J. Carman

发表

Direct association of tristetraprolin with the nucleoporin CAN/Nup214.

S. Nadler, J. Carman, 2004, Biochemical and biophysical research communications.

THU0239 IDENTIFICATION OF BIOMARKERS AND IMMUNE PATHWAYS FOR PERSONALIZED DRUG TARGETING IN PATIENTS WITH NEWLY DIAGNOSED PRIMARY SJÖGREN’S SYNDROME

A. Vissink, S. Kirov, H. Bootsma, 2019, Poster Presentations.

HuR Is Required for IL-17–Induced Act1-Mediated CXCL1 and CXCL5 mRNA Stabilization

S. Erzurum, Wen-pin Yang, H. Lipshitz, 2013, The Journal of Immunology.

StabilizationCXCL1 and CXCL5 mRNA Induced - HuR Is Required for IL-17

S. Erzurum, Wen-pin Yang, T. Hamilton, 2013 .

Act1 is a negative regulator in T and B cells via direct inhibition of STAT3

W. Leonard, F. Shi, C. Gu, 2018, Nature Communications.

IL-1 induces mitochondrial translocation of IRAK2 to suppress oxidative metabolism in adipocytes

Jonathan D. Smith, R. Schugar, J. M. Brown, 2020, Nature Immunology.

IRAK2 directs stimulus-dependent nuclear export of inflammatory mRNAs

Gao Zhou, F. Melchior, Jonathan D. Smith, 2017, eLife.

Autoimmune pathways in mice and humans are blocked by pharmacological stabilization of the TYK2 pseudokinase domain

K. McIntyre, C. Chaudhry, L. Salter-Cid, 2019, Science Translational Medicine.

A Systemic Lupus Erythematosus Endophenotype Characterized by Increased CD8 Cytotoxic Signature Associates with Renal Involvement

Somnath Bandyopadhyay, S. Nadler, R. Furie, 2017, ImmunoHorizons.

TLR-stimulated IRAKM activates caspase-8 inflammasome in microglia and promotes neuroinflammation

G. Dubyak, F. Shi, R. Ransohoff, 2018, The Journal of clinical investigation.

IL-17A–Induced PLET1 Expression Contributes to Tissue Repair and Colon Tumorigenesis

W. Ouyang, Wen-pin Yang, M. Kalady, 2017, The Journal of Immunology.

B cells from African American lupus patients exhibit an activated phenotype.

P. M. Davis, Clarence K. Zhang, S. Nadler, 2016, JCI insight.

Selective IRAK4 Inhibition Attenuates Disease in Murine Lupus Models and Demonstrates Steroid Sparing Activity

K. McIntyre, Wen-pin Yang, S. Ruepp, 2017, The Journal of Immunology.

This information is current as Demonstrates Steroid Sparing Activity Disease in Murine Lupus Models and Selective IRAK 4 Inhibition Attenuates

K. McIntyre, Wen-pin Yang, S. Ruepp, 2016 .

Abatacept Does Not Induce Direct Gene Expression Changes in Antigen-Presenting Cells

P. M. Davis, Han Chang, Wen-pin Yang, 2009, Journal of Clinical Immunology.

Optimization of Nicotinamides as Potent and Selective IRAK4 Inhibitors with Efficacy in a Murine Model of Psoriasis.

J. Barrish, D. Xie, N. Murugesan, 2020, ACS medicinal chemistry letters.

Improving the pharmacokinetic and CYP inhibition profiles of azaxanthene-based glucocorticoid receptor modulators-identification of (S)-5-(2-(9-fluoro-2-(4-(2-hydroxypropan-2-yl)phenyl)-5H-chromeno[2,3-b]pyridin-5-yl)-2-methylpropanamido)-N-(tetrahydro-2H-pyran-4-yl)-1,3,4-thiadiazole-2-carboxamide

Michael G. Yang, Michael A. Galella, K. McIntyre, 2015, Journal of medicinal chemistry.

Azaxanthene based selective glucocorticoid receptor modulators: design, synthesis, and pharmacological evaluation of (S)-4-(5-(1-((1,3,4-thiadiazol-2-yl)amino)-2-methyl-1-oxopropan-2-yl)-5H-chromeno[2,3-b]pyridin-2-yl)-2-fluoro-N,N-dimethylbenzamide (BMS-776532) and its methylene homologue (BMS-7918

A. Doweyko, D. Shuster, J. Barrish, 2011, Journal of medicinal chemistry.

IL-17A Recruits Rab35 to IL-17R to Mediate PKCα-Dependent Stress Fiber Formation and Airway Smooth Muscle Contractility

D. Sheppard, J. Zepp, A. Echard, 2019, The Journal of Immunology.

Assessing the risk of drug crystallization in vivo.

E. Janovitz, D. Drexler, S. Ruepp, 2019, Journal of pharmacological and toxicological methods.

Characterization of a helper T lymphocyte defect in vitamin A-deficient mice.

S. Smith, C. Hayes, J. Carman, 1989, Journal of immunology.

Discovery of acylurea isosteres of 2-acylaminothiadiazole in the azaxanthene series of glucocorticoid receptor agonists.

Michael G. Yang, A. Doweyko, D. Shuster, 2014, Bioorganic & medicinal chemistry letters.

Use of isolated immature-stage B cells to understand negative selection and tolerance induction at the molecular level

J. Monroe, R. Wechsler-Reya, M. Birkeland, 1996, Immunologic research.

Psoriasis-associated variant Act1 D10N with impaired regulation by Hsp90

W. Ouyang, V. Kuchroo, S. Misra, 2012, Nature Immunology.

Psoriasis-associated variant Act1 D10N with impaired regulation by Hsp90

W. Ouyang, V. Kuchroo, S. Misra, 2012, Nature immunology.

Inactivation of the enzyme GSK3α by the kinase IKKi promotes AKT-mTOR signaling pathway that mediates interleukin-1-induced Th17 cell maintenance.

J. Woodgett, J. Qin, R. Jope, 2012, Immunity.

IL-17 induced NOTCH1 activation in oligodendrocyte progenitor cells enhances proliferation and inflammatory gene expression

R. Ransohoff, S. Miller, D. Hambardzumyan, 2017, Nature Communications.

Immunity to Trichinella spiralis infection in vitamin A-deficient mice

F. Nashold, C. Hayes, J. Carman, 1992, The Journal of experimental medicine.

Circulating T Cell Subpopulations Correlate With Immune Responses at the Tumor Site and Clinical Response to PD1 Inhibition in Non-Small Cell Lung Cancer

H. Dai, D. Greenawalt, S. Nadler, 2018, Front. Immunol..

Development of a Molecular Signature to Monitor Pharmacodynamic Responses Mediated by In Vivo Administration of Glucocorticoids

M. Weinblatt, N. Shadick, Somnath Bandyopadhyay, 2018, Arthritis & rheumatology.

Interferon-gamma suppresses B cell stimulation factor (BSF-1) induction of class II MHC determinants on B cells.

F. Finkelman, J. Ohara, J. Carman, 1986, Journal of immunology.

Act1 is a negative regulator in T and B cells via direct inhibition of STAT3

W. Leonard, F. Shi, K. Coppieters, 2018, Nature Communications.

Cytotoxic CD8+ T cells target citrullinated antigens in rheumatoid arthritis

W. Robinson, L. Donlin, S. Goodman, 2022, Nature Communications.

Abnormal regulation of IFN-gamma secretion in vitamin A deficiency.

C. Hayes, J. Carman, 1991, Journal of immunology.

Retinoid repletion of vitamin A-deficient mice restores IgG responses.

C. Hayes, J. Carman, T. Chun, 1992, The Journal of nutrition.

A single autosomal gene defect severely limits IgG but not IgM responses in B lymphocyte‐deficient A/WySnJ mice

C. Hayes, J. Carman, David J. Miller, 1992, European journal of immunology.

The Transcriptome of Paired Major and Minor Salivary Gland Tissue in Patients With Primary Sjögren’s Syndrome

A. Vissink, F. Spijkervet, H. Bootsma, 2021, Frontiers in Immunology.

Role of EGR1 in regulation of stimulus-dependent CD44 transcription in B lymphocytes

J. Monroe, J. Maltzman, J. Carman, 1996, Molecular and cellular biology.

The EGR1 protein contains a discrete transcriptional regulatory domain whose deletion results in a truncated protein that blocks EGR1-induced transcription.

J. Monroe, J. Carman, 1995, DNA and cell biology.

Immature stage B cells enter but do not progress beyond the early G1 phase of the cell cycle in response to antigen receptor signaling.

J. Monroe, R. Wechsler-Reya, J. Carman, 1996, Journal of immunology.

Discovery and structure-based design of 4,6-diaminonicotinamides as potent and selective IRAK4 inhibitors.

S. Spergel, C. Weigelt, M. Poss, 2017, Bioorganic & medicinal chemistry letters.