S. Noble

发表

GABAB receptors function as a heteromeric assembly of the subunits GABABR1 and GABABR2

Kenneth A. Jones, Beth Borowsky, B. Borowsky, 1998, Nature.

Benzothiophene containing Rho kinase inhibitors: Efficacy in an animal model of glaucoma.

A. Shiau, A. Clark, R. L. Davis, 2010, Bioorganic & medicinal chemistry letters.

N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 1. Discovery of a novel series of potent antihyperglycemic and antihyperlipidemic agents.

J. Lehmann, T. Willson, S. Kliewer, 1998, Journal of medicinal chemistry.

A novel N-aryl tyrosine activator of peroxisome proliferator-activated receptor-gamma reverses the diabetic phenotype of the Zucker diabetic fatty rat.

J. Lehmann, T. Willson, S. Kliewer, 1999, Diabetes.

Synthesis of oligodeoxynucleotides and oligodeoxynucleotide analogs using phosphoramidite intermediates

M. Caruthers, L. Mcbride, M. Dorman, 1984 .

Impact of biophysical parameters on the biological assessment of peptide nucleic acids, antisense inhibitors of gene expression

S. Brown, L. Babiss, J. Bisi, 1995 .

The synthesis and antiviral activity of 4-fluoro-1-beta-D-ribofuranosyl-1H-pyrazole-3-carboxamide.

C. J. Ashton, M. Hann, J. M. Woods, 1999, Nucleosides & nucleotides.

Synthesis and SAR of 2-aryl-3-aminomethylquinolines as agonists of the bile acid receptor TGR5.

T. Rao, A. Shiau, L. Staszewski, 2010, Bioorganic & medicinal chemistry letters.

The Resolution and Absolute Stereochemistry of the Enantiomers of cis-1-[2-(Hydroxymethyl)-1,3-oxathiolan-5-yl)cytosine (BCH189): Equipotent Anti-HIV Agents

R. Storer, S. Noble, B. Belleau, 1993 .

Synthesis and SAR of thiophene containing kinesin spindle protein (KSP) inhibitors.

T. Z. Hoffman, A. Shiau, D. Severance, 2007, Bioorganic & medicinal chemistry letters.

Pharmacological Characterization of KLYP961, a Dual Inhibitor of Inducible and Neuronal Nitric-Oxide Synthases

Nahid M. Yazdani, T. Rao, A. Shiau, 2011, Journal of Pharmacology and Experimental Therapeutics.

Enantiospecific synthesis of 3′-hetero-dideoxy nucleoside analogues as potential anti-HIV agents

R. Storer, S. Noble, M. Jones, 1992 .

Modulateurs quinazolinones de tgr5

T. Z. Hoffman, S. Noble, Anthony B. Pinkerton, 2007 .

Synthesis of some mimics of nucleoside triphosphates

M. Peel, D. Coe, R. Storer, 1991 .

Discovery of Lu AA33810: a highly selective and potent NPY5 antagonist with in vivo efficacy in a model of mood disorder.

O. Wiborg, W. Wong, M. Walker, 2011, Bioorganic & medicinal chemistry letters.

Synthesis and Biological Evaluation of Carbocyclic Analogues of Ribavirin

J. M. Woods, C. Penn, R. Storer, 1991 .

Discovery of dual inducible/neuronal nitric oxide synthase (iNOS/nNOS) inhibitor development candidate 4-((2-cyclobutyl-1H-imidazo[4,5-b]pyrazin-1-yl)methyl)-7,8-difluoroquinolin-2(1H)-one (KD7332) part 2: identification of a novel, potent, and selective series of benzimidazole-quinolinone iNOS/nNOS

Nahid M. Yazdani, T. Rao, A. Shiau, 2010, Journal of medicinal chemistry.

KD5170, a novel mercaptoketone-based histone deacetylase inhibitor that exhibits broad spectrum antitumor activity in vitro and in vivo

A. Saven, T. Rao, J. Malecha, 2008, Molecular Cancer Therapeutics.

Alpha-mercaptoketone based histone deacetylase inhibitors.

J. Malecha, T. Z. Hoffman, B. Wiley, 2008, Bioorganic & medicinal chemistry letters.

Identification of KD5170: a novel mercaptoketone-based histone deacetylase inhibitor.

T. Rao, J. Malecha, T. Z. Hoffman, 2008, Bioorganic & medicinal chemistry letters.

Discovery of inducible nitric oxide synthase (iNOS) inhibitor development candidate KD7332, part 1: Identification of a novel, potent, and selective series of quinolinone iNOS dimerization inhibitors that are orally active in rodent pain models.

Nahid M. Yazdani, J. Walsh, T. Rao, 2009, Journal of medicinal chemistry.

Synthesis and antiviral properties of some 2'-deoxy-5-(fluoroalkenyl)uridines.

R. T. Walker, S. Noble, P. Coe, 1982, Journal of medicinal chemistry.

3-arylimino-2-indolones are potent and selective galanin GAL3 receptor antagonists.

T. Blackburn, B. Lagu, H. Akunne, 2006, Journal of medicinal chemistry.

Novel 1,3-disubstituted-5,10-dihydro-5,10-dioxo-1H-benzo[g] isochromene-3 carboxamides as potent antitumor agents.

G. Attardo, R. Milburn, M. Luzzio, 1998, Bioorganic & medicinal chemistry letters.

Heteroaromatic-aminomethyl quinolones: potent and selective iNOS inhibitors.

Nahid M. Yazdani, T. Rao, A. Shiau, 2012, Bioorganic & medicinal chemistry letters.

Fmoc mediated synthesis of Peptide Nucleic Acids

R. Wiethe, S. A. Thomson, D. Ricca, 1995 .

Tetrahydrothiophene nucleosides as potential anti-HIV agents

R. Storer, S. Noble, M. Jones, 1991 .

Probing structural factors stabilizing antisense oligonucleotide duplexes: NMR studies of a DNA.DNA duplex containing a formacetal linkage.

N Bischofberger, F. Brown, K. Lin, 1992, Biochemistry.

Methylphosphonates as probes of protein-nucleic acid interactions.

M. Caruthers, E. Fisher, S. Noble, 1984, Nucleic acids research.

Tetrahydrothiophene Nucleosides as Potential anti-HIV Agents.

R. Storer, S. Noble, M. Jones, 1991 .

Inhibition of Inducible Nitric Oxide Synthase Expression by a Novel Small Molecule Activator of the Unfolded Protein Response

T. Rao, A. Shiau, C. Hassig, 2008, Current chemical genomics.

Water-soluble PDE4 inhibitors for the treatment of dry eye.

Jasmine Chen, J. Yanni, J. Malecha, 2010, Bioorganic & Medicinal Chemistry Letters.

KD 5170 , a novel mercaptoketone-based histone deacetylase inhibitor that exhibits broad spectrum antitumor activity in vitro and in vivo

A. Saven, T. Rao, J. Malecha, 2008 .

Expression of atrial natriuretic factor as a cleavable fusion protein with chloramphenicol acetyltransferase in Escherichia coli.

C. Dykes, S. Noble, A. Hobden, 1988, European journal of biochemistry.

Strand-invasion of duplex DNA by peptide nucleic acid oligomers.

L E Babiss, L. Babiss, J. Bisi, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Synthesis and structure-activity relationship of fluoro analogues of 8-{2-[4-(4-methoxyphenyl)piperazin-1yl]ethyl}-8-azaspiro[4.5]decane-7,9-dione as selective alpha(1d)-adrenergic receptor antagonists.

D. Craig, S. Noble, C. Gluchowski, 2005, Journal of medicinal chemistry.

GABA(B) receptors function as a heteromeric assembly of the subunits GABA(B)R1 and GABA(B)R2.

B. Borowsky, T. Branchek, D. Craig, 1998, Nature.

Novel 1,3-Disubstituted-5,10-dihydro-5,10-dioxo-1H-benzo [g]isochromene-3-carboxamides as Potent Antitumor Agents.

Tiechao Li, G. Attardo, R. Milburn, 2010 .

Synthesis and Cloning of a Gene Encoding Human Interleukin-1β (IL-1β)

C. Dykes, S. Noble, M. Mitchell, 1987 .

Synthesis and anti-HIV-1 activity of a series of imidazo[1,5-b]pyridazines.

M. Hann, D. Green, R. Bethell, 1993, Journal of medicinal chemistry.

Synthesis and anti‐HIV‐1 Activity of a Series of Imidazo(1,5‐b) pyridazines.

T. Willson, M. Hann, D. Green, 1994 .

Altered Cro repressors from engineered mutagenesis of a synthetic cro gene.

M. Caruthers, L. Bracco, D. Dodds, 1985, Proceedings of the National Academy of Sciences of the United States of America.

Synthesis and SAR of 2-aryl-3-aminomethylquinolines as agonists of the bile acid receptor TGR5.

T. Rao, A. Shiau, L. Staszewski, 2010, Bioorganic & Medicinal Chemistry Letters.