H. Hope

发表

Selective inhibition of the p38α MAPK–MK2 axis inhibits inflammatory cues including inflammasome priming signals

J. Monahan, J. Hirsch, Y. Alippe, 2018, The Journal of experimental medicine.

Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design.

David R. Anderson, S. Wright, V. Rao, 2017, Journal of medicinal chemistry.

Interleukin‐1β‐induced interleukin‐6 production in A549 cells is mediated by both phosphatidylinositol 3‐kinase and interleukin‐1 receptor‐associated kinase‐4

J. Monahan, H. Hope, H. Eda, 2011, Cell biology international.

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the MK2 Inhibitor ATI-450 in Healthy Subjects: A Placebo-Controlled, Randomized Phase 1 Study

J. Monahan, E. Hellriegel, H. Hope, 2021, Clinical pharmacology : advances and applications.

Structural bioinformatics-based prediction of exceptional selectivity of p38 MAP kinase inhibitor PH-797804.

Li Xing, R. Kurumbail, J. F. Schindler, 2009, Biochemistry.

Selective Inhibition of the MK2 Pathway: Data From a Phase IIa Randomized Clinical Trial in Rheumatoid Arthritis

A. Kivitz, A. Singhal, H. Hope, 2023, ACR open rheumatology.

Anti-Inflammatory Properties of a Novel N-Phenyl Pyridinone Inhibitor of p38 Mitogen-Activated Protein Kinase: Preclinical-to-Clinical Translation

Dean M. Messing, J. F. Schindler, G. Anderson, 2009, Journal of Pharmacology and Experimental Therapeutics.

SD0006: A Potent, Selective and Orally Available Inhibitor of p38 Kinase

R. Kurumbail, G. Anderson, J. Monahan, 2009, Pharmacology.

Pharmacokinetics and anti-inflammatory pharmacodynamics of prednisolone in cynomolgus monkey

A. Zutshi, M. Baratta, H. Hope, 2009, Xenobiotica; the fate of foreign compounds in biological systems.

Structural bioinformatics-based prediction of exceptional selectivity of p38 MAP kinase inhibitor PH-797804.

R. Kurumbail, J. F. Schindler, J. Monahan, 2009, Biochemistry.