M. Grifantini

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Selective inhibition of nicotinamide adenine dinucleotide kinases by dinucleoside disulfide mimics of nicotinamide adenine dinucleotide analogues.

Y. Sham, G. Magni, M. Di Stefano, 2009, Bioorganic & medicinal chemistry.

Synthesis, biological evaluation, and molecular modeling of ribose-modified adenosine analogues as adenosine receptor agonists.

Riccardo Petrelli, Barbara Costa, Ettore Novellino, 2005, Journal of medicinal chemistry.

From the covalent linkage of drugs to novel inhibitors of ribonucleotide reductase: synthesis and biological evaluation of valproic esters of 3'-C-methyladenosine.

R. Petrelli, L. Cappellacci, P. Kusumanchi, 2014, Bioorganic & medicinal chemistry letters.

Recent Progress in Histone Deacetylase Inhibitors as Anticancer Agents.

R. Petrelli, L. Cappellacci, F. Maggi, 2020, Current medicinal chemistry.

2-Chloro-N 6 -( 3 H)cyclopentyladenosine (( 3 H)CCPA) - a high affinity agonist radio Iigand for A 1 adenosine receptors

M. Lohse, G. Cristalli, S. Vittori, 1989 .

2-Chloro-N6-cyclopentyladenosine: a highly selective agonist at A1 adenosine receptors

K. Klotz, M. Lohse, G. Cristalli, 1988, Naunyn-Schmiedeberg's Archives of Pharmacology.

5'-Chloro-5'-deoxy-(±)-ENBA, a Potent and Selective Adenosine A1 Receptor Agonist, Alleviates Neuropathic Pain in Mice Through Functional Glial and Microglial Changes without Affecting Motor or Cardiovascular Functions

R. Petrelli, L. Cappellacci, C. Giordano, 2012, Molecules.

Inhibition of HIV-1 replication in macrophages by a heterodinucleotide of lamivudine and tenofovir.

M. Magnani, L. Cappellacci, C. Perno, 2007, The Journal of antimicrobial chemotherapy.

C-nucleoside analogues of furanfurin as ligands to A1 adenosine receptors.

C. Martini, K. Varani, B. Costa, 2000, Bioorganic & medicinal chemistry.

Adenosine receptor agonists: synthesis and biological evaluation of 1-deaza analogues of adenosine derivatives.

K. Klotz, M. Lohse, G. Cristalli, 1988, Journal of medicinal chemistry.

2-Chloro-N6-[3H]cyclopentyladenosine ([3HCCPA) —a high affinity agonist radioligand for A1 adenosine receptors

K. Klotz, M. Lohse, G. Cristalli, 1989, Naunyn-Schmiedeberg's Archives of Pharmacology.

Ribose-modified purine nucleosides as ribonucleotide reductase inhibitors. Synthesis, antitumor activity, and molecular modeling of N6-substituted 3'-C-methyladenosine derivatives.

A. Lavecchia, T. Szekeres, R. Petrelli, 2008, Journal of medicinal chemistry.

Synthesis and potency of novel uracil nucleotides and derivatives as P2Y2 and P2Y6 receptor agonists.

K. Jacobson, S. van Calenbergh, T. K. Harden, 2008, Bioorganic & medicinal chemistry.

Inhibition of HIV-1 Replication in Macrophages by Red Blood Cell-Mediated Delivery of a Heterodinucleotide of Lamivudine and Tenofovir

M. Magnani, R. Petrelli, L. Cappellacci, 2007, Nucleosides, nucleotides & nucleic acids.

2'-C-Methyl analogues of selective adenosine receptor agonists: synthesis and binding studies.

C. Martini, A. Lucacchini, L. Cappellacci, 1998, Journal of medicinal chemistry.

Targeting Nucleotide Dimers Containing Antiviral Nucleosides

C. Perno, M. Magnani, L. Cappellacci, 2005 .

Synthesis, structure, and antiproliferative activity of selenophenfurin, an inosine 5'-monophosphate dehydrogenase inhibitor analogue of selenazofurin.

G. Perra, P. la Colla, L. Cappellacci, 1997, Journal of medicinal chemistry.

8-Azaxanthine derivatives as antagonists of adenosine receptors.

C. Martini, A. Lucacchini, L. Cappellacci, 1994, Journal of medicinal chemistry.

Synthesis of Unsaturated Analogues of 9-[2(Phosphono- Methoxy)Propyl]Guanine as Antiviral Agents

G. Perra, M. Marongiu, P. Colla, 1997 .

Synthesis and Cytotoxic Activity of Selenophenfurin, a New Inhibitor of IMP Dehydrogenase

G. Perra, L. Cappellacci, P. Colla, 1997 .

Acyclic Nucleotides Related to Clitocine: Synthesis and Anti-HIV Activity

L. Cappellacci, P. Colla, G. A. Sheikha, 1995 .

Synthesis and IMP Dehydrogenase (Type I and Type II) Inhibitory Activity of Isosteric NAD Analogs Derived from Thiophenfurin and Furanfurin

F. Collart, E. Huberman, L. Cappellacci, 1997 .

Synthesis of 2-Azido-(R)-N6-p-hydroxyphenylisopropyladenosine (R-AHPIA) as Potential Photoaffinity Probe for A1 Adenosine Receptors

K. Klotz, M. Lohse, G. Cristalli, 1986 .

Adenosine deaminase from Saccharomyces cerevisiae: kinetics and interaction with transition and ground state inhibitors.

M. Falasca, G. Cristalli, G. Lupidi, 1992, Biochimica et biophysica acta.

Erythrocyte-mediated delivery of a new homodinucleotide active against human immunodeficiency virus and herpes simplex virus.

M. Magnani, L. Cappellacci, C. Perno, 2001, The Journal of antimicrobial chemotherapy.

A New Facile Synthesis and Antiviral Activity of Oxazofurin

L. Cappellacci, G. Piras, M. Marongiu, 1993 .

Antitumor activity of C-methyl-beta-D-ribofuranosyladenine nucleoside ribonucleotide reductase inhibitors.

T. Szekeres, R. Petrelli, L. Cappellacci, 2005, Journal of medicinal chemistry.

Decomposition pathways and in vitro HIV inhibitory effects of isoddA pronucleotides: toward a rational approach for intracellular delivery of nucleoside 5'-monophosphates.

P. la Colla, L. Cappellacci, J. Imbach, 1996, Journal of medicinal chemistry.

Synthesis and evaluation of the anti-HIV activity of aza and deaza analogues of isoddA and their phosphates as prodrugs.

P. la Colla, L. Cappellacci, G. Abu Sheikha, 1994, Journal of medicinal chemistry.

A New Tiazofurin Pronucleotide: Synthesis and Biological Evaluation of CycloSaligenyl-Tiazofurin Monophosphate

C. Martini, L. Cappellacci, P. Franchetti, 2003, Nucleosides, nucleotides & nucleic acids.

Synthesis of 4-amino-1-beta-D-ribofuranosyl-1H-pyrrolo[2,3-b]pyridine (1-deazatubercidin) as a potential antitumor agent.

G. Cristalli, S. Martelli, I. Antonini, 1982, Journal of medicinal chemistry.

A new C-nucleoside analogue of tiazofurin: synthesis and biological evaluation of 2-beta-D-ribofuranosylimidazole-4-carboxamide (imidazofurin).

L. Cappellacci, S. Marchetti, P. Franchetti, 2001, Bioorganic & medicinal chemistry letters.

Synthesis, conformational analysis, and biological activity of C-thioribonucleosides related to tiazofurin.

L. Cappellacci, J. Imbach, P. Franchetti, 2000, Journal of medicinal chemistry.

IMP dehydrogenase as a target of antitumor and antiviral chemotherapy.

L. Cappellacci, P. Franchetti, M. Grifantini, 1996, Farmaco.

Ribose-modified nucleosides as ligands for adenosine receptors: synthesis, conformational analysis, and biological evaluation of 1'-C-methyl adenosine analogues.

Barbara Costa, Claudia Martini, C. Martini, 2002, Journal of medicinal chemistry.

Investigation on the isomerization of 2-amino-3-aziridino-1,4-naphthoquinones to benzo[g]quinoxalines†

S. Martelli, Giovanni Casini, M. Grifantini, 1974 .

Potent and Selective Inhibitors of Human Immunodeficiency Virus Protease Structurally Related to L-694,746

P. la Colla, A. Pani, L. Cappellacci, 1998, Antiviral chemistry & chemotherapy.

Metal(II) complexes of 2,2′-bipyridyl-6-carbothioamide as anti-tumor and anti-fungal agents

G. Cristalli, S. Vittori, E. Lepri, 1988 .

Elucidation of the structure of the antineoplastic agents, 2-formylpyridine and 1-formylisoquinoline thiosemicarbazones.

S. Martelli, I. Antonini, P. Franchetti, 1977, Journal of medicinal chemistry.

Synthesis of 2,3,5,6‐tetrahydroimidazo[1,2‐c]quinazoline derivatives as potential narcotic antagonists

G. Cristalli, S. Martelli, I. Antonini, 1980 .

2,2'-Bipyridyl-6-carbothioamide derivatives as potential antitumor agents.

G. Cristalli, S. Martelli, I. Antonini, 1986, Il Farmaco; edizione scientifica.

Synthesis of N1-Aryl- and N1-Benzyl Substituted Imidazole-4- and Imidazole-5-carbaldehydes

G. Cristalli, S. Martelli, I. Antonini, 1983 .

Synthesis and Evaluation of Anti-HIV-1 and Antitumor Activity of 2′,3′-didehydro-2′,3′-dideoxy-3-deazaadenosine, 2′,3′-dideoxy-3-Deazaadenosine and Some 2′,3′-dideoxy-3-deaza-adenosine 5′-dialkyl Phosphates1

G. Cristalli, A. Pani, L. Cappellacci, 1991 .

Purine and Pyrimidine Nucleoside Analogs of 3'-C-Methyladenosine as Antitumor Agents

R. Petrelli, L. Cappellacci, P. Franchetti, 2006 .

Furanfurin and thiophenfurin: two novel tiazofurin analogues. Synthesis, structure, antitumor activity, and interactions with inosine monophosphate dehydrogenase.

C. Carrell, L. Cappellacci, A. O'Connor, 1995, Journal of medicinal chemistry.

8-Aza-1-deaza purine nucleosides as antiviral agents.

L. Cappellacci, M. Marongiu, P. Colla, 1994 .

8-Aza Derivatives of 3-Deazapurine Nucleosides. Synthesis and in vitro Evaluation of Antiviral and Antitumor Activity

P. la Colla, L. Cappellacci, G. Nocentini, 1993 .

8-Aza Analogues of Deaza Purine Nucleosides. Synthesis and Biological Evaluation of 8-Aza-1-deazaadenosine and 2′-Deoxy-8-aza-1-deazaadenosine

G. Lupidi, L. Cappellacci, G. Nocentini, 1992 .

Deaza analogues of adenosine as inhibitors of blood platelet aggregation.

G. Cristalli, S. Martelli, I. Antonini, 1984, Journal of pharmaceutical sciences.

Acid-catalysed, nucleophile-catalysed and thermal decomposition of 2-amino-3-(2′,2′-dimethylaziridino)-1,4-naphthoquinone†

G. Cristalli, S. Martelli, I. Antonini, 1980 .

Thermal decomposition of 2‐amino‐3‐aziridino‐1,4‐naphthoquinones

G. Cristalli, S. Martelli, I. Antonini, 1981 .

Improved synthesis and antitumor activity of 1-deazaadenosine.

G. Cristalli, S. Vittori, C. Geroni, 1987, Journal of medicinal chemistry.

Structure-activity relations in organophosphorus inhibited acetylcholinesterase reactivators. I. Methiodides of new mono- and dioximes with pyridine nucleus.

S. Martelli, M. Grifantini, M. Stein, 1969, Journal of pharmaceutical sciences.

Heterocyclic quinones with potential antitumor activity. 2. Synthesis and antitumor activity of some benzimidazole-4,7-dione derivatives.

G. Cristalli, S. Martelli, I. Antonini, 1988, Journal of medicinal chemistry.

Heterocyclic Quinones with Potential Antitumor Activity. A Convenient Synthesis of 5,6-Din1ethyl-4,7-benzimidazolediones.

S. Martelli, I. Antonini, P. Franchetti, 1982 .

8-Aza-analogues of PMEA and PMEG: Synthesis and In Vitro Anti-HIV Activity

L. Cappellacci, P. Colla, G. A. Sheikha, 1994 .

5'-Carbamoyl derivatives of 2'-C-methyl-purine nucleosides as selective A1 adenosine receptor agonists: affinity, efficacy, and selectivity for A1 receptor from different species.

K. Klotz, A. Lavecchia, C. Martini, 2008, Bioorganic & medicinal chemistry.

Synthesis of 5H‐Pyrrolo[1,2‐c]imidazole and 5H‐Pyrrolo[1,2‐a]imidazole

S. Martelli, P. Franchetti, M. Grifantini, 1976 .

Inhibition of adenosine deaminase from several sources by deaza derivatives of adenosine and EHNA.

G. Cristalli, G. Lupidi, F. Marmocchi, 1985, Journal of enzyme inhibition.

Synthesis of 3-Deazaclitocwe [2-Amino-3-nitro-4-(β-D-ribofuranosylamino)pyridine] as Cytotoxic Agent

G. Cristalli, S. Vittori, L. Cappellacci, 1991 .

N6-Cycloalkyl- and N6-bicycloalkyl-C5'(C2')-modified adenosine derivatives as high-affinity and selective agonists at the human A1 adenosine receptor with antinociceptive effects in mice.

K. Klotz, A. Lavecchia, R. Petrelli, 2009, Journal of medicinal chemistry.

Pharmacokinetic and antiretroviral activity in mice of oral [P(1),P(2)-bis[2-(adenin-9-yl)ethoxymethyl]phosphonate], a prodrug of 9-(2-phosphonylmethoxyethyl)adenine.

M. Magnani, S. Dominici, L. Cappellacci, 2002, The Journal of antimicrobial chemotherapy.

Inhibition of HIV-1 Replication in Macrophages by Red Blood Cell-Mediated Delivery of a Heterodinucleotide of Azidothymidine and 9-(R)-2-(Phosphono Methoxypropyl)adenine

C. Perno, M. Magnani, L. Cappellacci, 2001, Antiviral chemistry & chemotherapy.

A new acyclic heterodinucleotide active against human immunodeficiency virus and herpes simplex virus.

M. Magnani, L. Cappellacci, C. Perno, 2000, Antiviral research.

Adenosine deaminase inhibitors. Synthesis and biological activity of deaza analogues of erythro-9-(2-hydroxy-3-nonyl)adenine.

G. Cristalli, S. Vittori, G. Lupidi, 1988, Journal of medicinal chemistry.

Differentiation of isomeric 1-, 3- and 7-deazaadenosines by electron ionization mass spectrometry†

G. Cristalli, M. L. Reimer, M. Grifantini, 1990 .

3,7-Dideazapurine nucleosides. Synthesis and antitumor activity of 1-deazatubercidin and 2-chloro-2'-deoxy-3,7-dideazaadenosine.

G. Cristalli, S. Vittori, G. Nocentini, 1989, Journal of Medicinal Chemistry.

The synergistic apoptotic effects of thiophenfurin, an inosine monophosphate dehydrogenase inhibitor, in combination with retinoids in HL60 cells.

L. Cappellacci, M. Tolomeo, D. Simoni, 2007, Oncology reports.

Adenosine deaminase inhibitors. Synthesis of deaza analogues of erythro-9-(2-hydroxy-3-nonyl)adenine.

G. Cristalli, G. Lupidi, S. Martelli, 1984, Journal of medicinal chemistry.

Improved synthesis and antitumor activity of 1-deazaadenosine.

G. Cristalli, S. Vittori, C. Geroni, 1987, Journal of medicinal chemistry.

Improved Synthesis and Cytostatic Activity of 1-Deazaadenosine

G. Cristalli, S. Vittori, C. Geroni, 1987 .

Adenosine and 2-Chloroadenosine Deaza-Analogues as Adenosine Receptor Agonists1

G. Cristalli, W. Balduini, F. Cattabeni, 1985 .

Inhibition of adenosine deaminase by deaza derivatives of adenosine and purine riboside.

G. Cristalli, G. Lupidi, M. Grifantini, 1982, The Italian journal of biochemistry.

Nucleoside and non-nucleoside IMP dehydrogenase inhibitors as antitumor and antiviral agents.

P. Franchetti, M. Grifantini, P Franchetti, 1999, Current medicinal chemistry.

Synthesis and biological activity of novel N6-substituted and 2,N6-disubstituted adenine ribo- and 3'-C-methyl-ribonucleosides as antitumor agents.

Y. Yen, Bingsen Zhou, R. Petrelli, 2011, European journal of medicinal chemistry.

Synthesis and Antitumor Activity of 6–Substituted Purine and Deazapurine Nucleosides

G. Cristalli, E. Pesenti, S. Vittori, 1991 .

Synthesis and antitumor activity of 2-beta-D-ribofuranosyloxazole-4-carboxamide (oxazofurin).

G. Cristalli, S. Vittori, L. Cappellacci, 1990, Journal of medicinal chemistry.

Nucleoside and Non-nucleoside IMP Dehydrogenase- Inhibitors as Antitumor and Antiviral Agents

P. Franchetti, M. Grifantini, 1999, Current Medicinal Chemistry.

Synthesis and Antitumor Activity of a Heterodinucleotide of BVDU and Gemcitabine

R. Petrelli, L. Cappellacci, P. Franchetti, 2008, Nucleosides, nucleotides & nucleic acids.

3,7‐Dideazapurine Nucleosides. Synthesis and Antitumor Activity of 1‐Deazatubercidin and 2‐Chloro‐2′‐deoxy‐3,7‐dideazaadenosine.

G. Cristalli, S. Vittori, G. Nocentini, 1989 .

Synthesis and antiviral activity of 8-aza analogs of chiral [2-(phosphonomethoxy) propyl]guanines.

P. la Colla, L. Cappellacci, G. Piras, 1995, Journal of medicinal chemistry.

Adenosine deaminase inhibitors: synthesis and structure-activity relationships of imidazole analogues of erythro-9-(2-hydroxy-3-nonyl)adenine.

G. Cristalli, S. Vittori, A. Eleuteri, 1991, Journal of medicinal chemistry.

Adenosine Deaminase Inhibitors. Synthesis and Biological Activity of Deaza Analogues (V) and (X) of erythro-9-(2-Hydroxy-3-nonyl)adenine (XI).

G. Cristalli, S. Vittori, G. Lupidi, 1988 .

Histone deacetylase inhibition modulates deoxyribonucleotide pools and enhances the antitumor effects of the ribonucleotide reductase inhibitor 3'-C-methyladenosine in leukaemia cells.

T. Szekeres, A. Mai, D. Rotili, 2011, International journal of oncology.

New example of intramolecular 1,5-hydrogen transfer during diazotization reactions

S. Martelli, I. Antonini, P. Franchetti, 1976 .

Structure-activity relationships in reactivators of organophosphorus-inhibited acetylcholinesterase. V. Quaternary salts of hydroxyiminomethylimidazoles.

S. Martelli, M. Grifantini, M. Stein, 1972, Journal of pharmaceutical sciences.

C-glycosyl bond conformation in oxazofurin: crystallographic and computational studies of the oxazole analogue of tiazofurin.

D. Langs, H. Li, L. Cappellacci, 1994, Journal of medicinal chemistry.

Adenosine receptors as promising targets for the management of ocular diseases

L. Cappellacci, F. Del Bello, M. Grifantini, 2021, Medicinal Chemistry Research.

The antinociceptive effect of 2-chloro-2′-C-methyl-N6-cyclopentyladenosine (2′-Me-CCPA), a highly selective adenosine A1 receptor agonist, in the rat

F. Rossi, L. Cappellacci, S. Maione, 2007, PAIN.

The antinociceptive effect of 2-chloro-2 0-C-methyl-N-

F. Rossi, L. Cappellacci, S. Maione, 2007 .

Epigenetic agents as an adjunct to active chempotherapy in hematological tumor cell lines

R. Petrelli, L. Cappellacci, N. D’alessandro, 2012 .

N*-N*-S* tridentate ligand system as potential antitumor agents.

G. Cristalli, S. Martelli, I. Antonini, 1981, Journal of medicinal chemistry.

N*-N*-S* TRIDENTATE LIGAND SYSTEM AS POTENTIAL ANTITUMOR AGENTS

G. Cristalli, S. Martelli, I. Antonini, 1982 .

Photoaffinity Labeling of A 1-adenosine Receptors *

G. Cristalli, S. Vittori, M. Grifantini, 2011 .

5'-C-Ethyl-tetrazolyl-N(6)-substituted adenosine and 2-chloro-adenosine derivatives as highly potent dual acting A1 adenosine receptor agonists and A3 adenosine receptor antagonists.

Riccardo Petrelli, Ettore Novellino, Antonio Lavecchia, 2015, Journal of medicinal chemistry.

Adenosine Receptor with Antinociceptive Effects in Mice

K. Klotz, A. Lavecchia, R. Petrelli, 2009 .

Photoaffinity labeling of A1-adenosine receptors.

K. Klotz, M. Lohse, G. Cristalli, 1985, The Journal of biological chemistry.

Synthesis, conformational analysis, and biological activity of new analogues of thiazole-4-carboxamide adenine dinucleotide (TAD) as IMP dehydrogenase inhibitors.

D. B. Boyd, R. Petrelli, L. Cappellacci, 2005, Bioorganic & medicinal chemistry.

Dinucleoside Polyphosphate NAD Analogs as Potential NMN Adenylyltransferase Inhibitors. Synthesis and Biological Evaluation

G. Magni, L. Cappellacci, N. Raffaelli, 2003, Nucleosides, nucleotides & nucleic acids.

Isosteric analogues of nicotinamide adenine dinucleotide derived from furanfurin, thiophenfurin, and selenophenfurin as mammalian inosine monophosphate dehydrogenase (type I and II) inhibitors.

F. Collart, E. Huberman, L. Cappellacci, 1998, Journal of medicinal chemistry.

Structure-activity relationships of tiazofurin analogs: synthesis and computational studies of 4'-thio derivatives of thiophenfurin and furanfurin

L. Cappellacci, J. Imbach, S. Marchetti, 1999 .

TIAZOFURIN ANALOGS AS SELECTIVE AGONISTS OF A(1) ADENOSINE RECEPTORS

C. Martini, A. Lucacchini, L. Cappellacci, 1995 .

Development of C-Methyl Branched Purine Ribonucleoside Analogs: Chemistry, Biological Activity and Therapeutic Potential.

R. Petrelli, L. Cappellacci, M. Grifantini, 2016, Current medicinal chemistry.

Reactions of α-hydroxyimino derivatives of carbonyl compounds with bases—I: Derivatives of α,β-dihydroxyimino-butyric acid☆

F. Gualtieri, M. Grifantini, G. Alimenti, 1968 .

Tiazofurine ICN Pharmaceuticals.

M. Grifantini, 2000, Current opinion in investigational drugs.

The antinociceptive effect of 2-chloro-2′-C-methyl-N6-cyclopentyladenosine (2′-Me-CCPA), a highly selective adenosine A1 receptor agonist, in the rat

L. Cappellacci, S. Maione, L. Luongo, 2007, PAIN.

Purine and 1-deazapurine ribonucleosides and deoxyribonucleosides: synthesis and biological activity.

G. Cristalli, E. Pesenti, S. Vittori, 1991, Journal of medicinal chemistry.

Ribose-modified Mizoribine Analogues: Synthesis and Biological Evaluation

R. Petrelli, L. Cappellacci, P. Franchetti, 2005, Nucleosides, nucleotides & nucleic acids.

Synthesis of imidazo[1,2-c] quinazoline and some of its methyl derivatives

P. Franchetti, M. Grifantini, 1970 .