J. Sikorski

发表

A nonpeptidyl mimic of superoxide dismutase with therapeutic activity in rats.

S. Cuzzocrea, J. Zweier, M. Currie, 1999, Science.

Carboxylated, heteroaryl-substituted chalcones as inhibitors of vascular cell adhesion molecule-1 expression for use in chronic inflammatory diseases.

C. Kunsch, M. Wasserman, J. Sikorski, 2007, Journal of medicinal chemistry.

Novel heteroaryl replacements of aromatic 3-tetrafluoroethoxy substituents in trifluoro-3-(tertiaryamino)-2-propanols as potent inhibitors of cholesteryl ester transfer protein.

B. Witherbee, D. Connolly, R. C. Durley, 2001, Bioorganic & medicinal chemistry letters.

Novel phenolic antioxidants as multifunctional inhibitors of inducible VCAM-1 expression for use in atherosclerosis.

C. Kunsch, S. Parthasarathy, M. Wasserman, 2002, Bioorganic & medicinal chemistry letters.

Chapter 22. Cholesteryl ester transfer protein as a potential therapeutic target to improve the HDL to LDL cholesterol ratio

K. Glenn, J. Sikorski, 2000 .

Scanning Alanine Mutagenesis and De-peptidization of a Candida albicans Myristoyl-CoA:ProteinN-Myristoyltransferase Octapeptide Substrate Reveals Three Elements Critical for Molecular Recognition*

J. Gordon, W. Rocque, C. Mcwherter, 1997, The Journal of Biological Chemistry.

Replacements for lysine in l-seryl-l-lysyl dipeptide amide inhibitors of candida albicans myristoyl-CoA:protein N-myristoyltransferase

C. Mcwherter, B. Devadas, J. Sikorski, 1997 .

N-myristoylation of Arf proteins in Candida albicans: an in vivo assay for evaluating antifungal inhibitors of myristoyl-CoA: protein N-myristoyltransferase.

J. Lodge, J. Gordon, C. Mcwherter, 1997, Microbiology.

Selective peptidic and peptidomimetic inhibitors of Candida albicans myristoylCoA: protein N-myristoyltransferase: a new approach to antifungal therapy.

J. Gordon, C. Mcwherter, D. Brown, 1997, Biopolymers.

A chiral recognition element with an unusual size constraint affects the potency and selectivity for peptidomimetic inhibitors of Candida albicans myristoyl-CoA:protein N-myristoyltransferase

C. Mcwherter, D. W. Kuneman, B. Devadas, 1996 .

Bio-active engineered 50 nm silica nanoparticles with bone anabolic activity: therapeutic index, effective concentration, and cytotoxicity profile in vitro.

G. Beck, Shin-woo Ha, M. Weitzmann, 2014, Toxicology in vitro : an international journal published in association with BIBRA.

Isolation and structural elucidation of the tetrahedral intermediate in the epsp synthase enzymatic pathway

K. Anderson, Kenneth A. Johnson, A. Benesi, 1988 .

Evaluation of 5-enolpyruvoylshikimate-3-phosphate synthase substrate and inhibitor binding by stopped-flow and equilibrium fluorescence measurements.

K. Anderson, K. Johnson, J. Sikorski, 1988, Biochemistry.

Observation by 13C NMR of the EPSP synthase tetrahedral intermediate bound to the enzyme active site.

K. Anderson, A. Benesi, G. Leo, 1990, Biochemistry.

EPSP synthase: binding studies using isothermal titration microcalorimetry and equilibrium dialysis and their implications for ligand recognition and kinetic mechanism.

R. Frazier, J. E. Ream, J. Sikorski, 1992, Biochemistry.

Stereospecific inhibition of CETP by chiral N,N-disubstituted trifluoro-3-amino-2-propanols.

B. Witherbee, D. Connolly, R. C. Durley, 2000, Biochemistry.

Titration calorimetric analysis of AcylCoA recognition by myristoylCoA:protein N-myristoyltransferase.

G. Gokel, J. Gordon, R. S. Bhatnagar, 1997, Biochemistry.

Chiral N,N-disubstituted trifluoro-3-amino-2-propanols are potent inhibitors of cholesteryl ester transfer protein.

B. Witherbee, D. Connolly, K. Glenn, 2002, Journal of medicinal chemistry.

Discovery of chiral N,N-disubstituted trifluoro-3-amino-2-propanols as potent inhibitors of cholesteryl ester transfer protein.

B. Witherbee, D. Connolly, K. Glenn, 2000, Journal of medicinal chemistry.

Phosphorus-31, nitrogen-15, and carbon-13 and NMR of glyphosate: comparison of pH titrations to the herbicidal dead-end complex with 5-enolpyruvoylshikimate-3-phosphate synthase

G. Leo, R. Sammons, S. Castellino, 1989 .

An efficient, regiocontrolled synthesis of 5-aryl-2-carbethoxypyrroles from 3-aryl-3-chloropropeniminium salts

J. Gupton, J. Sikorski, D. Krolikowski, 1992 .

Substrate synergism and the steady-state kinetic reaction mechanism for EPSP synthase from Escherichia coli.

M. C. Walker, K. Gruys, J. Sikorski, 1992, Biochemistry.

Triazole phosphonates. Electrophilic substitution of 1‐substituted‐1H‐1,2,4‐triazoles via lithiated triazole intermediates

D. Reitz, J. Sikorski, D. K. Anderson, 1986 .

The application of vinylogous iminium salts and related synthons to the preparation of trisubstituted pyridines

D. R. Wilkinson, James G. Tarrant, J. Gupton, 1995 .

The preparation of thiophene appended vinylogous iminium salts and their application to the regioselective synthesis of thienylpyrimidines and thienylpyrroles

D. R. Wilkinson, J. Gupton, J. Sikorski, 1994 .

The preparation and some reactions of a benzotriazole substituted vinamidinium salt

D. R. Wilkinson, A. Katritzky, J. Gupton, 1993 .

Soybean pod set enhancement with synthetic cytokinin analogs.

J. Sikorski, S. L. Ditson, D. R. Carlson, 1987, Plant physiology.

Selective reductions. 38. Reaction of thexylchloroborane-methyl sulfide complex in methylene chloride with selected organic compounds containing representative functional groups. Comparison of the reducing characteristics of thexylchloroborane, thexylborane, and diborane

H. Brown, J. Sikorski, J. Cha, 1986 .

Syntheses of new racemic NG‐(1‐iminoethyl)phosphalysine derivatives as potential inhibitors of nitric oxide synthase

W. M. Moore, G. Jerome, J. Sikorski, 2000 .

EPSP Synthase: The Design and Synthesis of Bisubstrate Inhibitors Incorporating Novel 3-Phosphate Mimics

Michael J. Miller, Ajit S. Shah, D. Schnur, 1993 .

THE APPLICATION OF SYMMETRICAL VINAMIDINIUM SALTS TO THE PREPARATION OF MONOSUBSTITUTED TRIAZOLO 1,5-A-PYRIMIDINES

J. Gupton, J. Sikorski, S. Petrich, 1995 .

The application of vinylogous iminium salt derivatives to the synthesis of Ningalin B hexamethyl ether

J. Gupton, J. Lukens, J. Sikorski, 2003 .

The application of vinylogous iminium salt derivatives to the regiocontrolled preparation of heterocyclic appended pyrazoles

D. R. Wilkinson, J. Gupton, Charles R. Hickenboth, 2002 .

The application of vinylogous iminium salt derivatives to a regiocontrolled and efficient relay synthesis of lukianol a and related marine natural products

J. Gupton, J. Sikorski, K. Krumpe, 1999 .

The application of disubstituted vinylogous iminium salts and related synthons to the regiocontrolled preparation of unsymmetrical 2,3,4-trisubstituted pyrroles

J. Gupton, J. Sikorski, M. Bruce, 1998 .

The Application of Vinylogous Iminium Salt Derivatives and Microwave Accelerated Vilsmeier-Haack Reactions to Efficient Relay Syntheses of the Polycitone and Storniamide Natural Products.

Jonathan E. Hempel, J. Gupton, Matthew B Coppock, 2008, Tetrahedron.

Further studies on the application of vinylogous amides and β-halovinylaldehydes to the regiospecific synthesis of unsymmetrical, polyfunctionalized 2,3,4- and 1,2,3,4- substituted pyrroles.

J. Gupton, J. Sikorski, Evan Clark, 2018, Tetrahedron.

The application of vinylogous iminium salt derivatives to an efficient relay synthesis of the pyrrole containing alkaloids polycitone A and B

J. Gupton, J. Sikorski, Austin B Scharf, 2005 .

An alternative preparation of the 2‐dimethylaminomethylene‐1,3‐bis(dimethylimmonio)propane salt from phosphonoacetic acids and some applications in heterocyclic synthesis

J. Gupton, J. Sikorski, Stanton Q. Smith, 1991 .

The application of vinylogous iminium salts and related synthons to the regiocontrolled preparation of 2,3- and 2,5-disubstituted pyrroles

J. Gupton, J. Sikorski, M. Bruce, 1996 .

The application of unsymmetrical vinylogous iminium salts and related synthons to the preparation of monosubstituted triazolo [1, 5-a]pyrimidines

J. Gupton, J. Sikorski, S. Petrich, 1994 .

Discovery of novel benzothiazolesulfonamides as potent inhibitors of HIV-1 protease.

P. Mehta, J. McDonald, K. Houseman, 2003, Bioorganic & medicinal chemistry.

6.20 – Atherosclerosis/Lipoprotein/Cholesterol Metabolism

J. Sikorski, 2007 .

Recent advances in therapeutic chalcones

J. Sikorski, C. Meng, L. Ni, 2004 .

Discovery of novel heteroaryl-substituted chalcones as inhibitors of TNF-alpha-induced VCAM-1 expression.

J. Gilmore, C. Kunsch, M. Wasserman, 2004, Bioorganic & medicinal chemistry letters.

Proximity effects. 2. Conformational influence of nonacyl groups on acyl group properties in N-monosubstituted amides and in other carboxylic acid derivatives: a 7-position proximity effect

J. Idoux, J. Sikorski, J. M. Scandrett, 1977 .

Oral cholesteryl ester transfer protein (CETP) inhibitors: a potential new approach for treating coronary artery disease.

J. Sikorski, 2006, Journal of medicinal chemistry.

Functionalized 3,5-dihydroxybenzoates as potent novel inhibitors of EPSP synthase.

M. C. Walker, M. Miller, J. E. Ream, 1994, Bioorganic & medicinal chemistry.

EPSP synthase inhibitor design II. The importance of the 3-phosphate group for ligand binding at the shikimate-3-phosphate site & the identification of 3-malonate ethers as novel 3-phosphate mimics.

Michael J. Miller, K. Anderson, K. Gruys, 1993 .

Design & synthesis of a novel EPSP synthase inhibitor based on its ternary complex with shikimate-3-phosphate and glyphosate

J. Font, K. Gruys, J. Sikorski, 1992 .

Synthesis and evaluation of two new inhibitors of EPSP synthase

J. Knowles, K. Anderson, T. Widlanski, 1991 .

A tetrahedral intermediate in the EPSP synthase reaction observed by rapid quench kinetics.

K. Anderson, K. Johnson, K A Johnson, 1988, Biochemistry.

Thexylchloroborane-methyl sulfide. A selective monohydroborating agent with exceptional regioselectivity

H. Brown, J. Sikorski, S. Kulkarni, 1980 .

EPSP synthase inhibitor design IV. New aromatic substrate analogs and symmetrical inhibitors containing novel 3-phosphate mimics.

Michael J. Miller, M. C. Walker, J. E. Ream, 1994 .

EPSP synthase inhibitor deisgn III. Synthesis & evaluation of a new 5-oxamic acid analog of EPSP which incorporates a malonate ether as a 3-phosphate mimic

M. C. Walker, J. Sikorski, S. Corey, 1993 .

Chapter 2 The heterocyclic chemistry associated with the herbicide glyphosate

J. Sikorski, 1997 .

Glyphosate: A Unique Global Herbicide

John E. Franz, Michael K. Mao, James A. Sikorski, 1997 .

Chemistry of amino acid thionoester derivatives. An unexpected change in the reaction course between heterocyclic-2-carboxylic acid hydrazides and N-substituted thionoglycinates. Preferential formation of 4-amino-1,2,4-triazole adducts over 1,3,4-oxadiazole products

J. Sikorski, D. A. Mischke, B. J. Schulte, 1987 .

Hydroboration. 60. Effect of structure on the relative reactivity of representative olefins toward hydroboration by thexylchloroborane-methyl sulfide

H. Brown, J. Sikorski, 1982 .

Syntheses of new conformationally constrained S‐[2‐[(1‐iminoethyl)amino] ethyl]homocysteine derivatives as potential nitric oxide synthase inhibitors

M. Toth, W. M. Moore, G. Jerome, 2002 .

New aromatic inhibitors of EPSP synthase incorporating hydroxymalonates as novel 3-phosphate replacements.

Ajit S. Shah, M. C. Walker, M. Miller, 1997, Bioorganic & medicinal chemistry.

Reevaluating glyphosate as a transition-state inhibitor of EPSP synthase: identification of an EPSP synthase.EPSP.glyphosate ternary complex.

K. Anderson, K. Gruys, K. Johnson, 1995, Biochemistry.

ADDITION COMPOUNDS OF ALKALI-METAL HYDRIDES. 23. PREPARATION OF POTASSIUM TRIISOPROPOXYBOROHYDRIDE IN IMPROVED PURITY

H. Brown, J. Sikorski, B. Nazer, 1983 .

Application of vinylogous carbamates and vinylogous aminonitriles to the regiospecific synthesis of uniquely functionalized pyrroles and quinolones.

J. Gupton, J. Sikorski, Evan Clark, 2018, Tetrahedron.

The application of vinylogous iminium salt derivatives to an efficient synthesis of the pyrrole containing alkaloids Rigidin and Rigidin E

Jonathan E. Hempel, J. Gupton, Charles R. Hickenboth, 2006 .

NEW SIMPLIFIED INHIBITORS OF EPSP SYNTHASE : THE IMPORTANCE OF RING SIZE FOR RECOGNITION AT THE SHIKIMATE 3-PHOSPHATE SITE

J. Font, M. L. Peterson, J. Sikorski, 1996 .

Application of 2-substituted vinamidinium salts to the synthesis of 2,4-disubstituted pyrroles

J. Gupton, J. Sikorski, D. Krolikowski, 1990 .

AGIX-4207 [2-[4-[[1-[[3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl]thio]-1-methylethyl]thio]-2,6-bis(1,1-dimethylethyl)phenoxy]acetic Acid], a Novel Antioxidant and Anti-Inflammatory Compound: Cellular and Biochemical Characterization of Antioxidant Activity and Inhibition of Redox-Sensitive Inflammat

A. Whalen, C. Kunsch, Xi-lin Chen, 2005, Journal of Pharmacology and Experimental Therapeutics.

UNDERSTANDING GLYPHOSATE'S MOLECULAR MODE OF ACTION WITH EPSP SYNTHASE : EVIDENCE FAVORING AN ALLOSTERIC INHIBITOR MODEL

K. Gruys, J. Sikorski, 1997 .

Syntheses of new 2-hydroxythiazol-5-yl and 3-hydroxy-1,2,4-triazol-5-ylphosphonic acids as potential cyclic spatial mimics of glyphosate

J. Sikorski, D. K. Anderson, D. L. Deuwer, 1995 .

An Enzyme-Targeted Herbicide Design Program Based on EPSP Synthase: Chemical Mechanism and Glyphosate Inhibition Studies

Michael J. Miller, K. Anderson, J. E. Ream, 1990 .

Optical Anisotropy of Poly (P‐Phenylene Terephthalamide) Fibres

A. A. Hamza, J. Sikorski, 1978 .

New EPSP synthase inhibitors: synthesis and evaluation of an aromatic tetrahedral intermediate mimic containing a 3-malonate ether as a 3-phosphate surrogate.

M. Miller, J. E. Ream, J. Sikorski, 1995, Bioorganic & medicinal chemistry.

Purification and Properties of 5-Enolpyruvylshikimate-3-Phosphate Synthase from Dark-Grown Seedlings of Sorghum bicolor.

J. E. Ream, J. Sikorski, H. Steinrücken, 1988, Plant physiology.

Structural requirements for pep binding To EPSP synthase

E. Logusch, R. Somerville, J. E. Ream, 1991 .

Insights from 31P NMR Studies of Substrate and Inhibitor Complexes with EPSP Synthase

K. Gruys, J. Sikorski, M. Walker, 1999 .

Cholesteryl ester transfer protein inhibitors as potential new therapies for coronary artery disease

J. Sikorski, 2006 .

Genetic and Biochemical Studies Establish That the Fungicidal Effect of a Fully Depeptidized Inhibitor of Cryptococcus neoformans Myristoyl-CoA:ProteinN-Myristoyltransferase (Nmt) Is Nmt-dependent*

J. Lodge, J. Gordon, C. Mcwherter, 1998, The Journal of Biological Chemistry.

Design and syntheses of potent and selective dipeptide inhibitors of Candida albicans myristoyl-CoA:protein N-myristoyltransferase.

J. Gordon, C. Mcwherter, J. Sikorski, 1995, Journal of medicinal chemistry.

Novel biologically active nonpeptidic inhibitors of myristoylCoA:protein N-myristoyltransferase.

J. Lodge, J. Gordon, C. Mcwherter, 1998, Journal of medicinal chemistry.

Conformationally constrained [p-(omega-aminoalkyl)phenacetyl]-L-seryl-L-lysyl dipeptide amides as potent peptidomimetic inhibitors of Candida albicans and human myristoyl-CoA:protein N-myristoyl transferase.

J. Gordon, C. Mcwherter, D. Brown, 1997, Journal of medicinal chemistry.

Identification of the reactive cysteines of Escherichia coli 5-enolpyruvylshikimate-3-phosphate synthase and their nonessentiality for enzymatic catalysis.

G. Kishore, S. Padgette, J. Sikorski, 1988, The Journal of biological chemistry.

Differential scanning calorimetric study of 5-enolpyruvoyl shikimate-3-phosphate synthase and its complexes with shikimate-3-phosphate and glyphosate: irreversible thermal transitions.

J. Sikorski, E. Merabet, H. K. Yuen, 1993, Biochimica et biophysica acta.

Biological Characterization of an Improved Pyrrole-Based Colchicine Site Agent Identified through Structure-Based Design

G. Kellogg, S. Mooberry, Chenxiao Da, 2016, Molecular Pharmacology.

Design and synthesis of novel imidazole-substituted dipeptide amides as potent and selective inhibitors of Candida albicans myristoylCoA:protein N-myristoyltransferase and identification of related tripeptide inhibitors with mechanism-based antifungal activity.

J. Lodge, J. Gordon, D. W. Kuneman, 1997, Journal of medicinal chemistry.

Structure and topological symmetry of the glyphosate target 5-enolpyruvylshikimate-3-phosphate synthase: a distinctive protein fold.

W. Stallings, K. Anderson, S. Abdel-Meguid, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Novel product from EPSP (5-enolpyruvoylshikimate 3-phosphate) synthase at equilibrium

G. Leo, R. Sammons, J. Sikorski, 1990 .

Oxidative Stress and the Use of Antioxidants for the Treatment of Rheumatoid Arthritis

C. Kunsch, J. Sikorski, C. L. Sundell, 2005 .

3-Methyl-4H-[1,2,4]-oxadiazol-5-one: a versatile synthon for protecting monosubstituted acetamidines

M. Promo, Jane L. Wang, J. Sikorski, 2004 .

Discovery of novel phenolic antioxidants as inhibitors of vascular cell adhesion molecule-1 expression for use in chronic inflammatory diseases.

C. Kunsch, M. Wasserman, U. Saxena, 2004, Journal of medicinal chemistry.

EPSP synthase inhibitor design I. Conformations of enzyme bound shikimate-3-phosphate and 5-enolpyruvoylshikimate-3-phosphate using TRNOE

G. Leo, R. Sammons, S. Castellino, 1992 .

Synthesis & characterization of N-amino-glyphosate as a potent analog inhibitor of E. coli EPSP synthase.

K. Anderson, J. E. Ream, J. Sikorski, 1993 .

New 4-(α-Hetero-Phosphonomethyl) Pyrrole 2-Carboxylates are EPSP Synthase Inhibitors

J. Font, J. Sikorski, S. Corey, 1999 .

Steady-state kinetic evaluation of the reverse reaction for Escherichia coli 5-enolpyruvoylshikimate-3-phosphate synthase.

K. Gruys, J. Sikorski, M. Marzabadi, 1993, Archives of biochemistry and biophysics.

(Z)-3-fluorophosphoenolpyruvate as a pseudosubstrate of EPSP synthase : enzymatic synthesis of a stable fluoro analog of the calalytic intermediate

R. Somerville, J. Sikorski, C. Jones, 1992 .