Abdallah Hamze

发表

An update on the use of sulfinate derivatives as versatile coupling partners in organic chemistry.

Jessy Aziz, Abdallah Hamze, 2020, Organic & biomolecular chemistry.

p-Toluenesulfonic acid-mediated cyclization of o-(1-alkynyl)anisoles or thioanisoles: synthesis of 2-arylsubstituted benzofurans and benzothiophenes

J. Peyrat, J. Brion, M. Alami, 2009 .

Synthesis and antitumor activity of benzils related to combretastatin A-4.

J. Bignon, A. Giraud, C. Mousset, 2008, Bioorganic & medicinal chemistry letters.

Regioselective hydrostannation of diarylalkynes directed by a labile ortho bromine atom: an easy access to stereodefined triarylolefins, hybrids of combretastatin A-4 and isocombretastatin A-4.

J. Bignon, S. Thoret, J. Brion, 2010, European journal of medicinal chemistry.

B‐Ring‐Modified isoCombretastatin A‐4 Analogues Endowed with Interesting Anticancer Activities

J. Wdzieczak‐Bakala, J. Bignon, C. Mousset, 2011, ChemMedChem.

Synthesis, Biological Evaluation of 1,1‐Diarylethylenes as a Novel Class of Antimitotic Agents

J. Wdzieczak‐Bakala, J. Bignon, A. Giraud, 2009, ChemMedChem.

Palladium‐Catalyzed One‐Pot Synthesis of 5‐(1‐Arylvinyl)‐1H‐benzimidazoles: Overcoming the Limitation of Acetamide Partners

J. Bignon, P. Retailleau, J. Brion, 2016 .

One-Pot Reaction between N-Tosylhydrazones and 2-Nitrobenzyl Bromide: Route to NH-Free C2-Arylindoles.

A. Hachem, M. Alami, Abdallah Hamze, 2018, The Journal of organic chemistry.

Exploration of potential prodrug approach of the bis-thiazolium salts T3 and T4 for orally delivered antimalarials.

H. Vial, S. Peyrottes, M. Boisbrun, 2010, Bioorganic & medicinal chemistry letters.

Developments of isoCombretastatin A-4 derivatives as highly cytotoxic agents.

M. Alami, Abdallah Hamze, O. Provot, 2020, European journal of medicinal chemistry.

How do we improve histone deacetylase inhibitor drug discovery?

Abdallah Hamze, 2020, Expert opinion on drug discovery.

Anti-Tumoral Effects of Anti-Progestins in a Patient-Derived Breast Cancer Xenograft Model

M. Lombès, N. Chabbert-Buffet, J. Fagart, 2016, Hormones and Cancer.

Cyclic bridged analogs of isoCA-4: Design, synthesis and biological evaluation.

J. Bignon, D. Borgel, F. Saller, 2020, European journal of medicinal chemistry.

1,1-Diheterocyclic Ethylenes Derived from Quinaldine and Carbazole as New Tubulin-Polymerization Inhibitors: Synthesis, Metabolism, and Biological Evaluation.

A. Paci, J. Bignon, B. Gigant, 2018, Journal of medicinal chemistry.

Pyrrolo-imidazo[1,2-a]pyridine Scaffolds through a Sequential Coupling of N-tosylhydrazones with Imidazopyridines and Reductive Cadogan Annulation, Synthetic Scope, and Application.

J. Bignon, P. Retailleau, M. Alami, 2019, The Journal of organic chemistry.

Synthesis of a 3-(α-styryl)benzo[b]-thiophene library via bromocyclization of alkynes and palladium-catalyzed to sylhydrazones cross-couplings: evaluation as antitubulin agents.

J. Bignon, J. Dubois, J. Brion, 2014, ACS combinatorial science.

Conformationnally restricted naphthalene derivatives type isocombretastatin A-4 and isoerianin analogues: synthesis, cytotoxicity and antitubulin activity.

J. Wdzieczak‐Bakala, J. Bignon, J. Rodrigo, 2012, European journal of medicinal chemistry.

Sulfinate derivatives: dual and versatile partners in organic synthesis.

S. Messaoudi, M. Alami, Jessy Aziz, 2014, Organic & biomolecular chemistry.

Solid‐Phase Synthesis of Substrate‐Based Dipeptides and Heterocyclic Pseudo‐dipeptides as Potential NO Synthase Inhibitors

J. Boucher, Jean‐François Hernandez, Jean Martinez, 2020, ChemMedChem.

Stereoretentive palladium-catalyzed arylation, alkenylation, and alkynylation of 1-thiosugars and thiols using aminobiphenyl palladacycle precatalyst at room temperature.

S. Messaoudi, J. Brion, M. Alami, 2015, Chemistry.

A fluorine scan of a tubulin polymerization inhibitor isocombretastatin A-4: Design, synthesis, molecular modelling, and biological evaluation.

J. Bignon, C. Lenoir, S. Apcher, 2018, European journal of medicinal chemistry.

One‐Pot Selective Functionalization of Nitrogen‐Containing Heterocycles with N‐tosylhydrazones and Amines

P. Retailleau, M. Alami, Abdallah Hamze, 2018 .

Cyclic peptides with a diversely substituted guanidine bridge: solid-phase synthesis and structural analysis.

L. Chiche, Jean‐François Hernandez, V. Lisowski, 2011, Chemistry.

Iron-catalyzed reductive cyclization of nitroarenes: Synthesis of aza-heterocycles and DFT calculations

G. Lefèvre, C. Tran, Abdallah Hamze, 2022, Chinese Chemical Letters.

TBAB-Catalyzed Csp 3 -N Bond Formation by Coupling Pyridotriazoles with Anilines: A New Route to (2-Pyridyl)alkylamines

P. Retailleau, M. Alami, Abdallah Hamze, 2019, European Journal of Organic Chemistry.

Mono- and bis-thiazolium salts have potent antimalarial activity.

H. Vial, E. Rubi, P. Arnal, 2005, Journal of medicinal chemistry.

Xphos ligand and platinum catalysts: A versatile catalyst for the synthesis of functionalized β-(E)-vinylsilanes from terminal alkynes

J. Brion, M. Alami, Abdallah Hamze, 2008 .

Suzuki Coupling Reactions of (E)- and (Z)-Chloroenynes with Boronic Acids: Versatile Access to Functionalized 1,3-Enynes

J. Brion, M. Alami, Abdallah Hamze, 2010 .

Therapeutic Modalities of Squalenoyl Nanocomposites in Colon Cancer: An Ongoing Search for Improved Efficacy

P. Couvreur, A. Maksimenko, J. Mougin, 2014, ACS nano.

Discovery and hit to lead optimization of novel combretastatin A-4 analogues: dependence of C-linker length and hybridization.

J. Peyrat, J. Brion, M. Alami, 2013, Anti-cancer agents in medicinal chemistry.

Design, synthesis and biological evaluation of quinoline-2-carbonitrile-based hydroxamic acids as dual tubulin polymerization and histone deacetylases inhibitors.

J. Bignon, G. Bollot, S. Apcher, 2022, European journal of medicinal chemistry.

Solid phase synthesis of mono- or disubstituted arginine containing peptides from an isothiocitrulline precursor

Jean‐François Hernandez, V. Lisowski, Céline Gandreuil, 2005 .

Sequential One-Pot Synthesis of 3-Arylbenzofurans from N-Tosylhydrazones and Bromophenol Derivatives.

V. Gandon, M. Alami, Abdallah Hamze, 2020, The Journal of organic chemistry.

One-pot hydrosilylation-protodesilylation of functionalized diarylalkynes : a highly selective access to Z-stilbenes. Application to the synthesis of combretastatin A-4

A. Giraud, J. Brion, M. Alami, 2008 .

Gold versus Palladium: A Regioselective Cycloisomerization of Aromatic Enynes

G. Frison, J. Brion, M. Alami, 2013 .

Synthesis of (R) and (S) enantiomers of Fmoc-protected 1,2,4-oxadiazole-containing β3-amino acids from Fmoc-(R)-β-HAsp(OtBu)-OH

Jean Martínez, Jean‐François Hernandez, Abdallah Hamze, 2003 .

Synthesis, biological evaluation, and structure-activity relationships of tri- and tetrasubstituted olefins related to isocombretastatin A-4 as new tubulin inhibitors.

J. Wdzieczak‐Bakala, J. Bignon, J. Dubois, 2013, Organic & biomolecular chemistry.

Copper-Catalyzed Coupling of N-Tosylhydrazones with Amines: Synthesis of Fluorene Derivatives

G. Frison, Montserrat Gómez, J. Brion, 2014 .

Recent Advances in Synthesis of Pyrrolo[3,2‐ b ]indole and Indolo[3,2‐ b ]indole Derivatives

J. Pozzo, Abdallah Hamze, O. Provot, 2022, Asian Journal of Organic Chemistry.

Imidazodipyridines via DMAP Catalyzed Domino N−H Carbonylation and 6π‐Electrocyclization: Synthetic Scope and Application

J. Bignon, P. Retailleau, Abderrahman El Bouakher, 2020 .

Mild Deprotection of Dithioacetals by TMSCl/NaI Association in CH 3 CN

M. Alami, Abdallah Hamze, O. Provot, 2020, European Journal of Organic Chemistry.

Three-component one-pot process to propargylic amines and related amide and sulfonamide compounds: application to the construction of 2-(aminomethyl)benzofurans and indoles

S. Sicsic, I. Berque-Bestel, J. Peyrat, 2007 .

Synthesis of Isocoumarin via PTSA-Catalyzed Annulation of Diarylalkynes

S. Messaoudi, J. Brion, M. Alami, 2008 .

3.10 Coupling Reactions Between sp Carbon Centers

S. Messaoudi, M. Alami, Abdallah Hamze, 2014 .

Synthesis of Isocoumarin via PTSA‐Catalyzed Annulation of Diarylalkynes.

S. Messaoudi, J. Brion, M. Alami, 2008 .

p-Toluenesulfonic acid-promoted selective functionalization of unsymmetrical arylalkynes: a regioselective access to various arylketones and heterocycles

J. Peyrat, J. Brion, M. Alami, 2010 .

Platinum oxide catalyzed silylation of aryl halides with triethylsilane: an efficient synthetic route to functionalized aryltriethylsilanes.

J. Brion, M. Alami, Abdallah Hamze, 2006, Organic letters.

Recent advances in the synthesis of pyrido[1,2-a]indoles.

M. Alami, Abdallah Hamze, O. Provot, 2021, Organic & biomolecular chemistry.

Copper Acetoacetonate [Cu(acac)2]/BINAP‐Promoted Csp3N Bond Formation via Reductive Coupling of N‐Tosylhydrazones with Anilines

J. Brion, M. Alami, Jessy Aziz, 2013 .

DMSO–PdI2 as a powerful oxidizing couple of alkynes into benzils: one-pot synthesis of nitrogen-containing five- or six-membered heterocycles

J. Bignon, C. Mousset, J. Brion, 2008 .

PtO2/PTSA system catalyzed regioselective hydration of internal arylalkynes bearing electron withdrawing groups

M. Alami, Abdallah Hamze, O. Provot, 2018, RSC advances.

Synthesis of Various 3-Substituted 1,2,4-Oxadiazole-Containing Chiral β3- and α-Amino Acids from Fmoc-Protected Aspartic Acid

Jean‐François Hernandez, Jean Martinez, P. Fulcrand, 2003 .

Palladium-Catalyzed One-Pot Reaction of Hydrazones, Dihaloarenes, and Organoboron Reagents: Synthesis and Cytotoxic Activity of 1,1-Diarylethylene Derivatives.

J. Bignon, J. Brion, M. Alami, 2015, The Journal of organic chemistry.

Catalytic three-component one-pot reaction of hydrazones, dihaloarenes, and amines.

J. Brion, M. Alami, Abdallah Hamze, 2013, Organic letters.

Three‐Component One‐Pot Process to Propargylic Amines and Related Amide and Sulfonamide Compounds: Application to the Construction of 2‐(Aminomethyl)benzofurans and Indoles.

S. Sicsic, I. Berque-Bestel, J. Peyrat, 2008 .

Copper-catalyzed reductive coupling of tosylhydrazones with amines: a convenient route to α-branched amines.

J. Brion, M. Alami, Abdallah Hamze, 2011, Organic & biomolecular chemistry.

Csp2-N bond formation via ligand-free Pd-catalyzed oxidative coupling reaction of N-tosylhydrazones and indole derivatives.

G. Frison, J. Brion, M. Alami, 2013, The Journal of organic chemistry.

Copper-catalyzed sulfonylation of N-tosylhydrazones followed by a one-pot C-N bond formation.

C. Tran, M. Alami, Abdallah Hamze, 2021, Organic & biomolecular chemistry.

Csp2-Csp2 and Csp2-N Bond Formation in a One-Pot Reaction between N-Tosylhydrazones and Bromonitrobenzenes: An Unexpected Cyclization to Substituted Indole Derivatives.

J. Bignon, A. Hachem, P. Retailleau, 2017, Organic letters.

A general synthesis of arylindoles and (1-arylvinyl)carbazoles via a one-pot reaction from N-tosylhydrazones and 2-nitro-haloarenes and their potential application to colon cancer.

J. Bignon, A. Hachem, J. Brion, 2016, Chemical communications.

Transition-Metal-Free Synthesis of Polysubstituted Cyclopropane Derivatives from N-Tosylhydrazones and their Cytotoxic Activities

J. Bignon, J. Brion, M. Alami, 2015 .

A One‐Pot Three‐Step Synthesis of Z‐Trisubstituted Olefins from Arylalkynes and Their Cyclization into 4‐Aryl‐2H‐chromenes

J. Brion, M. Alami, Abdallah Hamze, 2012 .

Palladium-catalyzed coupling of N-tosylhydrazones with ortho substituted aryl halides: synthesis of 4-arylchromenes and related heterocycles

J. Brion, M. Alami, Abdallah Hamze, 2011 .

Pd-catalyzed reaction of sterically hindered hydrazones with aryl halides: synthesis of tetra-substituted olefins related to iso-combretastatin A4.

J. Peyrat, J. Brion, M. Alami, 2010, Organic letters.

Expeditious synthesis of 1,1-diarylethylenes related to isocombretastatin A-4 (isoCA-4) via palladium-catalyzed arylation of N-tosylhydrazones with aryl triflates

J. Brion, M. Alami, Abdallah Hamze, 2009 .

Rapid synthesis of 4-arylchromenes from ortho-substituted alkynols: A versatile access to restricted isocombretastatin A-4 analogues as antitumor agents.

J. Bignon, J. Rodrigo, J. Dubois, 2015, European journal of medicinal chemistry.

Synthesis and Biological Activities of Pyrazino[1,2-a]indole and Pyrazino[1,2-a]indol-1-one Derivatives

C. Tran, M. Alami, Abdallah Hamze, 2021, Pharmaceuticals.

An efficient coupling of N-tosylhydrazones with 2-halopyridines: synthesis of 2-α-styrylpyridines endowed with antitumor activity.

J. Bignon, J. Dubois, J. Peyrat, 2013, Organic & biomolecular chemistry.

Synthesis, biological evaluation and molecular modeling studies of imidazo[1,2-a]pyridines derivatives as protein kinase inhibitors.

O. Lozach, B. Baratte, S. Ruchaud, 2016, European journal of medicinal chemistry.

Design and Synthesis of Tubulin and Histone Deacetylase Inhibitor Based on iso-Combretastatin A-4.

J. Bignon, G. Bollot, K. Benihoud, 2018, Journal of medicinal chemistry.

Metal-Catalyzed Synthesis of 1,1-Diarylethylene Scaffolds

M. Alami, Abdallah Hamze, O. Provot, 2017 .

Synthesis of benzofulvenes through chemoselective Sonogashira and Barluenga couplings of ortho ethynyl-N-tosylhydrazones and cycloisomerization

J. Brion, M. Alami, Jessy Aziz, 2015 .

Tandem one-pot palladium-catalyzed coupling of hydrazones, haloindoles, and amines: synthesis of amino-N-vinylindoles and their effect on human colon carcinoma cells.

J. Bignon, J. Brion, M. Alami, 2014, The Journal of organic chemistry.

Synthesis of ortho/ortho'-substituted 1,1-diarylethylenes through cross-coupling reactions of sterically encumbered hydrazones and aryl halides.

J. Brion, M. Alami, Abdallah Hamze, 2013, The Journal of organic chemistry.

DMSO–PdI2 as a powerful oxidizing couple of alkynes into benzils: one-pot synthesis of nitrogen-containing five- or six-membered heterocycles

J. Bignon, C. Mousset, J. Brion, 2008 .

Hydrostannation of Alkynes

M. Alami, Abdallah Hamze, O. Provot, 2019, ACS Catalysis.

Recent Developments in the Photochemical Synthesis of Functionalized Imidazopyridines

C. Tran, Abdallah Hamze, 2022, Molecules.

Recent Progress on the Mild Deprotection of Dithioketals, Dithioacetals, and Oxathiolanes

J. Pozzo, Abdallah Hamze, O. Provot, 2022, European Journal of Organic Chemistry.

Chlorotrimethylsilane and Sodium Iodide: A Useful Combination for the Regioselective Deoxygenation of Arylalkyl-α-Diketones

M. Alami, Abdallah Hamze, O. Provot, 2017 .

Synthesis of 1,1-diarylethylenes via efficient iron/copper co-catalyzed coupling of 1-arylvinyl halides with Grignard reagents.

J. Brion, M. Alami, Abdallah Hamze, 2012, Organic letters.

Selective Metal-Free Deoxygenation of Unsymmetrical 1,2-Dicarbonyl Compounds by Chlorotrimethylsilane and Sodium Iodide.

J. Brion, M. Alami, Abdallah Hamze, 2016, Organic letters.

A new strategy for selective targeting of progesterone receptor with passive antagonists.

M. Lombès, N. Chabbert-Buffet, G. Meduri, 2013, Molecular endocrinology.

Palladium-catalyzed Markovnikov terminal arylalkynes hydrostannation: application to the synthesis of 1,1-diarylethylenes.

J. Brion, M. Alami, Abdallah Hamze, 2009, The Journal of organic chemistry.

Platinum chloride/Xphos-catalyzed regioselective hydrosilylation of functionalized terminal arylalkynes

J. Brion, M. Alami, Abdallah Hamze, 2008 .

Platinum oxide catalyzed hydrosilylation of unsymmetrical internal aryl alkynes under ortho-substituent regiocontrol.

J. Brion, M. Alami, Abdallah Hamze, 2005, Organic letters.

Regioselective Hydrostannation of Highly Hindered Arylalkynes under Ortho Directing Effects

J. Brion, M. Alami, Abdallah Hamze, 2010 .

Characterization of the Annonaceous acetogenin, annonacinone, a natural product inhibitor of plasminogen activator inhibitor-1

G. Ferry, F. Adam, D. Lawrence, 2016, Scientific Reports.

Design, synthesis and anticancer properties of IsoCombretaQuinolines as potent tubulin assembly inhibitors.

J. Bignon, C. Lenoir, J. Dubois, 2017, European journal of medicinal chemistry.

Isocombretastatins a versus combretastatins a: the forgotten isoCA-4 isomer as a highly promising cytotoxic and antitubulin agent.

J. Wdzieczak‐Bakala, J. Bignon, J. Dubois, 2009, Journal of medicinal chemistry.

p-Toluenesulfonic Acid-Promoted Selective Functionalization of Unsymmetrical Arylalkynes: A Regioselective Access to Various Arylketones and Heterocycles.

J. Peyrat, J. Brion, M. Alami, 2010 .

N,N-bis-heteroaryl methylamines: Potent anti-mitotic and highly cytotoxic agents.

J. Bignon, J. Dubois, M. Alami, 2019, European journal of medicinal chemistry.

Design, synthesis and anticancer properties of 5-arylbenzoxepins as conformationally restricted isocombretastatin A-4 analogs.

J. Wdzieczak‐Bakala, J. Bignon, C. Lenoir, 2013, European journal of medicinal chemistry.

Discovery of Isoerianin Analogues as Promising Anticancer Agents

J. Wdzieczak‐Bakala, J. Bignon, J. Dubois, 2011, ChemMedChem.

Identification of a new series of flavopiridol-like structures as kinase inhibitors with high cytotoxic potency.

P. Colas, P. Bonnet, J. Bignon, 2020, European journal of medicinal chemistry.

An Efficient Coupling of N‐Tosylhydrazones with 2‐Halopyridines: Synthesis of 2‐α‐Styrylpyridines Endowed with Antitumor Activity.

J. Bignon, J. Dubois, J. Peyrat, 2013 .

One‐Pot Hydrosilylation—Protodesilylation of Functionalized Diarylalkynes: A Highly Selective Access to (Z)‐Stilbenes. Application to the Synthesis of Combretastatin A‐4.

A. Giraud, J. Brion, M. Alami, 2008 .

Anticancer properties of indole derivatives as IsoCombretastatin A-4 analogues.

M. Diederich, J. Bignon, Laura Gallego-Yerga, 2021, European journal of medicinal chemistry.

MPHT-Promoted Bromocyclization of ortho-Substituted Arylalkynes: Application to the Synthesis of 2-Substituted 3-Bromobenzofurans and -Benzo[b]thiophenes

J. Brion, M. Alami, Abdallah Hamze, 2010 .

Catalyst-Free Synthesis of Functionalized 4-Substituted-4H-Benzo[d][1,3]oxazines via Intramolecular Cyclization of ortho-Amide-N-tosylhydrazones.

P. Retailleau, C. Tran, M. Alami, 2023, The Journal of organic chemistry.

Synthesis of Dihydro‐5H‐benzo[c]‐fluorenes, Dihydroindeno[c]‐Chromenes and Thiochromenes via Intramolecular Cyclization and their Effect on Human Leukemia Cells

J. Bignon, C. Tran, Abdallah Hamze, 2022, Advanced Synthesis & Catalysis.

Reversion of apoptotic resistance of TP53-mutated Burkitt lymphoma B-cells to spindle poisons by exogenous activation of JNK and p38 MAP kinases

J. Feuillard, J. Brion, M. Alami, 2014, Cell Death and Disease.

Solid-phase synthesis of arginine-containing peptides and fluorogenic substrates using a side-chain anchoring approach.

Jean‐François Hernandez, Jean Martinez, Abdallah Hamze, 2004, The Journal of organic chemistry.

Solid-phase synthesis of dipeptidic and pseudo-dipeptidic potential NOS inhibitors through a side-chain anchoring approach.

Jean‐François Hernandez, Jean Martinez, P. Fulcrand, 2009, Advances in Experimental Medicine and Biology.

Palladium-catalyzed Markovnikov terminal arylalkynes hydrostannation: application to the synthesis of 1,1-diarylethylenes.

J. Brion, M. Alami, Abdallah Hamze, 2009, Journal of Organic Chemistry.

Synthesis, Biological Evaluation of 1,1‐Diarylethylenes as a Novel Class of Antimitotic Agents

J. Wdzieczak‐Bakala, J. Bignon, A. Giraud, 2009, ChemMedChem.

Regiocontrol of the palladium-catalyzed tin hydride addition to Z-enynols: remarkable Z-directing effects.

J. Brion, M. Alami, Abdallah Hamze, 2007, The Journal of organic chemistry.

Toward a Greener Barluenga-Valdés Cross-Coupling: Microwave-Promoted C-C Bond Formation with a Pd/PEG/H2O Recyclable Catalytic System.

V. Gandon, M. Alami, Abdallah Hamze, 2019, Organic letters.