Lesley J. Murray

发表

Design of Selective PAK1 Inhibitor G-5555: Improving Properties by Employing an Unorthodox Low-pK a Polar Moiety.

Xianrui Zhao, Ignacio Aliagas, Ronen Marmorstein, 2015, ACS medicinal chemistry letters.

Structure-Based Design of GNE-495, a Potent and Selective MAP4K4 Inhibitor with Efficacy in Retinal Angiogenesis.

Kevin Chen, Ping Wu, Stephen Schmidt, 2015, ACS medicinal chemistry letters.

Discovery of dihydrothieno- and dihydrofuropyrimidines as potent pan Akt inhibitors.

Tyler T. Risom, J. Blake, B. Brandhuber, 2010, Bioorganic & medicinal chemistry letters.

Second generation 2-pyridyl biphenyl amide inhibitors of the hedgehog pathway.

D. Sutherlin, Leslie B. Lee, F. D. de Sauvage, 2010, Bioorganic & medicinal chemistry letters.

In vivo Antitumor Activity of MEK and Phosphatidylinositol 3-Kinase Inhibitors in Basal-Like Breast Cancer Models

Wei Zhou, Guy Cavet, Zachary Boyd, 2009, Clinical Cancer Research.

Discovery of a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins and clinical candidate for the treatment of cancer (GDC-0152).

Zhaoyang Wen, Brigitte Maurer, Vickie Tsui, 2012, Journal of medicinal chemistry.

Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents

David P. Davis, K. Hoeflich, L. Friedman, 2008, The Journal of cell biology.

Antitumor efficacy of the novel RAF inhibitor GDC-0879 is predicted by BRAFV600E mutational status and sustained extracellular signal-regulated kinase/mitogen-activated protein kinase pathway suppression.

M. Belvin, S. Seshagiri, Z. Modrušan, 2009, Cancer research.

Chemically Diverse Group I p21-Activated Kinase (PAK) Inhibitors Impart Acute Cardiovascular Toxicity with a Narrow Therapeutic Window.

I. Aliagas, K. Hoeflich, Weiru Wang, 2016, Journal of medicinal chemistry.

pHUSH: a single vector system for conditional gene expression

David P. Davis, S. Seshagiri, K. Hoeflich, 2007 .

Leveraging the Pre-DFG Residue Thr-406 To Obtain High Kinase Selectivity in an Aminopyrazole-Type PAK1 Inhibitor Series.

F. Diederich, G. Manning, I. Aliagas, 2015, ACS medicinal chemistry letters.

GDC-0449-a potent inhibitor of the hedgehog pathway.

K. Kotkow, L. Rubin, D. Sutherlin, 2009, Bioorganic & medicinal chemistry letters.

Design and evaluation of 1,7-naphthyridones as novel KDM5 inhibitors.

Jun Liang, P. Trojer, R. Cummings, 2016, Bioorganic & medicinal chemistry letters.

From a novel HTS hit to potent, selective, and orally bioavailable KDM5 inhibitors.

Jun Liang, P. Trojer, Y. Ran, 2017, Bioorganic & medicinal chemistry letters.

Lead optimization of a pyrazolo[1,5-a]pyrimidin-7(4H)-one scaffold to identify potent, selective and orally bioavailable KDM5 inhibitors suitable for in vivo biological studies.

Jun Liang, P. Trojer, R. Cummings, 2016, Bioorganic & medicinal chemistry letters.

Fragment-based identification and optimization of a class of potent pyrrolo[2,1-f][1,2,4]triazine MAP4K4 inhibitors.

Anthony M Giannetti, Ping Wu, Brandon J. Bravo, 2014, Bioorganic & medicinal chemistry letters.

Rate-Determining and Rate-Limiting Steps in the Clearance and Excretion of a Potent and Selective p21-Activated Kinase Inhibitor: A Case Study of Rapid Hepatic Uptake and Slow Elimination in Rat

J. Rudolph, Ning Liu, M. Durk, 2016, Drug metabolism letters.

Structure-Guided Design of Group I Selective p21-Activated Kinase Inhibitors.

I. Aliagas, K. Hoeflich, Weiru Wang, 2015, Journal of medicinal chemistry.

Discovery of selective 4-Amino-pyridopyrimidine inhibitors of MAP4K4 using fragment-based lead identification and optimization.

Anthony M Giannetti, Ping Wu, Brandon J. Bravo, 2014, Journal of medicinal chemistry.

Discovery of a Potent (4 R,5 S)-4-Fluoro-5-methylproline Sulfonamide Transient Receptor Potential Ankyrin 1 Antagonist and Its Methylene Phosphate Prodrug Guided by Molecular Modeling.

C. Brotherton-Pleiss, M. Volgraf, Jun Chen, 2018, Journal of medicinal chemistry.

Corrigendum to “GDC-0449—A potent inhibitor of the hedgehog pathway” [Bioorg. Med. Chem. Lett. 19 (2009) 5576]

K. Kotkow, L. Rubin, D. Sutherlin, 2010 .

pHUSH: a single vector system for conditional gene expression

David P. Davis, S. Seshagiri, K. Hoeflich, 2007, BMC Biotechnology.

Structure-Guided Design of Group I Selective p21-Activated Kinase Inhibitors.

I. Aliagas, K. Hoeflich, Weiru Wang, 2015, Journal of medicinal chemistry.

pHUSH: a single vector system for conditional gene expression

David P. Davis, S. Seshagiri, K. Hoeflich, 2007, BMC Biotechnology.