H. Tager

发表

Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney.

S. Seino, G. Bell, S. Post, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Disposition of the phenylalanine B25 side chain during insulin-receptor and insulin-insulin interactions.

R. Mirmira, H. Tager, 1991, Biochemistry.

Identification and localization of glucagon-related peptides in rat brain.

R. Dinerstein, M. Hohenboken, H. Tager, 1980, Proceedings of the National Academy of Sciences of the United States of America.

C-peptide and insulin secretion. Relationship between peripheral concentrations of C-peptide and insulin and their secretion rates in the dog.

K. Polonsky, D. Cohen, T. Karrison, 1984, The Journal of clinical investigation.

Alterations in Immunoreactive Proinsulin and Insulin Clearance Induced by Weight Loss in NIDDM

K. Polonsky, R. Henry, B. Gumbiner, 1994, Diabetes.

Internalization and degradation of a low affinity insulin ([LeuB24]insulin) by rat adipocytes

J. Olefsky, A. Green, H. Tager, 1982, FEBS letters.

Relationship between negative cooperativity and insulin action.

J. Olefsky, T. Ciaraldi, A. Green, 1981, Biochemistry.

[LeuB24]insulin and [AlaB24]insulin: altered structures and cellular processing of B24-substituted insulin analogs.

E. Kaiser, R. Assoian, H. Tager, 1982, Proceedings of the National Academy of Sciences of the United States of America.

Interactions of a hybrid insulin/insulin-like growth factor-I analog with chimeric insulin/type I insulin-like growth factor receptors.

R. Mirmira, L. Schäffer, A. S. Andersen, 1993, The Journal of biological chemistry.

Comparative Aspects of Proinsulin and Insulin Structure and Biosynthesis

D. Steiner, J. Peterson, S. Emdin, 1973 .

Mechanism of action of des-His1-[Glu9]glucagon amide, a peptide antagonist of the glucagon receptor system.

S. Post, H. Tager, P. Rubinstein, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Circulating forms of somatostatinlike immunoreactivity in human plasma.

K. Polonsky, S. Shoelson, J. Jaspan, 1986, The American journal of physiology.

Hepatic glucagon metabolism. Correlation of hormone processing by isolated canine hepatocytes with glucagon metabolism in man and in the dog.

W. Hagopian, H. Tager, 1987, The Journal of clinical investigation.

Methods for the assessment of peptide precursors. Studies insulin biosynthesis.

D. Steiner, A. Rubenstein, H. Tager, 1975, Methods in enzymology.

Identification and processing of proglucagon in pancreatic islets

D. Steiner, H. Tager, R. Carroll, 1979, Nature.

Mutant Human Insulins and Insulin Structure-Function Relationships

H. Tager, 1990 .

Insulin Gene Mutations and Abnormal Products of the Human Insulin Gene

H. Tager, 1987 .

Proinsulin radioimmunoassay in the evaluation of insulinomas and familial hyperproinsulinemia.

K. Polonsky, R. Cohen, A. Rubenstein, 1986, Metabolism: clinical and experimental.

Lilly lecture 1983. Abnormal products of the human insulin gene.

H. Tager, 1984, Diabetes.

Models of peptide biosynthesis: the molecular and cellular basis of insulin production.

D. Steiner, S. Chan, A. Rubenstein, 1986, Clinical and investigative medicine. Medecine clinique et experimentale.

Biosynthesis of insulin and glucagon: a view of the current state of the art.

Å. Lernmark, D. Steiner, S. Chan, 2008, Ciba Foundation symposium.

Differential immunoreactivity of plasma glucagon components in man: studies with different glucagon antibodies.

K. Polonsky, D. Soybel, E. Rayfield, 1983, The Journal of clinical endocrinology and metabolism.

[(125I]IodotyrosylB1]insulin. Semisynthesis, receptor binding, and cell-mediated degradation of a B chain-labeled insulin.

R. Assoian, H. Tager, 1981, The Journal of biological chemistry.

Metabolism of C-peptide in the dog. In vivo demonstration of the absence of hepatic extraction.

K. Polonsky, T. Schwartz, D. Cohen, 1983, The Journal of clinical investigation.

Iodotyrosylation of peptides using tertiary-Butyloxycarbonyl-L-[125I]iodotyrosine N-hydroxysuccinimide ester.

R. Assoian, P. Blix, A. Rubenstein, 1980, Analytical biochemistry.

Human insulin B24 (Phe----Ser). Secretion and metabolic clearance of the abnormal insulin in man and in a dog model.

K. Polonsky, S. Shoelson, A. Zeidler, 1984, The Journal of clinical investigation.

Characteristics of binding of a low affinity, noncooperative insulin [( LeuB25]insulin) to IM-9 lymphocytes.

J. Olefsky, A. Green, A. Rubenstein, 1983, Endocrinology.

Diabetes due to secretion of an abnormal insulin.

J. Olefsky, M. Kobayashi, O. Kolterman, 1980, The New England journal of medicine.

Identification of a Point Mutation in the Human Insulin Gene Giving Rise to a Structurally Abnormal Insulin (Insulin Chicago)

D. Steiner, S. Kwok, A. Rubenstein, 1983, Diabetes.

[LeuB24]insulin is an insulin agonist at the liver in vivo.

G. Taborsky, D. Figlewicz, J. Best, 1983, The American journal of physiology.

Hypoglycemic action of 2-aminonorbornane-2-carboxylic acid in the rat.

H. Christensen, H. Tager, 1971, Biochemical and biophysical research communications.

Factitious hypoglycemia. Diagnosis by measurement of serum C-peptide immunoreactivity and insulin-binding antibodies.

J. A. Scarlett, J. Olefsky, J. Jaspan, 1977, The New England journal of medicine.

Biochemical and clinical implications of proinsulin conversion intermediates.

S. Shoelson, R. Cohen, A. Rubenstein, 1985, The Journal of clinical investigation.

Primary structures of the proinsulin connecting peptides of the rat and the horse.

D. Steiner, H. Tager, 1972, The Journal of biological chemistry.

Isolation and biogenesis of a new peptide from pancreatic islets

T. Schwartz, H. Tager, 1981, Nature.

Intestinal and pancreatic glucagon-like peptides. Evidence for identity of higher molecular weight forms.

H. Tager, J. Markese, 1979, The Journal of biological chemistry.

Characterization of a mutant human insulin species.

J. Olefsky, A. Rubenstein, M. Saekow, 1980, The Journal of biological chemistry.

Semisynthesis and biological activity of porcine [LeuB24]insulin and [LeuB25]insulin.

J. Olefsky, E. Kaiser, R. Assoian, 1980, Proceedings of the National Academy of Sciences of the United States of America.

Peptide intermediates in the cellular metabolism of insulin.

R. Assoian, H. Tager, 1982, The Journal of biological chemistry.

A spectroscopic investigation of the conformational dynamics of insulin in solution.

H. Tager, I. Pittman, Isaiah Pittman, 1995, Biochemistry.

BIOSYNTHESIS OF ISLET CELL HORMONES

D. Steiner, R. Assoian, S. Chan, 1980, Annals of the New York Academy of Sciences.

Identification of prosomatostatin in pancreatic islets.

D. Steiner, H. Tager, R. Carroll, 1980, Proceedings of the National Academy of Sciences of the United States of America.

In vitro stimulation of insulin release by non-metabolizable, transport-specific amino acids.

Å. Lernmark, J. Sehlin, H. Christensen, 1971, Biochimica et biophysica acta.

[28] Methods for the assessment of peptide precursors. Studies on insulin biosynthesis

D. Steiner, A. Rubenstein, H. Tager, 1975 .

Immunoreactive "glucagons" in pancreatic islets.

H. Tager, J. Markese, 1976, Metabolism: clinical and experimental.

An insulin-like growth factor I/insulin hybrid exhibiting high potency for interaction with the type I insulin-like growth factor and insulin receptors of placental plasma membranes.

R. Mirmira, J. Cara, H. Tager, 1990, The Journal of biological chemistry.

Role of the COOH-terminal B-chain domain in insulin-receptor interactions. Identification of perturbations involving the insulin mainchain.

H. Tager, S. Nakagawa, 1987, The Journal of biological chemistry.

Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain , gastrointestinal tract , and kidney ( gene / G protein-coupled receptor / neuropeptide )

G. Bell, Yuichiro Yamada, S. Post, 2004 .

A bicyclic amino acid to improve discriminations among transport systems.

M. Handlogten, H. Christensen, R. Zand, 1969, The Journal of biological chemistry.

Importance of main-chain flexibility and the insulin fold in insulin-receptor interactions.

H. Tager, S. Nakagawa, 1993, Biochemistry.

Studies on the conversion of proinsulin to insulin. II. Evidence for a chymotrypsin-like cleavage in the connecting peptide region of insulin precursors in the rat.

D. Steiner, S. Emdin, H. Tager, 1973, The Journal of biological chemistry.

Surface receptors for pancreatic ha hepatocytes: Qualitative and quanti hormone-target cell interactions (insulin/glucagon/pancreatic polypeptide/hepatocyte isolation/horn

H. Arthur, H. Tager, V. Bonnevie-Nielsen, 2016 .

Implications of replacing peptide bonds in the COOH-terminal B chain domain of insulin by the psi (CH2-NH) linker.

T. Schwartz, K. Madsen, N. L. Johansen, 2009, International journal of peptide and protein research.

Insulin-like and glucagon-like peptides in insect hemolymph

K. Kramer, H. Tager, C. N. Childs, 1980 .

Receptor binding and cell-mediated metabolism of [125I]monoiodoglucagon by isolated canine hepatocytes.

W. Hagopian, H. Tager, 1984, The Journal of biological chemistry.

Structural determinants of ligand recognition by type I insulin-like growth factor receptors: use of semisynthetic insulin analog probes.

J. Cara, H. Tager, S. Nakagawa, 1988, Endocrinology.

High titer glucagon antisera.

M. Hohenboken, H. Tager, J. Markese, 1977, Endocrinology.

Isolation of a glucagon-containing peptide: primary structure of a possible fragment of proglucagon.

D. Steiner, H. Tager, 1973, Proceedings of the National Academy of Sciences of the United States of America.

Coupling of peptides to albumin with difluorodinitrobenzene.

H. Tager, 1976, Analytical biochemistry.

Isolation and amino-acid sequence determination of monkey insulin and proinsulin.

D. Steiner, G. Steffens, A. Rubenstein, 1984, Hoppe-Seyler's Zeitschrift fur physiologische Chemie.

Three mutant insulins in man

T. Sanke, S. Shoelson, M. Haneda, 1983, Nature.

Implications of invariant residue LeuB6 in insulin-receptor interactions.

H. Tager, S. Nakagawa, 1991, The Journal of biological chemistry.

Ion-Exchange Method for the Determination of Plasma Ammonia Nitrogen with the Berthelot Reaction

H. Tager, J. R. Elliott, G. R. Kingsley, 1970 .

Heterogeneity of glucagon receptors of rat hepatocytes: a synthetic peptide probe for the high affinity site.

E. Kaiser, R. Assoian, H. Tager, 1984, Biochemical and biophysical research communications.

2-Aminonorbornane-2-carboxylic acid. Preparation, properties, and identification of the four isomers

H. Christensen, H. Tager, 1972 .

Insulin-like hypoglycemic and immunological activities in honeybee royal jelly.

K. Kramer, H. Tager, R. D. Speirs, 1977, Journal of insect physiology.

Glucagon-like and insulin-like hormones of the insect neurosecretory system.

K. Kramer, H. Tager, R. D. Speirs, 1976, The Biochemical journal.

Transport of the four isomers of 2-aminonorbornane-2-carboxylic acid in selected mammalian systems and in Escherichia coli.

H. Christensen, H. Tager, 1971, The Journal of biological chemistry.

Insulin Wakayama: familial mutant insulin syndrome in Japan

K. Polonsky, D. Steiner, T. Sanke, 1987, Diabetologia.

Proteolytic processing in the biosynthesis of insulin and other proteins.

D. Steiner, J. Peterson, W. Kemmler, 1974, Federation proceedings.

Lessons Learned From Molecular Biology of Insulin-Gene Mutations

D. Steiner, T. Sanke, K. Nanjo, 1990, Diabetes Care.

Tumor hypoglycemia: relationship to high molecular weight insulin-like growth factor-II.

K. Polonsky, G. Bell, M. Kew, 1990, The Journal of clinical investigation.

PROCESSING MECHANISMS IN THE BIOSYNTHESIS OF PROTEINS *

D. Steiner, H. Tager, P. Quinn, 1980, Annals of the New York Academy of Sciences.

Formation of biologically active peptides

Å. Lernmark, D. Steiner, K. Gabbay, 1980, Proceedings of the Royal Society of London. Series B. Biological Sciences.

Abnormal Products of the Human Insulin Gene

H. Tager, 1984, Diabetes.

Perturbation of insulin-receptor interactions by intramolecular hormone cross-linking. Analysis of relative movement among residues A1, B1, and B29.

H. Tager, S. Nakagawa, 1989, The Journal of biological chemistry.

Identification of a mutant human insulin predicted to contain a serine-for-phenylalanine substitution.

M Fickova, S. Shoelson, E. Kaiser, 1983, Proceedings of the National Academy of Sciences of the United States of America.

Structural domains and conformational adjustments directing insulin-receptor interactions

R. Mirmira, H. Tager, S. Nakagawa, 1993 .

Importance of aliphatic side-chain structure at positions 2 and 3 of the insulin A chain in insulin-receptor interactions.

H S Tager, S H Nakagawa, H. Tager, 1992, Biochemistry.

Glucagon-like immunoreactivity in insect corpus cardiacum

K. Kramer, H. Tager, J. Markese, 1975, Nature.

Characterization of a glucagon receptor-linked protease from canine hepatic plasma membranes. Partial purification, kinetic analysis, and determination of sites for hormone processing.

H. Tager, M. Sheetz, 1988, The Journal of biological chemistry.

Identification of a Mg(2+)- and guanyl nucleotide-dependent glucagon receptor cycle by use of permeabilized canine hepatocytes.

H. Miyazaki, S. Post, H. Tager, 1992, The Journal of biological chemistry.

Products of Therapeutic Insulins in the Blood of Insulin-dependent (Type I) Diabetic Patients

S. Shoelson, D. Robbins, H. Tager, 1985, Diabetes.

5 – Proteolytic Cleavage in the Posttranslational Processing of Proteins

D. Steiner, H. Tager, P. Quinn, 1980 .

Role of the phenylalanine B25 side chain in directing insulin interaction with its receptor. Steric and conformational effects.

H S Tager, S H Nakagawa, H. Tager, 1986, The Journal of biological chemistry.

A human proinsulin variant at arginine 65

D. Robbins, Y. Kanazawa, P. Blix, 1981, Nature.

A structurally abnormal insulin causing human diabetes

J. Olefsky, M. Kobayashi, O. Kolterman, 1979, Nature.

Biosynthesis of insulin and glucagon.

D. Steiner, H. Tager, C. Patzelt, 1981, Methods in cell biology.

SOME BIOCHEMICAL ASPECTS OF HORMONE EVOLUTION

D. Steiner, H. Tager, S. J. Chan, 1976 .

Biologic and clinical importance of proinsulin.

D. Robbins, A. Rubenstein, H. Tager, 1984, The New England journal of medicine.

The conformational stability and flexibility of insulin with an additional intramolecular cross-link.

D. Brems, H. Tager, S. Nakagawa, 1991, Journal of Biological Chemistry.

Importance of the character and configuration of residues B24, B25, and B26 in insulin-receptor interactions.

R. Mirmira, R G Mirmira, H S Tager, 1991, The Journal of biological chemistry.

Biochemistry: A Functional Approach

H. Tager, 1984 .

Role of the phenylalanine B24 side chain in directing insulin interaction with its receptor. Importance of main chain conformation.

R. Mirmira, R G Mirmira, H S Tager, 1989, The Journal of biological chemistry.

Mutational analysis of invariant valine B12 in insulin: implications for receptor binding.

D. Steiner, H. Tager, S. Nakagawa, 2000, Biochemistry.

Analysis of glucagon-receptor interactions on isolated canine hepatocytes. Formation of reversibly and irreversibly cell-associated hormone.

H. Tager, D. Bharucha, 1990, The Journal of biological chemistry.

The Limitations to and Valid Use of C-Peptide as a Marker of the Secretion of Insulin

K. Polonsky, T. Karrison, W. Pugh, 1986, Diabetes.

Familial hyperproinsulinemia. Two cohorts secreting indistinguishable type II intermediates of proinsulin conversion.

S. Shoelson, D. Robbins, A. Rubenstein, 1984, The Journal of clinical investigation.

Maintenance of the B-chain beta-turn in [GlyB24] insulin mutants: a steady-state fluorescence anisotropy study.

D. Steiner, H. Tager, S. Nakagawa, 1997, Biochemistry.

Human pancreatic icosapeptide: isolation, sequence, and immunocytochemical localization of the COOH-terminal fragment of the pancreatic polypeptide precursor.

T. Schwartz, F. Sundler, R. Håkanson, 1984, Proceedings of the National Academy of Sciences of the United States of America.

Receptor-linked proteolysis of membrane-bound glucagon yields a membrane-associated hormone fragment.

H. Tager, M. Sheetz, 1988, The Journal of biological chemistry.

Glucagon receptors on isolated hepatocytes and hepatocyte membrane vesicles. Discrete populations with ligand- and environment-dependent affinities.

H. Tager, V. Bonnevie‐Nielsen, 1983, The Journal of biological chemistry.

Insect glucagon-like peptides: Evidence for a high molecular weight form in midgut from Manducta sexta (L.)

K. Kramer, H. Tager, 1980 .