D. O’Boyle

发表

HCV NS5A replication complex inhibitors. Part 5: discovery of potent and pan-genotypic glycinamide cap derivatives.

A. Good, N. Meanwell, J. Lemm, 2013, Bioorganic & medicinal chemistry letters.

Latent herpes simplex virus type 1 transcripts in peripheral and central nervous system tissues of mice map to similar regions of the viral genome

E. Lavi, N. Fraser, D. O’Boyle, 1988, Journal of virology.

Discovery and development of hepatitis C virus NS5A replication complex inhibitors.

N. Meanwell, D. Langley, J. Lemm, 2014, Journal of medicinal chemistry.

Deletion of the VP16 open reading frame of herpes simplex virus type 1

S. Weinheimer, D. O’Boyle, Boyd, 1992, Journal of virology.

Hepatitis C virus NS5A replication complex inhibitors: the discovery of daclatasvir.

L. Hamann, A. Fura, N. Meanwell, 2014, Journal of medicinal chemistry.

In vitro proteolytic activity and active-site identification of the human cytomegalovirus protease.

C. Mapelli, M. Hail, S. Weinheimer, 1994, European journal of biochemistry.

The Effect of Internal Autocleavage on Kinetic Properties of the Human Cytomegalovirus Protease Catalytic Domain (*)

K. Wager-Smith, S. Weinheimer, D. O’Boyle, 1995, The Journal of Biological Chemistry.

Investigation of the specificity of the herpes simplex virus type 1 protease by point mutagenesis of the autoproteolysis sites

I. Deckman, P. Mccann, D. O’Boyle, 1994, Journal of virology.

HCV NS5A replication complex inhibitors. Part 4. Optimization for genotype 1a replicon inhibitory activity.

N. Meanwell, J. Lemm, B. Pearce, 2014, Journal of medicinal chemistry.

Substrate requirements of the HSV-1 and CMV proteases in vitro using peptides derived from their maturation and release sites

C. Mapelli, S. Weinheimer, C. Meyers, 1995 .

Inhibitors of HCV NS5A: From Iminothiazolidinones to Symmetrical Stilbenes.

N. Meanwell, M. Deshpande, Scott W. Martin, 2011, ACS medicinal chemistry letters.

Development of a Cell-Based High-Throughput Specificity Screen Using a Hepatitis C Virus-Bovine Viral Diarrhea Virus Dual Replicon Assay

J. Lemm, R. Colonno, M. Gao, 2005, Antimicrobial Agents and Chemotherapy.

Comparison of Daclatasvir Resistance Barriers on NS5A from Hepatitis C Virus Genotypes 1 to 6: Implications for Cross-Genotype Activity

B. Kienzle, Lingling Jia, M. Gao, 2014, Antimicrobial Agents and Chemotherapy.

HCV NS5A replication complex inhibitors. Part 3: discovery of potent analogs with distinct core topologies.

A. Good, N. Meanwell, J. Lemm, 2013, Bioorganic & medicinal chemistry letters.

Hepatitis C virus NS5A replication complex inhibitors. Part 6: Discovery of a novel and highly potent biarylimidazole chemotype with inhibitory activity toward genotypes 1a and 1b replicons.

A. Good, N. Meanwell, J. Lemm, 2014, Journal of medicinal chemistry.

Latent herpes simplex virus type 1 transcription in human trigeminal ganglia

E. Lavi, N. Fraser, D. O’Boyle, 1988, Journal of virology.

Genotypic and phenotypic analysis of variants resistant to hepatitis C virus nonstructural protein 5A replication complex inhibitor BMS‐790052 in Humans: In Vitro and In Vivo Correlations

Xin Huang, Min Gao, Susan Roberts, 2011, Hepatology.

Persistence of Resistant Variants in Hepatitis C Virus-Infected Patients Treated with the NS5A Replication Complex Inhibitor Daclatasvir

M. Gao, R. Fridell, Jin‐Hua Sun, 2013, Antimicrobial Agents and Chemotherapy.

Restriction endonuclease patterns of cytomegalovirus after passage in humans.

S. Plotkin, D. O’Boyle, N. Fraser, 1987, The Journal of infectious diseases.

Functional conservations of the alkaline nuclease of herpes simplex type 1 and human cytomegalovirus.

W. Newcomb, J. Brown, S. Weller, 1998, Virology.

Hepatitis C Virus RNA Elimination and Development of Resistance in Replicon Cells Treated with BMS-790052

Lingling Jia, M. Gao, R. Fridell, 2012, Antimicrobial Agents and Chemotherapy.

In Vitro Activity of BMS-790052 on Hepatitis C Virus Genotype 4 NS5A

Lingling Jia, M. Gao, R. Fridell, 2011, Antimicrobial Agents and Chemotherapy.

Identification of Hepatitis C Virus NS5A Inhibitors

N. Meanwell, M. Deshpande, Scott W. Martin, 2009, Journal of Virology.

The effects of NS5A inhibitors on NS5A phosphorylation, polyprotein processing and localization.

L. Hamann, N. Meanwell, J. Lemm, 2011, The Journal of general virology.

Specific Inhibition of Bovine Viral Diarrhea Virus Replicase

J. Lemm, R. Colonno, M. Gao, 2003, Journal of Virology.

HCV NS5A replication complex inhibitors.

M. Gao, D. O’Boyle, S. Roberts, 2016, Current opinion in pharmacology.

Resensitizing daclatasvir-resistant hepatitis C variants by allosteric modulation of NS5A

Min Gao, Nicholas A. Meanwell, Yong Tu, 2015, Nature.

HCV NS5A replication complex inhibitors. Part 2: investigation of stilbene prolinamides.

N. Meanwell, J. Lemm, M. Gao, 2012, Bioorganic & medicinal chemistry letters.

Stimulation of the Herpes Simplex Virus Type I Protease by Antichaeotrophic Salts (*)

I. Deckman, R. Colonno, S. Weinheimer, 1995, The Journal of Biological Chemistry.

Identification of a novel peptide substrate of HSV-1 protease using substrate phage display.

S. Weinheimer, K. Pokornowski, D. O’Boyle, 1997, Virology.

Autoproteolysis of herpes simplex virus type 1 protease releases an active catalytic domain found in intermediate capsid particles

I. Deckman, M. Cordingley, B. Roizman, 1993, Journal of virology.

Identification of the serine residue at the active site of the herpes simplex virus type 1 protease.

R. Colonno, S. Weinheimer, D. O’Boyle, 1994, The Journal of biological chemistry.

Synergistic Activity of Combined NS5A Inhibitors

N. Meanwell, M. Cockett, M. Gao, 2015, Antimicrobial Agents and Chemotherapy.