D. Doolittle

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Correlation of hematologic markers of inflammation and lung function: a comparison of asymptomatic smokers and nonsmokers

Carr J. Smith, S. McKarns, C. Smith, 1996, Human & experimental toxicology.

Limitations of the scrape-loading/dye transfer technique to quantify inhibition of gap junctional intercellular communication

S. McKarns, D. Doolittle, 2004, Cell Biology and Toxicology.

Evaluation of eight in vitro assays for assessing the cytotoxicity of cigarette smoke condensate.

D. Doolittle, D. Bombick, K. Putnam, 2002, Toxicology in vitro : an international journal published in association with BIBRA.

Mutant yields and mutational spectra of the heterocyclic amines MeIQ and PhIP at the S1 locus of human-hamster AL cells with activation by chick embryo liver (CELC) co-cultures.

T. Puck, M. Shibuya, P. Sinclair, 1999, Mutation research.

Mutagenic activity of a series of synthetic and naturally occurring heterocyclic amines in Salmonella.

A. Debnath, C. Hansch, T. Lawlor, 1992, Mutation research.

Response to “Cigarette smoke comparative toxicology”

T. Perfetti, Carr J. Smith, D. Doolittle, 2001 .

Altered methylation in gene-specific and GC-rich regions of DNA is progressive and nonrandom during promotion of skin tumorigenesis.

Ammie N. Bachman, J. Goodman, G. Curtin, 2006, Toxicological sciences : an official journal of the Society of Toxicology.

Urinary thromboxane, prostacyclin, cortisol, and 8-hydroxy-2'-deoxyguanosine in nonsmokers exposed and not exposed to environmental tobacco smoke.

T. Fischer, D. Heavner, Carr J. Smith, 2001, Toxicological sciences : an official journal of the Society of Toxicology.

An Analysis of the Role of Tobacco-Specific Nitrosamines in the Carcinogenicity of Tobacco Smoke

D. Doolittle, B. Brown, A. J. Borschke, 2003, Nonlinearity in biology, toxicology, medicine.

The in vivo-in vitro hepatocyte assay for assessing DNA repair and DNA replication: studies in the CD-1 mouse.

D. Doolittle, G. Muller, H. Scribner, 1987, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Measurement of genotoxic activity in multiple tissues following inhalation exposure to dimethylnitrosamine.

P. Working, E. Bermudez, B. Butterworth, 1984, Mutation research.

Influence of intestinal bacteria, sex of the animal, and position of the nitro group on the hepatic genotoxicity of nitrotoluene isomers in vivo.

B. Butterworth, D. Doolittle, J. M. Sherrill, 1983, Cancer research.

Differential c‐myc expression profiles in normal human bronchial epithelial cells following treatment with benzo[a]pyrene, benzo[a]pyrene‐4,5 epoxide, and benzo[a]pyrene‐7,8‐9,10 diol epoxide

D. Doolittle, W. Fields, B. Brown, 2004, Molecular carcinogenesis.

Quantification of changes in c-myc mRNA levels in normal human bronchial epithelial (NHBE) and lung adenocarcinoma (A549) cells following chemical treatment.

D. Doolittle, D. Bombick, K. Putnam, 2001, Toxicological sciences : an official journal of the Society of Toxicology.

Quantitative studies on the in vitro metabolic activation of dimethylnitrosamine by rat liver postmitochondrial supernatant.

J. Goodman, D. Doolittle, David J. Doolittle, 1984, Environmental health perspectives.

Quantitative studies on metabolic activation in vitro employing benzo[a]pyrene as the test compound.

J. Goodman, J. Newton, D. Doolittle, 1983, Mutation research.

URINARY PROSTACYCLIN IN NONSMOKERS LIVING WITH SMOKERS

T. Fischer, G. Scherer, W. Morgan, 1998 .

DNA adduct formation in mice following dermal application of smoke condensates from cigarettes that burn or heat tobacco

A. Hayes, A. Mosberg, D. Doolittle, 1992, Environmental and molecular mutagenesis.

Comparison of the cytotoxic and mutagenic potential of liquid smoke food flavourings, cigarette smoke condensate and wood smoke condensate.

D. Doolittle, D. Bombick, K. Putnam, 1999, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Urinary mutagenicity and thioethers in nonsmokers: role of environmental tobacco smoke (ETS) and diet.

G. Scherer, F. Adlkofer, T. Ruppert, 1996, Mutation research.

Molecular toxicology endpoints in rodent inhalation studies.

P. Ayres, B. Bombick, S. McKarns, 1995, Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie.

Recommendations for the performance of UDS tests in vitro and in vivo.

H. Mori, C. Mcqueen, G. Brambilla, 1994, Mutation research.

Comparative studies of DNA adduct formation in mice following dermal application of smoke condensates from cigarettes that burn or primarily heat tobacco.

D. Meckley, A. Mosberg, D. Doolittle, 1998, Mutation research.

Role of oxygen free radicals in the induction of sister chromatid exchanges by cigarette smoke

D. Doolittle, B. Brown, C. Lee, 1989, Environmental and molecular mutagenesis.

The effect of cotinine or cigarette smoke co-administration on the formation of O6-methylguanine adducts in the lung and liver of A/J mice treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)

P. Ayres, D. Doolittle, C. J. Chang, 1999, Toxicological sciences : an official journal of the Society of Toxicology.

Active and passive smoking and pathological indicators of lung cancer--a report of limited value?

D. Doolittle, 1993, JAMA.

Comparative study of DNA adduct formation in mice following inhalation of smoke from cigarettes that burn or primarily heat tobacco

P. Ayres, B. Bombick, A. Mosberg, 1997, Environmental and molecular mutagenesis.

Urinary mutagenicity in nonsmokers following exposure to fresh diluted sidestream cigarette smoke.

B. A. Ryan, W. Morgan, C. Smith, 2000, Mutation research.

Chemical and biological studies of a new cigarette that primarily heats tobacco. Part 3. In vitro toxicity of whole smoke.

P. Ayres, B. Bombick, D. Doolittle, 1998, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Cytogenetic Studies in Laboratory Animals Exposed by Inhalation to Mainstream Smoke or Environmental Tobacco Smoke

A. Hayes, C. Coggins, D. Doolittle, 1994 .

Correlation between hydrophobicity of short-chain aliphatic alcohols and their ability to alter plasma membrane integrity.

W. S. Caldwell, C. Hansch, S. McKarns, 1997, Fundamental and applied toxicology : official journal of the Society of Toxicology.

Gap junction intercellular communication and cytotoxicity in normal human cells after exposure to smoke condensates from cigarettes that burn or primarily heat tobacco.

S. McKarns, M. Morton, D. Doolittle, 2000, Toxicology in vitro : an international journal published in association with BIBRA.

Relationship between hepatotoxicity and induction of replicative DNA synthesis following single or multiple doses of carbon tetrachloride.

D. Doolittle, G. Muller, H. Scribner, 1987, Journal of toxicology and environmental health.

Tyrosinase enhances the covalent modification of DNA by dopamine.

K. Vrana, A. Stokes, D. Doolittle, 1996, Brain research. Molecular brain research.

"IARC Group 2B carcinogens" reported in cigarette mainstream smoke.

T. Perfetti, C. Smith, D. Doolittle, 2000, Food and Chemical Toxicology.

The genotoxic activity of glycerol in an in vitro test battery.

D. Doolittle, D. A. Lee, C. Lee, 1988, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Blood parameters associated with atherogenic and thrombogenic risk in smokers and nonsmokers with similar life-styles.

S. McKarns, C. Smith, V. Payne, 1995, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc.

The effect of a 2-h exposure to cigarette smoke on the metabolic activation of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in A/J mice.

P. Ayres, E. Richter, D. Doolittle, 2001, Chemico-biological interactions.

Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in A/J mouse lung and effect of cigarette smoke exposure on in vivo metabolism to biological reactive intermediates.

E. Richter, D. Doolittle, A. Tricker, 2001, Advances in experimental medicine and biology.

An international literature survey of "IARC Group I carcinogens" reported in mainstream cigarette smoke.

Carr J. Smith, C. Smith, D. Doolittle, 1997, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

"IARC group 2A Carcinogens" reported in cigarette mainstream smoke.

T. Perfetti, D J Doolittle, Carr J. Smith, 2000, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Biological stress response terminology: Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose-response framework.

Edward J Calabrese, Thomas B Knudsen, Jim E Riviere, 2007, Toxicology and applied pharmacology.

Chromosomal Alterations

M. Bender, T. Cremer, S. Manoir, 1994, Springer Berlin Heidelberg.

Comparative QSAR evidence for a free-radical mechanism of phenol-induced toxicity.

C. Hansch, D J Doolittle, C Hansch, 2000, Chemico-biological interactions.

Dopamine Covalently Modifies DNA in a Tyrosinase-Enhanced Manner

K. Vrana, A. Stokes, D. Doolittle, 1996 .

Erratum to 'IARC Group 2B carcinogens' reported in cigarette mainstream smoke [Food and Chemical Toxicology 38 (2000) 825-848]

T. Perfetti, Carr J. Smith, D. Doolittle, 2001 .

COMPARISON OF C-MYC EXPRESSION IN NORMAL HUMAN BRONCHIAL EPITHELIAL CELLS AND LUNG CANCER CELL LINES USING A QUANTITATIVE FLUORESCENCE-BASED REVERSE TRANSCRIPTASE-POLYMERASE CHAIN REACTION METHOD

D. Doolittle, D. Bombick, W. Fields, 1999 .

Effect of cooking methods on the mutagenicity of food and on urinary mutagenicity of human consumers.

A. Hayes, E. Vesell, D. Doolittle, 1989, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Gene expression profiling of cultured human bronchial epithelial and lung carcinoma cells.

D J Doolittle, D. Doolittle, G M Hellmann, 2001, Toxicological sciences : an official journal of the Society of Toxicology.

Comparative cytotoxicity studies of smoke condensates from different types of cigarettes and tobaccos.

D. Doolittle, D. Bombick, K. Putnam, 1998, Toxicology in vitro : an international journal published in association with BIBRA.

CYTOTOXICITY ASSESSMENT OF WHOLE SMOKE AND VAPOR PHASE OF MAINSTREAM AND SIDESTREAM CIGARETTE SMOKE FROM THREE KENTUCKY REFERENCE CIGARETTES

P. Ayres, D. Doolittle, D. Bick, 1997 .

A Fluorescent Method for the Measurement of Intracellular Hydroperoxides in Living Mammalian Cells

D. Doolittle, D. Bombick, 1992 .

A quantitative approach to assessing intercellular communication: studies on cigarette smoke condensates.

S. McKarns, D. Doolittle, 1991, Toxicology and applied pharmacology.

Assessment of mitochondrial membrane potential as an indicator of cytotoxicity.

D. Doolittle, D. Bombick, C. A. Rahn, 1991, Fundamental and applied toxicology : official journal of the Society of Toxicology.

THE TIME COURSE OF EXPRESSION OF GENES INVOLVED IN SPECIFIC PATHWAYS IN NORMAL HUMAN BRONCHIAL EPITHELIAL CELLS FOLLOWING EXPOSURE TO CIGARETTE SMOKE

B. Bombick, W. Morgan, D. Doolittle, 2008, Experimental lung research.

Use of primary cultures of human hepatocytes in toxicology studies.

B E Butterworth, T. Smith-Oliver, G. Michalopoulos, 1989, Cancer research.

Assessment of chemically induced DNA repair in primary cultures of human bronchial epithelial cells.

B. Butterworth, D. Doolittle, J. Furlong, 1985, Toxicology and applied pharmacology.

A comparison of the mainstream smoke chemistry and mutagenicity of a representative sample of the US cigarette market with two Kentucky reference cigarettes (K1R4F and K1R5F).

M. Borgerding, J. Swauger, B. Bombick, 2000, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

A comparison of the mutagenicity of mainstream cigarette smoke condensates from a representative sample of the U.S. cigarette market with a Kentucky reference cigarette (K1R4F).

D. C. Rees, V. Payne, D. Doolittle, 1995, Mutation research.

Technology Review: Molecular Approaches for Quantifying DNA Synthesis and Cell Proliferation During Rodent Bioassays

P. Ayres, S. McKarns, D. Doolittle, 1991 .

Effect of pyrolysis temperature on the mutagenicity of tobacco smoke condensate.

T. Perfetti, B. Bombick, C. Smith, 2001, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Comparative studies on the genotoxic activity of mainstream smoke condensate from cigarettes which burn or only heat tobacco

C. Rudd, A. Hayes, J. Mirsalis, 1990, Environmental and molecular mutagenesis.

Progressive alterations in global and GC-rich DNA methylation during tumorigenesis.

R. Watson, J. Goodman, G. Curtin, 2003, Toxicological sciences : an official journal of the Society of Toxicology.

Comparative genotoxicity testing of mainstream whole smoke from cigarettes which burn or heat tobacco.

A. Hayes, D. Doolittle, G. Burger, 1990, Mutation research.

Analysis of cytogenetic effects in bone-marrow cells of rats subchronically exposed to smoke from cigarettes which burn or only heat tobacco.

P. Ayres, C. Coggins, S. McKarns, 1990, Mutation research.

Histopathology, Urine Mutacenicity, and Bone Marrow Cytocenetics of Mice Exposed Nose-Only to Smoke from Cigarettes that Burn or Heat Tobacco

A. Hayes, P. Ayres, C. Coggins, 1990 .

Ninety-day inhalation study in rats, using aged and diluted sidestream smoke from a reference cigarette: DNA adducts and alveolar macrophage cytogenetics.

A. Hayes, C. Coggins, D. Doolittle, 1993, Fundamental and applied toxicology : official journal of the Society of Toxicology.

Fourteen-day inhalation study in rats, using aged and diluted sidestream smoke from a reference cigarette. II. DNA adducts and alveolar macrophage cytogenetics.

A. Hayes, C. Coggins, D. Doolittle, 1992, Fundamental and applied toxicology : official journal of the Society of Toxicology.

Assessment of chemically-induced DNA repair in rat tracheal epithelial cells.

B. Butterworth, D. Doolittle, 1984, Carcinogenesis.

Distinct regulatory profiles of interleukins and chemokines in response to cigarette smoke condensate in normal human bronchial epithelial (NHBE) cells.

T. Steichen, B. Bombick, D. Doolittle, 2008, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

Upper airways sensory irritation responses of mice exposed to mainstream smoke from four cigarette types

T. Steichen, P. Ayres, D. Doolittle, 2010, Inhalation toxicology.

A comparative study of hepatic DNA repair, DNA replication and hepatotoxicity in the CD-1 mouse following multiple administrations of dimethylnitrosamine.

D. Doolittle, G. Muller, H. Scribner, 1987, Mutation research.

Unscheduled DNA synthesis in rat tracheal epithelial cells, hepatocytes and spermatocytes following exposure to methyl chloride in vitro and in vivo.

R. D. White, T. Smith-Oliver, P. Working, 1986, Mutation research.

Autocrine regulation of cell cycle progression in normal human keratinocytes

G. Curtin, D. Doolittle, D. Bombick, 1996, In Vitro Cellular & Developmental Biology - Animal.

Chemical and biological studies of a newCigarette that primarily heats tobacco. Part 2. In vitro toxicology of mainstreamsmoke condensate

B. Bombick, W. Morgan, D. Doolittle, 1998 .

Chemical and biological studies of a new cigarette that primarily heats tobacco. Part 2. In vitro toxicology of mainstream smoke condensate.

B. Bombick, W. Morgan, D. Doolittle, 1998, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Inhibition of mutagenicity of N-nitrosamines by tobacco smoke and its constituents.

B. Bombick, D. Doolittle, C. Lee, 1996, Mutation research.

The effect of tobacco smoke, nicotine, and cotinine on the mutagenicity of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL).

D. Doolittle, B. Brown, C. Lee, 2001, Mutation research.

The effect of exposure to nicotine, carbon monoxide, cigarette smoke or cigarette smoke condensate on the mutagenicity of rat urine.

D. Doolittle, C. Lee, Chin K. Lee, 1991, Mutation research.

Comparative 13-Week Inhalation Study of Cigarette Smoke from Cigarettes Containing Cast Sheet Tobacco

P. Ayres, D. Pence, J. Swauger, 2007, Inhalation toxicology.

Evaluation of the Genotoxic and Cytotoxic Potential of Mainstream Whole Smoke and Smoke Condensate from a Cigarette Containing a Novel Carbon Filter

M. Borgerding, P. Ayres, B. Bombick, 1997 .

"IARC group 2B Carcinogens" reported in cigarette mainstream smoke.

M. Mullens, T. Perfetti, D J Doolittle, 2000, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

The role of glutathione in the toxicity of smoke condensates from cigarettes that burn or heat tobacco.

C. Waldren, C. Smith, D. Doolittle, 2001, Free radical biology & medicine.

Replicative dna synthesis in tissues of the rat exposed to aged and diluted sidestream smoke

J. Sagartz, P. Ayres, C. Coggins, 1995 .

Evaluation of the genotoxic and cytotoxic potential of mainstream whole smoke and smoke condensate from a cigarette containing a novel carbon filter.

M. Borgerding, P. Ayres, B. Bombick, 1997, Fundamental and applied toxicology : official journal of the Society of Toxicology.

Comparative studies of the mutagenicity of urine from smokers and non-smokers on a controlled non-mutagenic diet.

A. Hayes, E. Vesell, D. Doolittle, 1990, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Gene expression in normal human bronchial epithelial (NHBE) cells following in vitro exposure to cigarette smoke condensate.

M. W. Ogden, D. Doolittle, W. Fields, 2005, Toxicological sciences : an official journal of the Society of Toxicology.

Inhibitory activity of cigarette-smoke condensate on the mutagenicity of heterocyclic amines.

M. Borgerding, K. Chang, D. Doolittle, 1994, Mutation research.

Relationship between FTC 'tar' and urine mutagenicity in smokers of tobacco-burning or Eclipse cigarettes.

B. Bombick, W. Morgan, Carr J. Smith, 2002, Mutation research.

Chemical and Biological Studies of a Cigarette That Heats Rather Than Burns Tobacco

A. Hayes, M. Borgerding, K. T. McManus, 1990, Journal of clinical pharmacology.

The role of chemical structure and cell type in the cytotoxicity of low-molecular-weight aldehydes and pyridines

D. Doolittle, D. Bombick, 1995 .

Human urine mutagenicity study comparing cigarettes which burn or primarily heat tobacco.

B. Bombick, W. Morgan, Carr J. Smith, 1996, Mutation research.

Fourteen-day inhalation study in rats, using aged and diluted sidestream smoke from a reference cigarette: II. DNA adducts and alveolar macrophage cytogenetics

A. Hayes, C. Coggins, D. Doolittle, 1992 .

The genotoxic potential of nicotine and its major metabolites.

A. Hayes, D J Doolittle, A W Hayes, 1995, Mutation research.

The use of rat urine extracted on XAD-2 resin and assayed in a microsuspension-modified Ames test as an in vivo indicator of genotoxic exposure.

D. Doolittle, D. A. Lee, C. A. Rahn, 1988, Mutation research.

Increased DNA methylation in the HoxA5 promoter region correlates with decreased expression of the gene during tumor promotion

R. Watson, J. Goodman, G. Curtin, 2004, Molecular carcinogenesis.

Correlations between urinary nicotine or cotinine and urinary mutagenicity in smokers on controlled diets

D. Doolittle, E. Riccio, E. R. Nestman, 1991, Environmental and molecular mutagenesis.

Evaluation of the carcinogenic potential of 2,4-dinitrofluorobenzene and its implications regarding mutagenicity testing.

S. Warren, J. Trosko, D. Doolittle, 1982, Carcinogenesis.

Vanillin (3-methoxy-4-hydroxybenzaldehyde) inhibits mutation induced by hydrogen peroxide, N-methyl-N-nitrosoguanidine and mitomycin C but not (137)Cs gamma-radiation at the CD59 locus in human-hamster hybrid A(L) cells.

D. Gustafson, C. Waldren, C. Smith, 2000, Mutagenesis.

A comparison of in vitro toxicities of cigarette smoke condensate from Eclipse cigarettes and four commercially available ultra low-"tar" cigarettes.

J. Swauger, B. Bombick, A. Mosberg, 2004, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Comparative study of DNA adduct formation in mice following inhalation of smoke from cigarettes that burn or primarily heat tobacco

P. Ayres, B. Bombick, A. Mosberg, 1997, Environmental and molecular mutagenesis.

Genetic toxicology studies comparing the activity of sidestream smoke from cigarettes which burn or only heat tobacco.

C. Rudd, A. Hayes, J. Mirsalis, 1990, Mutation research.

Human urine mutagenicity study comparing cigarettes which burn or only heat tobacco.

J. Robinson, J. D. Debethizy, S. McKarns, 1989, Mutation research.

Absorption of nicotine from a cigarette that does not burn tobacco.

J. Robinson, A. Hayes, J. D. Debethizy, 1988, Pharmacology.

Comparative studies of the mutagenicity of environmental tobacco smoke from cigarettes that burn or primarily heat tobacco

B. Bombick, P. Nelson, D. Doolittle, 1998, Environmental and molecular mutagenesis.