C. Dufresne

发表

Preparation of exo-6-benzyl-exo-2-(m-hydroxyphenyl)-1-dimethylaminomethylbicyclo[2.2.2.]octane. A non-peptide mimic of enkephalins

P. Belanger, C. Dufresne, 1986 .

Isolation and Structure of the Cytostatic Linear Depsipeptide Dolastatin 15

R. Cerny, Jean M. Schmidt, G. Pettit, 1989 .

Simon K. Kearsley, Claude Dufresne, S. Kearsley, 1995 .

Isolation and structure of the cell growth inhibitory constituents from the western Pacific marine sponge Axinella sp.

M. Boyd, J. Leet, R. Cerny, 1991, Journal of medicinal chemistry.

New fungal metabolites as potential antihypercholesterolemics and anticancer agents

J. D. Karkas, J. Gibbs, K. Silverman, 1995 .

NEW CLASS OF POTENT LIGANDS FOR THE HUMAN PERIPHERAL CANNABINOID RECEPTOR

P. Prasit, Y. Leblanc, D. Guay, 1996 .

Discovery, biosynthesis, and mechanism of action of the zaragozic acids: potent inhibitors of squalene synthase.

G. Bills, C. Dufresne, J. Bergstrom, 1995, Annual Review of Microbiology.

Isolation and structure of the powerful cell growth inhibitor cephalostatin 1

D. L. Herald, Jean M. Schmidt, G. Pettit, 1988 .

Structure activity relationships of tetrahydrocannabinol analogues on human cannabinoid receptors

K. Metters, Y. Gareau, M. Labelle, 1996 .

Expanding the Scope of HTMS Methods

Bernard K. Choi, N. Geoghagen, Kristian K. Jensen, 2011 .

The development of potent non-peptidic PTP-1B inhibitors.

E. Asante-Appiah, Y. Boie, B. Kennedy, 2004, Bioorganic & medicinal chemistry letters.

The zaragozic acids : structure elucidation of a new class of squalene synthase inhibitors

O. Hensens, R. Reamer, J. Liesch, 1993 .

Isolation and structure of the cell growth inhibitory depsipeptides dolastatins 11 and 12

Jean M. Schmidt, R. Nieman, G. Pettit, 1989 .

Identification of prostaglandin D2 receptor antagonists based on a tetrahydropyridoindole scaffold.

D. Denis, Y. Leblanc, G. O'neill, 2008, Bioorganic & medicinal chemistry letters.

The discovery of a new structural class of potent orally active leukotriene D4 antagonists

R. Young, P. Prasit, A. Ford-hutchinson, 1992 .

Discovery of L-740,515, a potent thienopyridine cysLT1 receptor (LTD4 receptor) antagonist

R. Young, A. Ford-hutchinson, Y. Leblanc, 1995 .

Evolution of a series of non-quinoline leukotriene D4 receptor antagonist; synthesis and sar of benzothiazoles and thiazoles substituted benzyl alcohols as potent LTD4 antagonists

R. Young, A. Ford-hutchinson, R. Zamboni, 1995 .

Isolation and structure of the cytostatic depsipeptide dolastatin 13 from the sea hare Dolabella auricularia

R. Cerny, D. L. Herald, Jean M. Schmidt, 1989 .

Isolation, structure determination and squalene synthase activity of L-731,120 and L-731,128, alkyl citrate analogs of zaragozic acids A and B

P. Salmon, K. Wilson, H. Joshua, 1995 .

Distribution of zaragozic acids (squalestatins) among filamentous ascomycetes

F. Peláez, G. Bills, G. Harris, 1994 .

The isolation and structure elucidation of zaragozic acid C, a novel potent squalene synthase inhibitor.

K. Wilson, F. Peláez, G. Bills, 1992 .

Carbazate as a glycine bioisostere in restricticin.

A. Patchett, K. Wilson, K. Bartizal, 1996, The Journal of antibiotics.

L-656,224 (7-chloro-2-[(4-methoxyphenyl)methyl]-3- methyl-5-propyl-4-benzofuranol): a novel, selective, orally active 5-lipoxygenase inhibitor.

A. Ford-hutchinson, A. Maycock, C. Mcfarlane, 1987, Canadian journal of physiology and pharmacology.

Structure elucidation of L-687,781, a new β-1,3-D-glucan synthesis inhibitor.

K. Wilson, C. Dufresne, F. Vanmiddlesworth, 1991 .

A series of non-quinoline cysLT1 receptor antagonists: SAR study on pyridyl analogs of Singulair.

P. Prasit, J. Gauthier, R. Zamboni, 1998, Bioorganic & medicinal chemistry letters.

Reactions of 2-phenyl-4H-1,3,2-benzodioxaborin, a stable ortho-quinone methide precursor

J. Crawford, M. Bernstein, J. Scheigetz, 1992 .

Antineoplastic agents. 214. Isolation and structure of cephalostatins 7-9

M. Boyd, Jean M. Schmidt, G. Pettit, 1992 .

The Hemetsberger-Knittel Synthesis of Substituted 5-, 6-, and 7-Azaindoles

Y. Leblanc, Zhaoyin Wang, P. Roy, 2005 .

Facile preparations of 4-fluororesorcinol

J. Scheigetz, P. Belanger, C. Dufresne, 1988 .

The chemistry of the blue stain fungi. Part 2. Some essential metal levels of diseased and healthy lodgepole pine

B. Kratochvil, W. Ayer, E. Allen, 1986 .

A general synthesis of quinolinones and benzothiazine 1,1-dioxides via ring closing metathesis

C. Dufresne, C. Sturino, J. Poulin, 2008 .

Progress towards the decalin portion of (+)-compactin

N. Tsou, C. Dufresne, Vincent Mascitti, 2002 .

Reductive deoxygenation of aryl aldehydes and ketones and benzylic, allylic, and tertiary alcohols by zinc iodide-sodium cyanoborohydride

J. Scheigetz, P. Belanger, C. Dufresne, 1986 .

Citricolic Acid, a Novel Type of Fungal Metabolite

W. Ayer, C. Dufresne, 2010 .

The Synthesis of Phenylhydrazines from bis(2,2,2-Trichloroethyl) Azodicarboxylates and Electron-Rich Arenes

Y. Leblanc, C. Dufresne, Carl Berthelette, 1997 .

Reductive deoxygenation of aryl aldehydes and ketones by tert-butylamine-borane and aluminum chloride

Sylvie L. Tardif, J. Scheigetz, C. Dufresne, 1989 .

Discovery of [(3-bromo-7-cyano-2-naphthyl)(difluoro)methyl]phosphonic acid, a potent and orally active small molecule PTP1B inhibitor.

Claude Dufresne, Yves Leblanc, Michel Therien, 2008, Bioorganic & medicinal chemistry letters.

Dichlorophenylborane a new reagent for the preparation of 2-phenyl-4H-1,3,2-benzodioxaborins

C. K. Lau, M. Bernstein, C. Dufresne, 1993 .

ortho-Specific alkylation of phenols via 1,3,2-benzodioxaborins

J. Scheigetz, P. Belanger, C. Dufresne, 1989 .

Dichlorophenylborane, a new reagent for the preparation of 2-phenyl-4H-1,2,3-benzodioxaborins

C. K. Lau, M. Bernstein, C. Dufresne, 1993 .

ortho-Specific Alkylation of Phenols via 1,3,2-Benzodioxaborins.

J. Scheigetz, P. Belanger, C. Dufresne, 1990 .

Isolation and structure of rolliniastatin 2: A new cell growth inhibitory acetogenin from Rollinia mucosa

J. Leet, D. Schaufelberger, Jean M. Schmidt, 1989 .

An In-House Built Semiautomated Countercurrent Chromatography Workstation

Claude Dufresne, Kevin Blake, Christopher S. Napolitano, 2009 .

Zaragozic acids D and D2: potent inhibitors of squalene synthase and of Ras farnesyl-protein transferase.

K. Wilson, K. Silverman, D. Zink, 1993, Journal of natural products.

Automated Agar Plate Streaker: A Linear Plater on Society for Biomolecular Sciences Standard Plates

Jesús Martín, O. Genilloud, F. Peláez, 2006, Journal of biomolecular screening.

Determination of the relative and absolute stereochemistry of sphingofungins A, B, C, and D

K. Wilson, R. Mosley, C. Dufresne, 1992 .

Synthesis and stereochemistry of 11-substituted 5,6,7,8,9,10-hexahydro-6,9-methanobenzocyclooctenes

J. Springer, R. Young, J. Scheigetz, 1982 .

Development of 2,3-dihydro-6-(3-phenoxypropyl)-2-(2-phenylethyl)-5-benzofuranol (L-670,630) as a potent and orally active inhibitor of 5-lipoxygenase.

D. Riendeau, R. Young, A. Ford-hutchinson, 1992, Journal of medicinal chemistry.

Illudinic acid, a novel illudane sesquiterpene antibiotic.

G. Platas, F. Peláez, A. González del Val, 1997, Journal of natural products.

Reductive Deoxygenation of Aryl Aldehydes and Ketones by tert-Butylamine-Borane and Aluminum Chloride.

Sylvie L. Tardif, J. Scheigetz, C. Dufresne, 1989 .

Antineoplastic agents. 190. Isolation and structure of the cyclodepsipeptide dolastatin 14

R. Cerny, Jean M. Schmidt, G. Pettit, 1990 .

Antineoplastic agents. 193. Isolation and structure of the cyclic peptide hymenistatin 1

R. Cerny, G. Pettit, C. Dufresne, 1990 .

Isolation and structure of the unusual Indian Ocean Cephalodiscus gilchristi components, cephalostatins 5 and 6l

Jean M. Schmidt, G. Pettit, C. Dufresne, 1989 .

Antineoplastic Agents. Part 193. Isolation and Structure of the Cyclic Peptide Hymenistatin 1

R. Cerny, G. Pettit, C. Dufresne, 1990 .

Zaragozic acids: a family of fungal metabolites that are picomolar competitive inhibitors of squalene synthase.

J. D. Karkas, O. Hensens, M. Kurtz, 1993, Proceedings of the National Academy of Sciences of the United States of America.

A General Synthesis of Quinolinones and Benzothiazine 1,1-Dioxides via Ring Closing Metathesis.

C. Dufresne, C. Sturino, J. Poulin, 2008 .

The structure of PTP-1B in complex with a peptide inhibitor reveals an alternative binding mode for bisphosphonates.

Claude Dufresne, Yves Leblanc, E. Asante-Appiah, 2002, Biochemistry.

Restricticin, a novel glycine-containing antifungal agent.

R. Schwartz, K. Wilson, R. Fromtling, 1991, The Journal of antibiotics.

Discovery of potent and selective DP1 receptor antagonists in the azaindole series.

D. Denis, Y. Leblanc, G. O'neill, 2009, Bioorganic & medicinal chemistry letters.

One-pot synthesis of precocene I and II and a formal synthesis of robustadial A and B via 2-phenyl-4H-1,3,2-benzodioxaborin

M. Bernstein, C. Dufresne, C. Lau, 1994 .

Conformation-assisted Inhibition of Protein-tyrosine Phosphatase-1B Elicits Inhibitor Selectivity over T-cell Protein-tyrosine Phosphatase*

C. Desponts, E. Asante-Appiah, B. Kennedy, 2006, Journal of Biological Chemistry.

The design and synthesis of nonpeptide compounds as mimics of a conformation of methionine-enkephaline

J. Springer, R. Young, J. Scheigetz, 1982 .

Isolation by Low-Pressure Column Chromatography

G. Salituro, C. Dufresne, 1998 .

Antineoplastic agents, 177. Isolation and structure of phyllanthostatin 6.

D. Schaufelberger, R. Nieman, G. Pettit, 1990, Journal of Natural Products.

A cell-sparing electric field stimulation technique for high-throughput screening of voltage-gated ion channels.

Christopher S. Napolitano, O. McManus, J. Herrington, 2006, Assay and drug development technologies.

Label-free high-throughput screening via mass spectrometry: a single cystathionine quantitative method for multiple applications.

Claude Dufresne, Gergely M Makara, Bernard K. Choi, 2009, Assay and drug development technologies.

AN IMPROVED SYNTHESIS OF ETHYL 4-HYDROXY-3-METHYLBENZOFURAN-2-CARBOXYLATE

J. Scheigetz, P. Belanger, C. Dufresne, 1988 .

An Improved Synthesis of Ethyl 4-Hydroxy-3-methylbenzofuran-2-carboxylate.

J. Scheigetz, P. Belanger, C. Dufresne, 1988 .

Isolation by Ion-Exchange Methods

C. Dufresne, 1998 .

Selective protection and relative importance of the carboxylic acid groups of zaragozic acid A for squalene synthase inhibition.

K. Wilson, R. Marquis, W. Parsons, 1994, Journal of medicinal chemistry.

Novel zaragozic acids from Leptodontidium elatius

K. Wilson, E. Jones, C. Dufresne, 1996 .

Selective Protection and Relative Importance of the Carboxylic Acid Groups of Zargozic Acid A for Squalene Synthase Inhibition.

K. Wilson, R. Marquis, W. Parsons, 1994 .

L-741,494, a fungal metabolite that is an inhibitor of interleukin-1 beta converting enzyme.

O. Hensens, R. Borris, J. Liesch, 1994, Journal of natural products.

Label-free high-throughput screening via mass spectrometry: a single cystathionine quantitative method for multiple applications.

Bernard K. Choi, N. Geoghagen, Kristian K. Jensen, 2009, Assay and drug development technologies.

New Class of Potent Ligands for the Human Peripheral Cannabinoid Receptor.

P. Prasit, Y. Leblanc, D. Guay, 1997 .