J. Coe

发表

Varenicline: An α4β2 Nicotinic Receptor Partial Agonist for Smoking Cessation

Brian T. O’Neill, Yi Lu, Huang Jianhua, 2005 .

METABOLISM AND DISPOSITION OF VARENICLINE, A SELECTIVE α4β2 ACETYLCHOLINE RECEPTOR PARTIAL AGONIST, IN VIVO AND IN VITRO

R. Obach, R. Obach, T. O’Connell, 2006, Drug Metabolism and Disposition.

Varenicline: new treatment with efficacy in smoking cessation.

V. Reus, H. Rollema, R. Obach, 2007, Drugs of today.

Synthesis of 2,3,4,5-tetrahydro-1,5-methano-1H-3-benzazepine via oxidative cleavage and reductive amination strategies

S. Caron, Enrique Vazquez, J. Coe, 2004 .

In pursuit of alpha4beta2 nicotinic receptor partial agonists for smoking cessation: carbon analogs of (-)-cytisine.

F. Tingley, H. Rollema, B. O’Neill, 2005, Bioorganic & medicinal chemistry letters.

3,5-Bicyclic aryl piperidines: a novel class of alpha4beta2 neuronal nicotinic receptor partial agonists for smoking cessation.

F. Tingley, H. Rollema, B. O’Neill, 2005, Bioorganic & medicinal chemistry letters.

In pursuit of α4β2 nicotinic receptor partial agonists for smoking cessation: Carbon analogs of (−)-cytisine

F. Tingley, H. Rollema, B. O’Neill, 2005 .

Discovery of 4-(5-methyloxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]nonane (CP-810,123), a novel alpha 7 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders in schizophrenia: synthesis, SAR development, and in vivo efficacy in cognition models.

R. J. Mather, Anne W. Schmidt, R. Hurst, 2010, Journal of medicinal chemistry.

Varenicline: An α4β2 Nicotinic Acetylcholine Receptor Partial Agonist as an Aid to Smoking Cessation

S. Rennard, D. Gonzales, C. Oncken, 2006 .

Varenicline: an alpha4beta2 nicotinic receptor partial agonist for smoking cessation.

F. Tingley, J. Heym, H. Rollema, 2005, Journal of medicinal chemistry.

Metabolism and disposition of varenicline, a selective alpha4beta2 acetylcholine receptor partial agonist, in vivo and in vitro.

R. Obach, T. O’Connell, J. Coe, 2006, Drug metabolism and disposition: the biological fate of chemicals.

Kiloscale Buchwald–Hartwig Amination: Optimized Coupling of Base-Sensitive 6-Bromoisoquinoline-1-carbonitrile with (S)-3-Amino-2-methylpropan-1-ol

Jeffrey B. Sperry, J. Coe, K. E. Wiglesworth, 2014 .

Selection of a Novel Anti-Nicotine Vaccine: Influence of Antigen Design on Antibody Function in Mice

A. Brown, H. Davis, M. McCluskie, 2013, PloS one.

Access to 7β-analogs of codeine with mixed μ/δ agonist activity via 6,7-α-epoxide opening.

J. Coe, P. Magnus, Bahman Ghavimi, 2013, Bioorganic & medicinal chemistry letters.

&agr;4&bgr;2 nicotinic acetylcholine receptor partial agonists with low intrinsic efficacy have antidepressant-like properties

Y. Mineur, M. Picciotto, P. Seymour, 2011, Behavioural pharmacology.

Preclinical properties of the α4β2 nAChR partial agonists varenicline, cytisine and dianicline translate to clinical efficacy for nicotine dependence

D. Bertrand, S. Bertrand, H. Rollema, 2009 .

Varenicline has antidepressant-like activity in the forced swim test and augments sertraline's effect.

Y. Mineur, M. Picciotto, P. Seymour, 2009, European journal of pharmacology.

Transcriptional Profiling of a Selective CREB Binding Protein Bromodomain Inhibitor Highlights Therapeutic Opportunities.

Kevin Lee, R. Denny, M. Pletcher, 2015, Chemistry & biology.

A novel series of [3.2.1] azabicyclic biaryl ethers as alpha3beta4 and alpha6/4beta4 nicotinic receptor agonists.

R. J. Mather, R. Hurst, J. Lowe, 2010, Bioorganic & medicinal chemistry letters.

Varenicline: Discovery Synthesis and Process Chemistry Developments

J. Coe, Harry H. Watson, R. Singer, 2007 .

Cyclopentadiene: The Impact of Storage Conditions on Thermal Stability

D. Ende, J. Coe, D. Whritenour, 2007 .

Formation of 3-halobenzyne: solvent effects and cycloaddition adducts.

J. Coe, Michael C. Wirtz, J. Candler, 2004, Organic letters.

Unexpected migration and oxidative cyclization of substituted 2-acetophenone triflates under basic conditions: synthetic and mechanistic insights.

J. Coe, P. Brooks, Michael G. Vetelino, 2003, The Journal of organic chemistry.

Access to Highly Substituted 7-Azaindoles from 2-Fluoropyridines via 7-Azaindoline Intermediates.

J. Mousseau, Alpay Dermenci, C. Allais, 2015, Organic letters.

Discovery and Lead Optimization of Atropisomer D1 Agonists with Reduced Desensitization.

R. Kozak, David L. Gray, B. Rai, 2018, Journal of medicinal chemistry.

Pyridine analogs of (−)-cytisine and varenicline: cholinergic receptor probes

B. O’Neill, E. Arnold, J. Coe, 2008 .

Development of a Scalable Synthesis for an Inhaled pan-JAK Inhibitor

J. Coe, Seungwon Chung, L. Samp, 2019, Organic Process Research & Development.

Direct activation of relatively unstrained carbon-carbon bonds in homogeneous systems.

Guangbin Dong, Alpay Dermenci, J. Coe, 2014, Organic chemistry frontiers : an international journal of organic chemistry.

Syntheses of the opioid substructures 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocine and 2,3,4,5-te

J. Coe, P. Brooks, Michael G. Vetelino, 2011 .

Twisted amide reduction under Wolff-Kishner conditions: synthesis of a benzo-1-aza-adamantane derivative.

J. Bordner, J. Coe, Ivan J. Samardjiev, 2003, Journal of the American Chemical Society.

2‐Chloromethyl‐3‐trimethylsilyl‐1‐propene

J. Coe, D. Perry, 2001 .

Formation of benzynes from 2,6-dihaloaryllithiums: mechanistic basis of the regioselectivity.

Antonio Ramirez, D. B. Collum, J. Coe, 2004, Journal of the American Chemical Society.

High-Throughput Ligand Screening Enables the Enantioselective Conjugate Borylation of Cyclobutenones to Access Synthetically Versatile Tertiary Cyclobutylboronates.

Rory M. McDonald, N. Sach, D. Hall, 2019, Angewandte Chemie.

High‐Throughput Ligand Screening Enables the Enantioselective Conjugate Borylation of Cyclobutenones to Access Synthetically Versatile Tertiary Cyclobutylboronates

N. Sach, D. Hall, W. Farrell, 2019, Angewandte Chemie.

Synthesis of 4-azepanones and heteroaromatic-fused azepines

S. Sakya, David L. Gray, Kees Pouwer, 2012 .

Total synthesis of (+/-)-cytisine via the intramolecular heck cyclization of activated N-alkyl glutarimides.

J. Coe, 2000, Organic letters.

A mild method for the conversion of activated aryl methyl groups to carboxaldehydes via the uncatalyzed periodate cleavage of enamines

J. Coe, Michael G. Vetelino, 1994 .

Studies of an intramolecular Diels-Alder approach to the nargenicins: involvement of boatlike transition states in the cyclizations of substituted 1,7,9-decatrien-3-ones

W. Roush, J. Coe, 1989 .

Convenient preparation of N-substituted indoles by modified Leimgruber-Batcho indole synthesis

J. Coe, Michael G. Vetelino, Michael J. Bradlee, 1996 .

Studies on the synthesis of nargenicin A1. An example of anintramolecular diels-alder reaction that proceeds with a boat-likeconformation of the connecting chain

W. Roush, J. Coe, 1987 .

Design considerations for chiral frustrated Lewis pairs: B/N FLPs derived from 3,5-bicyclic aryl piperidines.

D. Stephan, J. Coe, Susanna Sampaolesi, 2018, Dalton transactions.

Indenes via fulvene intermediates

D. Kemp, J. Coe, Michael G. Vetelino, 1994 .

3,5-Bicyclic aryl piperidines: A novel class of α4β2 neuronal nicotinic receptor partial agonists for smoking cessation

F. Tingley, H. Rollema, B. O’Neill, 2005 .

Chapter 16. Varenicline (Chantix): An α4β2 Nicotinic Receptor Partial Agonist for Smoking Cessation

J. Coe, R. Singer, Frank R. Busch and, 2010 .

Boron Trichloride/Tetra-n-Butylammonium Iodide: A Mild, Selective Combination Reagent for the Cleavage of Primary Alkyl Aryl Ethers

G. Woodworth, J. Coe, P. Brooks, 1999 .

Delineating the role of cooperativity in the design of potent PROTACs for BTK

Graham M. West, James Smith, V. Shanmugasundaram, 2018, Proceedings of the National Academy of Sciences.

Design and Synthesis of a Pan-Janus Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and Skin.

Yogesh Sabnis, J. Chrencik, G. Whitlock, 2017, Journal of medicinal chemistry.

Rationale, pharmacology and clinical efficacy of partial agonists of α4β2 nACh receptors for smoking cessation

Stephen M. Stahl, S. Stahl, R. Hurst, 2007 .

Rationale, pharmacology and clinical efficacy of partial agonists of alpha4beta2 nACh receptors for smoking cessation.

Stephen M Stahl, S. Stahl, R. Hurst, 2007, Trends in pharmacological sciences.

Pharmacological profile of the α4β2 nicotinic acetylcholine receptor partial agonist varenicline, an effective smoking cessation aid

R. J. Mather, R. Hurst, F. Tingley, 2007, Neuropharmacology.

Pharmacological profile of the alpha4beta2 nicotinic acetylcholine receptor partial agonist varenicline, an effective smoking cessation aid.

R. Hurst, F. Tingley, Y. Lu, 2007, Neuropharmacology.

Rational approach to highly potent and selective apoptosis signal-regulating kinase 1 (ASK1) inhibitors.

R. Kurumbail, D. Hepworth, J. Guzova, 2017, European journal of medicinal chemistry.

Identification of Cyanamide-Based Janus Kinase 3 (JAK3) Covalent Inhibitors.

J. Bauman, J. Telliez, J. Chrencik, 2018, Journal of medicinal chemistry.

Chapter 4 Case History: Chantix™/Champix™ (Varenicline Tartrate), a Nicotinic Acetylcholine Receptor Partial Agonist as a Smoking Cessation Aid

H. Rollema, B. O’Neill, J. Coe, 2009 .

Design of a Janus Kinase 3 (JAK3) Specific Inhibitor 1-((2S,5R)-5-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one (PF-06651600) Allowing for the Interrogation of JAK3 Signaling in Humans.

M. Hegen, J. Telliez, J. Chrencik, 2017, Journal of medicinal chemistry.

Structure-Based Design of Highly Selective Inhibitors of the CREB Binding Protein Bromodomain.

R. Denny, P. Brennan, M. Pletcher, 2017, Journal of medicinal chemistry.

Convenient preparation of 9-cis-retinoic acid

T. O’Connell, J. Coe, 1994 .

A preparation of high specific activity [11,12-3H]-9-cis-retinoic acid

J. Coe, P. Towers, C. Hawes, 1995 .

Convenient Preparation of 9‐cis‐Retinoic Acid.

T. O’Connell, J. Coe, 1994 .

Partial Agonists of the α3β4* Neuronal Nicotinic Acetylcholine Receptor Reduce Ethanol Consumption and Seeking in Rats

R. Hurst, J. Lowe, S. Bartlett, 2011, Neuropsychopharmacology.

Catalytic Enantioselective Synthesis of a cis-β-Boronyl Cyclobutylcarboxyester Scaffold and Its Highly Diastereoselective Nickel/Photoredox Dual-Catalyzed Csp3–Csp2 Cross-Coupling to Access Elusive trans-β-Aryl/Heteroaryl Cyclobutylcarboxyesters

N. Sach, D. Hall, W. Farrell, 2020, ACS Catalysis.

Enantioselective synthesis of nicotinic receptor probe 7,8-difluoro-1,2,3,4,5,6- hexahydro-1,5-methano-3-benzazocine.

Teresa W. Makowski, Steven J. Brenek, J. A. Ragan, 2006, Organic letters.

Correction to “Catalytic Enantioselective Synthesis of a cis-β-Boronyl Cyclobutylcarboxyester Scaffold and Its Highly Diastereoselective Nickel/Photoredox Dual-Catalyzed Csp3–Csp2 Cross-Coupling to Access Elusive trans-β-Aryl/Heteroaryl Cyclobutylcarboxyesters”

N. Sach, D. Hall, M. Reese, 2021, ACS Catalysis.

Pre‐clinical properties of the α4β2 nicotinic acetylcholine receptor partial agonists varenicline, cytisine and dianicline translate to clinical efficacy for nicotine dependence

D. Bertrand, F. Tingley, S. Bertrand, 2010, British journal of pharmacology.

Varenicline: An α4β2 Nicotinic Receptor Partial Agonist for Smoking Cessation

J. Heym, H. Rollema, B. O’Neill, 2005 .