Ning Gao

发表

Pyrrolamide DNA Gyrase Inhibitors: Fragment-Based Nuclear Magnetic Resonance Screening To Identify Antibacterial Agents

Ning Gao, Haihong Ni, Oluyinka Green, 2011, Antimicrobial Agents and Chemotherapy.

Identification through structure-based methods of a bacterial NAD(+)-dependent DNA ligase inhibitor that avoids known resistance mutations.

P. Boriack-Sjodin, Kerry E. Murphy-Benenato, Ning Gao, 2014, Bioorganic & medicinal chemistry letters.

Mechanism of Action for Respiratory Syncytial Virus Inhibitor RSV604

Olga Yuzhakov, Andrew D. Scott, Sreerupa Challa, 2014, Antimicrobial Agents and Chemotherapy.

EED-Targeted PROTACs Degrade EED, EZH2, and SUZ12 in the PRC2 Complex.

David M. Wilson, Fiona Pachl, S. Fawell, 2019, Cell chemical biology.

ETX2514 is a broad-spectrum β-lactamase inhibitor for the treatment of drug-resistant Gram-negative bacteria including Acinetobacter baumannii

D. Ehmann, S. McLeod, Camilo Velez-Vega, 2017, Nature Microbiology.

Development of a novel BCL6 PROTAC to provide insight into small molecule targeting of BCL6

David M. Wilson, Qing Cao, M. Waring, 2018 .

Development of a Novel B-Cell Lymphoma 6 (BCL6) PROTAC To Provide Insight into Small Molecule Targeting of BCL6.

David M. Wilson, Qing Cao, M. Waring, 2018, ACS chemical biology.

Discovery of Pyrazolo[1,5-a]pyrimidine B-Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors.

Matthew Grist, C. Chuaqui, Qing Cao, 2017, Journal of medicinal chemistry.

Time-dependent, reversible, oxaborole inhibition of Escherichia coli leucyl-tRNA synthetase measured with a continuous fluorescence assay.

A. Shapiro, Ning Gao, D. McKinney, 2012, Analytical biochemistry.

Structure‐Based Design of Selective Noncovalent CDK12 Inhibitors

Toan B. Nguyen, M. Haddrick, A. Ferguson, 2018, ChemMedChem.

miR-99b-3p is induced by vitamin D3 and contributes to its antiproliferative effects in gastric cancer cells by targeting HoxD3

Chen Huang, Haopeng Li, Yang Yang, 2019, Biological chemistry.

Fluorescence anisotropy-based measurement of Pseudomonas aeruginosa penicillin-binding protein 2 transpeptidase inhibitor acylation rate constants.

A. Shapiro, Ning Gao, Jason Thresher, 2014, Analytical biochemistry.

Overexpression of Pseudomonas aeruginosa LpxC with its inhibitors in an acrB-deficient Escherichia coli strain.

S. McLeod, P. Ross, F. Reck, 2014, Protein expression and purification.

Target-Based Resistance in Pseudomonas aeruginosa and Escherichia coli to NBTI 5463, a Novel Bacterial Type II Topoisomerase Inhibitor

T. Dougherty, D. Ehmann, F. Reck, 2014, Antimicrobial Agents and Chemotherapy.

Continuous fluorescence anisotropy-based assay of BOCILLIN FL penicillin reaction with penicillin binding protein 3.

A. Shapiro, Ning Gao, Jason Thresher, 2013, Analytical biochemistry.

A Homogeneous, High-Throughput-Compatible, Fluorescence Intensity–Based Assay for UDP-N-Acetylenolpyruvylglucosamine Reductase (MurB) with Nanomolar Product Detection

James D. Whiteaker, Jian Huang, A. Shapiro, 2012, Journal of biomolecular screening.

A High-Throughput, Homogeneous, Fluorescence Resonance Energy Transfer-Based Assay for Phospho-N-acetylmuramoyl-pentapeptide Translocase (MraY)

A. Shapiro, Ning Gao, H. Jahić, 2012, Journal of biomolecular screening.

In Vitro Validation of Acetyltransferase Activity of GlmU as an Antibacterial Target in Haemophilus influenzae*

L. Otterbein, T. Keating, S. Lahiri, 2011, The Journal of Biological Chemistry.

The Cholesterol-Binding Sequence in Monomeric C-Reactive Protein Binds to the SARS-CoV-2 Spike Receptor-Binding Domain and Blocks Interaction With Angiotensin-Converting Enzyme 2

Ning Gao, Xiao-ling Liu, Hai-yun Li, 2022, Frontiers in Immunology.

Synthesis, Structure, and SAR of Tetrahydropyran-Based LpxC Inhibitors.

Matthew D. Miller, P. Ross, Michael R. Hale, 2014, ACS medicinal chemistry letters.

Exploring the UDP pocket of LpxC through amino acid analogs.

Matthew D. Miller, Wei Yang, P. Ross, 2013, Bioorganic & medicinal chemistry letters.

High-throughput, homogeneous, fluorescence intensity-based measurement of adenosine diphosphate and other ribonucleoside diphosphates with nanomolar sensitivity.

A. Shapiro, Ning Gao, L. Hajec, 2011, Analytical biochemistry.

Cytotoxicities, telomerase and topoisomerases I inhibitory activities and interactions of terpyridine derivatives with DNAs

Chunying Wei, Ning Gao, 2015, Chemical Research in Chinese Universities.

Selective inhibitors of bacterial t-RNA-(N(1)G37) methyltransferase (TrmD) that demonstrate novel ordering of the lid domain.

Ning Gao, T. Grebe, Jian Huang, 2013, Journal of medicinal chemistry.

Phase-selective gelators based on closed-chain glucose derivatives: their applications in the removal of dissolved aniline/nitrobenzene, and toxic dyes from contaminated water

Xin Zhang, Ning Gao, Ning Xu, 2015 .

Novel Rapidly Diversifiable Antimicrobial RNA Polymerase Switch Region Inhibitors with Confirmed Mode of Action in Haemophilus influenzae

D. Moustakas, A. Shapiro, Ning Gao, 2012, Journal of bacteriology.

Decoding the Mechanism of Shen Qi Sha Bai Decoction in Treating Acute Myeloid Leukemia Based on Network Pharmacology and Molecular Docking

Shuangnian Xu, Ning Gao, Xin Ding, 2021, Frontiers in Cell and Developmental Biology.

Interactions of the Diazabicyclooctane Serine β-Lactamase Inhibitor ETX1317 with Target Enzymes

A. Shapiro, Ning Gao, 2020, ACS infectious diseases.

Ceftazidime-Avibactam Resistance Mutations V240G, D179Y, and D179Y/T243M in KPC-3 β-Lactamase Do Not Alter Cefpodoxime-ETX1317 Susceptibility.

Alita A. Miller, A. Shapiro, Samir H. Moussa, 2020, ACS infectious diseases.

Kinetics of Avibactam Inhibition against Class A, C, and D β-Lactamases

D. Ehmann, P. Ross, S. Fisher, 2013, The Journal of Biological Chemistry.

Reversibility of Covalent, Broad-Spectrum Serine β-Lactamase Inhibition by the Diazabicyclooctenone ETX2514.

April Chen, Alita A. Miller, A. Shapiro, 2017, ACS infectious diseases.

Mode Of Inhibition of a novel DNA gyrase inhibitor with activity against Neisseria gonorrhoeae Inhibition of Neisseria gonorrhoeae type II Topoisomerases by the Novel Spiropyrimidinetrione AZD 0914 * #

D. Ehmann, P. Doig, S. D. Mills, 2015 .

Antibacterial Therapy (PPAT) To Validate PPAT as a Target for -Phosphopantetheine Adenylyltransferase ' Discovery of Inhibitors of 4

M. Johnstone, Ning Gao, Jason Thresher, 2014 .

Discovery of Inhibitors of 4′-Phosphopantetheine Adenylyltransferase (PPAT) To Validate PPAT as a Target for Antibacterial Therapy

H. Ni, M. Johnstone, S. Lahiri, 2013, Antimicrobial Agents and Chemotherapy.

Negamycin induces translational stalling and miscoding by binding to the small subunit head domain of the Escherichia coli ribosome

Matthew D. Miller, J. Cate, A. Ferguson, 2014, Proceedings of the National Academy of Sciences.

Rapid identification of novel allosteric PRC2 inhibitors.

A. Bloecher, K. Jones, P. Rawlins, 2019, ACS chemical biology.

Molecular Mechanisms of Sulbactam Antibacterial Activity and Resistance Determinants in Acinetobacter baumannii

D. Ehmann, M. Huband, R. Giacobbe, 2015, Antimicrobial Agents and Chemotherapy.

Quantitative investigation of the affinity of human respiratory syncytial virus phosphoprotein C-terminus binding to nucleocapsid protein

G. Sproat, R. Overman, A. Shapiro, 2014, Virology Journal.

Novel Bacterial NAD+-Dependent DNA Ligase Inhibitors with Broad-Spectrum Activity and Antibacterial Efficacy In Vivo

Kenneth D. Johnson, Wei Yang, A. Eakin, 2010, Antimicrobial Agents and Chemotherapy.

The Role of a Novel Auxiliary Pocket in Bacterial Phenylalanyl-tRNA Synthetase Druggability

S. McLeod, A. Ferguson, A. Shapiro, 2014, The Journal of Biological Chemistry.

Structure guided understanding of NAD+ recognition in bacterial DNA ligases.

S. D. Mills, S. Lahiri, G. Walkup, 2012, ACS chemical biology.

In Vivo Activity and Antibacterial Efficacy Ligase Inhibitors with Broad-Spectrum

Kenneth D. Johnson, A. Eakin, S. D. Mills, 2013 .

Novel Bacterial NAD +-dependent DNA Ligase Inhibitors with 3 Broad Spectrum Activity and Antibacterial Efficacy In Vivo 4 5 6 Running title : Novel Bacterial NAD +-dependent DNA Ligase Inhibitors 7 8 9

Kenneth D. Johnson, Wei Yang, A. Eakin, 2010 .

A homogeneous, high-throughput fluorescence resonance energy transfer-based DNA polymerase assay.

A. Shapiro, Ning Gao, L. Hajec, 2005, Analytical biochemistry.

A Homogeneous, High-Throughput Fluorescence Anisotropy-Based DNA Supercoiling Assay

D. Ehmann, S. Prasad, A. Shapiro, 2010, Journal of biomolecular screening.

A Homogeneous, High-Thr oughput Fluor escence Anisotropy-Based DNA Super coiling Assay

S. Prasad, A. Shapiro, Ning Gao, 2010 .

Crystal structure of A. aeolicus LpxC with bound product suggests alternate deacetylation mechanism

Matthew D. Miller, P. Ross, N. Olivier, 2015, Proteins.

Inhibition of Neisseria gonorrhoeae Type II Topoisomerases by the Novel Spiropyrimidinetrione AZD0914*

D. Ehmann, G. Basarab, P. Doig, 2015, The Journal of Biological Chemistry.

Target-Based Whole-Cell Screening by 1H NMR Spectroscopy

Qing Cao, A. Breeze, S. McLeod, 2015, Angewandte Chemie.

Real-Time Monitoring of New Delhi Metallo-β-Lactamase Activity in Living Bacterial Cells by 1H NMR Spectroscopy**

A. Breeze, S. McLeod, Ning Gao, 2014, Angewandte Chemie.

Screening-based discovery of the first novel ATP competitive inhibitors of the Staphylococcus aureus essential enzyme UMP kinase.

P. Doig, E. Gorseth, Ning Gao, 2013, Biochemical and biophysical research communications.

Target-Based Resistance in Pseudomonas aeruginosa and Escherichia coli to NBTI 1 5463 , a Novel Bacterial Type II Topoisomerase Inhibitor 2 3 4 5

T. Dougherty, D. Ehmann, B. Shapiro, 2014 .

Dimerization of isolated Pseudomonas aeruginosa lipopolysaccharide transporter component LptA.

A. Shapiro, Ning Gao, R. Gu, 2014, Biochemical and biophysical research communications.

SAR and Structural Analysis of Siderophore-Conjugated Monocarbam Inhibitors of Pseudomonas aeruginosa PBP3.

A. Ferguson, Kerry E. Murphy-Benenato, Ning Gao, 2015, ACS medicinal chemistry letters.

Interactions of terpyridines and their Pt(II) complexes with G-quadruplex DNAs and telomerase inhibition.

Chunying Wei, Ning Gao, Lijun Ren, 2013, International journal of biological macromolecules.

Phosphorylation of Glutamine Synthetase on Threonine 301 Contributes to Its Inactivation During Epilepsy

M. Pangalos, N. Brandon, S. Moss, 2019, Front. Mol. Neurosci..

Antibody fragments structurally enable a drug-discovery campaign on the cancer target Mcl-1

S. Kazmirski, D. Hargreaves, P. Rawlins, 2019, Acta crystallographica. Section D, Structural biology.

Discovery of ATP-Competitive Inhibitors of tRNAIle Lysidine Synthetase (TilS) by High-Throughput Screening

S. Tentarelli, H. Plant, Jarrod Walsh, 2014, Journal of biomolecular screening.

Real-Time Monitoring of New Delhi Metallo-β-Lactamase Activity in Living Bacterial Cells by 1H NMR Spectroscopy**

A. Breeze, S. McLeod, Ning Gao, 2014, Angewandte Chemie.

A High-Throughput–Compatible Fluorescence Anisotropy-Based Assay for Competitive Inhibitors of Escherichia coli UDP-N-Acetylglucosamine Acyltransferase (LpxA)

Wei Yang, P. Ross, A. Shapiro, 2013, Journal of biomolecular screening.

A High-Throughput Absorbance-Based Assay for Methionine Produced by Methionine Aminopeptidase Using S-Adenosyl-L-Methionine Synthetase

James D. Whiteaker, A. Shapiro, G. Walkup, 2011, Journal of biomolecular screening.

Fluorescence anisotropy-based measurement of Pseudomonas aeruginosa penicillin-binding protein 2 transpeptidase inhibitor acylation rate constants.

A. Shapiro, Ning Gao, Jason Thresher, 2014, Analytical biochemistry.