S. Howard

发表

Application of fragment screening and fragment linking to the discovery of novel thrombin inhibitors.

Gianni Chessari, Chris Abell, Christopher W Murray, 2006, Journal of medicinal chemistry.

Preparation of diamines by lithiation-substitution of imidazolidines and pyrimidines.

Neil J. Ashweek, S. Howard, I. Coldham, 2003, Organic & biomolecular chemistry.

Synthesis of chiral 1,2-diamines by asymmetric lithiation-substitution.

R. Copley, S. Howard, I. Coldham, 2001, Organic letters.

Human lysosomal and jack bean alpha-mannosidases are retaining glycosidases.

S. Withers, J. McCarter, K. Moremen, 1997, Biochemical and biophysical research communications.

Identification of Asp197 as the catalytic nucleophile in the family 38 α‐mannosidase from bovine kidney lysosomes

S. Withers, G. Evjen, O. Tollersrud, 2000, FEBS letters.

Fragment-based discovery of type I inhibitors of maternal embryonic leucine zipper kinase.

F. Sommen, A. Sharff, V. Berdini, 2015, ACS medicinal chemistry letters.

The synthesis, testing and use of 5-fluoro-α-d-galactosyl fluoride to trap an intermediate on green coffee bean α-galactosidase and identify the catalytic nucleophile

S. Withers, A. Zhu, S. Howard, 2000 .

Lignocellulose biotechnology: issues of bioconversion and enzyme production

Rl Howard, E Abotsi, El Jansen van Rensburg, 2003 .

Fragment-based discovery of the pyrazol-4-yl urea (AT9283), a multitargeted kinase inhibitor with potent aurora kinase activity.

Mladen Vinković, Paul G Wyatt, Jayne Curry, 2009, Journal of medicinal chemistry.

A Fragment-Derived Clinical Candidate for Antagonism of X-Linked and Cellular Inhibitor of Apoptosis Proteins: 1-(6-[(4-Fluorophenyl)methyl]-5-(hydroxymethyl)-3,3-dimethyl-1 H,2 H,3 H-pyrrolo[3,2- b]pyridin-1-yl)-2-[(2 R,5 R)-5-methyl-2-([(3R)-3-methylmorpholin-4-yl]methyl)piperazin-1-yl]ethan-1-one

G. Chessari, P. Williams, G. Saxty, 2018, Journal of medicinal chemistry.

Stereocontrolled syntheses of polyhydroxy indolizidines, including 8a-epi-, 6,8a-diepi- and 1,6-diepi-castanospermine, starting from malic acid

F. Leeper, S. Howard, 1995 .

Discovery of novel 1H-imidazol-2-yl-pyrimidine-4,6-diamines as potential antimalarials.

K. Kuhen, E. Winzeler, N. Gray, 2010, Bioorganic & medicinal chemistry letters.

Enantioselective synthesis of substituted pyrrolidines by dynamic resolution.

G. P. Vennall, S. Dufour, S. Howard, 2002, Angewandte Chemie.

Enantioselective synthesis of substituted pyrrolidines by dynamic resolution.

G. P. Vennall, S. Dufour, S. Howard, 2002, Angewandte Chemie.

Bromoketone C-Glycosides, a New Class of β-Glucanase Inactivators†

S. Withers, S. Howard, 1998 .

Labeling and identification of the postulated acid/base catalyst in the alpha-glucosidase from Saccharomyces cerevisiae using a novel bromoketone C-glycoside.

S. Withers, S. Howard, 1998, Biochemistry.

Fragment-Based Discovery of 7-Azabenzimidazoles as Potent, Highly Selective, and Orally Active CDK4/6 Inhibitors.

Paul N. Mortenson, M. Congreve, R. Cheng, 2012, ACS medicinal chemistry letters.

Structure-Based Design of Type II Inhibitors Applied to Maternal Embryonic Leucine Zipper Kinase.

V. Berdini, D. Brehmer, J. Linders, 2015, ACS medicinal chemistry letters.

The synthesis, testing and use of 5-fluoro-alpha-D-galactosyl fluoride to trap an intermediate on green coffee bean alpha-galactosidase and identify the catalytic nucleophile.

S. Withers, A. Zhu, S. Howard, 2000, Carbohydrate research.

Discovery of ASTX029, A Clinical Candidate Which Modulates the Phosphorylation and Catalytic Activity of ERK1/2.

C. Murray, V. Berdini, L. Fazal, 2021, Journal of medicinal chemistry.

Fragment-based discovery of 6-azaindazoles as inhibitors of bacterial DNA ligase.

Paul N. Mortenson, E. Chiarparin, T. Heightman, 2014, ACS medicinal chemistry letters.

Structure-Based Design of Potent and Orally Active Isoindolinone Inhibitors of MDM2-p53 Protein-Protein Interaction.

M. Noble, J. Endicott, G. Chessari, 2021, Journal of medicinal chemistry.

Fragment-based drug discovery and its application to challenging drug targets.

Amanda J Price, Steven Howard, Benjamin D Cons, 2017, Essays in biochemistry.

Cell-based optimization of novel benzamides as potential antimalarial leads

K. Kuhen, E. Winzeler, N. Gray, 2009, Bioorganic & medicinal chemistry letters.

287 POSTER Fragment-based discovery of AT9283; a multi-targeted kinase inhibitor with potent Aurora kinase activity

V. Berdini, P. Wyatt, L. Fazal, 2008 .

Fragment-based discovery of the pyrazol-4-yl urea (AT9283), a multitargeted kinase inhibitor with potent aurora kinase activity.

V. Berdini, P. Wyatt, L. Fazal, 2009, Journal of medicinal chemistry.