Madeline E. Kavanagh

发表

Selective inhibitors of JAK1 targeting a subtype-restricted allosteric cysteine

Landon R. Whitby, B. Cravatt, J. Chick, 2022, bioRxiv.

Substrate Fragmentation for the Design of M. tuberculosis CYP121 Inhibitors

A. Munro, C. Abell, J. Gray, 2016, ChemMedChem.

Spirooxindoles as novel 3D-fragment scaffolds: Synthesis and screening against CYP121 from M. tuberculosis.

C. Abell, A. Coyne, Madeline E. Kavanagh, 2016, Bioorganic & medicinal chemistry letters.

The development of CNS-active LRRK2 inhibitors using property-directed optimisation.

M. Doddareddy, M. Kassiou, Madeline E. Kavanagh, 2013, Bioorganic & medicinal chemistry letters.

Selective inhibitors of JAK1 targeting an isoform-restricted allosteric cysteine

Landon R. Whitby, B. Cravatt, J. Chick, 2022, Nature Chemical Biology.

Selective inhibitors of JAK1 targeting an isoform-restricted allosteric cysteine

Landon R. Whitby, B. Cravatt, J. Chick, 2022, Nature Chemical Biology.

Effect of DMSO on Protein Structure and Interactions Assessed by Collision-Induced Dissociation and Unfolding.

D. Chan, A. Munro, C. Abell, 2017, Analytical chemistry.

Synthesis of Biologically Active Seven-Membered-Ring Heterocycles

M. Kassiou, T. Reekie, Madeline E. Kavanagh, 2013 .

Fragment-Based Approaches to the Development of Mycobacterium tuberculosis CYP121 Inhibitors

D. Chan, A. Munro, C. Abell, 2016, Journal of medicinal chemistry.

Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors

Stuart P. McElroy, Philip S. Jones, M. Page, 2021, Nature Chemistry.

Fragment Profiling Approach to Inhibitors of the Orphan M. tuberculosis P450 CYP144A1.

A. Bender, A. Zoufir, A. Munro, 2017, Biochemistry.

A proteome-wide atlas of lysine-reactive chemistry

B. Cravatt, L. Kiessling, M. Hayward, 2021, Nature Chemistry.

Optimisation of LRRK2 inhibitors and assessment of functional efficacy in cell-based models of neuroinflammation.

M. Doddareddy, M. Kassiou, G. Guillemin, 2015, European journal of medicinal chemistry.

Structural Characterization and Ligand/Inhibitor Identification Provide Functional Insights into the Mycobacterium tuberculosis Cytochrome P450 CYP126A1

A. Munro, C. Abell, D. Leys, 2016, The Journal of Biological Chemistry.

A new strategy for hit generation: Novel in cellulo active inhibitors of CYP121A1 from Mycobacterium tuberculosis via a combined X-ray crystallographic and phenotypic screening approach (XP screen)

A. Munro, C. Abell, D. Leys, 2022, European journal of medicinal chemistry.

Glutathione supports lipid abundance in vivo

Ying Chen, V. Vasiliou, I. Harris, 2023, bioRxiv.

Structural characterization of CYP144A1 – a cytochrome P450 enzyme expressed from alternative transcripts in Mycobacterium tuberculosis

A. Munro, C. Abell, D. Matak-Vinkovic, 2016, Scientific Reports.

Fragment-based development of small molecule inhibitors targeting Mycobacterium tuberculosis cholesterol metabolism

A. Coyne, Fátima Ortega-Muro, K. J. McLean, 2024, bioRxiv.