J. Muckelbauer

发表

X‐Ray Crystal Structure of Bone Marrow Kinase in the X Chromosome: A Tec Family Kinase

D. Xie, J. Sack, Chiehying Y Chang, 2011, Chemical biology & drug design.

Quinazolines as cyclin dependent kinase inhibitors.

G L Trainor, C. Chang, G. Trainor, 2001, Bioorganic & medicinal chemistry letters.

Discovery of a Partial Glucokinase Activator Clinical Candidate: Diethyl ((3-(3-((5-(Azetidine-1-carbonyl)pyrazin-2-yl)oxy)-5-isopropoxybenzamido)-1H-pyrazol-1-yl)methyl)phosphonate (BMS-820132).

Steven A. Spronk, K. Behnia, J. Barrish, 2022, Journal of medicinal chemistry.

Structure determination of coxsackievirus B3 to 3.5 A resolution.

M G Rossmann, M. Rossmann, A. Zlotnick, 1995, Acta crystallographica. Section D, Biological crystallography.

Discovery and Preclinical Evaluation of BMS-711939, an Oxybenzylglycine Based PPARα Selective Agonist.

M. Blanar, Rongan Zhang, S. Krystek, 2016, ACS medicinal chemistry letters.

Synthesis and in vivo evaluation of cyclic diaminopropane BACE-1 inhibitors.

A. Good, J. Macor, J. Marcinkeviciene, 2011, Bioorganic & medicinal chemistry letters.

Design, synthesis and structure-activity relationships of azole acids as novel, potent dual PPAR alpha/gamma agonists.

Wei Wang, Jonathan Lippy, Arthur M Doweyko, 2009, Bioorganic & medicinal chemistry letters.

CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH Compound_5 AKA 4-[(2-CARBAMOYLPHEN YL)AMINO]-6-[(5-FLUOROPYRIDIN-2-YL)AMINO]-N-METHYLPYRIDINE -3-CARBOXAMIDE

S. Spergel, K. McIntyre, J. Tokarski, 2019 .

Discovery of furo[2,3-d][1,3]thiazinamines as beta amyloid cleaving enzyme-1 (BACE1) inhibitors.

J. Macor, Chiehying Y Chang, M. Ahlijanian, 2016, Bioorganic & medicinal chemistry letters.

Discovery of S3-Truncated, C-6 Heteroaryl Substituted Aminothiazine β-Site APP Cleaving Enzyme-1 (BACE1) Inhibitors.

J. Macor, H. Lewis, Chiehying Y Chang, 2016, Journal of medicinal chemistry.

Identification of a Potent, Selective, and Efficacious Phosphatidylinositol 3-Kinase δ (PI3Kδ) Inhibitor for the Treatment of Immunological Disorders.

K. McIntyre, Sidney Pitt, G. Schieven, 2017, Journal of medicinal chemistry.

Small Molecule Reversible Inhibitors of Bruton's Tyrosine Kinase (BTK): Structure-Activity Relationships Leading to the Identification of 7-(2-Hydroxypropan-2-yl)-4-[2-methyl-3-(4-oxo-3,4-dihydroquinazolin-3-yl)phenyl]-9H-carbazole-1-carboxamide (BMS-935177).

K. McIntyre, J. Barrish, A. Mathur, 2016, Journal of medicinal chemistry.

Identification of imidazo[1,2-b]pyridazine TYK2 pseudokinase ligands as potent and selective allosteric inhibitors of TYK2 signalling.

J. Tokarski, D. Xie, N. Araníbar, 2017, MedChemComm.

Identification of Imidazo[1,2-b]pyridazine Derivatives as Potent, Selective, and Orally Active Tyk2 JH2 Inhibitors.

James Lin, K. McIntyre, J. Tokarski, 2019, ACS medicinal chemistry letters.

Synthesis and evaluation of indenopyrazoles as cyclin-dependent kinase inhibitors. 3. Structure activity relationships at C3

Angela Smallwood, Chong-Hwan Chang, Steven P. Seitz, 2002 .

Discovery of 6-Fluoro-5-(R)-(3-(S)-(8-fluoro-1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)-2-methylphenyl)-2-(S)-(2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro-1H-carbazole-8-carboxamide (BMS-986142): A Reversible Inhibitor of Bruton's Tyrosine Kinase (BTK) Conformationally Constrained by Two Locked

Michael A. Galella, K. McIntyre, J. Barrish, 2016, Journal of medicinal chemistry.

Bicyclic Heterocyclic Replacement of an Aryl Amide Leading to Potent and Kinase-Selective Adaptor Protein 2-Associated Kinase 1 Inhibitors.

Vijay T. Ahuja, J. Macor, S. E. Kiefer, 2022, Journal of medicinal chemistry.

The structure of coxsackievirus B3 at 3.5 A resolution.

M G Rossmann, M. Rossmann, D. Pevear, 1995, Structure.

Synthesis and evaluation of indenopyrazoles as cyclin-dependent kinase inhibitors. Part 4: Heterocycles at C3.

Chong-Hwan Chang, G. Trainor, S. Cox, 2004, Bioorganic & medicinal chemistry letters.

Design and synthesis of carbazole carboxamides as promising inhibitors of Bruton's tyrosine kinase (BTK) and Janus kinase 2 (JAK2).

Zheng Yang, Neha Surti, Jonathan S Lippy, 2015, Bioorganic & medicinal chemistry letters.

Discovery, Structure-Activity Relationships, and In Vivo Evaluation of Novel Aryl Amides as Brain Penetrant Adaptor Protein 2-Associated Kinase 1 (AAK1) Inhibitors for the Treatment of Neuropathic Pain.

Vijay T. Ahuja, J. Macor, L. Bristow, 2021, Journal of medicinal chemistry.

Purine derivatives as potent Bruton's tyrosine kinase (BTK) inhibitors for autoimmune diseases.

Andrew Tebben, Qian Ruan, Neha Surti, 2014, Bioorganic & medicinal chemistry letters.

Discovery of an oxybenzylglycine based peroxisome proliferator activated receptor alpha selective agonist 2-((3-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)benzyl)(methoxycarbonyl)amino)acetic acid (BMS-687453).

Wei Wang, Jun Li, Ying Wang, 2010, Journal of medicinal chemistry.

Phthalazinone-based lactams and cyclic ureas as ROCK2 selective inhibitors.

Yan Zou, R. Wexler, J. Muckelbauer, 2023, Bioorganic & medicinal chemistry letters.

Identification of 5H-Chromeno[3,4-c]pyridine and 6H-Isochromeno[3,4-c]pyridine Derivatives as Potent and Selective Dual ROCK Inhibitors.

R. Wexler, J. Muckelbauer, Zilun Hu, 2020, Bioorganic & medicinal chemistry letters.

Using yeast surface display to engineer a soluble and crystallizable construct of hematopoietic progenitor kinase 1 (HPK1).

D. Xie, S. Sheriff, D. Lipovšek, 2020, Acta crystallographica. Section F, Structural biology communications.

The structure of coxsackievirus B3.

M. Rossmann, J. Muckelbauer, 1997, Current topics in microbiology and immunology.

Synthesis and structure-activity relationships of 2-aryl-4-oxazolylmethoxy benzylglycines and 2-aryl-4-thiazolylmethoxy benzylglycines as novel, potent PPARalpha selective activators- PPARalpha and PPARgamma selectivity modulation.

Daniel Meyers, Jonathan Lippy, Rongan Zhang, 2010, Bioorganic & medicinal chemistry letters.

Discovery of pyrrolo[2,1-f][1,2,4]triazine-based inhibitors of adaptor protein 2-associated kinase 1 for the treatment of pain

A. Good, J. Macor, L. Bristow, 2023, Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents.

Monosubstituted γ-lactam and conformationally constrained 1,3-diaminopropan-2-ol transition-state isostere inhibitors of β-secretase (BACE).

A. Good, J. Macor, J. Marcinkeviciene, 2011, Bioorganic & medicinal chemistry letters.

Acyl guanidine inhibitors of β-secretase (BACE-1): optimization of a micromolar hit to a nanomolar lead via iterative solid- and solution-phase library synthesis.

Ramesh Padmanabha, A. Good, J. Macor, 2012, Journal of medicinal chemistry.

Synthesis and SAR of indole-and 7-azaindole-1,3-dicarboxamide hydroxyethylamine inhibitors of BACE-1.

J. Macor, J. Marcinkeviciene, P. Morin, 2011, Bioorganic & medicinal chemistry letters.

CRYSTAL STRUCTURE OF RHO-ASSOCIATED PROTEIN KINASE 2 (ROCK2) IN COMPLEX WITH A POTENT AND SELECTIVE DUAL ROCK INHIBITOR

J. Muckelbauer, 2020 .

Identification of N-Methyl Nicotinamide and N-Methyl Pyridazine-3-Carboxamide Pseudokinase Domain Ligands as Highly Selective Allosteric Inhibitors of Tyrosine Kinase 2 (TYK2).

S. Spergel, K. McIntyre, J. Tokarski, 2019, Journal of medicinal chemistry.

X‐Ray Crystal Structure of Bone Marrow Kinase in the X Chromosome: A Tec Family Kinase

D. Xie, J. Sack, Chiehying Y Chang, 2011, Chemical biology & drug design.