C. Boileau

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Diacerein inhibits the synthesis of resorptive enzymes and reduces osteoclastic differentiation/survival in osteoarthritic subchondral bone: a possible mechanism for a protective effect against subchondral bone remodelling

J. Pelletier, J. Martel-Pelletier, C. Boileau, 2008, Arthritis research & therapy.

Regulation of the expression of 5-lipoxygenase-activating protein/5-lipoxygenase and the synthesis of leukotriene B(4) in osteoarthritic chondrocytes: role of transforming growth factor beta and eicosanoids.

J. Pelletier, J. Martel-Pelletier, S. Laufer, 2004, Arthritis and rheumatism.

The in situ up-regulation of chondrocyte interleukin-1-converting enzyme and interleukin-18 levels in experimental osteoarthritis is mediated by nitric oxide.

J. Pelletier, J. Martel-Pelletier, F. Moldovan, 2002, Arthritis and rheumatism.

Oral treatment with PD-0200347, an α2δ ligand, reduces the development of experimental osteoarthritis by inhibiting the chondrocytes metalloproteases and inducible nitric oxide synthase gene expression and synthesis

J. Martel-Pelletier, J. Pelletier, C. Flory, 2004, Arthritis Research & Therapy.

Oral treatment with PD-0200347, an alpha2delta ligand, reduces the development of experimental osteoarthritis by inhibiting metalloproteinases and inducible nitric oxide synthase gene expression and synthesis in cartilage chondrocytes.

J. Pelletier, J. Martel-Pelletier, C. Flory, 2005, Arthritis and rheumatism.

PD-0200347, an alpha2delta ligand of the voltage gated calcium channel, inhibits in vivo activation of the Erk1/2 pathway in osteoarthritic chondrocytes: a PKCalpha dependent effect.

J. Martel-Pelletier, J. Pelletier, C. Flory, 2006, Annals of the rheumatic diseases.

PD-0200347, an α2δ ligand of the voltage gated calcium channel, inhibits in vivo activation of the Erk1/2 pathway in osteoarthritic chondrocytes: a PKCα dependent effect

J. Pelletier, J. Martel-Pelletier, J. Pelletier, 2005 .

The inhibition of subchondral bone resorption in the early phase of experimental dog osteoarthritis by licofelone is associated with a reduction in the synthesis of MMP-13 and cathepsin K.

J. Pelletier, J. Martel-Pelletier, S. Laufer, 2004, Bone.

Interleukin 17, a nitric oxide-producing cytokine with a peroxynitrite-independent inhibitory effect on proteoglycan synthesis.

J. Pelletier, J. Martel-Pelletier, P. Netter, 2002, The Journal of rheumatology.

Proteinase-activated Receptor-2 Gene Disruption Limits the Effect of Osteoarthritis on Cartilage in Mice: A Novel Target in Joint Degradation

J. Pelletier, J. Martel-Pelletier, B. Lussier, 2011, The Journal of Rheumatology.

Extracellular localization of galectin-3 has a deleterious role in joint tissues

J. Pelletier, J. Martel-Pelletier, P. Reboul, 2007, Arthritis research & therapy.

Identification in human osteoarthritic chondrocytes of proteins binding to the novel regulatory site AGRE in the human matrix metalloprotease 13 proximal promoter.

J. Pelletier, J. Martel-Pelletier, J. Bidwell, 2006, Arthritis and rheumatism.

The peroxisome proliferator-activated receptor gamma agonist pioglitazone reduces the development of cartilage lesions in an experimental dog model of osteoarthritis: in vivo protective effects mediated through the inhibition of key signaling and catabolic pathways.

J. Pelletier, J. Martel-Pelletier, H. Fahmi, 2007, Arthritis and rheumatism.

The protective effect of licofelone on experimental osteoarthritis is correlated with the downregulation of gene expression and protein synthesis of several major cartilage catabolic factors: MMP-13, cathepsin K and aggrecanases

J. Pelletier, J. Martel-Pelletier, S. Laufer, 2005, Arthritis research & therapy.

Animal models of osteoarthritis

R. Altman, J. Pelletier, J. Martel-Pelletier, 2011 .

Protective effects of total fraction of avocado/soybean unsaponifiables on the structural changes in experimental dog osteoarthritis: inhibition of nitric oxide synthase and matrix metalloproteinase-13

J. Pelletier, J. Martel-Pelletier, C. Boileau, 2009, Arthritis research & therapy.

Differential gene expression and regulation of the bone morphogenetic protein antagonists follistatin and gremlin in normal and osteoarthritic human chondrocytes and synovial fibroblasts

J. Pelletier, J. Martel-Pelletier, P. Ranger, 2004 .

Modulation of OPG, RANK and RANKL by human chondrocytes and their implication during osteoarthritis.

J. Pelletier, J. Martel-Pelletier, S. Kwan Tat, 2009, Rheumatology.

Oral treatment with a Brachystemma calycinum D don plant extract reduces disease symptoms and the development of cartilage lesions in experimental dog osteoarthritis: inhibition of protease-activated receptor 2

J. Pelletier, J. Martel-Pelletier, M. Moreau, 2009, Annals of the rheumatic diseases.

Identification of opticin, a member of the small leucine-rich repeat proteoglycan family, in human articular tissues: a novel target for MMP-13 in osteoarthritis.

J. Pelletier, J. Martel-Pelletier, P. Roughley, 2008, Osteoarthritis and cartilage.

Licofelone (ML-3000), a dual inhibitor of 5-lipoxygenase and cyclooxygenase, reduces the level of cartilage chondrocyte death in vivo in experimental dog osteoarthritis: inhibition of pro-apoptotic factors.

J. Pelletier, J. Martel-Pelletier, S. Laufer, 2002, The Journal of rheumatology.

Proteinase-activated receptor (PAR)-2 activation impacts bone resorptive properties of human osteoarthritic subchondral bone osteoblasts.

J. Pelletier, J. Martel-Pelletier, D. Lajeunesse, 2009, Bone.

The BMP antagonists follistatin and gremlin in normal and early osteoarthritic cartilage: an immunohistochemical study.

J. Martel-Pelletier, J. Pelletier, C. Boileau, 2009, Osteoarthritis and cartilage.

Differential regulation of the bone morphogenic protein antagonist chordin in human normal and osteoarthritic chondrocytes

J. Martel-Pelletier, J. Pelletier, C. Boileau, 2006, Annals of the rheumatic diseases.

Activation of proteinase-activated receptor 2 in human osteoarthritic cartilage upregulates catabolic and proinflammatory pathways capable of inducing cartilage degradation: a basic science study

J. Pelletier, J. Martel-Pelletier, H. Fahmi, 2007, Arthritis research & therapy.

PD-0200347, an a2d ligand of the voltage gated calcium channel, inhibits in vivo activation of the Erk1/2 pathway in osteoarthritic chondrocytes: a PKCa dependent effect

J. Martel-Pelletier, C. Flory, C. Boileau, 2006 .

PD-0200347, AN α 2 δ LIGAND OF VOLTAGE-DEPENDENT CALCIUM CHANNEL, INHIBITS IN VIVO THE ACTIVATION OF THE ERK1/2 PATHWAY IN OSTEOARTHRITIC CHONDROCYTES: A PKC α -DEPENDENT EFFECT

J. Pelletier, J. Martel-Pelletier, C. Flory, 2005 .

Diacerein reduces the level of cartilage chondrocyte DNA fragmentation and death in experimental dog osteoarthritic cartilage at the same time that it inhibits caspase-3 and inducible nitric oxide synthase.

J. Pelletier, J. Martel-Pelletier, F. Mineau, 2003, Clinical and experimental rheumatology.

Treatment with ephrin B2 positively impacts the abnormal metabolism of human osteoarthritic chondrocytes

J. Pelletier, J. Martel-Pelletier, M. Lavigne, 2009, Arthritis research & therapy.

Intracellular localisation of galectin-3 has a protective role in chondrocyte survival

J. Martel-Pelletier, J. Pelletier, P. Reboul, 2007, Annals of the rheumatic diseases.

The regulation of human MMP-13 by licofelone, an inhibitor of cyclo-oxygenases and 5-lipoxygenase, in human osteoarthritic chondrocytes is mediated by the inhibition of the p38 MAP kinase signalling pathway

J. Pelletier, J. Martel-Pelletier, J. Pelletier, 2004, Annals of the rheumatic diseases.

Galectin-3 surface expression on human adult chondrocytes: a potential substrate for collagenase-3

J. Pelletier, J. Martel-Pelletier, J. Pelletier, 2004, Annals of the rheumatic diseases.

Coagulation/fibrinolysis balance in septic shock related to cytokines and clinical state.

J. Bienvenu, A. Lepape, C. Boileau, 1994, Haemostasis.

Cartilage in normal and osteoarthritis conditions.

Johanne Martel-Pelletier, Jean-Pierre Pelletier, J. Pelletier, 2008, Best practice & research. Clinical rheumatology.

Subcellular localization of coagulation factor II receptor-like 1 in neurons governs angiogenesis

M. Hollenberg, M. Montoya-Zavala, G. Andelfinger, 2014, Nature Medicine.

Experimental models of osteoarthritis: usefulness in the development of disease-modifying osteoarthritis drugs/agents

R. Altman, J. Pelletier, J. Martel-Pelletier, 2010 .

Histone deacetylase inhibitors suppress interleukin-1beta-induced nitric oxide and prostaglandin E2 production in human chondrocytes.

H. Afif, J. Pelletier, J. Martel-Pelletier, 2008, Osteoarthritis and cartilage.

Identification of new biomarkers for sarcopenia and characterization of cathepsin D biomarker

Y. Henrotin, C. Boileau, C. L'hôte, 2021 .

Activation of the receptor EphB4 by its specific ligand ephrin B2 in human osteoarthritic subchondral bone osteoblasts.

J. Pelletier, J. Martel-Pelletier, S. Kwan Tat, 2008, Arthritis and rheumatism.

Limitation of the in vitro whole blood assay for predicting the COX selectivity of NSAIDs in clinical use.

D. Loeuille, H. Blain, F. Lapicque, 2002, British journal of clinical pharmacology.

Galectin-3 in osteoarthritis: from a protective to a destructive role

J. Martel-Pelletier, J. Pelletier, P. Reboul, 2004, Arthritis Research & Therapy.

Nitric oxide (NO) and cartilage metabolism: NO effects are modulated by superoxide in response to IL-1.

P. Netter, J. Jouzeau, C. Boileau, 2002, Biorheology.

Magnetic resonance imaging can accurately assess the long-term progression of knee structural changes in experimental dog osteoarthritis

J. Raynauld, J. Pelletier, J. Martel-Pelletier, 2007, Annals of the rheumatic diseases.

Treatment with Tiludronic Acid Helps Reduce the Development of Experimental Osteoarthritis Lesions in Dogs with Anterior Cruciate Ligament Transection Followed by Reconstructive Surgery: A 1-Year Study with Quantitative Magnetic Resonance Imaging

J. Pelletier, J. Martel-Pelletier, M. Moreau, 2011, The Journal of Rheumatology.

Quantitative Magnetic Resonance Imaging Transection Followed by Reconstructive Surgery : A 1-Year Study with Experimental Osteoarthritis Lesions in Dogs with Anterior Cruciate Ligament Treatment with Tiludronic Acid Helps Reduce the Development of LUSSIER and

J. Pelletier, J. Martel-Pelletier, M. Moreau, 2010 .

Licofelone reduces progression of structural changes in a canine model of osteoarthritis under curative conditions: effect on protease expression and activity.

J. Pelletier, J. Martel-Pelletier, M. Moreau, 2006, The Journal of rheumatology.

039 VALIDITY OF PAIN ASSESSMENT METHODS IN THE EXPERIMENTAL DOG POND-NUKI MODEL

G. Beauchamp, J. Pelletier, J. Martel-Pelletier, 2009 .

077 RELATIONSHIP BETWEEN CANINE STIFLE STRUCTURAL DAMAGES AND FUNCTIONAL IMPAIRMENT IN EXPERIMENTAL OSTEOARTHRITIS: PODOBAROMETRIC GAIT ANALYSIS COUPLED WITH 1.5 TESLA MAGNETIC RESONANCE IMAGING

J. Raynauld, J. Pelletier, J. Martel-Pelletier, 2009 .

J. Pelletier, J. Martel-Pelletier, M. Moreau, 2009, Annals of the rheumatic diseases.

Oral treatment with PD-0200347, an α2δ ligand, reduces the development of experimental osteoarthritis by inhibiting metalloproteinases and inducible nitric oxide synthase gene expression and synthesis in cartilage chondrocytes†

J. Pelletier, J. Martel-Pelletier, C. Flory, 2005 .

Histone deacetylase inhibitors suppress interleukin-1beta-induced nitric oxide and prostaglandin E2 production in human chondrocytes.

H. Afif, J. Pelletier, J. Martel-Pelletier, 2008, Osteoarthritis and cartilage.