Y. Amano

发表

Lead generation and examples opinion regarding how to follow up hits.

Masaya Orita, Tatsuya Niimi, K. Ohno, 2011, Methods in enzymology.

Structural insights into binding of inhibitors to soluble epoxide hydrolase gained by fragment screening and X-ray crystallography.

Tomohiko Yamaguchi, Y. Amano, E. Tanabe, 2014, Bioorganic & medicinal chemistry.

AR‐NE3A, a New Macromolecular Crystallography Beamline for Pharmaceutical Applications at the Photon Factory

Masahiko Hiraki, Yusuke Yamada, Naohiro Matsugaki, 2010 .

Unique "delta lock" structure of telmisartan is involved in its strongest binding affinity to angiotensin II type 1 receptor.

R. Morishita, I. Komuro, J. Higaki, 2011, Biochemical and biophysical research communications.

Discovery and structural characterization of peficitinib (ASP015K) as a novel and potent JAK inhibitor.

K. Nakai, Ayako Moritomo, Takayuki Inoue, 2018, Bioorganic & medicinal chemistry.

Structural basis for the activation of PPARgamma by telmisartan

M. Orita, M. Takeuchi, Tomohiko Yamaguchi, 2010 .

Discovering a hidden binding site of spermidine synthase inhibitors for Chagas disease by combining molecular simulations and X-ray crystallography

T. Ishida, Y. Akiyama, M. Sekijima, 2021 .

Structural insights into the novel inhibition mechanism of Trypanosoma cruzi spermidine synthase.

T. Niimi, Y. Amano, H. Sakashita, 2015, Acta crystallographica. Section D, Biological crystallography.

In silico, in vitro, X-ray crystallography, and integrated strategies for discovering spermidine synthase inhibitors for Chagas disease

T. Ishida, Y. Akiyama, M. Sekijima, 2017, Scientific Reports.

Effect of Fms-like tyrosine kinase 3 (FLT3) ligand (FL) on antitumor activity of gilteritinib, a FLT3 inhibitor, in mice xenografted with FL-overexpressing cells

Tomoyuki Suzuki, Taku Yoshida, T. Eguchi, 2019, Oncotarget.

Structures of complexes of type 5 17β-hydroxysteroid dehydrogenase with structurally diverse inhibitors: insights into the conformational changes upon inhibitor binding.

Tomohiko Yamaguchi, T. Niimi, Y. Amano, 2015, Acta crystallographica. Section D, Biological crystallography.

Discovery and biological evaluation of 1-{2,7-diazaspiro[3.5]nonan-2-yl}prop-2-en-1-one derivatives as covalent inhibitors of KRAS G12C with favorable metabolic stability and anti-tumor activity.

Kazushi Watanabe, K. Mori, O. Kaneko, 2022, Bioorganic & medicinal chemistry.

Structural basis for telmisartan-mediated partial activation of PPAR gamma

K. Ohno, M. Orita, M. Takeuchi, 2012, Hypertension Research.

Fragment-Based Discovery of Pyrimido[1,2-b]indazole PDE10A Inhibitors.

T. Mihara, Y. Amano, I. Namatame, 2018, Chemical & pharmaceutical bulletin.

Novel benzimidazole derivatives as phosphodiesterase 10A (PDE10A) inhibitors with improved metabolic stability.

T. Mihara, Y. Amano, M. Yamazaki, 2014, Bioorganic & medicinal chemistry.

Design and synthesis of novel benzimidazole derivatives as phosphodiesterase 10A inhibitors with reduced CYP1A2 inhibition.

S. Kikuchi, Toshihiro Watanabe, T. Mihara, 2013, Bioorganic & medicinal chemistry.

Addressing phototoxicity observed in a novel series of biaryl derivatives: discovery of potent, selective and orally active phosphodiesterase 10A inhibitor ASP9436.

S. Kikuchi, T. Mihara, K. Hattori, 2015, Bioorganic & medicinal chemistry.

Synthesis, SAR study, and biological evaluation of novel quinoline derivatives as phosphodiesterase 10A inhibitors with reduced CYP3A4 inhibition.

S. Kikuchi, T. Mihara, K. Hattori, 2015, Bioorganic & medicinal chemistry.

In silico, in vitro, X-ray crystallography, and integrated strategies for discovering spermidine synthase inhibitors for Chagas disease

T. Ishida, Y. Akiyama, M. Sekijima, 2017, Scientific Reports.

Identification of N-ethylmethylamine as a novel scaffold for inhibitors of soluble epoxide hydrolase by crystallographic fragment screening.

Tomohiko Yamaguchi, Y. Amano, E. Tanabe, 2015, Bioorganic & medicinal chemistry.

Synthesis and structure-activity relationships of pyrimidine derivatives as potent and orally active FGFR3 inhibitors with both increased systemic exposure and enhanced in vitro potency.

Ikumi Kuriwaki, M. Kameda, Kazuhiko Iikubo, 2021, Bioorganic & medicinal chemistry.

Synthesis, SAR study, and biological evaluation of novel 2,3-dihydro-1H-imidazo[1,2-a]benzimidazole derivatives as phosphodiesterase 10A inhibitors.

Y. Amano, Koichi Yonezawa, M. Yamazaki, 2019, Bioorganic & medicinal chemistry.

Discovery of a Hidden Trypanosoma cruzi Spermidine Synthase Binding Site and Inhibitors through In Silico, In Vitro, and X-ray Crystallography

T. Ishida, Y. Akiyama, M. Sekijima, 2023, ACS omega.