D. Downs

发表

Design of Potent Inhibitors for Human Brain Memapsin 2 (β-Secretase).

Dongwoo Shin, Jacques Ermolieff, Arun K. Ghosh, 2000, Journal of the American Chemical Society.

Isolation and characterization of recombinant human apolipoprotein C-II expressed in Escherichia coli.

C. S. Wang, K. Jackson, D. Downs, 1996, Biochimica et biophysica acta.

Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein.

J. Tang, G. Koelsch, X. Lin, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Compositions de memapsine 2 tronquee et traitements associes

D. Downs, Wan Pin Chang, Jordan Tang, 2006 .

Candida albicans secreted aspartic proteases 4–6 induce apoptosis of epithelial cells by a novel Trojan horse mechanism

Arun K. Ghosh, Hao Wu, Jordan J. N. Tang, 2013, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

A quick and large-scale density gradient subfractionation method for low density lipoproteins.

D. Downs, D. M. Lee, 1982, Journal of lipid research.

Modified heparin-Sepharose procedure for determination of plasma lipolytic activities of normolipidemic and hyperlipidemic subjects after injection of heparin.

C. S. Wang, D. Downs, H. B. Bass, 1981, Clinical chemistry.

Proline-rich domain and glycosylation are not essential for the enzymic activity of bile salt-activated lipase. Kinetic studies of T-BAL, a truncated form of the enzyme, expressed in Escherichia coli.

C. S. Wang, Y. Y. Xu, D. Downs, 1994, Biochemistry.

Hyperlipidemia in acute lymphoblastic leukemia.

C. S. Wang, P. Blackett, D. Downs, 1984, Annals of clinical and laboratory science.

Kinetics of acylglycerol sequential hydrolysis by human milk bile salt activated lipase and effect of taurocholate as fatty acid acceptor.

J. Hartsuck, C. S. Wang, D. Downs, 1988, Biochemistry.

Acylglycerol reactivity and reaction mechanism of bovine milk lipoprotein lipase.

J. Hartsuck, C. S. Wang, D. Downs, 1990, Biochimica et biophysica acta.

Isolation and characterization of an apoA-II-containing lipoprotein (LP-A-II:B complex) from plasma very low density lipoproteins of patients with Tangier disease and type V hyperlipoproteinemia.

R. Gregg, H. Brewer, C. S. Wang, 1991, Journal of lipid research.

Photolysis of diphenylmethyl diphenylacetate in the presence and absence of cupric ion: the fate of the diphenylmethyl radical

B. DeGraff, D. Downs, S. B. Simmers, 1988 .

Enzymic properties of recombinant BACE2.

Xuejun C. Zhang, D. Downs, Xinli Lin, 2002, European journal of biochemistry.

β‐Secretase inhibitor GRL‐8234 rescues age‐related cognitive decline in APP transgenic mice

D. Holtzman, Wanpin Chang, G. Koelsch, 2011, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

The FASEB Journal • Research Communication Amyloid-beta reduction by memapsin 2 (beta-secretase) immunization

Wanpin Chang, K. Fung, D. Downs, 2022 .

Highly Selective and Potent Human β‐Secretase 2 (BACE2) Inhibitors against Type 2 Diabetes: Design, Synthesis, X‐ray Structure and Structure–Activity Relationship Studies

Arun K. Ghosh, A. Mesecar, M. Brindisi, 2019, ChemMedChem.

Human aspartic protease memapsin 2 cleaves the b-secretase site of b-amyloid precursor protein

G. Koelsch, D. Downs, Xinli Lin, 2000 .

In vivo inhibition of Aβ production by memapsin 2 (β‐secretase) inhibitors

Arun K. Ghosh, Vajira Weerasena, Wanpin Chang, 2004, Journal of neurochemistry.

Structure of human milk bile salt activated lipase.

C. S. Wang, K. Jackson, D. Downs, 1991, Biochemistry.

Studies on the substrate specificity of purified human milk bile salt-activated lipase.

A. Kuksis, C. S. Wang, D. Downs, 1983, The Journal of biological chemistry.

Lipolytic degradation of human very low density lipoproteins by human milk lipoprotein lipase: the identification of lipoprotein B as the main lipoprotein degradation product.

C. S. Wang, D. Weiser, P. Alaupovic, 1986, Archives of biochemistry and biophysics.

Crystal structure of the catalytic domain of human bile salt activated lipase

Xuejun C. Zhang, S. Terzyan, D. Downs, 2000, Protein science : a publication of the Protein Society.

Design of potent and highly selective inhibitors for human β-secretase 2 (memapsin 1), a target for type 2 diabetes

Arun K. Ghosh, A. Mesecar, E. L. Cárdenas, 2016, Chemical science.

Mass spectrometric characterization and glycosylation profile of bovine pancreatic bile salt-activated lipase.

C. S. Wang, K. Jackson, X. Zhang, 1998, Protein expression and purification.