J. Tino

发表

X‐Ray Crystal Structure of Bone Marrow Kinase in the X Chromosome: A Tec Family Kinase

D. Xie, J. Sack, Chiehying Y Chang, 2011, Chemical biology & drug design.

Discovery of a Partial Glucokinase Activator Clinical Candidate: Diethyl ((3-(3-((5-(Azetidine-1-carbonyl)pyrazin-2-yl)oxy)-5-isopropoxybenzamido)-1H-pyrazol-1-yl)methyl)phosphonate (BMS-820132).

Steven A. Spronk, K. Behnia, J. Barrish, 2022, Journal of medicinal chemistry.

Novel Peroxisome Proliferator-Activated Receptor α Agonists Lower Low-Density Lipoprotein and Triglycerides, Raise High-Density Lipoprotein, and Synergistically Increase Cholesterol Excretion with a Liver X Receptor Agonist

M. Blanar, Rongan Zhang, Jun Li, 2008, Journal of Pharmacology and Experimental Therapeutics.

Discovery and Preclinical Evaluation of BMS-711939, an Oxybenzylglycine Based PPARα Selective Agonist.

M. Blanar, Rongan Zhang, S. Krystek, 2016, ACS medicinal chemistry letters.

Biologic-like In Vivo Efficacy with Small Molecule Inhibitors of TNFα Identified Using Scaffold Hopping and Structure-Based Drug Design Approaches.

D. Shuster, J. Macor, J. Yanchunas, 2020, Journal of medicinal chemistry.

synergistically increase cholesterol excretion with an LXR agonist.

M. Blanar, Rongan Zhang, Jun Li, 2008 .

In vitro Free Radical Scavenging and Antioxidant Activities of Aqueous Extracts of Crateva adansonii

J. Tino, C. Ugwu, P. Ogueche, 2018 .

Enhanced Gastrointestinal Motility with Orally Active Ghrelin Receptor Agonists

P. Distefano, J. Hixon, K. Longo, 2009, Journal of Pharmacology and Experimental Therapeutics.

Discovery of a potent and novel motilin agonist.

R. Stoffel, Huabin Sun, R. Seethala, 2004, Journal of medicinal chemistry.

Tricyclic Sulfones as Potent, Selective and Efficacious RORγt Inverse Agonists - Exploring C6 and C8 SAR Using Late-Stage Functionalization.

Michael G. Yang, D. Shuster, C. Weigelt, 2020, Bioorganic & medicinal chemistry letters.

A High-Throughput BRET Cellular Target Engagement Assay Links Biochemical to Cellular Activity for Bruton’s Tyrosine Kinase

B. Arey, C. Chaudhry, A. Tebben, 2019, SLAS discovery : advancing life sciences R & D.

Identification of highly potent and selective PI3Kδ inhibitors.

G. Schieven, C. Weigelt, M. Poss, 2017, Bioorganic & medicinal chemistry letters.

Identification of a Potent, Selective, and Efficacious Phosphatidylinositol 3-Kinase δ (PI3Kδ) Inhibitor for the Treatment of Immunological Disorders.

K. McIntyre, Sidney Pitt, G. Schieven, 2017, Journal of medicinal chemistry.

Discovery and optimization of (R)-prolinol-derived agonists of the Growth Hormone Secretagogue receptor (GHSR).

R. Stoffel, S. Gerritz, D. Gordon, 2008, Bioorganic & medicinal chemistry letters.

(D)-2-tert-Butoxycarbonylamino-5,5-difluoro-5-phenyl-pentanoic acid: synthesis and incorporation into the growth hormone secretagogues.

W. Humphreys, R. Seethala, P. Sleph, 2008, Bioorganic & medicinal chemistry letters.

Study of potential curves by UHF-type methods. VI: Spin-extended Hartree-Fock method

J. Tino, V. Klimo, 1984 .

Discovery of 7-(3-(piperazin-1-yl)phenyl)pyrrolo[2,1-f][1,2,4]triazin-4-amine derivatives as highly potent and selective PI3Kδ inhibitors.

C. Weigelt, M. Poss, J. Sack, 2017, Bioorganic & medicinal chemistry letters.

Spin density calculations in semiempirical restricted and unrestricted SCF MO methods

J. Tino, 1970 .

Small Molecule Reversible Inhibitors of Bruton's Tyrosine Kinase (BTK): Structure-Activity Relationships Leading to the Identification of 7-(2-Hydroxypropan-2-yl)-4-[2-methyl-3-(4-oxo-3,4-dihydroquinazolin-3-yl)phenyl]-9H-carbazole-1-carboxamide (BMS-935177).

K. McIntyre, J. Barrish, A. Mathur, 2016, Journal of medicinal chemistry.

Tetrazole based amides as growth hormone secretagogues.

R. Seethala, G. Grover, P. Sleph, 2008, Bioorganic & medicinal chemistry letters.

Tetrahydroisoquinoline 1-carboxamides as growth hormone secretagogues.

R. Stoffel, K. Dickinson, R. Seethala, 2005, Bioorganic & medicinal chemistry letters.

Separation of Bruton's tyrosine kinase inhibitor atropisomers by supercritical fluid chromatography.

A. Mathur, Peng Li, J. Tino, 2019, Journal of chromatography. A.

Discovery, synthesis, and structure-activity studies of tetrazole based growth hormone secretagogues.

K. Dickinson, R. Seethala, G. Grover, 2007, Bioorganic & medicinal chemistry letters.

Driving Potency with Rotationally Stable Atropisomers: Discovery of Pyridopyrimidinedione-Carbazole Inhibitors of BTK.

Michael A. Galella, K. McIntyre, J. Barrish, 2020, ACS medicinal chemistry letters.

Total synthesis of a fully protected palytoxin carboxylic acid

J. B. White, M. Martinelli, W. Christ, 1989 .

Synthesis of SQ-32,829, a new nucleoside antiviral agent

J. Tino, R. Zahler, G. Jacobs, 1989 .

Design and synthesis of tetrazole-based growth hormone secretagogue: the SAR studies of the O-benzyl serine side chain.

W. Humphreys, K. Dickinson, R. Seethala, 2008, Bioorganic & medicinal chemistry letters.

Discovery of a tetrazole-based growth hormone secretagogue: 4-(hydroxybutyl)carbamic acid 2-{5-[1-(2-amino-2-methylpropionylamino)-2- benzyloxyethyl]tetrazol-1-yl}ethyl ester (BMS-317180).

W. Humphreys, K. Dickinson, R. Seethala, 2007, Journal of medicinal chemistry.

Aminodiol HIV protease inhibitors. Synthesis and structure-activity relationships of P1/P1' compounds: correlation between lipophilicity and cytotoxicity.

S. Spergel, O. Kocy, J. Barrish, 1996, Journal of medicinal chemistry.

Discovery of 6-Fluoro-5-(R)-(3-(S)-(8-fluoro-1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)-2-methylphenyl)-2-(S)-(2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro-1H-carbazole-8-carboxamide (BMS-986142): A Reversible Inhibitor of Bruton's Tyrosine Kinase (BTK) Conformationally Constrained by Two Locked

Michael A. Galella, K. McIntyre, J. Barrish, 2016, Journal of medicinal chemistry.

An After-Effect of Pressure to the ESR Spectra of Irradiated PMMA

J. Tino, F. Szőcs, 1973 .

E.S.R. study of alkaline, oxidative degradation of saccharides. Identification of 2,5-dihydroxy-p-benzosemiquinone

I. Šimkovic, J. Plaček, J. Tino, 1983 .

Differences in antiviral activities for isomers of a fluorinated cyclobutane nucleoside analog

G. Vite, J. Tino, R. Zahler, 1993 .

Synthesis and antiviral activity of novel isonucleoside analogs.

S. Spergel, J. Clark, J. Tino, 1993, Journal of medicinal chemistry.

2-hydroxy-N-arylbenzenesulfonamides as ATP-citrate lyase inhibitors.

Dong Cheng, Ramesh Padmanabha, Kristen Pike, 2007, Bioorganic & medicinal chemistry letters.

Synthesis and antiviral activity of 1-cyclobutyl-5-(2-bromovinyl)uracil nucleoside analogues and related compounds.

M. Young, G. Bisacchi, J. Tino, 1992, Journal of medicinal chemistry.

Molecular approach in the study of the processes of formation of the lattice of oxides. Characteristic features of coordination of AlO3 structural elements

G. M. Zhidomirov, J. Tino, S. Beran, 1987 .

α-hydroxyamide derived aminodiols as potent inhibitors of hiv protease

Ping Chen, S. Spergel, J. Barrish, 1995 .

Discovery of Branebrutinib (BMS-986195): A Strategy for Identifying a Highly Potent and Selective Covalent Inhibitor Providing Rapid in Vivo Inactivation of Bruton's Tyrosine Kinase (BTK).

Michael A. Galella, K. McIntyre, J. Macor, 2019, Journal of medicinal chemistry.

Bruton's tyrosine kinase inhibitor BMS-986142 in experimental models of rheumatoid arthritis enhances efficacy of agents representing clinical standard-of-care

K. McIntyre, A. Fura, K. Gillooly, 2017, PloS one.

Ab initio potential energy surface of the lowest triplet BH+2 collision complex

J. Urban, V. Klimo, J. Tino, 1986 .

Discovery of BMS-986251: A Clinically Viable, Potent, and Selective RORγt Inverse Agonist.

D. Shuster, J. Macor, C. Weigelt, 2020, ACS medicinal chemistry letters.

An MTP inhibitor that normalizes atherogenic lipoprotein levels in WHHL rabbits.

H. Jamil, C. Chu, R. Gregg, 1998, Science.

Conversion of carbazole carboxamide based reversible inhibitors of Bruton's tyrosine kinase (BTK) into potent, selective irreversible inhibitors in the carbazole, tetrahydrocarbazole, and a new 2,3-dimethylindole series.

C. Chaudhry, P. Carter, Neha Surti, 2018, Bioorganic & medicinal chemistry letters.

Design and synthesis of carbazole carboxamides as promising inhibitors of Bruton's tyrosine kinase (BTK) and Janus kinase 2 (JAK2).

Zheng Yang, Neha Surti, Jonathan S Lippy, 2015, Bioorganic & medicinal chemistry letters.

Antiviral properties of aminodiol inhibitors against human immunodeficiency virus and protease

J. Barrish, E. Gordon, A. Patick, 1995, Antimicrobial agents and chemotherapy.

Purine derivatives as potent Bruton's tyrosine kinase (BTK) inhibitors for autoimmune diseases.

Andrew Tebben, Qian Ruan, Neha Surti, 2014, Bioorganic & medicinal chemistry letters.

Rationally Designed, Conformationally Constrained Inverse Agonists of RORγt ‒ Identification of a Potent, Selective Series with Biologic-Like In Vivo Efficacy.

K. McIntyre, D. Shuster, J. Macor, 2019, Journal of medicinal chemistry.

Novel Tricyclic Pyroglutamide Derivatives as Potent RORγt Inverse Agonists Identified using a Virtual Screening Approach.

D. Shuster, J. Macor, C. Weigelt, 2020, ACS medicinal chemistry letters.

Discovery of an oxybenzylglycine based peroxisome proliferator activated receptor alpha selective agonist 2-((3-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)benzyl)(methoxycarbonyl)amino)acetic acid (BMS-687453).

Wei Wang, Jun Li, Ying Wang, 2010, Journal of medicinal chemistry.

Optimization of 1H-tetrazole-1-alkanenitriles as potent orally bioavailable growth hormone secretagogues.

W. Humphreys, K. Dickinson, R. Seethala, 2008, Bioorganic & medicinal chemistry letters.

Synthesis and structure-activity relationships of 2-aryl-4-oxazolylmethoxy benzylglycines and 2-aryl-4-thiazolylmethoxy benzylglycines as novel, potent PPARalpha selective activators- PPARalpha and PPARgamma selectivity modulation.

Daniel Meyers, Jonathan Lippy, Rongan Zhang, 2010, Bioorganic & medicinal chemistry letters.

Annulation Reaction Enables the identification of an Exocyclic Amide Tricyclic Chemotype as Retinoic Acid Receptor-Related Orphan Receptor Gamma (RORγ/RORc) Inverse Agonists.

Michael A. Galella, C. Weigelt, M. Cvijic, 2020, Bioorganic & medicinal chemistry letters.

Positron annihilation studies of polyethylene filled with ultrasil

O. Šauša, J. Tino, J. Krištiak, 1993 .

Structural Analysis of the Native and Drug Resistant HIV-1 Proteinases Complexed With an Aminodiol Inhibitor

Alexander Wlodawer, Jukka Kervinen, Pin-Fang Lin, 1996, Protein & Peptide Letters.

Enhanced Gastrointestinal Motility with Orally Active Ghrelin Receptor Agonists

P. Distefano, J. Hixon, K. Longo, 2009, Journal of Pharmacology and Experimental Therapeutics.