M. Laporte

发表

Diversity-Oriented Synthesis of a Library of Substituted Tetrahydropyrones Using Oxidative Carbon-Hydrogen Bond Activation and Click Chemistry

P. Wipf, R. Farid, Lei Liu, 2011, Molecules.

Small Molecule Therapeutics Birinapant ( TL 32711 ) , a Bivalent SMAC Mimetic , Targets TRAF 2-Associated cIAPs , Abrogates TNF-Induced NFk B Activation , and Is Active in Patient-Derived Xenograft Models

Yigong Shi, G. Kapoor, Y. Mitsuuchi, 2014 .

Exploratory Synthetic Studies of the α-Methoxylation of Amides via Cuprous Ion-Promoted Decomposition of o-Diazobenzamides†

G. Han, M. Parvez, S. Weinreb, 1996 .

Allosteric Indole Amide Inhibitors of p97: Identification of a Novel Probe of the Ubiquitin Pathway.

Vsevolod A. Peshkov, F. Zhang, P. Wipf, 2016, ACS medicinal chemistry letters.

Synthesis and in silico screening of a library of β-carboline-containing compounds

John R. Goodell, Lirong Wang, X. Xie, 2012, Beilstein journal of organic chemistry.

A New Synthesis of Gefitinib

P. Wipf, Taber S. Maskrey, M. Laporte, 2018, Synlett.

HCS campaign to identify selective inhibitors of IL-6-induced STAT3 pathway activation in head and neck cancer cell lines.

G. M. Wilson, P. Wipf, J. Grandis, 2015, Assay and drug development technologies.

Birinapant, a smac-mimetic with improved tolerability for the treatment of solid tumors and hematological malignancies.

Yigong Shi, G. Kapoor, C. Day, 2014, Journal of medicinal chemistry.

Condensation reactions of guanidines with bis-electrophiles: Formation of highly nitrogenous heterocycles.

P. Wipf, M. Laporte, David M. Arnold, 2013, Tetrahedron.

Radical [3 + 2]-annulation of divinylcyclopropanes: rapid synthesis of complex meloscine analogs.

S. Geib, D. Curran, M. Laporte, 2014, Organic letters.

Synthesis and Optimization of Nitroxide-Based Inhibitors of Ferroptotic Cell Death in Cancer Cells and Macrophages.

P. Wipf, J. Janjic, Taber S. Maskrey, 2022, ACS medicinal chemistry letters.

Optimization of pyrazole-containing 1,2,4-triazolo-[3,4-b]thiadiazines, a new class of STAT3 pathway inhibitors.

Vsevolod A. Peshkov, P. Wipf, J. Grandis, 2016, Bioorganic & medicinal chemistry letters.

Domino Reactions in Library Synthesis

John R. Goodell, P. Wipf, M. Laporte, 2013 .

Electrophilic Oxidation and [1,2]-Rearrangement of the Biindole Core of Birinapant.

S. Condon, M. D. Alexander, M. Laporte, 2016, ACS medicinal chemistry letters.

A New Enantioselective Approach to Total Synthesis of the Securinega Alkaloids: Application to (−)‐Norsecurinine and Phyllanthine

G. Han, S. Weinreb, M. Laporte, 2000 .

A threonine turnstile defines a dynamic amphiphilic binding motif in the AAA ATPase p97 allosteric binding site.

Brian D. Peyser, P. Wipf, M. Arkin, 2017, Organic & biomolecular chemistry.

Construction of a spirooxindole amide library through nitrile hydrozirconation-acylation-cyclization cascade.

Lirong Wang, X. Xie, Chunliang Lu, 2013, ACS combinatorial science.

5-Hydroxyindoles by intramolecular alkynol-furan diels-alder cycloaddition.

P. Wipf, M. Laporte, Jie Xu, 2013, The Journal of organic chemistry.

Tetrahydrobenzothiophene inhibitors of hepatitis C virus NS5B polymerase.

D. Young, L. Leister, S. Chunduru, 2006, Bioorganic & medicinal chemistry letters.

Total syntheses of the Securinega alkaloids (+)-14,15-dihydronorsecurinine, (-)-norsecurinine, and phyllanthine.

G. Han, S. Weinreb, M. Laporte, 2000, The Journal of organic chemistry.

REACTIONS OF AN O-QUINONE MONOIMIDE WITH PYRROLES

E. A. Williams, M. Laporte, H. Heine, 1995 .

A New Synthesis of 4,5,6,7-Tetrahydropyrazolo[1,5-c]pyrimidines by a Retro-Mannich Cascade Rearrangement

P. Wipf, D. Huryn, R. Colombo, 2014 .

PTPRT epigenetic silencing defines lung cancer with STAT3 activation and can direct STAT3 targeted therapies

Ludmila V. Danilova, J. Herman, P. Wipf, 2020, Epigenetics.

Birinapant (TL32711), a Bivalent SMAC Mimetic, Targets TRAF2-Associated cIAPs, Abrogates TNF-Induced NF-κB Activation, and Is Active in Patient-Derived Xenograft Models

Yigong Shi, G. Kapoor, Y. Mitsuuchi, 2014, Molecular Cancer Therapeutics.

Chemical methodology as a source of small-molecule checkpoint inhibitors and heat shock protein 70 (Hsp70) modulators

P. Wipf, D. Huryn, J. Brodsky, 2011, Proceedings of the National Academy of Sciences.

Optimization of Phenyl Indole Inhibitors of the AAA+ ATPase p97

P. Wipf, M. Arkin, Stacie L. Bulfer, 2018, ACS medicinal chemistry letters.

Structure-Activity Study of Bioisosteric Trifluoromethyl and Pentafluorosulfanyl Indole Inhibitors of the AAA ATPase p97.

P. Wipf, M. Arkin, Stacie L. Bulfer, 2015, ACS medicinal chemistry letters.

The discovery and structure-activity relationships of pyrano[3,4-b]indole-based inhibitors of hepatitis C virus NS5B polymerase.

T. Herbertz, D. Young, S. Condon, 2010, Bioorganic & medicinal chemistry letters.

The Discovery of Pyrano[3,4‐b]indole‐Based Allosteric Inhibitors of HCV NS5B Polymerase with In Vivo Activity

N. Kneteman, A. Howe, J. O'Connell, 2008, ChemMedChem.

2-Guanidinoquinazolines as new inhibitors of the STAT3 pathway.

P. Wipf, J. Grandis, D. Huryn, 2014, Bioorganic & Medicinal Chemistry Letters.

Optimization of 1,2,4-Triazole-Based p97 Inhibitors for the Treatment of Cancer

P. Wipf, Neal Green, D. Huryn, 2023, ACS Medicinal Chemistry Letters.

Process Development and Synthesis of Birinapant: Large Scale Preparation and Acid-Mediated Dimerization of the Key Indole Intermediate

Arthur J. L. Cooper, S. Condon, H. Cao, 2016 .

The discovery and structure-activity relationships of pyrano[3,4-b]indole based inhibitors of hepatitis C virus NS5B polymerase.

A. Gopalsamy, T. Herbertz, D. Young, 2010, Bioorganic & Medicinal Chemistry Letters.

Synthesis and characterization of a soluble, polymeric 5-phenyltetrazolate-bridged aquo cobalt(II) complex

M. Laporte, R. Maguire, J. L. Richards, 1978 .

2-Guanidinoquinazolines as new inhibitors of the STAT3 pathway.

P. Wipf, J. Grandis, D. Huryn, 2014, Bioorganic & medicinal chemistry letters.

5-Hydroxyindoles by intramolecular alkynol-furan diels-alder cycloaddition.

P. Wipf, M. Laporte, Jie Xu, 2013, The Journal of organic chemistry.