Ke Ding

发表

Targeted inhibition of ZAK ameliorates renal interstitial fibrosis.

Han Liu, Xiaoyun Lu, Jing Nie, 2022, Translational research : the journal of laboratory and clinical medicine.

Design, synthesis, and biological evaluation of 3-(1H-1,2,3-triazol-1-yl)benzamide derivatives as Potent Pan Bcr-Abl inhibitors including the threonine(315)→isoleucine(315) mutant.

Xiaoyun Lu, Zheng-chao Tu, Fengxiang Zhang, 2012, Journal of medicinal chemistry.

The antihelmenthic phosphate niclosamide impedes renal fibrosis by inhibiting homeodomain-interacting protein kinase 2 expression.

Jing Nie, F. Zhu, Zhanmei Zhou, 2017, Kidney international.

Identification of New Small-Molecule Inducers of Estrogen-related Receptor α (ERRα) Degradation.

Yan Zhang, Yong Xu, Shan Li, 2019, ACS medicinal chemistry letters.

Discovery of the First Examples of Threonine Tyrosine Kinase PROTAC Degraders.

Yong Xu, Xiaoyun Lu, Ke Ding, 2022, Journal of medicinal chemistry.

Design, synthesis, and in vitro biological evaluation of 1H-1,2,3-triazole-4-carboxamide derivatives as new anti-influenza A agents targeting virus nucleoprotein.

Yong Xu, Yih-Shyun E. Cheng, Xiaoyun Lu, 2012, Journal of medicinal chemistry.

Design and synthesis of N-(4-aminopyridin-2-yl)amides as B-Raf(V600E) inhibitors.

Xiaoyun Lu, Jie Ma, Jiayi Shen, 2016, Bioorganic & medicinal chemistry letters.

Design, synthesis, and biological evaluation of Bcr-Abl PROTACs to overcome T315I mutation

S. Tu, Xiaoyun Lu, Zheng-chao Tu, 2020, Acta pharmaceutica Sinica. B.

Small-Molecule CSF1R Inhibitors as Anticancer Agents.

Xiaoyun Lu, Zhen Wang, Ke Ding, 2019, Current medicinal chemistry.

Identification of Pyrazolo[1,5-a]pyridine-3-carboxamide Diaryl Derivatives as Drug Resistant Antituberculosis Agents.

S. Franzblau, Xiaoyun Lu, Jiayi Shen, 2019, ACS medicinal chemistry letters.

Pyrazolo[1,5- a]pyridine Inhibitor of the Respiratory Cytochrome bcc Complex for the Treatment of Drug-Resistant Tuberculosis.

Xiaoyun Lu, Zhe Wang, A. Lenaerts, 2018, ACS infectious diseases.

Discovery of new chemical entities as potential leads against Mycobacterium tuberculosis.

Xiaoyun Lu, Tianyu Zhang, Zhi-yong Liu, 2016, Bioorganic & medicinal chemistry letters.

Design, Synthesis, and Biological Evaluation of Pyrazolo[1,5-a]pyridine-3-carboxamides as Novel Antitubercular Agents.

Xiaoyun Lu, Zheng-chao Tu, Tianyu Zhang, 2015, ACS medicinal chemistry letters.

Up-regulation of N-cadherin by Collagen I-activated Discoidin Domain Receptor 1 in Pancreatic Cancer Requires the Adaptor Molecule Shc1*

A. Lazenby, Keith R. Johnson, Ke Ding, 2016, The Journal of Biological Chemistry.

Optimization of Brigatinib as New Wild-Type Sparing Inhibitors of EGFRT790M/C797S Mutants.

Tao Zhang, Lin-jiang Tong, C. Yun, 2022, ACS medicinal chemistry letters.

Structure-Based Design of 5-Methylpyrimidopyridone Derivatives as New Wild-Type Sparing Inhibitors of Epidermal Growth Factor Receptor Triple Mutant (EGFRL858R/T790M/C797S).

Wei Xu, Ruibo Wu, Jian Ding, 2019, Journal of medicinal chemistry.

Discovery of JND3229 as a New EGFRC797S Mutant Inhibitor with In Vivo Monodrug Efficacy.

Yi Chen, Jian Ding, C. Yun, 2018, ACS medicinal chemistry letters.

A patent review of discoidin domain receptor 1 (DDR1) modulators (2014-present)

Ke Ding, Jing Guo, Zhen Zhang, 2020, Expert opinion on therapeutic patents.

3‐aminopyrazolopyrazine derivatives as spleen tyrosine kinase inhibitors

Xiaoyun Lu, Zheng-chao Tu, Jiayi Shen, 2016, Chemical biology & drug design.

Conformational Constrained 4-(1-Sulfonyl-3-indol)yl-2-phenylaminopyrimidine Derivatives as New Fourth-Generation Epidermal Growth Factor Receptor Inhibitors Targeting T790M/C797S Mutations.

Tao Zhang, Lin-jiang Tong, Xiaoyun Lu, 2022, Journal of medicinal chemistry.

Fibroblast Growth Factor Receptor 4 (FGFR4) Selective Inhibitors as Hepatocellular Carcinoma Therapy: Advances and Prospects.

J. Smaill, Xiaoyun Lu, A. Patterson, 2018, Journal of medicinal chemistry.

Development and application of novel electrophilic warheads in target identification and drug discovery.

Hongyan Sun, Liqian Gao, Zhengqiu Li, 2021, Biochemical pharmacology.

Y08060: A Selective BET Inhibitor for Treatment of Prostate Cancer.

Yan Zhang, Yong Xu, C. Zhang, 2018, ACS medicinal chemistry letters.

New thiazole carboxamides as potent inhibitors of Akt kinases.

Honglin Li, Xianwen Cao, Xiaoyun Lu, 2012, Bioorganic & medicinal chemistry letters.

Identification and characterization of N9-methyltransferase involved in converting caffeine into non-stimulatory theacrine in tea

I. Abe, Xiaoyun Lu, R. He, 2020, Nature Communications.

Recent advance in the design of small molecular modulators of estrogen-related receptors.

Xiaoyun Lu, Ke Ding, Lijie Peng, 2012, Current pharmaceutical design.

Two-photon fluorescent turn-on probes for highly efficient detection and profiling of thiols in live cells and tissues

Lin Li, Zhengqiu Li, Yi Tan, 2021, Biological chemistry.

Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors.

Hongyan Sun, Zheng-chao Tu, Zhengqiu Li, 2022, Journal of medicinal chemistry.

Discovery of a Highly Potent and Selective Dual PROTAC Degrader of CDK12 and CDK13

A. Chinnaiyan, J. Tien, Zhen Wang, 2022, Journal of medicinal chemistry.

Discovery of Hexahydrofuro[3,2-b]furans as New Kinase-Selective and Orally Bioavailable JAK3 Inhibitors for the Treatment of Leukemia Harboring a JAK3 Activating Mutant.

Zheng-chao Tu, Zhen Wang, Zhengqiu Li, 2022, Journal of medicinal chemistry.

A novel reactive turn-on probe capable of selective profiling and no-wash imaging of Bruton's tyrosine kinase in live cells.

R. Wu, Zhengqiu Li, Ke Ding, 2019, Chemical communications.

Design, synthesis and biological evaluation of 3-(imidazo[1,2-a]pyrazin-3-ylethynyl)-2-methylbenzamides as potent and selective pan-tropomyosin receptor kinase (TRK) inhibitors.

Yong Xu, Lei Zhang, Xiaoyun Lu, 2019, European journal of medicinal chemistry.

Synthesis and identification of GZD856 as an orally bioavailable Bcr-AblT315I inhibitor overcoming acquired imatinib resistance

Xiaoyun Lu, Deping Wang, Ke Ding, 2017, Journal of enzyme inhibition and medicinal chemistry.

Hybrid pyrimidine alkynyls inhibit the clinically resistance related Bcr-Abl(T315I) mutant.

Xiaoyun Lu, Deping Wang, R. Yu, 2015, Bioorganic & medicinal chemistry letters.

Hybrid compounds as new Bcr/Abl inhibitors.

Xiang Li, X. Li, Xiaoyun Lu, 2011, Bioorganic & medicinal chemistry letters.

Discovery of New Monocarbonyl Ligustrazine-Curcumin Hybrids for Intervention of Drug-Sensitive and Drug-Resistant Lung Cancer.

Jide Tian, Yihua Zhang, C. Ren, 2016, Journal of medicinal chemistry.

Overexpression of ZAKβ in human osteosarcoma cells enhances ZAKα expression, resulting in a synergistic apoptotic effect

W. Kuo, V. Viswanadha, Chih-Yang Huang, 2018, Cell biochemistry and function.

Cell- and Tissue-Based Proteome Profiling and Dual Imaging of Apoptosis Markers with Probes Derived from Venetoclax and Idasanutlin

Yong Xu, P. Hao, Zhengqiu Li, 2018, Angewandte Chemie.

Proteome-wide Identification of Off-Targets of a Potent EGFRL858R/T790M Mutant Inhibitor.

P. Hao, Zhengqiu Li, Peng Lyu, 2022, ACS medicinal chemistry letters.

Identification of U937JAK3-M511I Acute Myeloid Leukemia Cells as a Sensitive Model to JAK3 Inhibitor

Zheng-chao Tu, Ke Ding, Zhang Zhang, 2022, Frontiers in Oncology.

2H-Azirine-based Reagents for Chemoselective Bioconjugation at Carboxyl Residues inside Live Cells.

Xingfeng Yin, W. Ye, Zhengqiu Li, 2020, Journal of the American Chemical Society.

A toxin-deformation dependent inhibition mechanism in the T7SS toxin-antitoxin system of Gram-positive bacteria

Xiaoyun Lu, Zhengqiu Li, Ke Ding, 2022, Nature Communications.

Discovery of Isoform-Selective Akt3 Degraders Overcoming Osimertinib-Induced Resistance in Non-Small Cell Lung Cancer Cells.

J. Smaill, Liang Chen, A. Patterson, 2022, Journal of medicinal chemistry.

The synthesis and biological evaluation of sanguinarine derivatives as anti-non-small cell lung cancer agents.

Xiaoyun Lu, Ke Ding, Zhang Zhang, 2020, RSC medicinal chemistry.

Integrated phenotypic screening and activity-based protein profiling to reveal potential therapy targets of pancreatic cancer.

P. Hao, Zhengqiu Li, Ke Ding, 2019, Chemical communications.

Discovery of the First Highly Selective and Broadly Effective Macrocycle-Based Type II TRK Inhibitors that Overcome Clinically Acquired Resistance.

S. Xiang, Xiaoyun Lu, Zheng-chao Tu, 2022, Journal of medicinal chemistry.

GZD856, a novel potent PDGFRα/β inhibitor, suppresses the growth and migration of lung cancer cells in vitro and in vivo.

Xiaoyun Lu, Deping Wang, R. Yu, 2016, Cancer letters.

Investigation of Covalent Warheads in the Design of 2-Aminopyrimidine-based FGFR4 Inhibitors.

J. Smaill, Yongheng Chen, Xiaoyun Lu, 2021, ACS medicinal chemistry letters.

1-Methyl-3-((4-(quinolin-4-yloxy)phenyl)amino)-1H-pyrazole-4-carboxamide derivatives as new rearranged during Transfection (RET) kinase inhibitors capable of suppressing resistant mutants in solvent-front regions.

Zheng-chao Tu, Zhen Wang, Ke Ding, 2022, European journal of medicinal chemistry.

Identification and synthesis of low-molecular weight cholecystokinin B receptor (CCKBR) agonists as mediators of long-term synaptic potentiation

Yanmei Zhang, Jufang He, Zheng-chao Tu, 2019, Medicinal Chemistry Research.

JND4135, a New Type II TRK Inhibitor, Overcomes TRK xDFG and Other Mutation Resistance In Vitro and In Vivo

Xiaoyun Lu, Zheng-chao Tu, Ke Ding, 2022, Molecules.

Identification of compound D2923 as a novel anti-tumor agent targeting CSF1R

Yi Chen, Jian Ding, Lin-jiang Tong, 2018, Acta Pharmacologica Sinica.

Pyrazolo[1,5-a]pyridine-3-carboxamide hybrids: Design, synthesis and evaluation of anti-tubercular activity.

Xiaoyun Lu, Tianyu Zhang, B. Wan, 2017, European journal of medicinal chemistry.

2,4-Diarylamino-pyrimidines as kinase inhibitors co-targeting IGF1R and EGFR(L⁸⁵⁸R/T⁷⁹⁰M).

J. Smaill, Jian Ding, Lin-jiang Tong, 2015, Bioorganic & medicinal chemistry letters.

Tetrazole-Based Probes for Integrated Phenotypic Screening, Affinity-Based Proteome Profiling, and Sensitive Detection of a Cancer Biomarker.

P. Hao, S. Yao, Ke Cheng, 2017, Angewandte Chemie.

Pyrimido[4,5-d]pyrimidin-4(1H)-one derivatives as selective inhibitors of EGFR threonine790 to methionine790 (T790M) mutants.

Honglin Li, Shaomeng Wang, Shiliang Li, 2013, Angewandte Chemie.

Design, synthesis, and biological evaluation of novel conformationally constrained inhibitors targeting epidermal growth factor receptor threonine⁷⁹⁰ → methionine⁷⁹⁰ mutant.

Ke Ding, Zhang Zhang, Yong Xu, 2012, Journal of medicinal chemistry.

N-(3-Ethynyl-2,4-difluorophenyl)sulfonamide Derivatives as Selective Raf Inhibitors.

Yong Xu, J. Smaill, Donghai Wu, 2015, ACS medicinal chemistry letters.

Identification and optimization of new dual inhibitors of B-Raf and epidermal growth factor receptor kinases for overcoming resistance against vemurafenib.

Xiaoyun Lu, Qingwen Zhang, Zheng-chao Tu, 2014, Journal of medicinal chemistry.

Identification of GZD824 as an orally bioavailable inhibitor that targets phosphorylated and nonphosphorylated breakpoint cluster region-Abelson (Bcr-Abl) kinase and overcomes clinically acquired mutation-induced resistance against imatinib.

Xiaoyun Lu, Zheng-chao Tu, Deping Wang, 2013, Journal of medicinal chemistry.

1-Phenyl-4-benzoyl-1H-1,2,3-triazoles as orally bioavailable transcriptional function suppressors of estrogen-related receptor α.

Lei Duan, Shili Xu, Ke Ding, 2013, Journal of medicinal chemistry.

2-Aminopyrimidine Derivatives as New Selective Fibroblast Growth Factor Receptor 4 (FGFR4) Inhibitors.

Yong Xu, J. Smaill, Xiaoyun Lu, 2017, ACS medicinal chemistry letters.

Combined inhibition of DDR1 and Notch signaling is a therapeutic strategy for KRAS-driven lung adenocarcinoma

M. Barbacid, M. Hidalgo, D. Santamaría, 2016, Nature Medicine.

Applications of activity-based protein profiling (ABPP) and bioimaging in drug discovery.

Zhengqiu Li, Jiaqian Xu, Ke Ding, 2019, Chemistry, an Asian journal.

Crenolanib‐Derived Probes Suitable for Cell‐ and Tissue‐Based Protein Profiling and Single‐Cell Imaging

Xingfeng Yin, Zhengqiu Li, Ke Ding, 2019, Chembiochem : a European journal of chemical biology.

Minimalist linkers suitable for irreversible inhibitors in simultaneous proteome profiling, live-cell imaging and drug screening.

P. Hao, Zhengqiu Li, Ke Ding, 2019, Chemical communications.

Cell- and Tissue-Based Proteome Profiling and Bioimaging with Probes Derived from a Potent AXL Kinase Inhibitor.

P. Hao, Zhengqiu Li, Lin Li, 2018, Chemistry, an Asian journal.

Cell- and Tissue-Based Proteome Profiling and Dual Imaging of Apoptosis Markers with Probes Derived from Venetoclax and Idasanutlin.

Yong Xu, P. Hao, Zhengqiu Li, 2018, Angewandte Chemie.

Competitive affinity-based proteome profiling and imaging to reveal potential cellular targets of betulinic acid.

Ke Ding, Piliang Hao, P. Hao, 2017, Chemical communications.

Quantitative, Wide-Spectrum Kinase Profiling in Live Cells for Assessing the Effect of Cellular ATP on Target Engagement

T. Willson, S. Knapp, S. Müller, 2017, Cell chemical biology.

New Promise and Opportunities for Allosteric Kinase Inhibitors.

J. Smaill, Xiaoyun Lu, Ke Ding, 2019, Angewandte Chemie.

Design, Synthesis, and Biological Evaluation of 2-Formyl Tetrahydronaphthyridine Urea Derivatives as New Selective Covalently Reversible FGFR4 Inhibitors.

Zheng-chao Tu, Ke Ding, Zhang Zhang, 2022, Journal of medicinal chemistry.

Design and synthesis of selective degraders of EGFRL858R/T790M mutant.

Lin-jiang Tong, Xiaoyun Lu, Hua Xie, 2020, European journal of medicinal chemistry.

Small-Molecule Inhibitors Directly Targeting KRAS as Anticancer Therapeutics.

J. Smaill, Xiaoyun Lu, Ke Ding, 2020, Journal of medicinal chemistry.

Design and Optimization of 3'-(Imidazo[1,2-a]pyrazin-3-yl)-[1,1'-biphenyl]-3-carboxamides as Selective DDR1 Inhibitors.

Yong Xu, Xiaoyun Lu, Zheng-chao Tu, 2020, ACS medicinal chemistry letters.

Inhibition of Discoidin Domain Receptor 1 Reduces Collagen-mediated Tumorigenicity in Pancreatic Ductal Adenocarcinoma

Huamin Wang, J. Fleming, D. Castrillon, 2017, Molecular Cancer Therapeutics.

Small Molecule Inhibitors of Discoidin Domain Receptors (DDRs)

Xiaoyun Lu, Ke Ding, 2016 .

Small molecule discoidin domain receptor kinase inhibitors and potential medical applications.

Xiaoyun Lu, Ke Ding, Yupeng Li, 2015, Journal of medicinal chemistry.

Discovery and optimization of 3-(2-(Pyrazolo[1,5-a]pyrimidin-6-yl)ethynyl)benzamides as novel selective and orally bioavailable discoidin domain receptor 1 (DDR1) inhibitors.

Ke Ding, Zhang Zhang, Yan Zhang, 2013, Journal of medicinal chemistry.

Discovery of HCD3514 as a potent EGFR inhibitor against C797S mutation in vitro and in vivo

K. Yu, Yi Chen, Jian Ding, 2023, Journal of Cancer.

Targeting EGFRL858R/T790M and EGFRL858R/T790M/C797S resistance mutations in NSCLC: Current developments in medicinal chemistry

J. Smaill, Xiaoyun Lu, Ke Ding, 2018, Medicinal research reviews.

Novel conjugates of endoperoxide and 4-anilinoquinazoline as potential anticancer agents.

X. Mao, Chongzhao Ran, Zheng-chao Tu, 2017, Bioorganic & medicinal chemistry letters.

Discovery of pteridin-7(8H)-one-based irreversible inhibitors targeting the epidermal growth factor receptor (EGFR) kinase T790M/L858R mutant.

Ke Ding, Honglin Li, Wei Zhou, 2013, Journal of medicinal chemistry.

Structure-Based Discovery and Optimization of Benzo[ d]isoxazole Derivatives as Potent and Selective BET Inhibitors for Potential Treatment of Castration-Resistant Prostate Cancer (CRPC).

Yan Zhang, Yong Xu, Donghai Wu, 2018, Journal of medicinal chemistry.

Design, synthesis, and biological evaluation of 2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidinyl derivatives as new irreversible epidermal growth factor receptor inhibitors with improved pharmacokinetic properties.

Ke Ding, Zhang Zhang, Xiaoyun Lu, 2013, Journal of medicinal chemistry.

1-Benzyl-4-phenyl-1H-1,2,3-triazoles improve the transcriptional functions of estrogen-related receptor γ and promote the browning of white adipose.

Yong Xu, J. Smaill, Donghai Wu, 2015, Bioorganic & medicinal chemistry.

2-Amino-2,3-dihydro-1H-indene-5-carboxamide-Based Discoidin Domain Receptor 1 (DDR1) Inhibitors: Design, Synthesis, and in Vivo Antipancreatic Cancer Efficacy

A. Bullock, R. Brekken, Xiaoyun Lu, 2019, Journal of medicinal chemistry.

Novel hybrids of (phenylsulfonyl)furoxan and anilinopyrimidine as potent and selective epidermal growth factor receptor inhibitors for intervention of non-small-cell lung cancer.

H. Ji, Chun Han, Jide Tian, 2013, Journal of medicinal chemistry.

Medicinal Chemistry Strategies for the Development of Kinase Inhibitors Targeting Point Mutations.

J. Smaill, Xiaoyun Lu, Ke Ding, 2020, Journal of medicinal chemistry.

Structure−Activity Relationship Study of Rakicidins: Overcoming Chronic Myeloid Leukemia Resistance to Imatinib with 4‐Methylester-Rakicidin A

Quan Zhang, Yue-hua Chen, Yahui Ding, 2016 .

Design, synthesis and biological evaluation of new molecules inhibiting epidermal growth factor receptor threonine790→ methionine790 mutant

Yong Xu, Xiaoyun Lu, Zheng-chao Tu, 2012 .

Structure-Based Design of Tetrahydroisoquinoline-7-carboxamides as Selective Discoidin Domain Receptor 1 (DDR1) Inhibitors

Yong Xu, A. Bullock, L. Yao, 2016, Journal of medicinal chemistry.

2-Oxo-3, 4-dihydropyrimido[4, 5-d]pyrimidinyl derivatives as new irreversible pan fibroblast growth factor receptor (FGFR) inhibitors.

Yong Xu, J. Smaill, Xiaoyun Lu, 2017, European journal of medicinal chemistry.

Synthesis and evaluation of 2-anilinopyrimidines bearing 3-aminopropamides as potential epidermal growth factor receptor inhibitors.

H. Ji, Chun Han, Yihua Zhang, 2014, European journal of medicinal chemistry.

Nitric oxide donating anilinopyrimidines: synthesis and biological evaluation as EGFR inhibitors.

H. Ji, Chun Han, Yihua Zhang, 2013, European journal of medicinal chemistry.

Design, synthesis, and Structure-Activity Relationships (SAR) of 3-vinylindazole derivatives as new selective tropomyosin receptor kinases (Trk) inhibitors.

Zheng-chao Tu, Sihua Zhu, Ke Ding, 2020, European journal of medicinal chemistry.

Rutin suppresses human-amylin/hIAPP misfolding and oligomer formation in-vitro, and ameliorates diabetes and its impacts in human-amylin/hIAPP transgenic mice.

P. Barran, G. Cooper, Donghai Wu, 2017, Biochemical and biophysical research communications.

Pyrido[2, 3-d]pyrimidin-7(8H)-ones as new selective orally bioavailable Threonine Tyrosine Kinase (TTK) inhibitors.

Yong Xu, Xiaoyun Lu, Zheng-chao Tu, 2020, European journal of medicinal chemistry.

Blocking interaction between SHP2 and PD‐1 denotes a novel opportunity for developing PD‐1 inhibitors

Chenqi Xu, C. Dong, Yahui Tian, 2020, EMBO molecular medicine.

C5-substituted pyrido[2,3-d]pyrimidin-7-ones as highly specific kinase inhibitors targeting the clinical resistance-related EGFRT790M mutant

Lei-Ping Yu, Jian Ding, Lin-jiang Tong, 2015 .

Rotational Freedom, Steric Hindrance, and Protein Dynamics Explain BLU554 Selectivity for the Hinge Cysteine of FGFR4.

J. Smaill, Xiaoyun Lu, M. Middleditch, 2019, ACS medicinal chemistry letters.

Evaluation of Benzamide Derivatives as New Influenza A Nucleoprotein Inhibitors

Yanmei Zhang, Zheng-chao Tu, M. Tortorella, 2016 .

Discovery of Cysteine-targeting Covalent Protein Kinase Inhibitors.

J. Smaill, Xiaoyun Lu, A. Patterson, 2021, Journal of medicinal chemistry.

Targeting the Non-Catalytic Functions: a New Paradigm for Kinase Drug Discovery?

Zhen Wang, Ke Ding, Xiaomei Ren, 2022, Journal of medicinal chemistry.

Benzoxazinone-containing 3,5-dimethylisoxazole derivatives as BET bromodomain inhibitors for treatment of castration-resistant prostate cancer.

Yan Zhang, Yong Xu, Guohui Li, 2018, European journal of medicinal chemistry.

Small-molecule BET inhibitors in clinical and preclinical development and their therapeutic potential.

Xiaoyun Lu, Zhen Wang, Ke Ding, 2015, Current topics in medicinal chemistry.

Discovery of AXL Degraders with Improved Potencies in Triple-Negative Breast Cancer (TNBC) Cells.

Yongxing Wang, Zheng-chao Tu, Zhen Wang, 2023, Journal of medicinal chemistry.

4-Oxo-1,4-dihydroquinoline-3-carboxamide Derivatives as New Axl Kinase Inhibitors.

Zheng-chao Tu, Zhengqiu Li, Ke Ding, 2016, Journal of medicinal chemistry.

Structure-based discovery of novel 4,5,6-trisubstituted pyrimidines as potent covalent Bruton's tyrosine kinase inhibitors.

Yihua Zhang, Zheng-chao Tu, Yi Zou, 2016, Bioorganic & medicinal chemistry letters.

Structural insights into the binding mechanism of IDO1 with hydroxylamidine based inhibitor INCB14943.

Tingting Xu, Ke Ding, Jinsong Liu, 2017, Biochemical and biophysical research communications.

Tyrosine Kinase 2 (TYK2) Allosteric Inhibitors To Treat Autoimmune Diseases.

Shili Xu, Ke Ding, Yu Chang, 2019, Journal of medicinal chemistry.

Targeted Treatments for Chronic Obstructive Pulmonary Disease (COPD) Using Low-Molecular-Weight Drugs (LMWDs).

Ke Ding, Xue Liang, Yang Zhou, 2019, Journal of medicinal chemistry.

A structure-guided optimization of pyrido[2,3-d]pyrimidin-7-ones as selective inhibitors of EGFRL858R/T790M mutant with improved pharmacokinetic properties.

Yong Xu, Lin-jiang Tong, C. Yun, 2017, European journal of medicinal chemistry.

Atovaquone derivatives as potent cytotoxic and apoptosis inducing agents.

Lei Duan, F. Zhou, D. Pei, 2009, Bioorganic & medicinal chemistry letters.

Characterization of an aromatic trifluoromethyl ketone as a new warhead for covalently reversible kinase inhibitor design.

Yongheng Chen, Zheng-chao Tu, Ke Ding, 2021, Bioorganic & medicinal chemistry.

Identification of Niclosamide as a New Small-Molecule Inhibitor of the STAT3 Signaling Pathway.

Qiang He, Ke Ding, Zhang Zhang, 2010, ACS medicinal chemistry letters.

Discovery of Benzo[cd]indol-2(1H)-ones as Potent and Specific BET Bromodomain Inhibitors: Structure-Based Virtual Screening, Optimization, and Biological Evaluation.

Yan Zhang, Ke Ding, Yong Xu, 2016, Journal of medicinal chemistry.

LS‐106, a novel EGFR inhibitor targeting C797S, exhibits antitumor activities both in vitro and in vivo

Kai Yu, Yi Chen, Jian Ding, 2021, Cancer science.

Pharmacophore and Molecular Docking Guided 3D-QSAR Study of Bacterial Enoyl-ACP Reductase (FabI) Inhibitors

Kun Huang, Ke Ding, Man Lv, 2012, International journal of molecular sciences.

Structure Based Design of N-(3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)benzenesulfonamides as Selective Leucine-Zipper and Sterile-α Motif Kinase (ZAK) Inhibitors.

Yan Zhang, Yong Xu, Chih-Yang Huang, 2017, Journal of medicinal chemistry.

Switch type I to type II TRK inhibitors for combating clinical resistance induced by xDFG mutation for cancer therapy.

S. Xiang, Zheng-chao Tu, Ke Ding, 2022, European journal of medicinal chemistry.

Discovery of novel TrkA allosteric inhibitors: Structure-based virtual screening, biological evaluation and preliminary SAR studies

S. Xiang, Xiaoyun Lu, Ke Ding, 2021, European Journal of Medicinal Chemistry.

Design, Synthesis, and Biological Evaluation of 3-(Imidazo[1,2-a]pyrazin-3-ylethynyl)-4-isopropyl-N-(3-((4-methylpiperazin-1-yl)methyl)-5-(trifluoromethyl)phenyl)benzamide as a Dual Inhibitor of Discoidin Domain Receptors 1 and 2

A. Bullock, R. Brekken, Tingting Xu, 2018, Journal of medicinal chemistry.

Tetrahydroisoquinoline-7-carboxamide Derivatives as New Selective Discoidin Domain Receptor 1 (DDR1) Inhibitors.

A. Bullock, R. Brekken, Xiaoyun Lu, 2017, ACS medicinal chemistry letters.

YL143, a novel mutant selective irreversible EGFR inhibitor, overcomes EGFRL858R, T790M‐mutant resistance in vitro and in vivo

Xiaoyun Lu, Zheng-chao Tu, Liyan Song, 2018, Cancer medicine.

Discovery of a novel third-generation EGFR inhibitor and identification of a potential combination strategy to overcome resistance

Yi Chen, Jian Ding, Lin-jiang Tong, 2020, Molecular Cancer.

Discovery and optimization of 1-(1H-indol-1-yl)ethanone derivatives as CBP/EP300 bromodomain inhibitors for the treatment of castration-resistant prostate cancer.

Cheng Zhang, Ke Ding, Donghai Wu, 2018, European journal of medicinal chemistry.

Secondary-structure switch regulates the substrate binding of a YopJ family acetyltransferase

Shuguang Yuan, L. Deslandes, Chengjun Zhu, 2021, Nature Communications.

Design, Synthesis, and Structure-Activity Relationships of 1,2,3-Triazole Benzenesulfonamides as New Selective Leucine-Zipper and Sterile-α Motif Kinase (ZAK) Inhibitors.

Chih-Yang Huang, M. Shibu, C. Yun, 2019, Journal of medicinal chemistry.

New benzimidazole-2-urea derivates as tubulin inhibitors.

Yong Xu, Dexin Kong, Xiaohong Yang, 2014, Bioorganic & medicinal chemistry letters.

Quantitative Proteomics Reveals Cellular Off-Targets of a DDR1 Inhibitor.

Hongyan Sun, Zhengqiu Li, Jiaqian Xu, 2020, ACS medicinal chemistry letters.

Identification of compound D2923 as a novel anti-tumor agent targeting CSF1R

Yi Chen, Jian Ding, Lin-jiang Tong, 2018, Acta Pharmacologica Sinica.

Novel Electrophilic Warhead Targeting a Triple-Negative Breast Cancer Driver in Live Cells Revealed by "Inverse Drug Discovery".

Huilin Li, S. Yao, Hongyan Sun, 2021, Journal of medicinal chemistry.

Cell-active, irreversible covalent inhibitors that selectively target the catalytic lysine of EGFR by using fluorosulfate-based SuFEx chemistry.

S. Sze, So Fong Cam Ngan, S. Yao, 2023, European journal of medicinal chemistry.

GZD2202, a novel TrkB inhibitor, suppresses BDNF-mediated proliferation and metastasis in neuroblastoma models

Xiaoyun Lu, Zheng-chao Tu, Zhen Wang, 2018, Journal of drug targeting.

Evaluation of aminohydantoins as a novel class of antimalarial agents.

D. Griggs, D. Goldberg, Xiaoyun Lu, 2014, ACS medicinal chemistry letters.

Affinity-based Protein Profiling Reveals Cellular Targets of Photoreactive Anticancer Inhibitors.

P. Hao, Ke Cheng, Jun‐Seok Lee, 2019, ACS chemical biology.

GZD824 as a FLT3, FGFR1 and PDGFRα Inhibitor Against Leukemia In Vitro and In Vivo

Zheng-chao Tu, Ke Ding, Zhang Zhang, 2020, Translational oncology.

Discovery of a novel third-generation EGFR inhibitor and identification of a potential combination strategy to overcome resistance

Yi Chen, Jian Ding, Lin-jiang Tong, 2020, Molecular Cancer.

Discovery of new Lenalidomide derivatives as potent and selective GSPT1 degraders.

Yongxing Wang, Zhen Wang, Ke Ding, 2023, European journal of medicinal chemistry.

Simultaneous Covalent Modification of K-Ras(G12D) and K-Ras(G12C) with Tunable Oxirane Electrophiles.

Zhongtang Yu, Zhengqiu Li, Ke Ding, 2023, Journal of the American Chemical Society.

Novel anaplastic lymphoma kinase inhibitors targeting clinically acquired resistance.

Xiaoyun Lu, Ke Ding, 2014, Journal of Medicinal Chemistry.

Discovery of 3-Aminopyrazole Derivatives as New Potent and Orally Bioavailable AXL Inhibitors.

Licheng Zhou, H. Hur, Zhen Wang, 2022, Journal of medicinal chemistry.

Quantitative data describing the impact of the flavonol rutin on in-vivo blood-glucose and fluid-intake profiles, and survival of human-amylin transgenic mice

P. Barran, G. Cooper, Donghai Wu, 2016, Data in brief.

A Novel Photocaged B-RafV600E Inhibitor toward Precise Melanoma Treatment.

Zhen Wang, Ke Ding, Xiaomei Ren, 2022, Bioorganic & medicinal chemistry letters.

Evaluation of spiropiperidine hydantoins as a novel class of antimalarial agents.

D. Griggs, D. Goldberg, M. Prinsen, 2015, Bioorganic & medicinal chemistry.

Small molecule discoidin domain receptor kinase inhibitors and potential medical applications.

Xiaoyun Lu, Ke Ding, Yupeng Li, 2015, Journal of medicinal chemistry.

Minimalist linkers suitable for irreversible inhibitors in simultaneous proteome profiling, live-cell imaging and drug screening.

P. Hao, Zhengqiu Li, Ke Ding, 2019, Chemical communications.

A novel reactive turn-on probe capable of selective profiling and no-wash imaging of Bruton's tyrosine kinase in live cells.

R. Wu, Zhengqiu Li, Ke Ding, 2019, Chemical communications.

Tetrazole-Based Probes for Integrated Phenotypic Screening, Affinity-Based Proteome Profiling, and Sensitive Detection of a Cancer Biomarker.

P. Hao, Ke Cheng, Jun‐Seok Lee, 2017, Angewandte Chemie.

Structural Mechanism and Inhibitors Targeting EGFR Exon 20 Insertion (Ex20ins) Mutations.

J. Smaill, Hao Chen, A. Patterson, 2023, Journal of medicinal chemistry.

Design, synthesis, and in vitro biological evaluation of 1H-1,2,3-triazole-4-carboxamide derivatives as new anti-influenza A agents targeting virus nucleoprotein.

Yong Xu, Yih-Shyun E. Cheng, Xiaoyun Lu, 2012, Journal of Medicinal Chemistry.

Structure Based Design of N-(3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)benzenesulfonamides as Selective Leucine-Zipper and Sterile-α Motif Kinase (ZAK) Inhibitors.

Yan Zhang, Yong Xu, Chih-Yang Huang, 2017, Journal of medicinal chemistry.

Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells.

Zhengqiu Li, Xiwen Xing, Ke Ding, 2022, ACS chemical biology.

Quinolone antibiotic derivatives as new selective Axl kinase inhibitors.

Xiaoyun Lu, Zheng-chao Tu, Ke Ding, 2019, European journal of medicinal chemistry.

Rational Design and Structure Validation of a Novel Peptide Inhibitor of the Adenomatous-Polyposis-Coli (APC)-Rho-Guanine-Nucleotide-Exchange-Factor-4 (Asef) Interaction.

Jian Zhang, K. Song, Xiuyan Yang, 2018, Journal of medicinal chemistry.

Structure-Based Optimization of the Third Generation Type II Macrocycle TRK Inhibitors with Improved Activity against Solvent-Front, xDFG, and Gatekeeper Mutations.

Ke Ding, Zhang Zhang, Zhi-Min Zhang, 2023, Journal of medicinal chemistry.

Combined inhibition of DDR1 and Notch signaling is a therapeutic strategy for KRAS-driven lung adenocarcinoma

M. Barbacid, M. Hidalgo, M. Serrano, 2016, Nature Medicine.