Andrea Astolfi

发表

A Comprehensive Structural Overview of p38α Mitogen‐Activated Protein Kinase in Complex with ATP‐Site and Non‐ATP‐Site Binders

G. Manfroni, V. Cecchetti, M. Barreca, 2018, ChemMedChem.

Modifications on C6 and C7 Positions of 3-Phenylquinolone Efflux Pump Inhibitors Led to Potent and Safe Antimycobacterial Treatment Adjuvants.

M. Viveiros, S. Sabatini, G. Manfroni, 2019, ACS infectious diseases.

Deciphering the Molecular Recognition Mechanism of Multidrug Resistance Staphylococcus aureus NorA Efflux Pump Using a Supervised Molecular Dynamics Approach

Maicol Bissaro, M. Sturlese, S. Moro, 2019, International journal of molecular sciences.

C-2 phenyl replacements to obtain potent quinoline-based Staphylococcus aureus NorA inhibitors

D. Pietrella, S. Sabatini, G. Manfroni, 2020, Journal of enzyme inhibition and medicinal chemistry.

Pharmacophore-Based Repositioning of Approved Drugs as Novel Staphylococcus aureus NorA Efflux Pump Inhibitors.

G. Kaatz, D. Pietrella, S. Sabatini, 2017, Journal of medicinal chemistry.

From Quinoline to Quinazoline‐Based S. aureus NorA Efflux Pump Inhibitors by Coupling a Focused Scaffold Hopping Approach and a Pharmacophore Search

S. Sabatini, G. Manfroni, Serena Massari, 2021, ChemMedChem.

Structural Modifications of the Quinolin-4-yloxy Core to Obtain New Staphylococcus aureus NorA Inhibitors

S. Sabatini, G. Manfroni, Serena Massari, 2020, International journal of molecular sciences.

New Insights On KCA3.1 Channel Modulation.

R. Iannitti, G. Manfroni, V. Cecchetti, 2020, Current pharmaceutical design.

From Serendipity to Rational Identification of the 5,6,7,8-Tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one Core as a New Chemotype of AKT1 Inhibitors for Acute Myeloid Leukemia

M. Loza, J. Brea, M. Morlando, 2022, Pharmaceutics.

p38α MAPK and Type I Inhibitors: Binding Site Analysis and Use of Target Ensembles in Virtual Screening

S. Sabatini, V. Cecchetti, M. Barreca, 2015, Molecules.

1,2,4-Triazolo[1,5-a]pyrimidines as a Novel Class of Inhibitors of the HIV-1 Reverse Transcriptase-Associated Ribonuclease H Activity

C. Pannecouque, E. Tramontano, S. Sabatini, 2020, Molecules.

The Pyrazolobenzothiazine Core as a New Chemotype of p38 Alpha Mitogen‐Activated Protein Kinase Inhibitors

M. Loza, J. Brea, S. Laufer, 2015, Chemical biology & drug design.

Pyridobenzothiazolones Exert Potent Anti-Dengue Activity by Hampering Multiple Functions of NS5 Polymerase.

S. Vasudevan, S. Sabatini, G. Manfroni, 2020, ACS medicinal chemistry letters.

Q-raKtion: A Semiautomated KNIME Workflow for Bioactivity Data Points Curation

S. Sabatini, Serena Massari, M. Barreca, 2022, J. Chem. Inf. Model..

A Comprehensive Structural Overview of p38α MAPK in Complex with Type I Inhibitors

G. Manfroni, V. Cecchetti, M. Barreca, 2015, ChemMedChem.

The Compelling Demand for an Effective PrPC-Directed Therapy against Prion Diseases

M. Barreca, Andrea Astolfi, G. Spagnolli, 2020, ACS medicinal chemistry letters.

PHARMACOLOGICAL PROTEIN INACTIVATION BY TARGETING FOLDING INTERMEDIATES

S. Orioli, P. Faccioli, M. Pennuto, 2020, bioRxiv.

Identification of compounds inhibiting prion replication and toxicity by removing PrPC from the cell surface

A. Dalle Vedove, P. Gatto, V. Bonetto, 2020, Journal of neurochemistry.

Discovery of potent p38α MAPK inhibitors through a funnel like workflow combining in silico screening and in vitro validation.

M. Loza, J. Brea, S. Laufer, 2019, European journal of medicinal chemistry.

Pharmacological inactivation of the prion protein by targeting a folding intermediate

S. Orioli, P. Faccioli, M. Pennuto, 2021, Communications biology.

Functionalized 2,1-benzothiazine 2,2-dioxides as new inhibitors of Dengue NS5 RNA-dependent RNA polymerase.

G. Quérat, S. Sabatini, G. Manfroni, 2018, European journal of medicinal chemistry.

New C-6 functionalized quinoline NorA inhibitors strongly synergize with ciprofloxacin against planktonic and biofilm growing resistant Staphylococcus aureus strains.

S. Sabatini, G. Manfroni, Serena Massari, 2022, European journal of medicinal chemistry.

Small Molecules Targeting DNA Polymerase Theta (POLθ) as Promising Synthetic Lethal Agents for Precision Cancer Therapy

S. Schenone, T. Bandiera, Serena Massari, 2023, Journal of medicinal chemistry.

Computer-Aided Identification of Kinase-Targeted Small Molecules for Cancer: A Review on AKT Protein

M. Barreca, Andrea Astolfi, Deborah Palazzotti, 2023, Pharmaceuticals.

Identification of a Druggable Intermediate along the Folding Pathway of the SARS-CoV-2 Receptor ACE2

P. Faccioli, G. Lolli, L. Pieri, 2020, 2004.13493.

Lowering the Expression of the SARS-CoV-2 Receptor ACE2 by Drug Repositioning.

P. Faccioli, G. Lolli, L. Pieri, 2020 .

Identification of Anti-Influenza A Compounds Inhibiting the Viral Non-Structural Protein 1 (NS1) Using a Type I Interferon-Driven Screening Strategy

L. Nencioni, J. Hiscott, Mariangela Agamennone, 2023, International journal of molecular sciences.

Fighting Antimicrobial Resistance: Insights on How the Staphylococcus aureus NorA Efflux Pump Recognizes 2-Phenylquinoline Inhibitors by Supervised Molecular Dynamics (SuMD) and Molecular Docking Simulations

M. Sturlese, S. Moro, S. Sabatini, 2023, J. Chem. Inf. Model..

Small Molecule Drugs Targeting Viral Polymerases

V. Cecchetti, M. Barreca, Andrea Astolfi, 2024, Pharmaceuticals.