H. Arakawa

发表

Mode of action of a new indolocarbazole anticancer agent, J-107088, targeting topoisomerase I.

K. Fukasawa, S. Nishimura, T. Yoshinari, 1999, Cancer research.

Novel antitumor indolocarbazole compound 6-N-formylamino-12,13-dihydro-1,11- dihydroxy-13-(beta-D-glucopyranosyl)-5H-indolo[2,3-a]pyrrolo[3,4- c]carbazole-5,7(6H)-dione (NB-506): induction of topoisomerase I-mediated DNA cleavage and mechanisms of cell line-selective cytotoxicity.

S. Nishimura, K. Noguchi, H. Suda, 1995, Cancer research.

In vivo Anti‐tumor Activity of a Novel Indolocarbazole Compound, J‐107088, on Murine and Human Tumors Transplanted into Mice

T. Kodera, S. Nishimura, M. Ohkubo, 1999, Japanese journal of cancer research : Gann.

Effect of genistein on topoisomerase activity and on the growth of [Val 12]Ha-ras-transformed NIH 3T3 cells.

T. Yoshinari, H. Arakawa, Y. Monden, 1988, Biochemical and biophysical research communications.

ED‐110, a Novel Indolocarbazole, Prevents the Growth of Experimental Tumors in Mice

H. Suda, T. Yoshinari, H. Arakawa, 1993, Japanese journal of cancer research : Gann.

Induction of topoisomerase I-mediated DNA cleavage by a new indolocarbazole, ED-110.

H. Suda, D. Uemura, T. Yoshinari, 1993, Cancer research.

Identification and cloning of a novel isoform of mouse secretory leukocyte protease inhibitor, mSLPI-beta, overexpressed in murine leukemias and a highly liver metastatic tumor, IMC-HA1 cells.

S. Nishimura, H. Arakawa, M. Morita, 1999, Advances in enzyme regulation.

Stereo(C7)‐dependent Topoisomerase II Inhibition and Tumor Growth Suppression by a New Quinolone, BO‐2367

T. Yoshinari, H. Arakawa, A. Okura, 1993, Japanese journal of cancer research : Gann.

CMAP: a novel cystatin-like gene involved in liver metastasis.

S. Nishimura, H. Arakawa, M. Morita, 1999, Cancer research.

Cystatin-like metastasis-associated protein mRNA expression in human colorectal cancer is associated with both liver metastasis and patient survival.

T. Utsunomiya, M. Mori, S. Nishimura, 2002, Clinical cancer research : an official journal of the American Association for Cancer Research.

Malolactomycin D, a potent inhibitor of transcription controlled by the Ras responsive element, inhibits Ras-mediated transformation activity with suppression of MMP-1 and MMP-9 in NIH3T3 cells

S. Nishimura, A. Hirano, H. Arakawa, 2001, Oncogene.

Synthesis and biological activities of topoisomerase I inhibitors, 6-arylmethylamino analogues of edotecarin.

S. Ito, T. Nishimura, M. Ohkubo, 2009, Journal of medicinal chemistry.

Protective effect of forphenicinol, a low molecular weight immunomodifier, against infection with Pseudomonas aeruginosa in mice and its mechanisms.

T. Takeuchi, H. Umezawa, M. Ishizuka, 1987, The Journal of antibiotics.

Effect of forphenicinol on the production of Ia-positive macrophages in mice with or without L1210 leukemia and on the growth of L1210 in immunized mice.

T. Takeuchi, H. Umezawa, M. Ishizuka, 1986, The Journal of antibiotics.

A new topoisomerase II inhibitor, BE-22179, produced by a streptomycete. I. Producing strain, fermentation, isolation and biological activity.

H. Suda, D. Uemura, T. Yoshinari, 1994, The Journal of antibiotics.

FERMENTATION , ISOLATION , PHYSICO-CHEMICAL AND BIOLOGICAL PROPERTIES

M. Okanishi, H. Suda, H. Arakawa, 2006 .

New antitumor substances, BE-12406A and BE-12406B, produced by a streptomycete. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties.

M. Okanishi, H. Suda, H. Arakawa, 1991, The Journal of antibiotics.

Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents

Tsuyoshi Arai, Hiroshi Hirai, Takashi Yoshizumi, 2009, Molecular Cancer Therapeutics.

ABCG2 confers resistance to indolocarbazole compounds by ATP-dependent transport.

S. Nishimura, H. Komatani, Rinako Nakagawa, 2002, Biochemical and biophysical research communications.

Identification of breast cancer resistant protein/mitoxantrone resistance/placenta-specific, ATP-binding cassette transporter as a transporter of NB-506 and J-107088, topoisomerase I inhibitors with an indolocarbazole structure.

H. Kotani, S. Nishimura, H. Komatani, 2001, Cancer research.

Synthesis and biological activities of NB-506 analogues modified at the glucose group.

T. Honma, S. Nishimura, H. Suda, 2000, Bioorganic & medicinal chemistry letters.

Synthesis and biological activities of topoisomerase I inhibitors, 6-N-amino analogues of NB-506.

S. Nishimura, T. Yoshinari, M. Ohkubo, 1999, Bioorganic & medicinal chemistry letters.

Novel indolocarbazole compound 6-N-formylamino-12,13-dihydro-1,11-dihydroxy- 13-(beta-D-glucopyranosyl)-5H-indolo[2,3-a]pyrrolo-[3,4-c]carbazole- 5,7(6H)-dione (NB-506): its potent antitumor activities in mice.

S. Nishimura, H. Suda, T. Yoshinari, 1995, Cancer research.

A new antitumor substance BE-13793C, produced by a streptomycete. Taxonomy, fermentation, isolation, structure determination and biological activity.

M. Okanishi, H. Suda, T. Yoshinari, 1991, The Journal of antibiotics.

Antimetastatic Effect of a Novel Indolocarbazole (NB‐506) on IMC‐HM Murine Tumor Cells Metastasized to the Liver

S. Nishimura, H. Arakawa, A. Okura, 1996, Japanese journal of cancer research : Gann.

Potent antitumor activity of quinolone compounds with an unsaturated aminoazabicyclo group at the C-7 position of the quinolone ring.

T. Yoshinari, H. Arakawa, A. Okura, 1996, Anti-cancer drug design.

A new antitumor antibiotic, BE-19412A, produced by a streptomycete.

H. Suda, H. Arakawa, S. Kamiya, 1998, The Journal of antibiotics.

Synthesis and biological activities of topoisomerase I inhibitors, 6-N-amino analogues of NB-506.

S. Nishimura, H. Suda, H. Kawamoto, 1999 .

Genomic construct and mapping of the gene for CMAP (leukocystatin/cystatin F, CST7) and identification of a proximal novel gene, BSCv (C20orf3).

S. Nishimura, Y. Hara, H. Arakawa, 2000, Genomics.

J-104,871, a novel farnesyltransferase inhibitor, blocks Ras farnesylation in vivo in a farnesyl pyrophosphate-competitive manner.

T. Kodera, Y. Iwasawa, S. Nishimura, 1998, Molecular pharmacology.