cholesteryl ester hydrolase activity is abolished in HSL macrophages but unchanged in macrophages lacking KIAA1363[S]

R. Zechner, B. Cravatt, K. Chiang, 2010, Journal of Lipid Research.

Protein carbamylation renders high-density lipoprotein dysfunctional.

P. Stiegler, M. Gauster, G. Marsche, 2011, Antioxidants & redox signaling.

and promotes insulin sensitivity in mice Loss of intestinal GATA4 prevents diet-induced obesity

R. Stollberger, Sascha Obrowsky, D. Kratky, 2013 .

Cholesteryl ester accumulation and accelerated cholesterol absorption in intestine-specific hormone sensitive lipase-null mice

Sascha Obrowsky, G. Haemmerle, D. Kratky, 2012, Biochimica et biophysica acta.

Loss of intestinal GATA4 prevents diet-induced obesity and promotes insulin sensitivity in mice.

C. Diwoky, R. Stollberger, Sascha Obrowsky, 2011, American journal of physiology. Endocrinology and metabolism.

Synthetic LXR agonist attenuates plaque formation in apoE-/- mice without inducing liver steatosis and hypertriglyceridemia*s⃞

M. Miyazaki, H. Ahammer, M. Trauner, 2009, Journal of lipid research.

The metabolism and drug–drug interaction potential of the selective prostacyclin receptor agonist selexipag

R. de Kanter, A. Treiber, S. Delahaye, 2018, Xenobiotica; the fate of foreign compounds in biological systems.

Verification of the Major Metabolic Oxidation Path for the Naphthoyl Group in Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells (CRTh2) Antagonist 2-(2-(1-Naphthoyl)-8-fluoro-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)acetic Acid (Setipiprant/ACT-129968).

H. Fretz, J. Segrestaa, T. Pfeifer, 2015, Journal of medicinal chemistry.

Discovery and Optimization of Isoquinoline Ethyl Ureas as Antibacterial Agents.

L. Prade, D. Ritz, P. Seiler, 2017, Journal of medicinal chemistry.

Discovery of a Potent, Selective T-type Calcium Channel Blocker as a Drug Candidate for the Treatment of Generalized Epilepsies.

R. de Kanter, Simon Stamm, E. A. Ertel, 2017, Journal of medicinal chemistry.

Preparation, Antiepileptic Activity, and Cardiovascular Safety of Dihydropyrazoles as Brain-Penetrant T-Type Calcium Channel Blockers.

J. Mosbacher, E. A. Ertel, O. Bezençon, 2016, Journal of medicinal chemistry.

Pro-angiogenic induction of myeloid cells for therapeutic angiogenesis can induce mitogen-activated protein kinase p38-dependent foam cell formation.

A. Reinisch, D. Strunk, D. Kratky, 2011, Cytotherapy.

Phase I and II metabolism and MRP2‐mediated export of bosentan in a MDCKII‐OATP1B1‐CYP3A4‐UGT1A1‐MRP2 quadruple‐transfected cell line

M. Mieth, J. König, A. Treiber, 2013, British journal of pharmacology.

Mobilization of cholesterol and fatty acids from choles-

R. Zechner, B. Cravatt, K. Chiang, 2010 .

Synthetic LXR agonist suppresses endogenous cholesterol biosynthesis and efficiently lowers plasma cholesterol.

Sascha Obrowsky, D. Kratky, U. Kompella, 2011, Current pharmaceutical biotechnology.

Characterization of the effects of the new inotropic agent BDF 9148 in isolated papillary muscles and myocytes of the guinea‐pig heart

U. Ravens, E. Wettwer, B. Armah, 1991, British journal of pharmacology.

Inhibition of the myocardial Ca2+‐current (ICa) by the enantiomers of DPI 201–106 and BDF 8784

U. Ravens, E. Wettwer, T. Pfeifer, 1991, British journal of pharmacology.

Structure-Activity Relationship, Drug Metabolism and Pharmacokinetics Properties Optimization, and in Vivo Studies of New Brain Penetrant Triple T-Type Calcium Channel Blockers.

R. de Kanter, Olivier Corminboeuf, O. Bezençon, 2016, Journal of Medicinal Chemistry.

Discovery and evaluation of Cav3.2-selective T-type calcium channel blockers.

E. A. Ertel, O. Bezençon, L. Remeň, 2017, Bioorganic & medicinal chemistry letters.

Discovery and evaluation of Cav3.1-selective T-type calcium channel blockers.

E. A. Ertel, O. Bezençon, L. Remeň, 2017, Bioorganic & medicinal chemistry letters.

First-in-Humans Study of the Safety, Tolerability, and Pharmacokinetics of ACT-451840, a New Chemical Entity with Antimalarial Activity

R. de Kanter, J. Dingemanse, T. Pfeifer, 2014, Antimicrobial Agents and Chemotherapy.

Characterisation of humic substances using atmospheric pressure chemical ionisation and electrospray ionisation mass spectrometry combined with size-exclusion chromatography.

R. Hoffmann, M. Spiteller, T. Pfeifer, 2001, Journal of chromatography. A.

Bioanalysis for plasma protein binding studies in drug discovery and drug development: views and recommendations of the European Bioanalysis Forum.

Thomas Pfeifer, Philip Timmerman, Pascal Delrat, 2014, Bioanalysis.