I. Linney

发表

2,7-Dioxo-2,3,4,5,6,7-hexahydro-1H-benzo[h][1,4]diazonine as a new template for the design of CCK(2) receptor antagonists.

J. G. Vinter, C. Low, M. Tozer, 2000, Journal of medicinal chemistry.

Design, Synthesis, and Structure−Activity Relationships of Novel Non-Imidazole Histamine H3 Receptor Antagonists

N. Shankley, I. Buck, S. Kalindjian, 2000 .

Discovery of a novel class of inhaled dual pharmacology muscarinic antagonist and β2 agonist (MABA) for the treatment of chronic obstructive pulmonary disease (COPD).

B. Riccardi, A. Rizzi, N. Cesari, 2021, Bioorganic & medicinal chemistry letters.

A highly selective and potent HPK1 inhibitor enhances immune cell activation and induces robust tumor growth inhibition in a murine syngeneic tumor model

P. Tummino, I. Waddell, D. Ciccone, 2020, European Journal of Cancer.

Recoverable chiral sulfoxides for asymmetric synthesis: application to stereoselective carbonyl reduction and the asymmetric synthesis of allylic alcohols

Heather Tye, M. Mahon, M. Wills, 1996 .

Discovery of Clinical Candidate CHF-6366: A Novel Super-soft Dual Pharmacology Muscarinic Antagonist and β2 Agonist (MABA) for the Inhaled Treatment of Respiratory Diseases.

S. Catinella, L. Venturi, P. Puccini, 2022, Journal of medicinal chemistry.

Novel, achiral 1,3,4-benzotriazepine analogues of 1,4-benzodiazepine-based CCK(2) antagonists that display high selectivity over CCK(1) receptors.

C. Low, C. Austin, I. Buck, 2006, Journal of medicinal chemistry.

Optimization of the in vitro and in vivo properties of a novel series of 2,4,5-trisubstituted imidazoles as potent cholecystokinin-2 (CCK2) antagonists.

J. Black, C. Low, N. Shankley, 2005, Journal of medicinal chemistry.

The asymmetric synthesis of allylic alcohols using a recoverable chiral sulphoxide

Heather Tye, M. Wills, I. Linney, 1994 .

A new class of recoverable chiral sulphoxide: Application to the asymmetric synthesis of β-hydroxy esters.

M. Wills, I. Linney, R. Butlin, 1992 .

Recoverable chiral sulfoxides for asymmetric synthesis: preparation, regeneration and application to the asymmetric aldol reaction

M. Mahon, M. Wills, I. Linney, 1993 .

Partial reduction of annulated heterocycles as a general route to medium rings containing oxygen and nitrogen.

T. Donohoe, M. Helliwell, I. Linney, 2001, Organic letters.

Flexible strategy for the synthesis of pyrrolizidine alkaloids.

T. Donohoe, I. Linney, G. Bhalay, 2008, Organic letters.

Achiral, selective CCK2 receptor antagonists based on a 1,3,5-benzotriazepine-2,4-dione template.

Eric Griffin, I. M. Mcdonald, I. Linney, 2008, Bioorganic & medicinal chemistry.

Discovery and characterization of novel, potent, non-peptide parathyroid hormone-1 receptor antagonists.

C. Low, C. Austin, D. Sykes, 2007, Journal of medicinal chemistry.

Optimization of 1,3,4-benzotriazepine-based CCK(2) antagonists to obtain potent, orally active inhibitors of gastrin-mediated gastric acid secretion.

J. Black, D. Sykes, I. Buck, 2007, Journal of medicinal chemistry.

A New Class of Recoverable Chiral Sulfoxide: Application to the Asymmetric Synthesis of β‐Hydroxy Esters.

M. Wills, I. Linney, R. Butlin, 2010 .

The Asymmetric Synthesis of Allylic Alcohols Using a Recoverable Chiral Sulfoxide.

Heather Tye, M. Wills, I. Linney, 2010 .

Synthesis of enantiopure dihydropyranones: aldol-based ring expansion of dihydrofurans.

T. Donohoe, M. Helliwell, A. Cowley, 2002, Organic letters.

Recoverable Chiral Sulfoxides for Asymmetric Synthesis: Preparation, Regeneration and Application to the Asymmetric Aldol Reaction.

M. Mahon, M. Wills, I. Linney, 1993 .

A Convenient Synthesis of N-Alkyl-(E)-1-alkenesulfonamides

A. Woolford, M. Tozer, I. Linney, 1998 .

Inhibitors of immuno-oncology target HPK1 – a patent review (2016 to 2020)

I. Linney, N. Kaila, 2021, Expert opinion on therapeutic patents.

Flexible strategy for the synthesis of pyrrolizidine alkaloids.

T. Donohoe, I. Linney, G. Bhalay, 2008, Organic letters.