E. Kemp

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Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo

Jo Lambert, Gerold Schuler, Khaled Ezzedine, 2012, Nature Genetics.

Vitiligo patients from India (Mumbai) show differences in clinical, demographic and autoantibody profiles compared to patients in western countries

D. Gawkrodger, K. Ghosh, A. Weetman, 2013, Journal of the European Academy of Dermatology and Venereology : JEADV.

Patho-immunological mechanisms of vitiligo: the role of the innate and adaptive immunities and environmental stress factors

S. Faraj, E. Kemp, David John Gawkrodger, 2021, Clinical and experimental immunology.

Immunoglobulin Gκ Antithyroid Peroxidase Antibodies in Hashimoto’s Thyroiditis: Epitope-Mapping Analysis1

B. Czarnocka, A. Weetman, P. Carayon, 1997 .

The CC genotype of the ERCC1 C118T single‐nucleotide polymorphism impacts positively on the efficacy of narrowband ultraviolet B therapy for vitiligo

E. Kemp, 2015, The British journal of dermatology.

Association between the angiotensin-converting enzyme gene insertion/deletion polymorphism and susceptibility to systemic lupus erythematosus in an Indian population

K. Ghosh, A. Weetman, M. Nadkar, 2015, Scandinavian journal of rheumatology.

An insertion/deletion polymorphism in the gene encoding angiotensin converting enzyme is not associated with generalised vitiligo in an English population

D. Gawkrodger, N. Gavalas, A. Weetman, 2005, Archives of Dermatological Research.

Low frequency of pendrin autoantibodies detected using a radioligand binding assay in patients with autoimmune thyroid disease.

A. Weetman, H. Sandhu, E. Kemp, 2013, The Journal of clinical endocrinology and metabolism.

Immunoscreening of phage-displayed cDNA-encoded polypeptides identifies B cell targets in autoimmune disease.

Anthony G. Wilson, A. Weetman, E. Waterman, 2002, Biochemical and biophysical research communications.

This is a repository copy of Serological proteome analysis reveals new specific biases in the IgM and IgG autoantibody repertoires in autoimmune polyendocrine syndrome type 1

Sophie Duban-deweer, P. Saugier-Veber, S. Dubucquoi, 2018 .

Serological proteome analysis reveals new specific biases in the IgM and IgG autoantibody repertoires in autoimmune polyendocrine syndrome type 1

J. Wemeau, Sophie Duban-deweer, P. Saugier-Veber, 2015, Autoimmunity.

Polymorphisms in the cytotoxic T lymphocyte antigen-4 gene region confer susceptibility to Addison's disease.

B. Lie, A. Weetman, D. Undlien, 2004, The Journal of clinical endocrinology and metabolism.

Analysis of allelic variants in the catalase gene in patients with the skin depigmenting disorder vitiligo.

D. Gawkrodger, N. Gavalas, A. Weetman, 2006, Biochemical and biophysical research communications.

Immunosuppressive therapy of autoimmune hypoparathyroidism in a patient with activating autoantibodies against the calcium‐sensing receptor

E. Brown, A. Weetman, B. Khadka, 2018, Clinical endocrinology.

Detection and localization of chemokine gene expression in autoimmune thyroid disease

A. Weetman, M. Woodroofe, E. Kemp, 2003, Clinical endocrinology.

Autoimmune hypercalcemia due to autoantibodies against the calcium-sensing receptor.

R. Corcoy, A. Weetman, E. Kemp, 2020, The Journal of clinical endocrinology and metabolism.

Melanoma cell migration is upregulated by tumour necrosis factor-α and suppressed by α-melanocyte-stimulating hormone

J. Haycock, S. Macneil, R. Lalla, 2004, British Journal of Cancer.

Pharmacodynamic studies of nasal tetracosactide with salivary glucocorticoids for a noninvasive Short Synacthen Test.

B. Keevil, T. Johnson, Alexandra S. Cross, 2020, The Journal of clinical endocrinology and metabolism.

Melanin-concentrating hormone and melanin-concentrating hormone receptors in mammalian skin physiopathology

A. Weetman, E. Kemp, E. H. Kemp, 2009, Peptides.

Implications of regulatory T cells in anti-cancer immunity: from pathogenesis to therapeutics

M. Dwivedi, R. Begum, S. Tiwari, 2022, Heliyon.

Autoimmune Aspects of Vitiligo

A. Weetman, E. Waterman, E. Kemp, 2001, Autoimmunity.

The Transcription Factors SOX9 and SOX10 Are Vitiligo Autoantigens in Autoimmune Polyendocrine Syndrome Type I*

J. Perheentupa, E. Husebye, O. Kämpe, 2001, The Journal of Biological Chemistry.

Activating autoantibodies against the calcium-sensing receptor detected in two patients with autoimmune polyendocrine syndrome type 1.

E. Brown, N. Gavalas, A. Weetman, 2009, The Journal of clinical endocrinology and metabolism.

Prevalence and clinical associations of calcium-sensing receptor and NALP5 autoantibodies in Finnish APECED patients.

A. Ranki, A. Weetman, N. Kluger, 2014, The Journal of clinical endocrinology and metabolism.

The calcium-sensing receptor is a target of autoantibodies in patients with autoimmune polyendocrine syndrome type 1.

E. Brown, N. Gavalas, A. Weetman, 2007, The Journal of clinical endocrinology and metabolism.

Calcium-sensing receptor autoantibody-mediated hypoparathyroidism associated with immune checkpoint inhibitor therapy: diagnosis and long-term follow-up

Julie M Simon, H. Tawbi, S. Patel, 2020, Journal for immunotherapy of cancer.

Epidemiology and Health-Related Quality of Life in Hypoparathyroidism in Norway

J. Svartberg, E. Husebye, E. Eriksen, 2016, The Journal of clinical endocrinology and metabolism.

Function-blocking autoantibodies to the melanin-concentrating hormone receptor in vitiligo patients

J. Haycock, D. Gawkrodger, N. Gavalas, 2006, Laboratory Investigation.

Autoantibodies in vitiligo patients are not directed to the melanocyte differentiation antigen MelanA/MART1

D. Gawkrodger, P. Watson, A. Weetman, 2002, Clinical and experimental immunology.

Vitiligo pathogenesis: autoimmune disease, genetic defect, excessive reactive oxygen species, calcium imbalance, or what else?

M. Zeegers, P. Bahadoran, J. Ortonne, 2008, Experimental dermatology.

alpha-Melanocyte-stimulating hormone, MSH 11-13 KPV and adrenocorticotropic hormone signalling in human keratinocyte cells.

J. Haycock, S. Macneil, E. Kemp, 2004, The Journal of investigative dermatology.

The genetic analysis of bacterial spore germination.

A. Moir, B. Corfe, E. Kemp, 1994, The Journal of applied bacteriology.

Tumour necrosis factor‐α antagonists as therapies for vitiligo

E. Kemp, 2015, The British journal of dermatology.

Alemtuzumab‐induced halo naevus‐like hypopigmentation – new insights into secondary skin autoimmunity in response to an immune cell‐depleting antibody

T. Ruck, D. Metze, R. Luiten, 2020, Journal of the European Academy of Dermatology and Venereology : JEADV.

Cloning and analysis of IgG kappa and IgG lambda anti-thyroglobulin autoantibodies from a patient with Hashimoto's thyroiditis: evidence for in vivo antigen-driven repertoire selection.

A. Weetman, E. Kemp, R. Mcintosh, 1996, Journal of immunology.

First report of anti-calcium-sensing receptor antibodies in a patient with Sjogren's syndrome and primary hypoparathyroidism.

E. Brown, A. Weetman, K. Swaminathan, 2011, Rheumatology.

Programmed death 1 expressing regulatory T cells in vitiligo

E. Kemp, 2015, The British journal of dermatology.

Immunoglobulin G kappa antithyroid peroxidase antibodies in Hashimoto's thyroiditis: epitope-mapping analysis.

B. Czarnocka, A. Weetman, P. Carayon, 1997, The Journal of clinical endocrinology and metabolism.

Immunoprecipitation of melanogenic enzyme autoantigens with vitiligo sera: evidence for cross‐reactive autoantibodies to tyrosinase and tyrosinase‐related protein‐2 (TRP‐2)

D. Gawkrodger, A. Weetman, E. Kemp, 1997, Clinical and experimental immunology.

Epitopes, avidity and IgG subclasses of tyrosine hydroxylase autoantibodies in vitiligo and alopecia areata patients

D. Gawkrodger, A. McDonagh, A. Weetman, 2012, The British journal of dermatology.

Analysis of immunoglobulin G kappa antithyroid peroxidase antibodies from different tissues in Hashimoto's thyroiditis.

J. Banga, A. Weetman, A. Gardas, 1997, The Journal of clinical endocrinology and metabolism.

Immunological pathomechanisms in vitiligo

A. Weetman, E. Waterman, E. Kemp, 2001, Expert Reviews in Molecular Medicine.

Immune Checkpoint Inhibitor-Induced Hypoparathyroidism Associated With Calcium-Sensing Receptor-Activating Autoantibodies

E. Brown, Yan Li, E. Kemp, 2018, The Journal of clinical endocrinology and metabolism.

Immune Checkpoint Inhibitor-Induced Autoimmune Hypoparathyroidism Associated with 1 Calcium-Sensing Receptor-Activating Autoantibodies 2

E. Kemp, P. Piranavan, Yan Li, 2019 .

Hypoparathyroidism: Genetics and Diagnosis

G. Guyatt, M. Brandi, F. Giusti, 2022, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Autoantibody responses to melanocytes in the depigmenting skin disease vitiligo.

D. Gawkrodger, N. Gavalas, A. Weetman, 2007, Autoimmunity reviews.

Autoimmune hypocalciuric hypercalcemia unresponsive to glucocorticoid therapy in a patient with blocking autoantibodies against the calcium-sensing receptor.

E. Brown, J. C. Pallais, A. Weetman, 2011, The Journal of clinical endocrinology and metabolism.

Acquired hypocalciuric hypercalcemia in a patient with CKD.

E. Brown, Chou-Long Huang, A. Weetman, 2013, American journal of kidney diseases : the official journal of the National Kidney Foundation.

Graves' Disease, Hypoparathyroidism, Systemic Lupus Erythematosus, Alopecia, and Angioedema: Autoimmune Polyglandular Syndrome Variant or Coincidence?

C. A. Koch, E. Melcescu, G. Uwaifo, 2013, International journal of immunopathology and pharmacology.

Demonstration of autoantibodies against tyrosine hydroxylase in patients with alopecia areata

A. McDonagh, A. Weetman, H. Sandhu, 2011, The British journal of dermatology.

The non-synonymous C1858T substitution in the PTPN22 gene is associated with susceptibility to the severe forms of alopecia areata.

R. Tazi-Ahnini, M. Cork, D. Wengraf, 2006, Human immunology.

Regulatory T cells in vitiligo: Implications for pathogenesis and therapeutics.

M. Mansuri, M. Dwivedi, N. Laddha, 2015, Autoimmunity reviews.

Autoimmunity in Vitiligo

D. Gawkrodger, A. Weetman, E. Kemp, 2011 .

Dominant Mutations in the Autoimmune Regulator AIRE Are Associated with Common Organ-Specific Autoimmune Diseases.

W. Newman, S. Fleishman, S. Johansson, 2015, Immunity.

Immune/Inflammatory Aspects

D. Gawkrodger, G. Girolomoni, A. Taïeb, 2010 .

Detection of tyrosinase autoantibodies in patients with vitiligo using 35S-labeled recombinant human tyrosinase in a radioimmunoassay.

D. Gawkrodger, S. Macneil, A. Weetman, 1997, The Journal of investigative dermatology.

Melanocyte antigen‐specific antibodies cannot be used as markers for recent disease activity in patients with vitiligo

D. Gawkrodger, A. Wolkerstorfer, J. Bos, 2013, Journal of the European Academy of Dermatology and Venereology : JEADV.

Autoantibodies against tyrosine hydroxylase in patients with non‐segmental (generalised) vitiligo

D. Gawkrodger, A. Weetman, E. Kemp, 2011, Experimental dermatology.

Autoantigens in vitiligo identified by the serological selection of a phage-displayed melanocyte cDNA expression library.

D. Gawkrodger, A. Weetman, E. Waterman, 2010, The Journal of investigative dermatology.

The melanin-concentrating hormone receptor 1, a novel target of autoantibody responses in vitiligo.

B. Hawes, K. O'neill, D. Gawkrodger, 2002, The Journal of clinical investigation.

Autoantibodies in vitiligo patients recognize multiple domains of the melanin-concentrating hormone receptor.

D. Gawkrodger, A. Weetman, E. Waterman, 2003, The Journal of investigative dermatology.

A single-nucleotide polymorphism in the gene encoding lymphoid protein tyrosine phosphatase (PTPN22) confers susceptibility to generalised vitiligo

D. Gawkrodger, I. Cantón, N. Gavalas, 2005, Genes and Immunity.

Autoantibodies as diagnostic and predictive markers of vitiligo.

E. Kemp, 2004, Autoimmunity.

Identification of epitopes on tyrosinase which are recognized by autoantibodies from patients with vitiligo.

D. Gawkrodger, A. Weetman, E. Waterman, 1999, The Journal of investigative dermatology.

Molecular mapping of epitopes on melanocyte‐specific protein Pmel17 which are recognized by autoantibodies in patients with vitiligo

D. Gawkrodger, A. Weetman, E. Waterman, 2001, Clinical and Experimental Immunology.

Immunophenotypic analysis reveals differences in circulating immune cells in peripheral blood of segmental and non-segmental vitiligo patients.

M. Willemsen, M. Bekkenk, R. Luiten, 2021, The Journal of investigative dermatology.

The antibody response against MART‐1 differs in patients with melanoma‐associated leucoderma and vitiligo

A. Wolkerstorfer, E. Tjin, R. Luiten, 2014, Pigment cell & melanoma research.

The Journal of Clinical Endocrinology & Metabolism Printed in U.S.A. Copyright © 2000 by The Endocrine Society Detection of Binding and Blocking Autoantibodies to the Human Sodium-Iodide Symporter in Patients with

T. Endo, R. Ajjan, A. Weetman, 2022 .

Inhibition of Tumor Necrosis Factor-α Stimulated NFκB/p65 in Human Keratinocytes by α-Melanocyte Stimulating Hormone and Adrenocorticotropic Hormone Peptides

J. Haycock, G. Ghanem, S. Macneil, 2002 .

Genome-wide analysis identifies a quantitative trait locus in the MHC class II region associated with generalized vitiligo age of onset.

Sheri L. Riccardi, R. Spritz, J. Lambert, 2011, The Journal of investigative dermatology.

Comprehensive association analysis of candidate genes for generalized vitiligo supports XBP1, FOXP3, and TSLP.

R. Spritz, J. Lambert, M. Picardo, 2011, The Journal of investigative dermatology.

Common variants in FOXP1 are associated with generalized vitiligo

Sheri L. Riccardi, Wayne T. McCormack, R. Spritz, 2010, Nature Genetics.

Variant of TYR and autoimmunity susceptibility loci in generalized vitiligo.

Jo Lambert, Khaled Ezzedine, Sheri L. Riccardi, 2010, The New England journal of medicine.

Genome-wide association studies of autoimmune vitiligo identify 23 new risk loci and highlight key pathways and regulatory variants

Jo Lambert, Markus Böhm, Khaled Ezzedine, 2016, Nature Genetics.

CTLA4 polymorphisms are associated with vitiligo, in patients with concomitant autoimmune diseases.

B. Lie, D. Gawkrodger, E. Husebye, 2005, Pigment cell research.

Anti-Melanoma immunity and local regression of cutaneous metastases in melanoma patients treated with monobenzone and imiquimod; a phase 2 a trial

Omgo E. Nieweg, J. Drijfhout, J. A. van der Hage, 2018, Oncoimmunology.

Antithyroid hormone autoantibodies in vitiligo

E. Kemp, 2014, The British journal of dermatology.

Inhibition of tumor necrosis factor-alpha stimulated NFkappaB/p65 in human keratinocytes by alpha-melanocyte stimulating hormone and adrenocorticotropic hormone peptides.

J. Haycock, G. Ghanem, S. Macneil, 2002, The Journal of investigative dermatology.

Association analysis of the cytotoxic T lymphocyte antigen-4 (CTLA-4) and autoimmune regulator-1 (AIRE-1) genes in sporadic autoimmune Addison's disease.

S. Pearce, S. Hurel, W. Kelly, 2000, The Journal of clinical endocrinology and metabolism.

Late-onset postsurgical hypoparathyroidism following parathyroidectomy for recurrent primary hyperparathyroidism: a case report and literature review

C. Marcocci, F. Cetani, E. Pardi, 2020, Endocrine.

Severe Symptomatic Hypocalcemia from HIV Related Hypoparathyroidism

A. Chaudhuri, S. Sandhu, E. Kemp, 2018, Case reports in endocrinology.

Development of a 3D human in vitro skin co‐culture model for detecting irritants in real‐time

A J Ryan, J. Haycock, A. Ryan, 2010, Biotechnology and bioengineering.

Induction of regulatory T cells: A role for probiotics and prebiotics to suppress autoimmunity.

M. Dwivedi, N. Laddha, E. Kemp, 2016, Autoimmunity reviews.

Vitiligo is an autoimmune disease in which depigmented skin results from the destruction of melanocytes1, with epidemiological association with other autoimmune diseases2. In previous linkage and genome-wide association studies

Stephanie A. Santorico, R. Spritz, J. Lambert, 2016 .

Real-time detection of stress in 3D tissue-engineered constructs using NF-kappaB activation in transiently transfected human dermal fibroblast cells.

Sheila MacNeil, John W Haycock, Umran Sarwar, 2007, Tissue engineering.

Mutation screening of PTPN22: association of the 1858T-allele with Addison's disease

T. Egeland, E. Husebye, D. Undlien, 2008, European Journal of Human Genetics.

PRKDC mutations associated with immunodeficiency, granuloma, and autoimmune regulator-dependent autoimmunity.

David J. Chen, M. van der Burg, L. Notarangelo, 2015, The Journal of allergy and clinical immunology.

Vitiligo following a combined liver-kidney transplant.

M. Clatworthy, P. Gibbs, Victoria Bradley, 2008, Nephrology, Dialysis and Transplantation.

Mapping of Human Autoantibody Binding Sites on the Calcium-Sensing Receptor

E. Brown, J. C. Pallais, N. Gavalas, 2009, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Localization of GerAA and GerAC Germination Proteins in the Bacillus subtilis Spore

A. Moir, B. Corfe, I. Feavers, 2001, Journal of bacteriology.

The genetic analysis of bacterial spore germination.

A. Moir, B. Corfe, E. Kemp, 1994, Society for Applied Bacteriology symposium series.

Autoantibodies against the calcium‐sensing receptor and cytokines in autoimmune polyglandular syndromes types 2, 3 and 4

G. Kahaly, A. Weetman, L. Frommer, 2018, Clinical endocrinology.

Calcium-Sensing Receptor Autoantibodies in Patients with Autoimmune Polyendocrine Syndrome Type 1: Epitopes, Specificity, Functional Affinity, IgG Subclass, and Effects on Receptor Activity

E. Brown, M. Brandi, A. Ranki, 2018, The Journal of Immunology.

Early-onset hypoparathyroidism and chronic keratitis revealing APECED

J. Bacchetta, A. Belot, A. Weetman, 2015, Clinical case reports.

Is there loss or qualitative changes in the expression of thyroid peroxidase protein in thyroid epithelial cancer?

E. Gubała, B. Jarzab, B. Czarnocka, 2001, British Journal of Cancer.