A. Barrios

发表

Discovery of a novel series of inhibitors of lymphoid tyrosine phosphatase with activity in human T cells.

Nunzio Bottini, Sheng Li, Tong Liu, 2011, Journal of medicinal chemistry.

Inhibition of lysosomal cysteine proteases by a series of Au(I) complexes: a detailed mechanistic investigation.

A. Barrios, Shamila S. Gunatilleke, 2006, Journal of medicinal chemistry.

A luminogenic lanthanide-based probe for the highly selective detection of nanomolar sulfide levels in aqueous samples.

B. Graham, K. Tuck, A. Barrios, 2017, Chemical communications.

The reactivity of well defined diiron(III) peroxo complexes toward substrates: addition to electrophiles and hydrocarbon oxidation.

S. Lippard, A. Barrios, D. Lecloux, 1999, Bioorganic & Medicinal Chemistry.

Histidine phosphorylation in metalloprotein binding sites.

A. Barrios, Cheryl L Mathis, 2021, Journal of inorganic biochemistry.

Amide Hydrolysis Effected by a Hydroxo-Bridged Dinickel(II) Complex: Insights into the Mechanism of Urease

S. Lippard, A. Barrios, 1999 .

Interaction of Urea with a Hydroxide-Bridged Dinuclear Nickel Center: An Alternative Model for the Mechanism of Urease

S. Lippard, A. Barrios, 2000 .

Scanning the prime-site substrate specificity of proteolytic enzymes: a novel assay based on ligand-enhanced lanthanide ion fluorescence.

C. Craik, A. Barrios, 2002, Bioorganic & medicinal chemistry letters.

Thiuram Disulfides as Pseudo‐irreversible Inhibitors of Lymphoid Tyrosine Phosphatase

R. Baron, N. Bottini, R. Kulkarni, 2013, ChemMedChem.

Identification of cystathionine β-synthase inhibitors using a hydrogen sulfide selective probe.

T. Majtan, J. Kraus, A. Barrios, 2013, Angewandte Chemie.

PTPs: Degrading the Undruggable.

A. Barrios, 2020, Journal of medicinal chemistry.

Identifying potent, selective protein tyrosine phosphatase inhibitors from a library of Au(I) complexes.

N. Bottini, Mark R. Karver, R. Kulkarni, 2009, Journal of medicinal chemistry.

pCAP-based peptide substrates: the new tool in the box of tyrosine phosphatase assays.

N. Bottini, T. Chung, E. Sergienko, 2014, Methods.

Lanthanide complexes as luminogenic probes to measure sulfide levels in industrial samples.

B. Graham, K. Tuck, A. Barrios, 2015, Analytica chimica acta.

Inhibition of lysosomal cysteine proteases by chrysotherapeutic compounds: a possible mechanism for the antiarthritic activity of Au(I).

A. Barrios, Aida Chircorian, 2004, Bioorganic & medicinal chemistry letters.

Tuning the Au(I)-mediated inhibition of cathepsin B through ligand substitutions.

A. Barrios, Shamila S. Gunatilleke, 2008, Journal of inorganic biochemistry.

Efficient delivery of cyclic peptides into mammalian cells with short sequence motifs.

R. Briesewitz, S. Jhiang, D. Pei, 2013, ACS chemical biology.

A highly efficient route to enantiomerically pure l-N-Bz-Pmp(t-Bu)2-OH and incorporation into a peptide-based protein tyrosine phosphatase inhibitor.

A. Barrios, C. Hubbard, 2008, Bioorganic & medicinal chemistry letters.

PEST‐domain‐enriched tyrosine phosphatase and glucocorticoids as regulators of anaphylaxis in mice

M. Garabedian, R. Kulkarni, A. Menon, 2012, Allergy.

Synthesis and PTP Inhibitory Activity of Illudalic Acid and Its Methyl Ether, with Insights into Selectivity for LAR PTP over Other Tyrosine Phosphatases under Physiologically Relevant Conditions.

Paratchata Batsomboon, G. Dudley, A. Barrios, 2019, Journal of natural products.

Small Molecules Targeting PTPσ-Trk Interactions Promote Sympathetic Nerve Regeneration.

Michael S. Cohen, B. Habecker, G. Dudley, 2022, ACS chemical neuroscience.

Highly sensitive peptide-based probes for protein tyrosine phosphatase activity utilizing a fluorogenic mimic of phosphotyrosine.

A. Barrios, S. Mitra, 2005, Bioorganic & medicinal chemistry letters.

Decomposition of alkyl-substituted urea molecules at a hydroxide-bridged dinickel center.

S. Lippard, A. Barrios, 2001, Inorganic chemistry.

Phthalazine-based dinucleating ligands afford dinuclear centers often encountered in metalloenzyme active sites.

S. Lippard, A. Barrios, 2001, Inorganic chemistry.

Diiron Complexes of 1,8-Naphthyridine-Based Dinucleating Ligands as Models for Hemerythrin

S. Lippard, Dongwhan Lee, Chuan He, 2000 .

A high throughput drug screen for Entamoeba histolytica identifies a new lead and target

M. Arkin, J. McKerrow, S. Reed, 2012, Nature Medicine.

Gold(I)-mediated inhibition of protein tyrosine phosphatases: a detailed in vitro and cellular study.

N. Bottini, Mark R. Karver, V. Orrù, 2008, Journal of medicinal chemistry.

Inhibition of cathepsin B by Au(I) complexes: a kinetic and computational study

J. Mccammon, A. Barrios, Shamila S. Gunatilleke, 2008, JBIC Journal of Biological Inorganic Chemistry.

Identifying and characterizing the biological targets of metallotherapeutics: Two approaches using Au(I)-protein interactions as model systems.

Mark R. Karver, A. Barrios, 2008, Analytical biochemistry.

Medicinal inorganic chemistry: a web themed issue.

Seth M. Cohen, M. Lim, A. Barrios, 2013, Chemical communications.

Intracellular metal detectors.

A. Barrios, 2006, ACS Chemical Biology.

Synthesis of 2-Alkyl-3-hydroxy-4-pyridinone-ribonucleosides, Potential Oral Iron Chelators

Gang Liu, S. Miller, A. Barrios, 1995 .

Rational design of a SHP-2 targeted, fluorogenic peptide substrate.

A. Barrios, Elena S. Ma, 2019, Bioorganic & medicinal chemistry letters.

Cellular biochemistry methods for investigating protein tyrosine phosphatases.

N. Bottini, Vanessa F Ahmed, S. Stanford, 2014, Antioxidants & redox signaling.

Early Endosomal Escape of a Cyclic Cell-Penetrating Peptide Allows Effective Cytosolic Cargo Delivery

N. Selner, D. Pei, Ziqing Qian, 2014, Biochemistry.

Profiling protein tyrosine phosphatase activity with mechanistic probes.

D. Krishnamurthy, A. Barrios, 2009, Current opinion in chemical biology.

In Vitro Assays for Measuring Protein Histidine Phosphatase Activity.

A. Barrios, Brandon S McCullough, 2020, Methods in molecular biology.

Dual colorimetric and fluorogenic probes for visualizing tyrosine phosphatase activity.

J. Round, K. Ullman, Colin W. Russell, 2017, Chemical communications.

Covalent Inhibition of the Lymphoid Tyrosine Phosphatase

N. Bottini, A. Barrios, Vanessa Ahmed, 2014, ChemMedChem.

A potent and selective small-molecule inhibitor for the lymphoid-specific tyrosine phosphatase (LYP), a target associated with autoimmune diseases.

Nunzio Bottini, N. Bottini, Zhon-Yin Zhang, 2013, Journal of medicinal chemistry.

Substrate Selection Influences Molecular Recognition in a Screen for Lymphoid Tyrosine Phosphatase Inhibitors

R. Baron, N. Bottini, R. Kulkarni, 2013, Chembiochem : a European journal of chemical biology.

High-throughput screen using a single-cell tyrosine phosphatase assay reveals biologically active inhibitors of tyrosine phosphatase CD45

S. Zhang, N. Bottini, S. Damle, 2012, Proceedings of the National Academy of Sciences.

Identifying Selective Protein Tyrosine Phosphatase Substrates and Inhibitors from a Fluorogenic, Combinatorial Peptide Library

A. Barrios, S. Mitra, 2008, Chembiochem : a European journal of chemical biology.

Oxidative inactivation of the lymphoid tyrosine phosphatase mediated by both general and active site directed NO donors.

A. Barrios, Caitlin E Karver, Vanessa Ahmed, 2011, Bioorganic & medicinal chemistry letters.

A series of peptide-based, fluorogenic probes for protein tyrosine phosphatase activity.

A. Barrios, S. Mitra, 2007, Analytical biochemistry.

Faculty Opinions recommendation of New uses for old drugs. Auranofin, a clinically established antiarthritic metallodrug, exhibits potent antimalarial effects in vitro: Mechanistic and pharmacological implications.

A. Barrios, 2008 .

Fluorogenic probes for imaging cellular phosphatase activity.

A. Barrios, Brandon S McCullough, 2020, Current opinion in chemical biology.

Modeling the Diiron Centers of Non-Heme Iron Enzymes. Preparation of Sterically Hindered Diiron(II) Tetracarboxylate Complexes and Their Reactions with Dioxygen

Stephen J. Lippard, S. Lippard, A. Barrios, 1998 .

Marine natural products as inhibitors of cystathionine beta-synthase activity.

M. K. Harper, C. Ireland, R. V. van Wagoner, 2015, Bioorganic & medicinal chemistry letters.

Inhibition of the lymphoid tyrosine phosphatase: the effect of zinc(II) ions and chelating ligand fragments on enzymatic activity.

Seth M. Cohen, A. Barrios, D. Puerta, 2014, Bioorganic & medicinal chemistry letters.

Auranofin is an apoptosis-simulating agent with in vitro and in vivo anti-leishmanial activity.

J. Lazo, M. Hickman, David A. Close, 2014, ACS chemical biology.

Gold(I) phosphine mediated selective inhibition of lymphoid tyrosine phosphatase.

N. Bottini, Mark R. Karver, D. Krishnamurthy, 2010, Journal of inorganic biochemistry.

Spectroscopic evidence for the formation of goldfingers.

A. Barrios, Matthew A. Franzman, 2008, Inorganic chemistry.

Gold(I) phosphine mediated selective inhibition of lymphoid tyrosine phosphatase.

N. Bottini, Mark R. Karver, D. Krishnamurthy, 2010, Journal of inorganic biochemistry.

Inhibition of the lymphoid tyrosine phosphatase: the effect of zinc(II) ions and chelating ligand fragments on enzymatic activity.

Seth M. Cohen, A. Barrios, Megan K. Thorson, 2014, Bioorganic & medicinal chemistry letters.