J. Witherington

发表

HIGHLIGHTS OF THE SOCIETY FOR MEDICINES RESEARCH SYMPOSIUM: APPROACHES TO LEAD GENERATION

P. Jeffrey, R. Lock, J. Witherington, 2009 .

6-heteroaryl-pyrazolo[3,4-b]pyridines: potent and selective inhibitors of glycogen synthase kinase-3 (GSK-3).

A. Naylor, A. Takle, J. Witherington, 2003, Bioorganic & medicinal chemistry letters.

5‐hydroxyindalpine, an agonist at the putative 5‐HT1P receptor, has no activity on human recombinant monoamine receptors but accelerates distension‐induced peristalsis in mouse isolated colon

G. Sanger, K. Lee, S. Ociepka, 2009, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

Oral administration of a centrally acting ghrelin receptor agonist to conscious rats triggers defecation

A. Muir, S. Butler, G. Sanger, 2009, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

Evidence that stimulation of ghrelin receptors in the spinal cord initiates propulsive activity in the colon of the rat

G. Sanger, J. Furness, D. Ferens, 2006, The Journal of physiology.

Functional and in situ hybridization evidence that preganglionic sympathetic vasoconstrictor neurons express ghrelin receptors

G. Sanger, J. Furness, P. Kitchener, 2010, Neuroscience.

Conformationally restricted indolopiperidine derivatives as potent CCR2B receptor antagonists.

I. Forbes, P. Groot, R. Ife, 2001, Bioorganic & medicinal chemistry letters.

Pyridone derivatives as potent and selective VLA-4 integrin antagonists.

N. Parr, A. Naylor, A. Takle, 2006, Bioorganic & medicinal chemistry letters.

Diastereoselective synthesis, activity and chiral stability of cyclic alkoxyketone inhibitors of cathepsin K.

R. Ife, J. Witherington, A. Gribble, 2001, Bioorganic & medicinal chemistry letters.

Solid-phase synthesis of cyclic alkoxyketones, inhibitors of the cysteine protease cathepsin K.

B. Garnier, R. Ife, J. Witherington, 2001, Bioorganic & medicinal chemistry letters.

CCR2: characterization of the antagonist binding site from a combined receptor modeling/mutagenesis approach.

I. Forbes, F. Blaney, A. Bridges, 2003, Journal of medicinal chemistry.

Effect of Superior Ovarian Nerve and Plexus Nerve Sympathetic Denervation on Ovarian-Derived Infertility Provoked by Estradiol Exposure to Rats

A. Sridhar, M. Del Campo, J. Witherington, 2019, Front. Physiol..

GSK189254, a Novel H3 Receptor Antagonist That Binds to Histamine H3 Receptors in Alzheimer's Disease Brain and Improves Cognitive Performance in Preclinical Models

Michael A. Briggs, Neil Upton, Robert P. Davis, 2007, Journal of Pharmacology and Experimental Therapeutics.

Cyclic ketone inhibitors of the cysteine protease cathepsin K.

Y. Ru, D. Veber, M. Hemling, 2001, Journal of medicinal chemistry.

Neuronal control of experimental colitis occurs via sympathetic intestinal innervation

A. Sridhar, J. Seppen, S. Meijer, 2018, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

Human-relevant near-organ neuromodulation of the immune system via the splenic nerve

D. Chew, Jason A. Miranda, D. Werling, 2021, Proceedings of the National Academy of Sciences.

5-aryl-pyrazolo[3,4-b]pyridines: potent inhibitors of glycogen synthase kinase-3 (GSK-3).

M. Saunders, J. Liddle, S. Garland, 2003, Bioorganic & medicinal chemistry letters.

Pyridone derivatives as potent, orally bioavailable VLA-4 integrin antagonists.

A. Naylor, A. Takle, J. Witherington, 2006, Bioorganic & medicinal chemistry letters.

Quantification of clinically applicable stimulation parameters for precision near-organ neuromodulation of human splenic nerves

E. Neufeld, N. Kuster, M. Schiefer, 2020, Communications Biology.

5-aryl-pyrazolo[3,4-b]pyridazines: potent inhibitors of glycogen synthase kinase-3 (GSK-3).

R. Ife, D. M. Hickey, D. Haigh, 2003, Bioorganic & medicinal chemistry letters.

6-aryl-pyrazolo[3,4-b]pyridines: potent inhibitors of glycogen synthase kinase-3 (GSK-3).

A. Naylor, A. Takle, J. Witherington, 2003, Bioorganic & Medicinal Chemistry Letters.

Identification of clinical candidates from the benzazepine class of histamine H3 receptor antagonists.

David M. Wilson, A. Medhurst, P. Jeffrey, 2013, Bioorganic & medicinal chemistry letters.

Therapeutic approaches towards the treatment of gastroinstestinal disorders.

J. Witherington, S. Collingwood, 2007, Drug news & perspectives.

Recent disclosures of clinical drug candidates.

J. Witherington, R. Armer, Peter Warne, 2008, Drug news & perspectives.