D. Farrens

发表

Requirement of Rigid-Body Motion of Transmembrane Helices for Light Activation of Rhodopsin

H. Khorana, C. Altenbach, W. Hubbell, 1996, Science.

Agonist-induced conformational changes in the G-protein-coupling domain of the β2 adrenergic receptor

P Ghanouni, B. Kobilka, P. Ghanouni, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Structural features and light-dependent changes in the cytoplasmic interhelical E-F loop region of rhodopsin: a site-directed spin-labeling study.

H. Khorana, C. Altenbach, W. Hubbell, 1996, Biochemistry.

Consensus and Variant cAMP-regulated Enhancers Have Distinct CREB-binding Properties*

M. Schumacher, R. Brennan, R. Goodman, 2001, The Journal of Biological Chemistry.

Rhodopsin in nanodiscs has native membrane-like photointermediates.

D. Kliger, James W. Lewis, H. Tsukamoto, 2011, Biochemistry.

Stability of Dark State Rhodopsin Is Mediated by a Conserved Ion Pair in Intradiscal Loop E-2*

D. Farrens, J. Janz, J. Fay, 2003, The Journal of Biological Chemistry.

Rhodopsin TM6 Can Interact with Two Separate and Distinct Sites on Arrestin: Evidence for Structural Plasticity and Multiple Docking Modes in Arrestin–Rhodopsin Binding

Abhinav Sinha, D. Farrens, Christopher T. Schafer, 2014, Biochemistry.

Single-cysteine substitution mutants at amino acid positions 306-321 in rhodopsin, the sequence between the cytoplasmic end of helix VII and the palmitoylation sites: sulfhydryl reactivity and transducin activation reveal a tertiary structure.

J. Klein-Seetharaman, H. Khorana, C. Altenbach, 1999, Biochemistry.

What site-directed labeling studies tell us about the mechanism of rhodopsin activation and G-protein binding

D. Farrens, 2010, Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology.

Characterization of silkworm chlorophyll metabolites as an active photosensitizer for photodynamic therapy.

C. Kim, R. Shoemaker, P. Song, 1992, Journal of natural products.

Functional Integrity of Membrane Protein Rhodopsin Solubilized by Styrene-Maleic Acid Copolymer.

D. Kliger, E. Chen, Jonathan Fay, 2021, Biophysical journal.

Surface-enhanced resonance Raman scattering (SERRS) spectroscopy applied to phytochrome and its model compounds. 2. Phytochrome and phycocyanin chromophores

P. Song, T. Cotton, R. E. Holt, 1989 .

Time-resolved circular dichroism of native oat phytochrome photointermediates

D. Kliger, P. Song, S. C. Bjorling, 1992 .

Time-resolved absorption studies of native etiolated oat phytochrome

D. Kliger, P. Song, S. C. Bjorling, 1992 .

Biogenesis of Phytochrome Apoprotein in Transgenic Organisms and its Assembly to the Chromophore

K. Tomizawa, P. Song, N. Ito, 1991 .

Engineering a functional blue-wavelength-shifted rhodopsin mutant.

D. Farrens, J. Janz, Jay M. Janz, 2001, Biochemistry.

Cysteine residues in the human cannabinoid receptor: only C257 and C264 are required for a functional receptor, and steric bulk at C386 impairs antagonist SR141716A binding.

D. Farrens, J. Fay, T. Dunham, 2005, Biochemistry.

Biosensor reveals multiple sources for mitochondrial NAD+

Melissa L. Stewart, Michael S. Cohen, R. Goodman, 2016, Science.

In vitro assembly of apophytochrome and apophytochrome deletion mutants expressed in yeast with phycocyanobilin.

M. Furuya, K. Tomizawa, P. Song, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Distance mapping in proteins using fluorescence spectroscopy: the tryptophan-induced quenching (TrIQ) method.

M. DeWitt, D. Farrens, S. E. Mansoor, 2010, Biochemistry.

Decay of an active GPCR: Conformational dynamics govern agonist rebinding and persistence of an active, yet empty, receptor state

D. Farrens, Christopher T. Schafer, J. Janz, 2016, Proceedings of the National Academy of Sciences of the United States of America.

Visualizing endogenous opioid receptors in living neurons using ligand-directed chemistry

John T. Williams, T. F. Murray, K. Rice, 2019, eLife.

Styrene-Maleic Acid Copolymer Effects on the Function of the GPCR Rhodopsin in Lipid Nanoparticles.

D. Kliger, E. Chen, D. Farrens, 2021, Biophysical journal.

Contributions of H G Khorana to understanding transmembrane signal transduction

T. Sakmar, D. Farrens, 2012 .

Structural Dynamics of the Signal Termination Process in Rhodopsin

D. Farrens, 2005 .

Role of the Retinal Hydrogen Bond Network in Rhodopsin Schiff Base Stability and Hydrolysis*

D. Farrens, J. Janz, Jay M. Janz, 2004, Journal of Biological Chemistry.

Monomeric rhodopsin is the minimal functional unit required for arrestin binding.

Abhinav Sinha, M. DeWitt, H. Tsukamoto, 2010, Journal of molecular biology.

Surface enhanced resonance Raman scattering (SERRS) as a probe of the structural differences between the Pr and Pfr forms of phytochrome

P. Song, T. Cotton, D. Farrens, 1989, FEBS letters.

Dynamics of Arrestin-Rhodopsin Interactions

W. Smith, Martha E. Sommer, D. Farrens, 2006, Journal of Biological Chemistry.

Surface-enhanced resonance Raman scattering spectroscopy applied to phytochrome and its model compounds. 1. Biliverdin photoisomers

P. Song, T. Cotton, R. E. Holt, 1989 .

Rhodopsin self-associates in asolectin liposomes.

K. Palczewski, D. Farrens, S. E. Mansoor, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Fluorescence spectroscopy of rhodopsins: insights and approaches.

U. Alexiev, D. Farrens, 2014, Biochimica et biophysica acta.

The Enzymatic Activity of Lipases Correlates with Polarity-Induced Conformational Changes: A Trp-Induced Quenching Fluorescence Study.

J. Vind, A. Svendsen, M. Bjerrum, 2015, Biochemistry.

Structural dynamics and energetics underlying allosteric inactivation of the cannabinoid receptor CB1

D. Farrens, J. Fay, 2015, Proceedings of the National Academy of Sciences.

A Key Agonist-induced Conformational Change in the Cannabinoid Receptor CB1 Is Blocked by the Allosteric Ligand Org 27569*

D. Farrens, J. Fay, 2012, The Journal of Biological Chemistry.

Assessing structural elements that influence Schiff base stability: mutants E113Q and D190N destabilize rhodopsin through different mechanisms

D. Farrens, J. Janz, Jay M. Janz, 2003, Vision Research.

Site-Selected Chromophore Oxidation of Phytochrome with Tetranitromethane

P. Song, W. Rüdiger, D. Farrens, 1989 .

Dynamics of Arrestin-Rhodopsin Interactions

W. Smith, J. Mcdowell, Martha E. Sommer, 2007, Journal of Biological Chemistry.

Structure and Function in Rhodopsin

H. Khorana, D. Farrens, G. Khorana, 1995, The Journal of Biological Chemistry.

Arrestin can act as a regulator of rhodopsin photochemistry

Martha E. Sommer, D. Farrens, 2006, Vision Research.

Structure of a Signaling Cannabinoid Receptor 1-G Protein Complex

Ron O. Dror, Brian K. Kobilka, Naomi R. Latorraca, 2019, Cell.

The conformations of the manganese transport regulator of Bacillus subtilis in its metal-free state.

R. Brennan, J. I. Kliegman, J. Helmann, 2007, Journal of molecular biology.

Functionally Different Agonists Induce Distinct Conformations in the G Protein Coupling Domain of the β2Adrenergic Receptor*

P Ghanouni, J. Lakowicz, B. Kobilka, 2001, The Journal of Biological Chemistry.

Mapping proximity within proteins using fluorescence spectroscopy. A study of T4 lysozyme showing that tryptophan residues quench bimane fluorescence.

H. Mchaourab, D. Farrens, S. E. Mansoor, 2002, Biochemistry.

Determination of protein secondary structure and solvent accessibility using site-directed fluorescence labeling. Studies of T4 lysozyme using the fluorescent probe monobromobimane.

H. Mchaourab, D. Farrens, S. E. Mansoor, 1999, Biochemistry.

Coupling ligand structure to specific conformational switches in the β2-adrenoceptor

Xavier Deupi, B. Kobilka, X. Deupí, 2006, Nature chemical biology.

Nanoscale high-content analysis using compositional heterogeneities of single proteoliposomes

Sune M. Christensen, S. Rasmussen, B. Kobilka, 2014, Nature Methods.

Functional independence of endogenous μ- and δ-opioid receptors co-expressed in cholinergic interneurons

D. Farrens, S. Arttamangkul, E. Platt, 2021, bioRxiv.

Distance Mapping in Proteins Using Fluorescence Spectroscopy: Tyrosine, like Tryptophan, Quenches Bimane Fluorescence in a Distance-Dependent Manner

D. Farrens, Amber M. Jones Brunette, 2014, Biochemistry.

A Constitutively Activating Mutation Alters the Dynamics and Energetics of a Key Conformational Change in a Ligand-free G Protein-coupled Receptor*

H. Tsukamoto, D. Farrens, 2013, The Journal of Biological Chemistry.

Dynamics of Arrestin-Rhodopsin Interactions

W. Smith, Martha E. Sommer, D. Farrens, 2005, Journal of Biological Chemistry.

Bacterial Mode of Replication with Eukaryotic-Like Machinery in a Hyperthermophilic Archaeon

O. Lichtarge, H. Bourne, C. Altenbach, 2000 .

Conformational Selection and Equilibrium Governs the Ability of Retinals to Bind Opsin*

D. Farrens, Christopher T. Schafer, 2014, The Journal of Biological Chemistry.

Hydrophobic amino acids in the retinal-binding pocket of bacteriorhodopsin.

S. Subramaniam, H. Khorana, D. Farrens, 1993, The Journal of biological chemistry.

The Magnitude of the Light-induced Conformational Change in Different Rhodopsins Correlates with Their Ability to Activate G Proteins*

A. Terakita, M. Koyanagi, H. Tsukamoto, 2009, The Journal of Biological Chemistry.

Retinal Attachment Instability Is Diversified among Mammalian Melanopsins*

Y. Kubo, A. Terakita, M. Koyanagi, 2015, The Journal of Biological Chemistry.

Rhodopsin Activation Exposes a Key Hydrophobic Binding Site for the Transducin α-Subunit C Terminus*

D. Farrens, J. Janz, 2004, Journal of Biological Chemistry.

Novel fluorescent GPCR biosensor detects retinal equilibrium binding to opsin and active G protein and arrestin signaling conformations.

D. Farrens, Christopher T. Schafer, Anthony Shumate, 2020, The Journal of biological chemistry.

Evidence that the Rhodopsin Kinase (GRK1) N-Terminus and the Transducin Gα C-Terminus Interact with the Same "Hydrophobic Patch" on Rhodopsin TM5.

Abhinav Sinha, L. David, D. Farrens, 2016, Biochemistry.

Single Proteoliposome High-Content Analysis Reveals Differences in the Homo-Oligomerization of GPCRs.

Sune M. Christensen, S. Rasmussen, B. Kobilka, 2018, Biophysical journal.

Domains Responsible for Constitutive and Ca2+-Dependent Interactions between Calmodulin and Small Conductance Ca2+-Activated Potassium Channels

A. Janowsky, B. Fakler, J. Adelman, 1999, The Journal of Neuroscience.

The membrane proximal region of the cannabinoid receptor CB1 N-terminus can allosterically modulate ligand affinity.

D. Farrens, J. Fay, 2013, Biochemistry.

High-throughput protein structural analysis using site-directed fluorescence labeling and the bimane derivative (2-pyridyl)dithiobimane.

D. Farrens, Steven E Mansoor, David L Farrens, 2004, Biochemistry.

SUBNANOSECOND SINGLE PHOTON TIMING MEASUREMENTS USING A PULSED DIODE‐LASER *

P. Song, D. Farrens, 1991, Photochemistry and photobiology.

Conformational Changes in Rhodopsin

D. Farrens, T. Dunham, David L. Farrens, 1999, The Journal of Biological Chemistry.

Conformational Selection and Equilibrium Governs the Ability of Retinals to Bind Opsin*

D. Farrens, Christopher T. Schafer, 2014, The Journal of Biological Chemistry.

The Enzymatic Activity of Lipases Correlates with Polarity-Induced Conformational Changes: A Trp-Induced Quenching Fluorescence Study.

J. Vind, A. Svendsen, M. Bjerrum, 2015, Biochemistry.

THE DISTANCE BETWEEN THE PHYTOCHROME CHROMOPHORE AND THE N‐TERMINAL CHAIN DECREASES DURING PHOTOTRANSFORMATION. A NOVEL FLUORESCENCE ENERGY TRANSFER METHOD USING LABELED ANTIBODY FRAGMENTS

P. Song, L. Pratt, D. Farrens, 1992, Photochemistry and photobiology.

Design, expression, and characterization of a synthetic human cannabinoid receptor and cannabinoid receptor/ G-protein fusion protein.

B. Nauert, D. Farrens, J. Fay, 2002, The journal of peptide research : official journal of the American Peptide Society.

Retinal Attachment Instability Is Diversified among Mammalian Melanopsins*

Y. Kubo, A. Terakita, M. Koyanagi, 2015, The Journal of Biological Chemistry.

Contributions of H G Khorana to understanding transmembrane signal transduction

T. Sakmar, D. Farrens, 2012, Resonance.

Structure and function in rhodopsin. Cysteines 65 and 316 are in proximity in a rhodopsin mutant as indicated by disulfide formation and interactions between attached spin labels.

H. Khorana, C. Altenbach, D. Farrens, 1996, Biochemistry.

A rapid, tag-free way to purify functional GPCRs

D. Farrens, Anthony D. Shumate, 2023, The Journal of biological chemistry.

Site-Directed Fluorescence Labeling (SDFL): TrIQ Methods Provide Insights Using the Fluorescent Probe Bimane

D. Farrens, Anthony D. Shumate, 2023, Applied Magnetic Resonance.

Purification of Functional CB1 and Analysis by Site-Directed Fluorescence Labeling Methods.

D. Farrens, J. Fay, 2017, Methods in enzymology.