H. Morishima

发表

Mode of action of a new indolocarbazole anticancer agent, J-107088, targeting topoisomerase I.

K. Fukasawa, S. Nishimura, T. Yoshinari, 1999, Cancer research.

In vivo Anti‐tumor Activity of a Novel Indolocarbazole Compound, J‐107088, on Murine and Human Tumors Transplanted into Mice

T. Kodera, S. Nishimura, M. Ohkubo, 1999, Japanese journal of cancer research : Gann.

The structure of pepstatin.

T. Aoyagi, T. Takeuchi, T. Takita, 1970, The Journal of antibiotics.

A new class of type I protein geranylgeranyltransferase (GGTase I) inhibitor.

M. Ohkubo, H. Morishima, T. Sagara, 2002, Bioorganic & medicinal chemistry letters.

Development of an orexin-2 receptor selective agonist, [Ala(11), D-Leu(15)]orexin-B.

H. Iwaasa, A. Kanatani, Shin-ichiro Egashira, 2003, Bioorganic & medicinal chemistry letters.

Carbapenem derivatives as potential inhibitors of various beta-lactamases, including class B metallo-beta-lactamases.

H. Morishima, K. Yamada, T. Hashizume, 1999, Antimicrobial agents and chemotherapy.

PURIFICATION AND CHARACTERIZATION OF A SIALIDASE INHIBITOR

T. Aoyagi, T. Takeuchi, M. Hamada, 2006 .

Inhibition of Growth of Human Tumor Cells in Nude Mice by a Metalloproteinase Inhibitor

S. Nishimura, H. Suda, H. Morishima, 1994, International journal of cancer.

Synthesis of a Homostatine-Containing Renin Inhibitor Which Incorporates a Sulfonemethylene Isostere at Its N-Terminus

H. Funabashi, M. Ohkubo, H. Morishima, 1990 .

Synthesis of Renin Inhibitors Containing a Sulfonemethylene Isostere at Their N-Terminals

H. Funabashi, M. Ohkubo, H. Morishima, 1990 .

A stereospecific synthesis of a renin inhibitor (BW-175) which incorporates a sulfonemethylene isostere and a dihydroxyethylene isostere.

H. Funabashi, H. Morishima, Seiichi Tanaka, 1990 .

In vitro antibacterial activity and mechanism of action of J-111,225, a novel 1beta-methylcarbapenem, against transferable IMP-1 metallo-beta-lactamase producers.

H. Morishima, T. Hashizume, R. Nagano, 2000, The Journal of antimicrobial chemotherapy.

Solid phase synthesis of aryl and heteroaryl amines using the Curtius rearrangement

M. Ohkubo, H. Morishima, T. Sagara, 1999 .

Tandem and two-directional asymmetric catalysis of the Mukaiyama aldol reaction

K. Mikami, H. Funabashi, H. Morishima, 1997 .

Structure--activity relationships of 1beta-methyl-2-(5-phenylpyrrolidin-3-ylthio)carbapenems.

Hiroki Sato, S. Sakuraba, H. Morishima, 2002, Bioorganic & Medicinal Chemistry.

Practical synthesis of a 1beta-methylcarbapenem, J-111,225, using 4-mercapto-2-[4-(N-methylaminomethyl)phenyl]pyrrolidine as a precursor.

S. Sakuraba, H. Satō, H. Morishima, 2001, Chemical & pharmaceutical bulletin.

SYNTHESIS OF DISSYMMETRIC INDOLOCARBAZOLE GLYCOSIDES USING THE MITSUNOBU REACTION AT THE GLYCOSYLATION STEP

T. Honma, S. Ito, T. Nishimura, 1997 .

Synthesis of NB-506, A new anticancer agent

H. Kawamoto, M. Ohkubo, H. Morishima, 1997 .

In Vitro Activities of Noveltrans-3,5-Disubstituted Pyrrolidinylthio-1β-Methylcarbapenems with Potent Activities against Methicillin-Resistant Staphylococcus aureus andPseudomonas aeruginosa

H. Morishima, T. Hashizume, R. Nagano, 2000, Antimicrobial Agents and Chemotherapy.

Tandem and Two‐Directional Asymmetric Catalysis of the Mukaiyama Aldol Reaction.

K. Mikami, H. Funabashi, H. Morishima, 1997 .

CC bond formation from schiff base and vinyloxyborane: Synthesis of β-amino acid derivatives

Y. Umezawa, M. Otsuka, M. Ohno, 1981 .

Lipase-catalyzed kinetic resolution of ethyl 3-aryl-3-hydroxypropionate: preparation of the side chain of a novel carbapenem, J-114,870

H. Morishima, Koji Yamada, Y. Sugimoto, 2000 .

Practical Synthesis of a 1β‐Methylcarbapenem, J‐111,225, Using 4‐Mercapto‐2‐[4‐(N‐methylaminomethyl)phenyl]pyrrolidine as a Precursor.

S. Sakuraba, H. Morishima, Koji Yamada, 2001 .

Discovery of novel trans-3,5-disubstituted pyrrolidinylthio-1beta-methylcarbapenems.

Y. Tsuchiya, S. Sakuraba, H. Satō, 2000, Bioorganic & medicinal chemistry.

A novel 1beta-methylcarbapenem, J-111,225: effects of the C-3 and C-5 stereochemistry of the pyrrolidinylthio side chain on antibacterial activities.

S. Sakuraba, H. Satō, H. Morishima, 2000, The Journal of antibiotics.

Therapeutic efficacy of J-111,225, a novel trans-3,5-disubstituted pyrrolidinylthio-1beta-methylcarbapenem, against experimental murine systemic infections.

H. Morishima, T. Hashizume, R. Nagano, 2000, The Journal of antimicrobial chemotherapy.

Carbapenem Derivatives as Potential Inhibitors of Various β-Lactamases, Including Class B Metallo-β-Lactamases

Rie Nagano, Koji Yamada, H. Morishima, 1999, Antimicrobial Agents and Chemotherapy.

Synthesis of the side chain of a novel carbapenem via iodine-mediated oxidative cyclization of (1R)-N-(1-aryl-3-butenyl)acetamide.

H. Morishima, Koji Yamada, T. Hashihayata, 2002, Chemical & pharmaceutical bulletin.

Diastereoselective synthesis of (2R,4R)-2-aryl-4-hydroxypyrrolidine: preparation of the side chain of novel carbapenem.

S. Sakuraba, M. Hirose, H. Morishima, 2001, Chemical & pharmaceutical bulletin.

Synthesis of J-111,347, a novel 1 beta-methylcarbapenem with broad-spectrum antibacterial activity.

S. Sakuraba, H. Morishima, N. Ohtake, 2000, Chemical & pharmaceutical bulletin.

Structure–activity relationships of trans-3,5-disubstituted pyrrolidinylthio-1β-methylcarbapenems. Part 1: J-111,347 and related compounds

Hiroki Sato, H. Morishima, N. Ohtake, 2000 .

Practical synthesis of indolopyrrolocarbazoles

T. Honma, T. Nishimura, M. Ohkubo, 1996 .

Stereoselective synthesis of (2s,3s,4r)-4-amino-3-hydroxy-2-methyl-pentanoic acid, an amino acid constituent of bleomycin, by aldold condensation)☆

Y. Umezawa, M. Otsuka, M. Ohno, 1982 .

Total synthesis of deglyco-bleomycin A2

Y. Umezawa, M. Otsuka, M. Ohno, 1981 .

Synthesis of forphenicinol and forphenicine.

T. Takeuchi, H. Umezawa, H. Morishima, 1982, The Journal of antibiotics.

Synthesis and Structure-activity Relationships of Amastatin Analogues, Inhibitors of Aminopeptidase A

T. Aoyagi, Kenji Nakamura, H. Umezawa, 1982 .

An efficient enantioselective preparation of 2-substituted-3-hydroxypropionic acids via chemo-enzymatic reaction

H. Funabashi, M. Ohkubo, H. Morishima, 1990 .

An Efficient Enantioselective Preparation of 2‐Substituted 3‐Hydroxypropionic Acids via Chemoenzymatic Reaction.

H. Funabashi, M. Ohkubo, H. Morishima, 1990 .

A novel nonpeptidic, orally active renin inhibitor.

Y. Sawasaki, H. Funabashi, H. Morishima, 1989, Biochemical and biophysical research communications.

MANNOSTATINS A AND B*: NEW INHIBITORS OF o-d-MANNOSIDASE, PRODUCED BY STREPTO VERTICILLIUM VERTICILLUS VAR

T. Aoyagi, T. Takeuchi, M. Hamada, 2006 .

Total synthesis of bleomycin A21)

Y. Umezawa, M. Otsuka, M. Ohno, 1982 .

Synthesis of the pyrimidine moiety of bleomycin

Y. Umezawa, M. Otsuka, M. Ohno, 1980 .

HYDROXYPEPSTATIN, A NEW PEPSTATIN PRODUCED BY STREPTOMYCES

T. Aoyagi, H. Naganawa, T. Takeuchi, 1973 .

Letter: X-ray structure determination of 4-amino-3-hydroxy-6-methylheptanoic acid, an amine component of pepstatin.

T. Takita, H. Umezawa, H. Nakamura, 1973, The Journal of antibiotics.

SYNTHESIS OF 4-AMINO-3 HYDROXY-6-METHYLHEPTANOIG ACID, AN AMINE COMPONENT OF PEPSTATIN

T. Takita, H. Umezawa, H. Morishima, 1973 .

A New Approach to the Stereospecific Synthesis of a Dihydroxyehylene Isostere

H. Funabashi, H. Morishima, Seiichi Tanaka, 1990 .

Synthesis and biological activities of NB-506 analogues modified at the glucose group.

T. Honma, S. Nishimura, H. Suda, 2000, Bioorganic & medicinal chemistry letters.

RETRO-SYNTHETIC MANIPULATION OF BLEOMYCINS

Y. Umezawa, M. Otsuka, M. Ohno, 1982 .

Synthesis and biological activities of NB-506 analogues: Effects of the positions of two hydroxyl groups at the indole rings.

T. Honma, S. Nishimura, H. Suda, 1999, Bioorganic & medicinal chemistry letters.

Synthesis and biological activities of topoisomerase I inhibitors, 6-N-amino analogues of NB-506.

S. Nishimura, T. Yoshinari, M. Ohkubo, 1999, Bioorganic & medicinal chemistry letters.

Different binding sites for the neuropeptide Y Y1 antagonists 1229U91 and J-104870 on human Y1 receptors

H. Iwaasa, T. Iwama, A. Kanatani, 2001, Peptides.

TOTAL SYNTHESIS OF BLEOMYCIN A2

Y. Umezawa, M. Otsuka, M. Ohno, 1982 .

A Synthetic Approach to the Pyrimidine Moiety of Bleomycin

Y. Umezawa, M. Otsuka, M. Ohno, 1979 .

A Novel 1β‐Methylcarbapenem, J‐111,225: Effects of the C‐3 and C‐5 Stereochemistry of the Pyrrolidinylthio Side Chain on Antibacterial Activities.

S. Sakuraba, H. Morishima, Koji Yamada, 2000 .

In Vitro Activities of Novel trans -3,5-Disubstituted Pyrrolidinylthio-1 b -Methylcarbapenems with Potent Activities against Methicillin-Resistant Staphylococcus aureus and Pseudomonas aeruginosa

H. Morishima, T. Hashizume, R. Nagano, 2000 .

Oxidation products of 2-arylphenanthro-[9,10-d]imidazoles—II : Structure and photochromism of oxidation products of 2-(4-methoxyphenyl)-phenanthro-[9,10-d]imidazole

M. Kouno, H. Morishima, H. Kakisawa, 1973 .

Synthesis and biological activities of topoisomerase I inhibitors, 6-N-amino analogues of NB-506.

S. Nishimura, H. Suda, H. Kawamoto, 1999 .

Stereospecific Synthesis of a Dihydroxyethylene Isostere of Cyclohexylalanine Amide, (2S,3R,4S)-4-Amino-5-Cyclohexyl-1-Morpholino-2,3-Pentanediol(ACMP) from a Protected Sugar

H. Morishima, M. Nakano, S. Atsuumi, 1990 .

Dicationic dithiocarbamate carbapenems with anti-MRSA activity.

H. Morishima, N. Ohtake, Y. Sugimoto, 2001, Bioorganic & medicinal chemistry.

Mannostatins A and B: new inhibitors of alpha-D-mannosidase, produced by Streptoverticillium verticillus var. quintum ME3-AG3: taxonomy, production, isolation, physico-chemical properties and biological activities.

T. Aoyagi, T. Takeuchi, M. Hamada, 1989, The Journal of antibiotics.