Bin Guo

发表

Docking-based structural splicing and reassembly strategy to develop novel deazapurine derivatives as potent B-RafV600E inhibitors

Weiliang Zhu, Jian Ding, Linghua Meng, 2017, Acta Pharmacologica Sinica.

Repositioning organohalogen drugs: a case study for identification of potent B-Raf V600E inhibitors via docking and bioassay

Weiliang Zhu, Jiye Shi, Bo Li, 2016, Scientific Reports.

Optimization of P2Y12 Antagonist Ethyl 6-(4-((Benzylsulfonyl)carbamoyl)piperidin-1-yl)-5-cyano-2-methylnicotinate (AZD1283) Led to the Discovery of an Oral Antiplatelet Agent with Improved Druglike Properties.

Yushe Yang, Jianjun Cheng, Wenhao Hu, 2019, Journal of medicinal chemistry.

DGAT1 inhibitors protect pancreatic β-cells from palmitic acid-induced apoptosis

Bin Guo, He-Yao Wang, You-hong Hu, 2020, Acta Pharmacologica Sinica.

Improved Practical Synthesis of DY‐038, an Oral Available Antiplatelet Agent

Xin Meng, Yushe Yang, Bin Guo, 2021 .

A novel low systemic diacylglycerol acyltransferase 1 inhibitor, Yhhu2407, improves lipid metabolism.

Youhong Hu, Jia Liu, Bin Guo, 2020, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Discovery of a low-systemic-exposure DGAT-1 inhibitor with a picolinoylpyrrolidine-2-carboxylic acid moiety.

Youhong Hu, Li-Fan Zeng, Bin Guo, 2017, Bioorganic & medicinal chemistry.

Design, synthesis, and structure-activity relationship studies of highly potent novel benzoxazinyl-oxazolidinone antibacterial agents.

Yanqin Huang, Suo Gao, H. Wang, 2011, Journal of medicinal chemistry.

Solubility-driven optimization of (pyridin-3-yl) benzoxazinyl-oxazolidinones leading to a promising antibacterial agent.

Yanqin Huang, Wenjing Chu, H. Wang, 2013, Journal of medicinal chemistry.

Discovery of Thieno[2,3-e]indazole Derivatives as Novel Oral Selective Estrogen Receptor Degraders with Highly Improved Antitumor Effect and Favorable Druggability.

Xin Meng, Yushe Yang, Bin Guo, 2022, Journal of medicinal chemistry.

Design, synthesis, and structure-activity and structure-pharmacokinetic relationship studies of novel [6,6,5] tricyclic fused oxazolidinones leading to the discovery of a potent, selective, and orally bioavailable FXa inhibitor.

Wenjing Chu, Xiaoyan Chen, Yushe Yang, 2014, Journal of medicinal chemistry.

Synthesis and biological evaluation of novel benzoxazinyl-oxazolidinones as potential antibacterial agents.

Wenjing Chu, H. Wang, Yushe Yang, 2013, Bioorganic & medicinal chemistry letters.

Synthesis and structure-activity relationship studies of novel [6,6,5] tricyclic oxazolidinone derivatives as potential antibacterial agents.

Wenjing Chu, H. Wang, Yushe Yang, 2015, Bioorganic & Medicinal Chemistry Letters.

Chlorogenic acid analogues from Gynura nepalensis protect H9c2 cardiomyoblasts against H2O2-induced apoptosis

Bin Guo, He-Yao Wang, Bang-wei Yu, 2016, Acta Pharmacologica Sinica.

DGAT1 inhibitors protect pancreatic β-cells from palmitic acid-induced apoptosis

Bin Guo, He-Yao Wang, You-hong Hu, 2020, Acta Pharmacologica Sinica.

Design, Synthesis, and Biological Evaluation of Novel DNA Gyrase-Inhibiting Spiropyrimidinetriones as Potent Antibiotics for Treatment of Infections Caused by Multidrug-Resistant Gram-Positive Bacteria.

C. Luo, Wenchao Lu, Yushe Yang, 2019, Journal of medicinal chemistry.

Improved synthesis of YG-056SP, a potent oxazolidinone antibacterial candidate against multi-drug resistant bacteria

Xin Meng, Yushe Yang, Bin Guo, 2019, Journal of Chemical Research.

Design, Synthesis, and Biological Evaluation of Novel Pyrimido[4,5-b]indole Derivatives Against Gram-Negative Multidrug-Resistant Pathogens.

C. Luo, Xin Meng, Yaru Xue, 2021, Journal of medicinal chemistry.

Synthesis and biological evaluation of novel potent FFA1 agonists containing 2,3-dihydrobenzo[b][1,4]dioxine.

Shimeng Guo, Yushe Yang, Xin Xie, 2019, Bioorganic & medicinal chemistry letters.

Design and optimization of 2,3-dihydrobenzo[b][1,4]dioxine propanoic acids as novel GPR40 agonists with improved pharmacokinetic and safety profiles.

Shimeng Guo, Yushe Yang, Xin Xie, 2018, Bioorganic & medicinal chemistry.

Design, synthesis and evaluation of potent G-protein coupled receptor 40 agonists

Wenjing Chu, Yushe Yang, Bin Guo, 2016 .