B. Joseph

发表

Targeting RNA structure in SMN2 reverses spinal muscular atrophy molecular phenotypes

F. Metzger, H. Schwalbe, M. Orozco, 2018, Nature Communications.

Recent advances in the synthesis and properties of 4-, 5-, 6- or 7-azaindoles

S. Routier, F. Suzenet, B. Joseph, 2013 .

Synthesis and biological evaluation of tetrahydro[1,4]diazepino[1,2-a]indol-1-ones as cyclin-dependent kinase inhibitors.

L. Meijer, O. Lozach, G. Fournet, 2014, European journal of medicinal chemistry.

Pyrazolo[1,5-a]-1,3,5-triazine as a purine bioisostere: access to potent cyclin-dependent kinase inhibitor (R)-roscovitine analogue.

Philippe Bernard, Florence Popowycz, Laurent Meijer, 2009, Journal of medicinal chemistry.

Synthesis and antiproliferative evaluation of pyrazolo[1,5-a]-1,3,5-triazine myoseverin derivatives.

C. Galmarini, F. Kozielski, F. Popowycz, 2009, Bioorganic & medicinal chemistry.

N-&-N, a new class of cell death-inducing kinase inhibitors derived from the purine roscovitine

L. Meijer, J. Endicott, G. Fournet, 2008, Molecular Cancer Therapeutics.

Synthesis of 8‐Substituted Pyrazolo[1,5‐a]‐1,3,5‐triazine Derivatives by Palladium‐Catalyzed Cross‐Coupling Reactions.

P. Bernard, F. Popowycz, P. Raboisson, 2007 .

Targeting low molecular weight cyclin E (LMW-E) in breast cancer

L. Meijer, K. Hunt, A. Multani, 2012, Breast Cancer Research and Treatment.

Synthesis of Substituted Azepino[3,4-b]indole-1,5-diones

B. Joseph, J. Mérour, Julien Perron, 2004 .

General and Easy Access to 11-Substituted 4-Hydroxy-2,3,4,5-tetrahydro[1,4]diazepino[1,2-a]indol-1-one Derivatives

G. Fournet, B. Joseph, Aurélien Putey, 2006 .

A Non-Classical Route to 2,3-Diiodoindoles from Indole-2-carboxylic Acids

F. Popowycz, B. Joseph, Aurélien Putey, 2007 .

Synthesis of 4-substituted azepino[3,4-b]indole-1,5-diones

B. Joseph, J. Mérour, Julien Perron, 2003 .

Synthesis of Pyrido[2,3-b]indole Derivatives via Diels–Alder Reactions of 2- and 3-Vinylpyrrolo[2,3-b]pyridines

B. Joseph, S. Léonce, J. Mérour, 2000 .

Indolobenzazepin-7-ones and 6-, 8-, and 9-membered ring derivatives as tubulin polymerization inhibitors: synthesis and structure--activity relationship studies.

C. Galmarini, F. Kozielski, Q. Do, 2009, Journal of medicinal chemistry.

Monodisperse polysarcosine-based highly-loaded antibody-drug conjugates† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c9sc00285e

C. Dumontet, G. Fournet, S. Papot, 2018, Chemical science.

Exatecan Antibody Drug Conjugates Based on a Hydrophilic Polysarcosine Drug-Linker Platform

E. Fourmaux, E. Matera, C. Dumontet, 2021, Pharmaceuticals.

Monomethyl Auristatin E Grafted-Liposomes to Target Prostate Tumor Cell Lines

E. Petiot, O. Maniti, G. Lollo, 2021, International journal of molecular sciences.

Structure-activity relationship of S-trityl-L-cysteine analogues as inhibitors of the human mitotic kinesin Eg5.

C. Laggner, F. Kozielski, D. Skoufias, 2008, Journal of Medicinal Chemistry.

Targeting Integrin-Dependent Adhesion and Signaling with 3-Arylquinoline and 3-Aryl-2-Quinolone Derivatives: A new Class of Integrin Antagonists

O. Vinogradova, D. Bouvard, G. Fournet, 2015, PloS one.

Ring closure metathesis of indole 2-carboxylic acid allylamide derivatives

B. Joseph, J. Mérour, V. Bénéteau, 2002 .

New 1-arylindoles based serotonin 5-HT7 antagonists. Synthesis and binding evaluation studies.

A. Bojarski, G. Satała, G. Fournet, 2014, European journal of medicinal chemistry.

Synthesis and Fluorescent Properties of New Heterobifunctional Fluorescent Probes

T. Besson, B. Joseph, P. Moreau, 1992 .

Intramolecular heck reaction: synthesis of potential antiinflammatory agents

B. Joseph, J. Mérour, O. Cornec, 1995 .

Inhibition of hepatitis C virus NS5B polymerase by S-trityl-L-cysteine derivatives.

N. Sakamoto, Neerja Kaushik-Basu, R. Ragno, 2012, European journal of medicinal chemistry.

Access to ring-fused azepino[3,4-b]indole-1,5-dione derivatives by ring-closing olefin metathesis

B. Joseph, J. Mérour, Julien Perron, 2004 .

Synthesis and biological evaluation in rat and cat of [18F]12ST05 as a potential 5-HT6 PET radioligand.

D. Le Bars, L. Zimmer, G. Fournet, 2007, Nuclear medicine and biology.

Tetrahedron report number 808 Synthesis and reactivity of 4-, 5- and 6-azaindoles

F. Popowycz, B. Joseph, J. Mérour, 2007 .

Meriolins (3-(pyrimidin-4-yl)-7-azaindoles): synthesis, kinase inhibitory activity, cellular effects, and structure of a CDK2/cyclin A/meriolin complex.

L. Meijer, J. Endicott, O. Lozach, 2008, Journal of medicinal chemistry.

Synthesis and Reactivity of 7-Azaindole (1H-Pyrrolo[2,3-b]pyridine)

F. Popowycz, S. Routier, B. Joseph, 2001 .

Impact of meriolins, a new class of cyclin-dependent kinase inhibitors, on malignant glioma proliferation and neo-angiogenesis.

L. Meijer, J. Honnorat, N. Loaëc, 2014, Neuro-oncology.

Synthesis and Reactivity of 4-, 5- and 6-Azaindoles.

F. Popowycz, B. Joseph, J. Mérour, 2007 .

Synthesis of latonduine derivatives via intramolecular Heck reaction

Lionel Joucla, T. Besson, B. Joseph, 2007 .

Synthesis of fused heterocycles with a benzazepinone moiety via intramolecular Heck coupling

Lionel Joucla, B. Joseph, Aurélien Putey, 2005 .

Synthesis and antiproliferative activity of clausine E, mukonine, and koenoline bioisosteres.

C. Galmarini, F. Popowycz, T. Besson, 2007, Bioorganic & medicinal chemistry.

Synthesis and Reactivity of 7-Azaindoles: 1H-Pyrrolo[2,3- B]pyridines

B. Joseph, J. Mérour, 2001 .

Synthesis of Indolo[3,2-c]quinoline and Pyrido[3′,2′ : 4,5] [3,2-c]quinoline Derivatives

A. Mouaddib, B. Joseph, J. Mérour, 2000 .

Synthesis of 2-, 3-, and 4-Substituted Pyrido[2,3-b]indoles by C–N, C–O, and C–C(sp) Bond Formation

D. Goyard, P. Goekjian, B. Joseph, 2010 .

Structure-activity relationship and multidrug resistance study of new S-trityl-L-cysteine derivatives as inhibitors of Eg5.

Christian Laggner, Florence Popowycz, C. Laggner, 2011, Journal of medicinal chemistry.

Intramolecular Heck Coupling of Alkenyl 3-Iodoindole-2-carboxamide Derivatives

B. Joseph, J. Mérour, L. Chacun-Lefevre, 2001 .

Synthesis, structure and enzymatic evaluation of new spiro oxathiazole sugar derivatives

R. Faure, J. Praly, B. Joseph, 1994 .

(Z)-Stereospecific Addition of Glycosylmercaptans on Nitrilium Betaines.1 Synthesis of 1-S-Glucopyranosyl Arylthiohydroximates

L. Brochard, B. Joseph, P. Rollin, 1994 .

Synthesis and in vitro cytotoxic evaluation of N-substituted benzo[5,6]cycloheptal[b]indoles.

D. Alagille, B. Joseph, S. Léonce, 2000, Chemical & pharmaceutical bulletin.

Synthesis and Antitumoral Evaluation of 12-Substituted 6,7-Dihydrobenzo[4,5]-cyclohept[1,2-b]indole Derivatives

B. Joseph, S. Léonce, J. Mérour, 1998 .

Chemoselective functionalization of α-carbolines at the C-2, C-3, C-4, and C-6 positions using Suzuki–Miyaura reactions

P. Goekjian, B. Joseph, D. Gueyrard, 2009 .

Meriolins, a new class of cell death inducing kinase inhibitors with enhanced selectivity for cyclin-dependent kinases.

L. Meijer, J. Endicott, M. Kubbutat, 2007, Cancer research.

Synthesis, cytotoxicity, DNA interaction and topoisomerase II inhibition properties of tetrahydropyrrolo[3,4-a]carbazole-1,3-dione and tetrahydropyrido-[3,2-b]pyrrolo[3,4-g]indole-1,3-dione derivatives.

C. Bailly, P. Colson, C. Houssier, 2001, Bioorganic & medicinal chemistry.

Preparation and reactivity of 5-substituted azepino[3,4-b]indoles

B. Joseph, N. Laurent, J. Mérour, 2005 .

Synthesis and Reactivity of Azepino[3,4-b]indol-5-yl Trifluoromethanesulfonate

B. Joseph, J. Mérour, L. Chacun-Lefevre, 2000 .

3-Aryl-2-quinolone derivatives: synthesis and characterization of in vitro and in vivo antitumor effects with emphasis on a new therapeutical target connected with cell migration.

Robert Kiss, Christine Decaestecker, Brigitte Lesur, 2002, Journal of medicinal chemistry.

Synthesis of 3‐Amino‐5H‐pyrrolo[2,3‐e]‐1,2,4‐triazines by Sonogashira/Copper(I)‐Catalyzed Heteroannulation.

G. Fournet, B. Joseph, C. Nyffenegger, 2007 .

Synthesis of 3-amino-5H-pyrrolo[2,3-e]-1,2,4-triazines by Sonogashira/copper(I)-catalyzed heteroannulation

G. Fournet, B. Joseph, C. Nyffenegger, 2007 .

First synthesis of pyrrolo[1,2:1′,2′]azepino[5,6-b]indole derivatives

B. Joseph, J. Mérour, Julien Perron, 2003 .

Synthesis of O-protected thiohydroximate-linked pseudodisaccharides

B. Joseph, P. Rollin, 1995 .

Novel cyclization of D-glucopyranosyl-(Z)-thiohydroximates leading to new anomeric spiro oxathiazole derivatives

J. Praly, B. Joseph, P. Rollin, 1993 .

Intramolecular Heck reaction: Synthesis of benzo[4,5]cyclohepta[b]indole derivatives

B. Joseph, J. Mérour, O. Cornec, 1998 .

Room-Temperature and Transition-Metal-Free Intramolecular α-Arylation of Ketones: A Mild Access to Tetracyclic Indoles and 7-Azaindoles.

R. Rossi, M. Médebielle, M. Puiatti, 2019, Organic letters.

Synthesis of 6-Substituted 5,6,7,12-Tetrahydrobenzo[4,5]cyclohept[b]indol-12-one Derivatives

A. Mouaddib, B. Joseph, S. Léonce, 1999 .

Synthesis of 5-substituted 2-(4- or 3-methoxyphenyl)-4(1H)-quinolones

G. Guillaumet, Sylvain Celanire, B. Joseph, 2003 .

Synthesis of aza-analogs of natural and artificial desulfoglucosinolates

B. Joseph, P. Rollin, 1993 .

Synthesis of 1,5-dithio-D-glucopyranose and some of its biologically relevant derivatives

B. Joseph, P. Rollin, 1993 .

Synthesis of indole glycosinolates, sugar variants of naturally occurring glucobrassicin

A. Quinsac, B. Joseph, P. Rollin, 1993 .

First synthesis of alpha glucosinolates

H. Driguez, B. Joseph, P. Rollin, 1990 .

Synthesis of Aza‐Analogues of Natural and Artificial Desulfoglucosinolates.

B. Joseph, P. Rollin, 1994 .

Sugar Thiochemistry. First Synthesis of 1,5-Dithio-D-Glucopyranose and Related Thia-Analogs of Glucosinolates

B. Joseph, P. Rollin, 1993 .

First Synthesis of a-Glucosinolates.

H. Driguez, B. Joseph, P. Rollin, 1991 .

Synthetic Studies on Indole Glucosinolates. Part 2. Synthesis of Indole Glycosinolates, Sugar Variants of Naturally Occurring Glucobrassicin.

A. Quinsac, B. Joseph, P. Rollin, 1993 .

Unexpected matrix interactions in liquid secondary ion mass spectrometry of two pyranosyl mercaptans.

A. Castellan, B. Joseph, P. Rollin, 2011, Rapid communications in mass spectrometry : RCM.

A New Class of Heteroaryl Thioglycosides. Synthesis of Pyrazol-3-yl Thioglycopyranosides.

B. Joseph, P. Rollin, 1994 .

Cytotoxic nucleoside analogues: different strategies to improve their clinical efficacy.

C. Galmarini, F. Popowycz, B. Joseph, 2008, Current medicinal chemistry.

Synthesis of [3H]‐labelled glucobrassicin, a potential radiotracer for metabolic studies of indole glucosinolates

S. Chevolleau, B. Joseph, P. Rollin, 1993 .

Convenient synthetic routes to 5-substituted 3-(4-methoxyphenyl)-4(1H)-quinolones

G. Guillaumet, B. Lesur, B. Joseph, 2003 .

Use of ATP analogs to inhibit HIV-1 transcription.

L. Meijer, K. Kehn-Hall, S. Nekhai, 2012, Virology.

1-(Phenylsulfonyl)indol-2-yl Triflate: A Versatile Reagent for the Synthesis of 2-Substituted Indoles

B. Joseph, J. Mérour, Béatrice Malpel, 1996 .

University of Groningen Targeting RNA structure in SMN 2 reverses spinal muscular atrophy molecular phenotypes

F. Metzger, H. Schwalbe, M. Orozco, 2018 .

Synthesis and Reactivity of 1,4‐Oxazinoindole Derivatives

G. Guillaumet, B. Joseph, Stanislas Mayer, 2002 .

8-Piperazinyl-2,3-dihydro-1,4-dioxino [2,3-b] pyridine derivatives: synthesis and interaction with 5-HT serotonin binding sites

G. Guillaumet, B. Joseph, Abdelhakim Benerab, 1994 .

8-Piperazinyl-2,3-dihydro-1,4-dioxino(2,3-b)pyridine Derivatives: Synthesis and Interaction with 5-HT Serotonin Binding Sites.

G. Guillaumet, B. Joseph, A. Benarab, 1994 .

Synthesis of 6,7-dihydrobenzo[4,5]cyclohept-[1,2-b]indol-12(5H)-one and related compounds

X. Solans, B. Joseph, M. Font‐Bardia, 1997 .

New insights into homopiperazine-based 5-HT1A/5-HT7R ligands: synthesis and biological evaluation

A. Bojarski, G. Guillaumet, F. Suzenet, 2010, Journal of enzyme inhibition and medicinal chemistry.

Synthesis of Pyrano[3,2-b]indole Derivatives Based on Intramolecular Hetero-DielsAlder of 2-Benzylidene-2,3-dihydro-1H-indol-3-ones

J. Leger, C. Jarry, B. Joseph, 2003 .

Synthesis and preliminary antiproliferative evaluation of 1,3,9-triazacyclopenta[b]fluorene derivatives

V. Thiéry, T. Besson, B. Joseph, 2005, Journal of enzyme inhibition and medicinal chemistry.

Synthesis of benzo[5,6]cyclohepta[b]indol-6-one derivatives

D. Alagille, B. Joseph, C. Rousseau, 1999 .

Synthesis of Imidazolo[5,4‐b]carbazole‐4,10‐quinones.

B. Joseph, G. Desforges, C. Montagne, 2004 .

Synthesis of 14-Membered Ring Jaspamide Derivatives

G. Guillaumet, Sylvain Celanire, B. Lesur, 2005 .

5‐Substituted 3,4‐dihydro‐3‐amino‐2H‐1‐benzopyran derivatives: synthesis and interaction with serotoninergic receptors

P. Renard, B. Pfeiffer, P. Delagrange, 2001, The Journal of pharmacy and pharmacology.